{"id":"https://openalex.org/W2072201455","doi":"https://doi.org/10.1021/ja801670v","title":"Synthetic Collagen Heterotrimers: Structural Mimics of Wild-Type and Mutant Collagen Type I","display_name":"Synthetic Collagen Heterotrimers: Structural Mimics of Wild-Type and Mutant Collagen Type I","publication_year":2008,"publication_date":"2008-05-16","ids":{"openalex":"https://openalex.org/W2072201455","doi":"https://doi.org/10.1021/ja801670v","mag":"2072201455","pmid":"https://pubmed.ncbi.nlm.nih.gov/18481852"},"language":"en","primary_location":{"id":"doi:10.1021/ja801670v","doi":"https://doi.org/10.1021/ja801670v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja801670v","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051098833","display_name":"Varun Gauba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Varun Gauba","raw_affiliation_strings":["Department of Chemistry and Department of Bioengineering, Rice University, 6100 Main Street, Mail Stop 60, Houston, Texas 77005","Department of Chemistry and Department of Bioengineering, Rice University, 6100 Main Street, Mail Stop 60, Houston, Texas 77005, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Bioengineering, Rice University, 6100 Main Street, Mail Stop 60, Houston, Texas 77005","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Chemistry and Department of Bioengineering, Rice University, 6100 Main Street, Mail Stop 60, Houston, Texas 77005, USA","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071074539","display_name":"Jeffrey D. Hartgerink","orcid":"https://orcid.org/0000-0002-3186-5395","observed_orcids":["https://orcid.org/0000-0002-3186-5395"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Hartgerink","raw_affiliation_strings":["Department of Chemistry and Department of Bioengineering, Rice University, 6100 Main Street, Mail Stop 60, Houston, Texas 77005"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Bioengineering, Rice University, 6100 Main Street, Mail Stop 60, Houston, Texas 77005","institution_ids":["https://openalex.org/I74775410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74775410"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.5948,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.96816512,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"130","issue":"23","first_page":"7509","last_page":"7515"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.04540000110864639,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9810000061988831},{"id":"https://openalex.org/keywords/heterotrimers","display_name":"heterotrimers","score":0.8259999752044678},{"id":"https://openalex.org/keywords/osteogenesis-imperfecta","display_name":"osteogenesis imperfecta","score":0.9919999837875366},{"id":"https://openalex.org/keywords/collagen-like-peptides","display_name":"collagen-like peptides","score":0.6629999876022339},{"id":"https://openalex.org/keywords/triple-helix","display_name":"triple helix","score":0.8420000076293945},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.5960000157356262},{"id":"https://openalex.org/keywords/thermal-stability","display_name":"thermal stability","score":0.7350000143051147},{"id":"https://openalex.org/keywords/model-systems","display_name":"model systems","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8784117698669434},{"id":"https://openalex.org/C10919887","wikidata":"https://www.wikidata.org/wiki/Q7843514","display_name":"Triple helix","level":2,"score":0.7924994230270386},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.6996527910232544},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.682976484298706},{"id":"https://openalex.org/C155181932","wikidata":"https://www.wikidata.org/wiki/Q24768908","display_name":"Collagen helix","level":3,"score":0.6600159406661987},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.554873526096344},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5266658663749695},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.5244008302688599},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.49734070897102356},{"id":"https://openalex.org/C2777668750","wikidata":"https://www.wikidata.org/wiki/Q749409","display_name":"Osteogenesis imperfecta","level":2,"score":0.49416330456733704},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.48382773995399475},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4745417535305023},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.441691130399704},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.43026331067085266},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.4228516221046448},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.4132276177406311},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.38648730516433716},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3733596205711365},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12530559301376343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010013","descriptor_name":"Osteogenesis Imperfecta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D040761","descriptor_name":"Biomimetic Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja801670v","doi":"https://doi.org/10.1021/ja801670v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja801670v","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:18481852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18481852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1551088059","https://openalex.org/W1964556609","https://openalex.org/W1969946367","https://openalex.org/W1972795725","https://openalex.org/W1975717636","https://openalex.org/W1979221090","https://openalex.org/W1981517018","https://openalex.org/W1981843090","https://openalex.org/W1985232050","https://openalex.org/W1991411742","https://openalex.org/W2002984839","https://openalex.org/W2003305541","https://openalex.org/W2004738770","https://openalex.org/W2008300542","https://openalex.org/W2013886278","https://openalex.org/W2015529161","https://openalex.org/W2021804512","https://openalex.org/W2026783024","https://openalex.org/W2026958540","https://openalex.org/W2030163251","https://openalex.org/W2035066110","https://openalex.org/W2043807000","https://openalex.org/W2045265652","https://openalex.org/W2045308367","https://openalex.org/W2051674637","https://openalex.org/W2055695196","https://openalex.org/W2062663556","https://openalex.org/W2066488767","https://openalex.org/W2067930179","https://openalex.org/W2093452004","https://openalex.org/W2102202837","https://openalex.org/W2111801168","https://openalex.org/W2121876863","https://openalex.org/W2138190502","https://openalex.org/W2144464679","https://openalex.org/W2145165079","https://openalex.org/W2773518039","https://openalex.org/W2954701605","https://openalex.org/W4230222460"],"related_works":["https://openalex.org/W2311911508","https://openalex.org/W2269601830","https://openalex.org/W2576209727","https://openalex.org/W2121876863","https://openalex.org/W2018069597","https://openalex.org/W2762231760","https://openalex.org/W4291001105","https://openalex.org/W1981843090","https://openalex.org/W1969489801","https://openalex.org/W2026783024"],"abstract_inverted_index":{"Collagen":[0],"type":[1,127],"I":[2,128],"is":[3],"an":[4,89,133],"AAB":[5,153],"heterotrimer":[6],"assembled":[7],"from":[8],"two":[9,207],"alpha1":[10,122],"chains":[11,22,125,139,188],"and":[12,86,94,156,226],"one":[13,157,205],"alpha2":[14,124],"chain.":[15],"Missense":[16],"mutations":[17,47,70,81,117,178,241],"in":[18,28,51,71,82,88,119,137,172,181,223,236],"either":[19,120],"of":[20,43,103,126,145,189,216,239],"these":[21],"that":[23,112,140,176,233],"substitute":[24],"a":[25,34,59,104,174,243],"glycine":[26,69,116,177,208,240],"residue":[27],"the":[29,52,73,80,101,115,121,143,166,190,198,221,237],"ubiquitous":[30],"X-Y-Gly":[31],"repeat":[32],"with":[33,210],"bulky":[35],"amino":[36],"acid":[37],"leads":[38],"to":[39,213],"osteogenesis":[40],"imperfecta":[41],"(OI)":[42],"varying":[44],"severity.":[45],"These":[46],"have":[48],"been":[49],"studied":[50],"past":[53],"using":[54],"collagen-like":[55,110],"peptide":[56],"homotrimers":[57],"as":[58],"model":[60,106],"system.":[61],"However,":[62],"homotrimers,":[63],"which":[64],"by":[65],"definition":[66],"will":[67],"contain":[68],"all":[72,186],"three":[74,138,147,187],"chains,":[75],"do":[76],"not":[77],"accurately":[78],"mimic":[79,114],"their":[83],"native":[84,214],"form":[85],"result":[87],"exaggerated":[90],"effect":[91],"on":[92],"stability":[93,225],"folding.":[95],"In":[96],"this":[97,194],"article,":[98],"we":[99,196,219],"report":[100,201],"design":[102,131],"novel":[105],"system":[107],"based":[108],"upon":[109],"heterotrimers":[111],"can":[113,141,169],"present":[118,180],"or":[123,159,185,206],"collagen.":[129],"This":[130],"utilizes":[132],"electrostatic":[134],"recognition":[135],"motif":[136],"force":[142],"interaction":[144],"any":[146],"peptides,":[148],"including":[149],"AAA":[150],"(all":[151,161],"same),":[152],"(two":[154],"same":[155],"different),":[158],"ABC":[160],"different)":[162],"triple":[163,191,231],"helices.":[164],"Therefore,":[165],"component":[167],"peptides":[168],"be":[170],"designed":[171],"such":[173],"way":[175],"are":[179],"zero,":[182],"one,":[183],"two,":[184],"helix.":[192],"With":[193],"design,":[195],"for":[197],"first":[199],"time":[200],"collagen":[202],"mutants":[203],"containing":[204],"substitutions":[209],"structures":[211],"relevant":[212],"forms":[215],"OI.":[217],"Furthermore,":[218],"demonstrate":[220],"difference":[222],"thermal":[224],"refolding":[227],"half-life":[228],"times":[229],"between":[230],"helices":[232],"vary":[234],"only":[235],"frequency":[238],"at":[242],"particular":[244],"position.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
