{"id":"https://openalex.org/W2072235136","doi":"https://doi.org/10.1002/cber.19841170421","title":"Amination, III. Trimethylsilanol as Leaving Group, V. Silylation\u2014Amination of Hydroxy N\u2010Heterocycles","display_name":"Amination, III. Trimethylsilanol as Leaving Group, V. Silylation\u2014Amination of Hydroxy N\u2010Heterocycles","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W2072235136","doi":"https://doi.org/10.1002/cber.19841170421","mag":"2072235136"},"language":"en","primary_location":{"id":"doi:10.1002/cber.19841170421","doi":"https://doi.org/10.1002/cber.19841170421","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cber.19841170421","pdf_url":null,"source":{"id":"https://openalex.org/S4210215837","display_name":"Chemische Berichte","issn_l":"0009-2940","issn":["0009-2940"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemische Berichte","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111576684","display_name":"Helmut Vorbr\u00fcggen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Helmut Vorbr\u00fcggen","raw_affiliation_strings":["Research Laboratories, Schering Aktiengesellschaft, P.O. Box 650311, D-1000 Berlin 65, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Schering Aktiengesellschaft, P.O. Box 650311, D-1000 Berlin 65, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046764052","display_name":"Konrad Krolikiewicz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konrad Krolikiewicz","raw_affiliation_strings":["Research Laboratories, Schering Aktiengesellschaft, P.O. Box 650311, D-1000 Berlin 65, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Schering Aktiengesellschaft, P.O. Box 650311, D-1000 Berlin 65, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111576684"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7772,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.89580038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"117","issue":"4","first_page":"1523","last_page":"1541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11441","display_name":"Organoboron and organosilicon chemistry","score":0.46000000834465027,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11441","display_name":"Organoboron and organosilicon chemistry","score":0.46000000834465027,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.17299999296665192,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11831","display_name":"Chemical Synthesis and Reactions","score":0.11900000274181366,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amination","display_name":"amination","score":0.8759999871253967},{"id":"https://openalex.org/keywords/silylation","display_name":"silylation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/trimethylsilanol","display_name":"trimethylsilanol","score":0.8569999933242798},{"id":"https://openalex.org/keywords/leaving-groups","display_name":"leaving groups","score":0.6700000166893005},{"id":"https://openalex.org/keywords/lewis-acid-catalysis","display_name":"Lewis acid catalysis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hexamethyldisiloxane","display_name":"hexamethyldisiloxane","score":0.8600000143051147},{"id":"https://openalex.org/keywords/in-situ-reaction","display_name":"in situ reaction","score":0.36399999260902405},{"id":"https://openalex.org/keywords/one-pot-synthesis","display_name":"one-pot synthesis","score":0.6330000162124634},{"id":"https://openalex.org/keywords/amines","display_name":"amines","score":0.47999998927116394},{"id":"https://openalex.org/keywords/heterocycle-functionalization","display_name":"heterocycle functionalization","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9656405448913574},{"id":"https://openalex.org/C5304478","wikidata":"https://www.wikidata.org/wiki/Q502457","display_name":"Silylation","level":3,"score":0.9243241548538208},{"id":"https://openalex.org/C198503264","wikidata":"https://www.wikidata.org/wiki/Q471635","display_name":"Amination","level":3,"score":0.9037262201309204},{"id":"https://openalex.org/C2776551725","wikidata":"https://www.wikidata.org/wiki/Q419440","display_name":"Hexamethyldisiloxane","level":3,"score":0.8191659450531006},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.6056703329086304},{"id":"https://openalex.org/C2779938440","wikidata":"https://www.wikidata.org/wiki/Q549876","display_name":"Reductive amination","level":3,"score":0.5773287415504456},{"id":"https://openalex.org/C2781056017","wikidata":"https://www.wikidata.org/wiki/Q410243","display_name":"Morpholine","level":2,"score":0.5713123679161072},{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.5281001925468445},{"id":"https://openalex.org/C2776382133","wikidata":"https://www.wikidata.org/wiki/Q4087","display_name":"Ammonia","level":2,"score":0.44892945885658264},{"id":"https://openalex.org/C163638829","wikidata":"https://www.wikidata.org/wiki/Q900337","display_name":"Lewis acids and bases","level":3,"score":0.4450593590736389},{"id":"https://openalex.org/C160964918","wikidata":"https://www.wikidata.org/wiki/Q320141","display_name":"Leaving group","level":3,"score":0.41035011410713196},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.37939950823783875},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.37861210107803345},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/cber.19841170421","doi":"https://doi.org/10.1002/cber.19841170421","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cber.19841170421","pdf_url":null,"source":{"id":"https://openalex.org/S4210215837","display_name":"Chemische Berichte","issn_l":"0009-2940","issn":["0009-2940"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemische Berichte","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W103704794","https://openalex.org/W169026698","https://openalex.org/W420218503","https://openalex.org/W607527786","https://openalex.org/W1966649585","https://openalex.org/W1968169577","https://openalex.org/W1968976569","https://openalex.org/W1981527198","https://openalex.org/W1987324198","https://openalex.org/W1996666213","https://openalex.org/W1997734813","https://openalex.org/W2011248143","https://openalex.org/W2016037544","https://openalex.org/W2018289933","https://openalex.org/W2019036660","https://openalex.org/W2043822176","https://openalex.org/W2044648680","https://openalex.org/W2046298210","https://openalex.org/W2053501473","https://openalex.org/W2054378658","https://openalex.org/W2057773059","https://openalex.org/W2064126469","https://openalex.org/W2066040099","https://openalex.org/W2069976049","https://openalex.org/W2087719314","https://openalex.org/W2089839476","https://openalex.org/W2095434156","https://openalex.org/W2095466072","https://openalex.org/W2102277053","https://openalex.org/W2147246228","https://openalex.org/W2156268260","https://openalex.org/W2165786297","https://openalex.org/W2167442302","https://openalex.org/W2204195482","https://openalex.org/W2313359191","https://openalex.org/W2314635099","https://openalex.org/W2315059649","https://openalex.org/W2320540329","https://openalex.org/W2326377376","https://openalex.org/W2327824094","https://openalex.org/W2328661431","https://openalex.org/W2330851308","https://openalex.org/W2331817865","https://openalex.org/W2396700340","https://openalex.org/W2410298625","https://openalex.org/W3147233384","https://openalex.org/W4230381919","https://openalex.org/W4230397167","https://openalex.org/W4239007437","https://openalex.org/W4241867810"],"related_works":["https://openalex.org/W2950521176","https://openalex.org/W2079805179","https://openalex.org/W4251518578","https://openalex.org/W2606807349","https://openalex.org/W105036265","https://openalex.org/W2041463748","https://openalex.org/W1982043391","https://openalex.org/W2054378658","https://openalex.org/W2952091504","https://openalex.org/W2329665157"],"abstract_inverted_index":{"Abstract":[0],"Hydroxy":[1],"N\u2010heterocycles":[2,30],"such":[3],"as":[4],"18,":[5],"21,":[6],"26,":[7],"and":[8,33,71,93],"others":[9],"are":[10,99],"efficiently":[11],"aminated":[12],"in":[13,42,68,74,84],"a":[14],"one\u2010step/one\u2010pot":[15],"procedure":[16,98],"by":[17,86],"silylation\u2010amination":[18],"to":[19,50,65],"give":[20],"20,":[21],"23":[22],"\u2013":[23],"25":[24],"etc.":[25],"Silylation":[26],"converts":[27],"aromatic":[28],"hydroxy":[29],"into":[31,90],"activated":[32],"lipophilic":[34],"intermediates":[35],"of":[36,63,95],"type":[37],"3,":[38],"8":[39],"which":[40],"react":[41],"situ":[43,85],"with":[44],"ammonia,":[45],"primary":[46],"or":[47,56],"secondary":[48],"amines":[49,64],"form":[51],"the":[52,78],"corresponding":[53],"mono\u2010,":[54],"bis\u2010":[55],"tris\u2010aminated":[57],"products":[58],"(5,":[59],"10).":[60],"This":[61],"addition\u2010elimination":[62],"O\u2010silylated":[66],"heterocycles":[67],"Lewis":[69],"acid\u2010catalyzed":[70],"proceeds":[72],"usually":[73],"high":[75],"yields":[76],"if":[77],"leaving":[79],"group":[80],"trimethylsilanol":[81],"is":[82],"converted":[83],"excess":[87],"silylated":[88],"agent":[89],"hexamethyldisiloxane.":[91],"Scope":[92],"limitations":[94],"this":[96],"simple":[97],"discussed.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}