{"id":"https://openalex.org/W2072225145","doi":"https://doi.org/10.4997/jrcpe.2009.425","title":"Statins: in the beginning","display_name":"Statins: in the beginning","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2072225145","doi":"https://doi.org/10.4997/jrcpe.2009.425","mag":"2072225145","pmid":"https://pubmed.ncbi.nlm.nih.gov/20509462"},"language":"en","primary_location":{"id":"doi:10.4997/jrcpe.2009.425","doi":"https://doi.org/10.4997/jrcpe.2009.425","is_oa":true,"landing_page_url":"https://doi.org/10.4997/jrcpe.2009.425","pdf_url":"https://doi.org/10.4997/jrcpe.2009.425","source":{"id":"https://openalex.org/S24543137","display_name":"The Journal of the Royal College of Physicians of Edinburgh","issn_l":"1478-2715","issn":["1478-2715","2042-8189"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Royal College of Physicians of Edinburgh","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.4997/jrcpe.2009.425","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113631233","display_name":"KS Lyons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"KS Lyons","raw_affiliation_strings":["Research Fellow, Department of Therapeutics and Pharmacology, Queen\u2019s University, Belfast","Department of Therapeutics and Pharmacology, Queen's University, Belfast. klyons01@qub.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Fellow, Department of Therapeutics and Pharmacology, Queen\u2019s University, Belfast","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"Department of Therapeutics and Pharmacology, Queen's University, Belfast. klyons01@qub.ac.uk","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072616845","display_name":"Mark Harbinson","orcid":"https://orcid.org/0000-0003-2186-4943","observed_orcids":["https://orcid.org/0000-0003-2186-4943"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]},{"id":"https://openalex.org/I1289110261","display_name":"Belfast Health and Social Care Trust","ror":"https://ror.org/02tdmfk69","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1289110261"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Harbinson","raw_affiliation_strings":["Senior Lecturer, Department of Therapeutics and Pharmacology, Queen\u2019s University, Belfast, and Consultant Cardiologist, Belfast Health and Social Care Trust, UK","School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Lecturer, Department of Therapeutics and Pharmacology, Queen\u2019s University, Belfast, and Consultant Cardiologist, Belfast Health and Social Care Trust, UK","institution_ids":["https://openalex.org/I126231945","https://openalex.org/I1289110261"]},{"raw_affiliation_string":"School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine","institution_ids":["https://openalex.org/I126231945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.423,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.67842055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"39","issue":"4","first_page":"362","last_page":"364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14275","display_name":"Historical Medical Research and Treatments","score":0.23909999430179596,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14475","display_name":"History of Science and Medicine","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":1.0},{"id":"https://openalex.org/keywords/history-of-drug-development","display_name":"drug development history","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cholesterol-lowering-drugs","display_name":"cholesterol-lowering drugs","score":0.7540000081062317},{"id":"https://openalex.org/keywords/history-of-pharmacology","display_name":"history of pharmacology","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C104950815","wikidata":"https://www.wikidata.org/wiki/Q415607","display_name":"HMG-CoA reductase","level":4,"score":0.6982359886169434},{"id":"https://openalex.org/C2910980524","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","level":3,"score":0.6812910437583923},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.5475883483886719},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5218157172203064},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.5160951018333435},{"id":"https://openalex.org/C2778176773","wikidata":"https://www.wikidata.org/wiki/Q2976049","display_name":"Drug class","level":3,"score":0.5087035298347473},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48009946942329407},{"id":"https://openalex.org/C2779123261","wikidata":"https://www.wikidata.org/wiki/Q407635","display_name":"Coenzyme A","level":4,"score":0.43673956394195557},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.42684346437454224},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4049069881439209},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24316948652267456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2137114405632019},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20434901118278503},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11213284730911255},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.093102365732193},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":true},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D049673","descriptor_name":"History, 20th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4997/jrcpe.2009.425","doi":"https://doi.org/10.4997/jrcpe.2009.425","is_oa":true,"landing_page_url":"https://doi.org/10.4997/jrcpe.2009.425","pdf_url":"https://doi.org/10.4997/jrcpe.2009.425","source":{"id":"https://openalex.org/S24543137","display_name":"The Journal of the Royal College of Physicians of Edinburgh","issn_l":"1478-2715","issn":["1478-2715","2042-8189"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Royal College of Physicians of Edinburgh","raw_type":"journal-article"},{"id":"pmid:20509462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20509462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of the Royal College of Physicians of Edinburgh","raw_type":"Biography"},{"id":"pmh:oai:pure.qub.ac.uk/portal:publications/d2e10868-85a1-4ce9-ad7e-e69a45f627dd","doi":null,"is_oa":false,"landing_page_url":"https://pure.qub.ac.uk/en/publications/d2e10868-85a1-4ce9-ad7e-e69a45f627dd","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lyons, K S & Harbinson, M 2009, 'Statins: in the beginning', Journal of the Royal College of Physicians of Edinburgh, vol. 39, no. 4, pp. 362-364.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2187103515","doi":null,"is_oa":false,"landing_page_url":"https://www.rcpe.ac.uk/sites/default/files/lyons_0.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.4997/jrcpe.2009.425","doi":"https://doi.org/10.4997/jrcpe.2009.425","is_oa":true,"landing_page_url":"https://doi.org/10.4997/jrcpe.2009.425","pdf_url":"https://doi.org/10.4997/jrcpe.2009.425","source":{"id":"https://openalex.org/S24543137","display_name":"The Journal of the Royal College of Physicians of Edinburgh","issn_l":"1478-2715","issn":["1478-2715","2042-8189"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Royal College of Physicians of Edinburgh","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3510296510","display_name":null,"funder_award_id":"EAT/3719/07","funder_id":"https://openalex.org/F4320320853","funder_display_name":"Public Health Agency"}],"funders":[{"id":"https://openalex.org/F4320320853","display_name":"Public Health Agency","ror":"https://ror.org/03ek62e72"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072225145.pdf","grobid_xml":"https://content.openalex.org/works/W2072225145.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1500847299","https://openalex.org/W1964836458","https://openalex.org/W1973491874","https://openalex.org/W1984531810","https://openalex.org/W1986675478","https://openalex.org/W1987126396","https://openalex.org/W2003741984","https://openalex.org/W2040604566","https://openalex.org/W2066281438","https://openalex.org/W2113540828","https://openalex.org/W2126287031","https://openalex.org/W2130760108","https://openalex.org/W2148463229","https://openalex.org/W2150500482","https://openalex.org/W2155598961","https://openalex.org/W2165524648","https://openalex.org/W2188271375","https://openalex.org/W4246764494"],"related_works":["https://openalex.org/W4235781447","https://openalex.org/W4225776398","https://openalex.org/W2516389605","https://openalex.org/W2934760560","https://openalex.org/W1500847299","https://openalex.org/W2115375853","https://openalex.org/W4402053554","https://openalex.org/W1986675478","https://openalex.org/W1675260112","https://openalex.org/W4405855226"],"abstract_inverted_index":{"Since":[0],"the":[1,15,45],"first":[2],"human":[3],"trial":[4],"of":[5,19,32],"a":[6],"hydroxymethylglutaryl-coenzyme":[7],"A":[8],"(HMG":[9],"CoA)":[10],"reductase":[11],"inhibitor":[12],"in":[13,17],"1978,":[14],"growth":[16],"importance":[18],"this":[20,33,39],"drug":[21,40],"class,":[22],"both":[23],"financially":[24],"and":[25],"medically,":[26],"has":[27],"been":[28],"staggering.":[29],"The":[30],"aim":[31],"paper":[34],"is":[35],"to":[36],"summarise":[37],"how":[38],"class":[41],"was":[42],"developed,":[43],"highlighting":[44],"role":[46],"ofAkira":[47],"Endo.":[48]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}