{"id":"https://openalex.org/W2072228040","doi":"https://doi.org/10.1074/jbc.m111.278598","title":"Hyaluronan Synthase 2 (HAS2) Promotes Breast Cancer Cell Invasion by Suppression of Tissue Metalloproteinase Inhibitor 1 (TIMP-1)","display_name":"Hyaluronan Synthase 2 (HAS2) Promotes Breast Cancer Cell Invasion by Suppression of Tissue Metalloproteinase Inhibitor 1 (TIMP-1)","publication_year":2011,"publication_date":"2011-10-21","ids":{"openalex":"https://openalex.org/W2072228040","doi":"https://doi.org/10.1074/jbc.m111.278598","mag":"2072228040","pmid":"https://pubmed.ncbi.nlm.nih.gov/22016393","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3234988"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.278598","doi":"https://doi.org/10.1074/jbc.m111.278598","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.278598","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m111.278598","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024590935","display_name":"Berit Olofsson","orcid":"https://orcid.org/0009-0009-0602-2183","observed_orcids":["https://orcid.org/0009-0009-0602-2183"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I4210133710","display_name":"Ludwig Cancer Research","ror":"https://ror.org/03gvptg28","country_code":"SE","type":"nonprofit","lineage":["https://openalex.org/I4210133710","https://openalex.org/I4210150094"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Berit Bernert","raw_affiliation_strings":["Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE-75124 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE-75124 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I4210133710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037392268","display_name":"Helena Porsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I4210133710","display_name":"Ludwig Cancer Research","ror":"https://ror.org/03gvptg28","country_code":"SE","type":"nonprofit","lineage":["https://openalex.org/I4210133710","https://openalex.org/I4210150094"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Helena Porsch","raw_affiliation_strings":["Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE-75124 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE-75124 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I4210133710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073348686","display_name":"Paraskevi Heldin","orcid":"https://orcid.org/0000-0002-6753-6294","observed_orcids":["https://orcid.org/0000-0002-6753-6294"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I4210133710","display_name":"Ludwig Cancer Research","ror":"https://ror.org/03gvptg28","country_code":"SE","type":"nonprofit","lineage":["https://openalex.org/I4210133710","https://openalex.org/I4210150094"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Paraskevi Heldin","raw_affiliation_strings":["Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE-75124 Uppsala, Sweden. Electronic address: evi.heldin@licr.uu.se","Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE-75124 Uppsala, Sweden. Electronic address:"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE-75124 Uppsala, Sweden. Electronic address: evi.heldin@licr.uu.se","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I4210133710"]},{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE-75124 Uppsala, Sweden. Electronic address:","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I4210133710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073348686"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I4210133710"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.2511,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.91915112,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"286","issue":"49","first_page":"42349","last_page":"42359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronan-synthase-2","display_name":"HAS2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/breast-cancer-invasion","display_name":"breast cancer invasion","score":0.7599999904632568},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.925000011920929},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.7279999852180481},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.859000027179718},{"id":"https://openalex.org/keywords/egf-signaling","display_name":"EGF signaling","score":0.7419999837875366},{"id":"https://openalex.org/keywords/basement-membrane-remodeling","display_name":"basement membrane remodeling","score":0.8920000195503235},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6820544600486755},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5899525880813599},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5192318558692932},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4748033583164215},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4745657742023468},{"id":"https://openalex.org/C2775965246","wikidata":"https://www.wikidata.org/wiki/Q4531845","display_name":"Tissue inhibitor of metalloproteinase","level":3,"score":0.46291524171829224},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44128337502479553},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.43617942929267883},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.4242137670516968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41738420724868774},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36017847061157227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35855942964553833},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35099101066589355},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.32331186532974243},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26310136914253235},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2576611042022705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23004141449928284},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.09055563807487488},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076002","descriptor_name":"Hyaluronan Synthases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016695","descriptor_name":"Glycosyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m111.278598","doi":"https://doi.org/10.1074/jbc.m111.278598","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.278598","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2518485","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3234988","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3234988","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3234988","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:22016393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22016393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.278598","doi":"https://doi.org/10.1074/jbc.m111.278598","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.278598","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320330412","display_name":"Scheme for Promotion of Academic and Research Collaboration","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W32471076","https://openalex.org/W335121520","https://openalex.org/W1488596745","https://openalex.org/W1489124662","https://openalex.org/W1493591863","https://openalex.org/W1552896374","https://openalex.org/W1557915717","https://openalex.org/W1603168304","https://openalex.org/W1710368740","https://openalex.org/W1729105152","https://openalex.org/W1979452780","https://openalex.org/W1984021937","https://openalex.org/W1985727076","https://openalex.org/W1986424092","https://openalex.org/W1987759181","https://openalex.org/W1990917414","https://openalex.org/W1993424211","https://openalex.org/W1999410927","https://openalex.org/W2003500892","https://openalex.org/W2004124116","https://openalex.org/W2008678914","https://openalex.org/W2008835126","https://openalex.org/W2010254599","https://openalex.org/W2013082155","https://openalex.org/W2014915378","https://openalex.org/W2016799783","https://openalex.org/W2017185391","https://openalex.org/W2027275036","https://openalex.org/W2030605936","https://openalex.org/W2037348497","https://openalex.org/W2037632318","https://openalex.org/W2043362010","https://openalex.org/W2045462226","https://openalex.org/W2047533360","https://openalex.org/W2047879184","https://openalex.org/W2052015840","https://openalex.org/W2052715441","https://openalex.org/W2054920879","https://openalex.org/W2059174198","https://openalex.org/W2061413060","https://openalex.org/W2061444420","https://openalex.org/W2063392635","https://openalex.org/W2063795678","https://openalex.org/W2064518643","https://openalex.org/W2067014191","https://openalex.org/W2067474105","https://openalex.org/W2071055382","https://openalex.org/W2071919220","https://openalex.org/W2074454757","https://openalex.org/W2075075502","https://openalex.org/W2084092470","https://openalex.org/W2085633191","https://openalex.org/W2093105418","https://openalex.org/W2103575733","https://openalex.org/W2109958848","https://openalex.org/W2112327424","https://openalex.org/W2112781551","https://openalex.org/W2113852915","https://openalex.org/W2115810495","https://openalex.org/W2128466784","https://openalex.org/W2144801666","https://openalex.org/W2145533255","https://openalex.org/W2148525194","https://openalex.org/W2152709198","https://openalex.org/W2153420545","https://openalex.org/W2159141617","https://openalex.org/W2159365419","https://openalex.org/W2171935083","https://openalex.org/W2803499602"],"related_works":["https://openalex.org/W3158542408","https://openalex.org/W2014915378","https://openalex.org/W2409378722","https://openalex.org/W1999410927","https://openalex.org/W2113431340","https://openalex.org/W2026608758","https://openalex.org/W1532810827","https://openalex.org/W1992804143","https://openalex.org/W4229716791","https://openalex.org/W260326945"],"abstract_inverted_index":{"Invasion":[0],"and":[1,11,120],"metastasis":[2],"are":[3],"the":[4,15,44,105,112,152,156],"primary":[5],"causes":[6],"of":[7,27,41,48,51,92,101,108,114,122,129,144,149,155],"breast":[8,30,52,175],"cancer":[9,53,176],"mortality,":[10],"increased":[12,90],"knowledge":[13],"about":[14],"molecular":[16],"mechanisms":[17],"involved":[18],"in":[19,29,43,65],"these":[20,109],"processes":[21],"is":[22],"highly":[23],"desirable.":[24],"High":[25],"levels":[26],"hyaluronan":[28,42,93],"tumors":[31],"have":[32],"been":[33],"correlated":[34],"with":[35,83,139],"poor":[36],"patient":[37],"survival.":[38],"The":[39,70],"involvement":[40],"early":[45],"invasive":[46,106],"phase":[47],"a":[49,77,169],"clone":[50],"cell":[54],"line":[55],"MDA-MB-231":[56,84],"that":[57,99],"forms":[58],"bone":[59,73],"metastases":[60],"was":[61,133],"studied":[62],"using":[63],"an":[64,89],"vivo-like":[66],"basement":[67,130],"membrane":[68,131],"model.":[69],"metastatic":[71],"to":[72,88],"tumor":[74],"cells":[75,85,110],"exhibited":[76],"7-fold":[78],"higher":[79],"hyaluronan-synthesizing":[80],"capacity":[81],"compared":[82],"predominately":[86],"due":[87],"expression":[91],"synthase":[94],"2":[95],"(HAS2).":[96],"We":[97],"found":[98],"knockdown":[100,148],"HAS2":[102,126,136,150,173],"completely":[103],"suppressed":[104,151],"capability":[107],"by":[111,135],"induction":[113,154],"tissue":[115],"metalloproteinase":[116],"inhibitor":[117],"1":[118],"(TIMP-1)":[119],"dephosphorylation":[121],"focal":[123,157],"adhesion":[124,158],"kinase.":[125],"knockdown-mediated":[127],"inhibition":[128],"remodeling":[132],"rescued":[134],"overexpression,":[137],"transfection":[138],"TIMP-1":[140],"siRNA,":[141],"or":[142],"addition":[143],"TIMP-1-blocking":[145],"antibodies.":[146],"Moreover,":[147],"EGF-mediated":[153],"kinase/PI3K/Akt":[159],"signaling":[160],"pathway.":[161],"Thus,":[162],"this":[163],"study":[164],"provides":[165],"new":[166],"insights":[167],"into":[168],"possible":[170],"mechanism":[171],"whereby":[172],"enhances":[174],"invasion.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}