{"id":"https://openalex.org/W2072109293","doi":"https://doi.org/10.1016/j.bmcl.2007.01.045","title":"A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice","display_name":"A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice","publication_year":2007,"publication_date":"2007-01-25","ids":{"openalex":"https://openalex.org/W2072109293","doi":"https://doi.org/10.1016/j.bmcl.2007.01.045","mag":"2072109293","pmid":"https://pubmed.ncbi.nlm.nih.gov/17292607"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2007.01.045","doi":"https://doi.org/10.1016/j.bmcl.2007.01.045","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2007.01.045","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076831020","display_name":"Lynn B. DeCarr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lynn B. DeCarr","raw_affiliation_strings":["Department of Metabolic Disorders Research, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Disorders Research, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052685680","display_name":"Thomas M. Buckholz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas M. Buckholz","raw_affiliation_strings":["Department of Research Technologies, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research Technologies, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042709066","display_name":"Lucinda F. Milardo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucinda F. Milardo","raw_affiliation_strings":["Department of Metabolic Disorders Research, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Disorders Research, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012992991","display_name":"Michelle R. Mays","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle R. Mays","raw_affiliation_strings":["Department of Metabolic Disorders Research, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Disorders Research, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111742491","display_name":"Astrid A. Ortiz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Astrid Ortiz","raw_affiliation_strings":["Department of Metabolic Disorders Research, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Disorders Research, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012426183","display_name":"Kevin J. Lumb","orcid":"https://orcid.org/0000-0003-2778-9956","observed_orcids":["https://orcid.org/0000-0003-2778-9956"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kevin J. Lumb","raw_affiliation_strings":["Department of Research Technologies, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research Technologies, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012426183"],"corresponding_institution_ids":[],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.774,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.65522727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"7","first_page":"1916","last_page":"1919"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropeptide-y2-receptor","display_name":"neuropeptide Y2 receptor","score":0.9539999961853027},{"id":"https://openalex.org/keywords/pegylation","display_name":"PEGylation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/peptide-agonists","display_name":"peptide agonists","score":0.871999979019165},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.7789999842643738},{"id":"https://openalex.org/keywords/appetite-regulation","display_name":"appetite regulation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pyy3-36","display_name":"PYY3-36","score":0.9089999794960022},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7110000252723694},{"id":"https://openalex.org/keywords/long-acting-drugs","display_name":"long-acting drugs","score":0.7039999961853027},{"id":"https://openalex.org/keywords/npy-y1-receptor","display_name":"NPY Y1 receptor","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8559163212776184},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.8085105419158936},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.6768285036087036},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6141662001609802},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5934523344039917},{"id":"https://openalex.org/C93984277","wikidata":"https://www.wikidata.org/wiki/Q24782073","display_name":"Neuropeptide Y receptor","level":4,"score":0.5861895084381104},{"id":"https://openalex.org/C3018685816","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food intake","level":2,"score":0.5854707956314087},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5660918354988098},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37728971242904663},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34656745195388794},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30041277408599854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017476","descriptor_name":"Receptors, Neuropeptide Y","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019894","descriptor_name":"Peptide YY","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D019894","descriptor_name":"Peptide YY","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2007.01.045","doi":"https://doi.org/10.1016/j.bmcl.2007.01.045","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2007.01.045","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:17292607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17292607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1913169251","https://openalex.org/W1967683719","https://openalex.org/W1968196420","https://openalex.org/W1968704139","https://openalex.org/W1986155861","https://openalex.org/W1989428888","https://openalex.org/W1992804002","https://openalex.org/W2000488672","https://openalex.org/W2022234371","https://openalex.org/W2030831607","https://openalex.org/W2038445365","https://openalex.org/W2049332877","https://openalex.org/W2079201209","https://openalex.org/W2079539251","https://openalex.org/W2091685843","https://openalex.org/W2096780893","https://openalex.org/W2131234408","https://openalex.org/W2134221479","https://openalex.org/W2146193981","https://openalex.org/W2155419918","https://openalex.org/W2157748967","https://openalex.org/W2170277935","https://openalex.org/W2320224826","https://openalex.org/W2336900611"],"related_works":["https://openalex.org/W2059135414","https://openalex.org/W2145313455","https://openalex.org/W1986155861","https://openalex.org/W2967980054","https://openalex.org/W2039594441","https://openalex.org/W2688932964","https://openalex.org/W2029701696","https://openalex.org/W2611695151","https://openalex.org/W2774128084","https://openalex.org/W2099661011"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}