{"id":"https://openalex.org/W2072082955","doi":"https://doi.org/10.1371/journal.pone.0099003","title":"Human Retinal Transmitochondrial Cybrids with J or H mtDNA Haplogroups Respond Differently to Ultraviolet Radiation: Implications for Retinal Diseases","display_name":"Human Retinal Transmitochondrial Cybrids with J or H mtDNA Haplogroups Respond Differently to Ultraviolet Radiation: Implications for Retinal Diseases","publication_year":2014,"publication_date":"2014-06-11","ids":{"openalex":"https://openalex.org/W2072082955","doi":"https://doi.org/10.1371/journal.pone.0099003","mag":"2072082955","pmid":"https://pubmed.ncbi.nlm.nih.gov/24919117","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4053329"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0099003","doi":"https://doi.org/10.1371/journal.pone.0099003","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0099003","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099003&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099003&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079952349","display_name":"Deepika Malik","orcid":"https://orcid.org/0000-0002-3722-6711","observed_orcids":["https://orcid.org/0000-0002-3722-6711"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepika Malik","raw_affiliation_strings":["Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084639380","display_name":"Tiffany Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiffany Hsu","raw_affiliation_strings":["Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070249220","display_name":"Payam Falatoonzadeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Payam Falatoonzadeh","raw_affiliation_strings":["Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018854248","display_name":"Javier C\u00e1ceres\u2010del\u2010Carpio","orcid":"https://orcid.org/0000-0001-5673-5709","observed_orcids":["https://orcid.org/0000-0001-5673-5709"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier C\u00e1ceres-del-Carpio","raw_affiliation_strings":["Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108130260","display_name":"Mohamed Tarek","orcid":"https://orcid.org/0009-0007-2747-2541","observed_orcids":["https://orcid.org/0009-0007-2747-2541"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG","US"],"is_corresponding":false,"raw_author_name":"Mohamed Tarek","raw_affiliation_strings":["Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America; Department of Ophthalmology, El-Minya University, El-Minya, Egypt","Department of Ophthalmology, El-Minya University, El-Minya, Egypt","Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America; Department of Ophthalmology, El-Minya University, El-Minya, Egypt","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I89466785"]},{"raw_affiliation_string":"Department of Ophthalmology, El-Minya University, El-Minya, Egypt","institution_ids":["https://openalex.org/I89466785"]},{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078489850","display_name":"Marilyn Chwa","orcid":"https://orcid.org/0000-0002-1874-6041","observed_orcids":["https://orcid.org/0000-0002-1874-6041"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marilyn Chwa","raw_affiliation_strings":["Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075683156","display_name":"Shari R. Atilano","orcid":"https://orcid.org/0000-0002-7729-7864","observed_orcids":["https://orcid.org/0000-0002-7729-7864"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shari R. Atilano","raw_affiliation_strings":["Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101741269","display_name":"Claudio Ram\u00edrez","orcid":"https://orcid.org/0000-0002-9239-999X","observed_orcids":["https://orcid.org/0000-0002-9239-999X"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudio Ramirez","raw_affiliation_strings":["Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054482428","display_name":"Anthony B. Nesburn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony B. Nesburn","raw_affiliation_strings":["Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America; Cedars-Sinai Medical Center, Los Angeles, California, United States of America","Cedars-Sinai Medical Center, Los Angeles, California, United States of America","Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America; Cedars-Sinai Medical Center, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I204250578"]},{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058044536","display_name":"David S. Boyer","orcid":"https://orcid.org/0000-0001-9219-1614","observed_orcids":["https://orcid.org/0000-0001-9219-1614"]},"institutions":[{"id":"https://openalex.org/I4210128744","display_name":"Retina Vitreous Associates Medical Group","ror":"https://ror.org/038kpzv03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128744"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Boyer","raw_affiliation_strings":["Retina-Vitreous Associates Medical Group; Beverly Hills, California, United States of America","Beverly Hills, California, United States of America","Retina-Vitreous Associates Medical Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Retina-Vitreous Associates Medical Group; Beverly Hills, California, United States of America","institution_ids":["https://openalex.org/I4210128744"]},{"raw_affiliation_string":"Beverly Hills, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"Retina-Vitreous Associates Medical Group","institution_ids":["https://openalex.org/I4210128744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108439897","display_name":"Baruch D. Kuppermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baruch D. Kuppermann","raw_affiliation_strings":["Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110195708","display_name":"S. Michal Jazwinski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Michal Jazwinski","raw_affiliation_strings":["Tulane Center for Aging, Tulane University, New Orleans, Louisiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Center for Aging, Tulane University, New Orleans, Louisiana, United States of America","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113517625","display_name":"Michael V. Miceli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael V. Miceli","raw_affiliation_strings":["Tulane Center for Aging, Tulane University, New Orleans, Louisiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Center for Aging, Tulane University, New Orleans, Louisiana, United States of America","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085274471","display_name":"Douglas C. Wallace","orcid":"https://orcid.org/0000-0002-7480-8278","observed_orcids":["https://orcid.org/0000-0002-7480-8278"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas C. Wallace","raw_affiliation_strings":["Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011864225","display_name":"Nitin Udar","orcid":"https://orcid.org/0000-0001-8533-9190","observed_orcids":["https://orcid.org/0000-0001-8533-9190"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitin Udar","raw_affiliation_strings":["Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013287462","display_name":"M. Cristina Kenney","orcid":"https://orcid.org/0000-0003-1765-1750","observed_orcids":["https://orcid.org/0000-0003-1765-1750"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. Cristina Kenney","raw_affiliation_strings":["Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America; Department of Pathology and Laboratory Medicine, University California Irvine, Irvine, California, United States of America","Department of Pathology and Laboratory Medicine, University California Irvine, Irvine, California, United States of America","Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America; Department of Pathology and Laboratory Medicine, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Gavin Herbert Eye Institute, University California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5013287462"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.466,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.81207188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"9","issue":"6","first_page":"e99003","last_page":"e99003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.32249999046325684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.32249999046325684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.2312999963760376,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.2272000014781952,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-haplogroups","display_name":"mtDNA haplogroups","score":0.8220000267028809},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.8230000138282776},{"id":"https://openalex.org/keywords/gene-expression-response","display_name":"gene expression response","score":0.8240000009536743},{"id":"https://openalex.org/keywords/complement-genes","display_name":"complement genes","score":0.6399999856948853},{"id":"https://openalex.org/keywords/apoptosis-related-genes","display_name":"apoptosis-related genes","score":0.7360000014305115},{"id":"https://openalex.org/keywords/inflammation-related-genes","display_name":"inflammatory genes","score":0.8579999804496765},{"id":"https://openalex.org/keywords/retinal-disease","display_name":"retinal disease","score":0.5090000033378601},{"id":"https://openalex.org/keywords/arpe-19-cells","display_name":"ARPE-19 cells","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6498816013336182},{"id":"https://openalex.org/C201526758","wikidata":"https://www.wikidata.org/wiki/Q80686","display_name":"Haplogroup","level":5,"score":0.6447936296463013},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.6124719381332397},{"id":"https://openalex.org/C78450430","wikidata":"https://www.wikidata.org/wiki/Q1356230","display_name":"Human mitochondrial DNA haplogroup","level":5,"score":0.48154786229133606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40102192759513855},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3076512813568115},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.28773829340934753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23671692609786987},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.11058446764945984},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.08178967237472534},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0770156979560852}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0099003","doi":"https://doi.org/10.1371/journal.pone.0099003","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0099003","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099003&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4053329","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4053329","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24919117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24919117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.807.8625","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.807.8625","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/98/29/pone.0099003.PMC4053329.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9f2ccfb6cc0d49d39cf771ce7acbda7a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9f2ccfb6cc0d49d39cf771ce7acbda7a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 2, p e99003 (2014)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt90p8z2d3","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/90p8z2d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PloS one, vol 9, iss 2","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt90p8z2d3","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/90p8z2d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE, vol 9, iss 6","raw_type":"article"},{"id":"pmh:qt90p8z2d3","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/90p8z2d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Malik, D; Hsu, T; Falatoonzadeh, P; C\u00c3\u00a1ceres-del-Carpio, J; Tarek, M; Chwa, M; \u00c2\u00a0et al.(2014). Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: Implications for retinal diseases. PLoS ONE, 9(6). doi: 10.1371/journal.pone.0099003. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/90p8z2d3","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0099003","doi":"https://doi.org/10.1371/journal.pone.0099003","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0099003","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099003&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G326859619","display_name":null,"funder_award_id":"AG 006168","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5729578629","display_name":"Cellular Aging in a Yeast Model System","funder_award_id":"R37AG006168","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306570","display_name":"Cantor Foundation, Iris & B. Gerald","ror":"https://ror.org/048yb3886"},{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320309451","display_name":"Lincy Foundation","ror":"https://ror.org/056ydqw55"},{"id":"https://openalex.org/F4320309524","display_name":"Skirball Foundation","ror":"https://ror.org/00wwe9h57"},{"id":"https://openalex.org/F4320310357","display_name":"Arnold and Mabel Beckman Initiative for Macular Research","ror":"https://ror.org/05avmtm72"},{"id":"https://openalex.org/F4320312354","display_name":"\u00d6gonfonden","ror":"https://ror.org/00n58s174"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072082955.pdf","grobid_xml":"https://content.openalex.org/works/W2072082955.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W146693421","https://openalex.org/W175034851","https://openalex.org/W1588097989","https://openalex.org/W1822386544","https://openalex.org/W1964637189","https://openalex.org/W1967234985","https://openalex.org/W1970924670","https://openalex.org/W1976102972","https://openalex.org/W1977422420","https://openalex.org/W1981186447","https://openalex.org/W1982738001","https://openalex.org/W1989558725","https://openalex.org/W1989580034","https://openalex.org/W1989747234","https://openalex.org/W1994133882","https://openalex.org/W1994461465","https://openalex.org/W2010365463","https://openalex.org/W2013647315","https://openalex.org/W2013742341","https://openalex.org/W2013999386","https://openalex.org/W2018822649","https://openalex.org/W2019541219","https://openalex.org/W2019890257","https://openalex.org/W2026119866","https://openalex.org/W2027498679","https://openalex.org/W2028083589","https://openalex.org/W2030227512","https://openalex.org/W2033711978","https://openalex.org/W2034366812","https://openalex.org/W2036950270","https://openalex.org/W2038511818","https://openalex.org/W2039847021","https://openalex.org/W2042499074","https://openalex.org/W2045049757","https://openalex.org/W2050199151","https://openalex.org/W2058407555","https://openalex.org/W2059817254","https://openalex.org/W2062957434","https://openalex.org/W2064703228","https://openalex.org/W2064959471","https://openalex.org/W2070301011","https://openalex.org/W2072056861","https://openalex.org/W2072451938","https://openalex.org/W2077513778","https://openalex.org/W2081208114","https://openalex.org/W2083364468","https://openalex.org/W2088866871","https://openalex.org/W2092659124","https://openalex.org/W2095343523","https://openalex.org/W2097573529","https://openalex.org/W2102457123","https://openalex.org/W2103939468","https://openalex.org/W2106868003","https://openalex.org/W2107143742","https://openalex.org/W2117957387","https://openalex.org/W2121835400","https://openalex.org/W2121919167","https://openalex.org/W2128544710","https://openalex.org/W2130748175","https://openalex.org/W2133036751","https://openalex.org/W2136647137","https://openalex.org/W2138356122","https://openalex.org/W2146095818","https://openalex.org/W2150029683","https://openalex.org/W2155236757","https://openalex.org/W2163133170","https://openalex.org/W2171184948","https://openalex.org/W2171753586","https://openalex.org/W2304821401","https://openalex.org/W4254246864"],"related_works":["https://openalex.org/W2128544710","https://openalex.org/W2133036751","https://openalex.org/W3194732802","https://openalex.org/W3172769043","https://openalex.org/W2148347142","https://openalex.org/W2063760505","https://openalex.org/W2132504343","https://openalex.org/W7096528857","https://openalex.org/W3174109839","https://openalex.org/W4412354737"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"has":[2],"been":[3],"recognized":[4],"that":[5,41,82,263],"cells":[6,241],"do":[7],"not":[8,18],"respond":[9],"equally":[10],"to":[11,24,44,52,57,112,192,235,248,300],"ultraviolet":[12],"(UV)":[13],"radiation":[14],"but":[15,228],"it":[16],"is":[17,22,85,96,251],"clear":[19],"whether":[20],"this":[21],"due":[23],"genetic,":[25],"biochemical":[26],"or":[27,134],"structural":[28],"differences":[29,264],"of":[30,48,60,72,115,159,271],"the":[31,46,93,218,245,256,261,293],"cells.":[32,144],"We":[33],"have":[34,80],"a":[35],"novel":[36],"cybrid":[37],"(cytoplasmic":[38],"hybrids)":[39],"model":[40],"allows":[42],"us":[43],"analyze":[45],"contribution":[47],"mitochondrial":[49],"DNA":[50],"(mtDNA)":[51],"cellular":[53,246],"response":[54,247],"after":[55,110,216],"exposure":[56,111],"sub-lethal":[58,113,249],"dose":[59],"UV.":[61],"mtDNA":[62,257,294],"can":[63],"be":[64,298],"classified":[65],"into":[66],"haplogroups":[67,139],"as":[68],"defined":[69],"by":[70,122,255],"accumulations":[71],"specific":[73],"single":[74],"nucleotide":[75],"polymorphisms":[76],"(SNPs).":[77],"Recent":[78],"studies":[79],"shown":[81],"J":[83,105,135,148,185,197,219],"haplogroup":[84,95,295],"high":[86],"risk":[87],"for":[88,152,163,174,203],"age-related":[89],"macular":[90],"degeneration":[91],"while":[92],"H":[94,108,130,146,193,237],"protective.":[97],"This":[98,259],"study":[99],"investigates":[100],"gene":[101,178],"expression":[102,179,201,269],"responses":[103],"in":[104,253,265,284,291],"cybrids":[106,109,149,171,186,198,220],"versus":[107],"doses":[114],"UV-radiation.":[116],"METHODOLOGY/PRINCIPAL":[117],"FINDINGS:":[118],"Cybrids":[119],"were":[120,150,172],"created":[121],"fusing":[123],"platelets":[124],"isolated":[125],"from":[126,279],"subjects":[127],"with":[128,140,156,242],"either":[129],"(n":[131,136],"=":[132,137],"3)":[133,138],"mitochondria-free":[141],"(Rho0)":[142],"ARPE-19":[143],"The":[145,181],"and":[147,161,169,177,183,211,225,232,268,274],"cultured":[151,162],"24":[153],"hours,":[154],"treated":[155,170],"10":[157],"mJ":[158],"UV-radiation":[160,250],"an":[164],"additional":[165],"120":[166,214],"hours.":[167],"Untreated":[168],"analyzed":[173],"growth":[175,189,266],"rates":[176,190,267],"profiles.":[180],"UV-treated":[182,236],"untreated":[184],"had":[187,221],"higher":[188],"compared":[191,234],"cybrids.":[194,238],"Before":[195],"treatment,":[196],"showed":[199],"lower":[200],"levels":[202,227,270],"CFH,":[204,223],"CD55,":[205,230],"IL-33,":[206],"TGF-A,":[207],"EFEMP-1,":[208],"RARA,":[209],"BCL2L13":[210],"BBC3.":[212],"At":[213],"hours":[215],"UV-treatment,":[217],"decreased":[222],"RARA":[224],"BBC3":[226],"increased":[229],"IL-33":[231],"EFEMP-1":[233],"CONCLUSION/SIGNIFICANCE:":[239],"In":[240],"identical":[243],"nuclei,":[244],"mediated":[252],"part":[254],"haplogroup.":[258],"supports":[260],"hypothesis":[262],"complement,":[272],"inflammation":[273],"apoptosis":[275],"genes":[276],"may":[277,297],"result":[278],"population-specific,":[280],"hereditary":[281],"SNP":[282],"variations":[283],"mtDNA.":[285],"Therefore,":[286],"when":[287],"analyzing":[288],"UV-induced":[289],"damage":[290],"tissues,":[292],"background":[296],"important":[299],"consider.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
