{"id":"https://openalex.org/W2072078083","doi":"https://doi.org/10.1007/s281-001-8165-0","title":"Somatic hypernnitation in human B cell subsets","display_name":"Somatic hypernnitation in human B cell subsets","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2072078083","doi":"https://doi.org/10.1007/s281-001-8165-0","mag":"2072078083","pmid":"https://pubmed.ncbi.nlm.nih.gov/11826615"},"language":"en","primary_location":{"id":"doi:10.1007/s281-001-8165-0","doi":"https://doi.org/10.1007/s281-001-8165-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s281-001-8165-0","pdf_url":null,"source":{"id":"https://openalex.org/S22664439","display_name":"Springer Seminars in Immunopathology","issn_l":"0344-4325","issn":["0344-4325","1432-2196"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Springer Seminars in Immunopathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032719628","display_name":"Nancy S. Longo","orcid":"https://orcid.org/0009-0008-6233-9428","observed_orcids":["https://orcid.org/0009-0008-6233-9428","https://orcid.org/0000-0001-6422-5100"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy S. Longo","raw_affiliation_strings":["National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043874873","display_name":"Peter E. Lipsky","orcid":"https://orcid.org/0000-0002-9287-1676","observed_orcids":["https://orcid.org/0000-0002-9287-1676"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter E. Lipsky","raw_affiliation_strings":["National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA","National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]},{"raw_affiliation_string":"National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2156,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.52562762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"4","first_page":"367","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"somatic hypermutation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/b-cell-subsets","display_name":"B cell subsets","score":0.9179999828338623},{"id":"https://openalex.org/keywords/immunoglobulin-genes","display_name":"immunoglobulin genes","score":0.746999979019165},{"id":"https://openalex.org/keywords/antibody-diversity","display_name":"antibody diversity","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5503128170967102},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5155372619628906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.452353298664093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3342941701412201},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26127368211746216},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15751993656158447}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004254","descriptor_name":"DNA Nucleotidyltransferases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005803","descriptor_name":"Genes, Immunoglobulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015322","descriptor_name":"Gene Rearrangement, B-Lymphocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016175","descriptor_name":"B-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018956","descriptor_name":"CD5 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020137","descriptor_name":"Base Pair Mismatch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027041","descriptor_name":"Somatic Hypermutation, Immunoglobulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045567","descriptor_name":"VDJ Recombinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s281-001-8165-0","doi":"https://doi.org/10.1007/s281-001-8165-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s281-001-8165-0","pdf_url":null,"source":{"id":"https://openalex.org/S22664439","display_name":"Springer Seminars in Immunopathology","issn_l":"0344-4325","issn":["0344-4325","1432-2196"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Springer Seminars in Immunopathology","raw_type":"journal-article"},{"id":"pmid:11826615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11826615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Springer seminars in immunopathology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W49699810","https://openalex.org/W171974083","https://openalex.org/W985865429","https://openalex.org/W1487862126","https://openalex.org/W1489752929","https://openalex.org/W1525531086","https://openalex.org/W1554806521","https://openalex.org/W1560486125","https://openalex.org/W1562353899","https://openalex.org/W1565321014","https://openalex.org/W1580707139","https://openalex.org/W1585006893","https://openalex.org/W1603729648","https://openalex.org/W1604932745","https://openalex.org/W1607648358","https://openalex.org/W1878687501","https://openalex.org/W1908705633","https://openalex.org/W1919334117","https://openalex.org/W1964075624","https://openalex.org/W1966796613","https://openalex.org/W1967155911","https://openalex.org/W1968950713","https://openalex.org/W1969154794","https://openalex.org/W1973554355","https://openalex.org/W1974596630","https://openalex.org/W1976118880","https://openalex.org/W1976499175","https://openalex.org/W1978648487","https://openalex.org/W1980404711","https://openalex.org/W1980800509","https://openalex.org/W1981239551","https://openalex.org/W1982289564","https://openalex.org/W1983306073","https://openalex.org/W1984127288","https://openalex.org/W1984248194","https://openalex.org/W1984314739","https://openalex.org/W1985067006","https://openalex.org/W1985264665","https://openalex.org/W1987380612","https://openalex.org/W1989563648","https://openalex.org/W1991979456","https://openalex.org/W1994676964","https://openalex.org/W1998416208","https://openalex.org/W2002043709","https://openalex.org/W2002705228","https://openalex.org/W2005566446","https://openalex.org/W2010377523","https://openalex.org/W2011763028","https://openalex.org/W2012648382","https://openalex.org/W2013628600","https://openalex.org/W2016913332","https://openalex.org/W2020034788","https://openalex.org/W2020615323","https://openalex.org/W2024234486","https://openalex.org/W2025028594","https://openalex.org/W2031549362","https://openalex.org/W2031638691","https://openalex.org/W2031778684","https://openalex.org/W2034477072","https://openalex.org/W2036930370","https://openalex.org/W2041278917","https://openalex.org/W2050582521","https://openalex.org/W2051519190","https://openalex.org/W2052084059","https://openalex.org/W2053247044","https://openalex.org/W2053470716","https://openalex.org/W2054941139","https://openalex.org/W2056807976","https://openalex.org/W2059557296","https://openalex.org/W2062168458","https://openalex.org/W2062487397","https://openalex.org/W2063339622","https://openalex.org/W2063662558","https://openalex.org/W2064208882","https://openalex.org/W2070341297","https://openalex.org/W2071495838","https://openalex.org/W2071534579","https://openalex.org/W2072498328","https://openalex.org/W2075100776","https://openalex.org/W2076747220","https://openalex.org/W2078597151","https://openalex.org/W2082066679","https://openalex.org/W2088005340","https://openalex.org/W2091424161","https://openalex.org/W2092413851","https://openalex.org/W2095180364","https://openalex.org/W2095283976","https://openalex.org/W2102572112","https://openalex.org/W2104588650","https://openalex.org/W2110627805","https://openalex.org/W2111792465","https://openalex.org/W2114745290","https://openalex.org/W2114939957","https://openalex.org/W2121855655","https://openalex.org/W2126867178","https://openalex.org/W2127933387","https://openalex.org/W2134443084","https://openalex.org/W2137995685","https://openalex.org/W2140185626","https://openalex.org/W2141326900","https://openalex.org/W2141798197","https://openalex.org/W2145700736","https://openalex.org/W2156272370","https://openalex.org/W2158633611","https://openalex.org/W2160930032","https://openalex.org/W2161243339","https://openalex.org/W2165608602","https://openalex.org/W2165802059","https://openalex.org/W2166617268","https://openalex.org/W2167016413","https://openalex.org/W2368121141","https://openalex.org/W2470016183","https://openalex.org/W2470508052","https://openalex.org/W2578150941","https://openalex.org/W2699602251","https://openalex.org/W4251633039","https://openalex.org/W4298349238","https://openalex.org/W4313344653","https://openalex.org/W4313347827","https://openalex.org/W4313376893"],"related_works":["https://openalex.org/W2154804875","https://openalex.org/W4239647250","https://openalex.org/W4205507291","https://openalex.org/W4233203512","https://openalex.org/W1979590805","https://openalex.org/W2593931034","https://openalex.org/W3161292037","https://openalex.org/W4214947871","https://openalex.org/W2013310889","https://openalex.org/W2084719762"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}