{"id":"https://openalex.org/W2072062858","doi":"https://doi.org/10.1093/eurheartj/ehi344","title":"Iconoclasts topple adaptive myocardial hypertrophy in aortic stenosisThe opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.","display_name":"Iconoclasts topple adaptive myocardial hypertrophy in aortic stenosisThe opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.","publication_year":2005,"publication_date":"2005-05-23","ids":{"openalex":"https://openalex.org/W2072062858","doi":"https://doi.org/10.1093/eurheartj/ehi344","mag":"2072062858","pmid":"https://pubmed.ncbi.nlm.nih.gov/15911565"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehi344","doi":"https://doi.org/10.1093/eurheartj/ehi344","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehi344","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/26/17/1697/9623887/ehi344.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/eurheartj/article-pdf/26/17/1697/9623887/ehi344.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002498747","display_name":"Henk P.J. Buermans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Henk P.J. Buermans","raw_affiliation_strings":["Laboratory of Physiology, Institute for Cardiovascular Research, VU Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology, Institute for Cardiovascular Research, VU Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016743789","display_name":"Walter J. Paulus","orcid":"https://orcid.org/0000-0002-1597-1737","observed_orcids":["https://orcid.org/0000-0002-1597-1737"]},"institutions":[{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Walter J. Paulus","raw_affiliation_strings":["Laboratory of Physiology, Institute for Cardiovascular Research, VU Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology, Institute for Cardiovascular Research, VU Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002498747"],"corresponding_institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"],"apc_list":{"value":5240,"currency":"EUR","value_usd":5922},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"17","first_page":"1697","last_page":"1699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aortic-stenosis","display_name":"aortic stenosis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.6299999952316284},{"id":"https://openalex.org/keywords/systolic-dysfunction","display_name":"systolic dysfunction","score":0.890999972820282},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.7839999794960022},{"id":"https://openalex.org/keywords/left-ventricular-mass-index","display_name":"left ventricular mass index","score":0.7559999823570251},{"id":"https://openalex.org/keywords/pressure-overload","display_name":"pressure overload","score":0.7889999747276306},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.878000020980835},{"id":"https://openalex.org/keywords/endothelin","display_name":"endothelin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cardiomyocyte-hypertrophy","display_name":"cardiomyocyte hypertrophy","score":0.5},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.4749999940395355},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.3140000104904175},{"id":"https://openalex.org/keywords/myocardial-necrosis","display_name":"myocardial necrosis","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9412142038345337},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6560604572296143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6080309748649597},{"id":"https://openalex.org/C3018418570","wikidata":"https://www.wikidata.org/wiki/Q1729124","display_name":"Myocardial hypertrophy","level":3,"score":0.4323940873146057},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.37335535883903503}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1093/eurheartj/ehi344","doi":"https://doi.org/10.1093/eurheartj/ehi344","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehi344","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/26/17/1697/9623887/ehi344.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},{"id":"pmid:15911565","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15911565","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal","raw_type":"Comment"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.532.4730","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.532.4730","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://eurheartj.oxfordjournals.org/content/26/17/1697.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.848.5711","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.848.5711","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dare.ubvu.vu.nl/bitstream/handle/1871/26819/188165.pdf%3Bjsessionid%3D5A0779C2CCC1D3793D22226746386CB0?sequence%3D1","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.853.786","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.853.786","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://eurheartj.oxfordjournals.org/content/ehj/26/17/1697.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.857.7309","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.857.7309","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://eurheartj.oxfordjournals.org/content/ehj/early/2005/05/23/eurheartj.ehi344.full.pdf","raw_type":"text"},{"id":"pmh:oai:dare.ubvu.vu.nl:1871/26819","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1871/26819","pdf_url":null,"source":{"id":"https://openalex.org/S4306400546","display_name":"Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"26","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:open-archive.highwire.org:ehj:ehi344v1","doi":null,"is_oa":false,"landing_page_url":"http://eurheartj.oxfordjournals.org/cgi/content/short/ehi344v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/2fda23b4-76aa-4008-91fe-018c818810f8","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/2fda23b4-76aa-4008-91fe-018c818810f8","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Buermans, H P J & Paulus, W J S 2005, 'Iconoclasts topple adaptive myocardial hypertrophy in aortic stenosis', European heart journal, vol. 26, no. 17, pp. 1697-1699. https://doi.org/10.1093/eurheartj/ehi344","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu2:oai:dare.ubvu.vu.nl:1871/26819","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1871/26819","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Heart Journal, 26(17), 1697","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/9343874c-64fb-40e3-9f72-a4de6317ef65","doi":null,"is_oa":true,"landing_page_url":"https://research.vumc.nl/en/publications/9343874c-64fb-40e3-9f72-a4de6317ef65","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Heart Journal, 26(17), 1697 - 1699. Oxford University Press","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/eurheartj/ehi344","doi":"https://doi.org/10.1093/eurheartj/ehi344","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehi344","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/26/17/1697/9623887/ehi344.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072062858.pdf","grobid_xml":"https://content.openalex.org/works/W2072062858.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2021027916","https://openalex.org/W2041043528","https://openalex.org/W2048907933","https://openalex.org/W2051293550","https://openalex.org/W2079156477","https://openalex.org/W2104475665","https://openalex.org/W2110155078","https://openalex.org/W2110545714","https://openalex.org/W2123889844","https://openalex.org/W2142454619"],"related_works":["https://openalex.org/W7095664348","https://openalex.org/W2123889844","https://openalex.org/W2907663674","https://openalex.org/W3164588262","https://openalex.org/W2742216964","https://openalex.org/W7096686620","https://openalex.org/W2786451618","https://openalex.org/W2107271489","https://openalex.org/W7099704366","https://openalex.org/W3125282955"],"abstract_inverted_index":{"The":[0,25,819,962,1181,1491],"opinions":[1,26],"expressed":[2,27,645],"in":[3,28,57,91,111,213,232,265,307,318,363,370,404,443,504,530,608,690,723,729,801,858,912,917,957,1019,1095,1147,1198,1208,1270,1277,1392,1528],"this":[4,29,129,166,774,958,1007,1156,1356,1448],"article":[5,30],"are":[6,31,356,822,1028,1058],"not":[7,32,686,1109],"necessarily":[8,33,1110],"those":[9,34],"of":[10,13,19,23,35,38,44,48,64,85,101,128,175,182,189,196,210,228,241,262,268,277,286,304,349,376,391,399,429,435,449,473,495,522,537,544,561,580,586,616,636,653,670,697,708,720,740,748,759,773,780,789,809,823,850,854,869,895,901,926,937,1088,1104,1125,1134,1142,1201,1205,1217,1368,1413,1450,1482,1516],"the":[11,14,20,36,39,45,83,98,105,118,126,187,192,207,221,225,275,305,328,333,341,374,407,507,637,695,698,704,724,730,738,741,746,757,771,795,810,859,924,1089,1114,1143,1151,1189,1199,1278,1316,1358,1393,1397,1457,1501,1513,1551],"Editors":[12,37],"European":[15,21,40,46],"Heart":[16,41],"Journal":[17,42],"or":[18,43,62,533,613,711,764,884,991,1480,1549],"Society":[22,47],"Cardiology.":[24,49],"This":[50,172,679,919,1283],"editorial":[51],"refers":[52],"to":[53,223,321,340,358,406,420,459,624,658,675,706,737,745,755,783,794,827,830,965,1000,1113,1158,1162,1169,1188,1225,1254,1274,1297,1335,1361,1416,1503,1512],"\u2018Left":[54],"ventricular":[55,88,546],"hypertrophy":[56,90,178,198,212,231,264,279,316,379,469,548,604,662,684,689,803,837,872,876,903,939,956,975,999,1046,1090,1107,1115,1145,1207,1231,1259,1327,1334,1415,1452,1463,1485,1511,1527],"aortic":[58,124,183,215,233,245,392,430,732,742,799,832,860,890,927,950,1038,1159,1529],"valve":[59],"stenosis:":[60],"preventive":[61],"promotive":[63],"systolic":[65,114,121,143,401,423,475],"dysfunction":[66],"and":[67,104,146,151,205,256,258,317,343,347,352,417,446,470,486,569,595,655,663,672,693,728,744,829,838,866,898,914,934,1012,1026,1036,1056,1130,1176,1267,1303,1309,1345,1383,1404,1440,1456,1461],"heart":[68,269,283,721,790,840,896,932,1023,1053,1394,1518],"failure?\u2019\u2020":[69],"by":[70,133,152,550,592,776,786,813,880,885,905,1071,1128,1183,1410,1434,1445,1493,1534],"M.":[71],"Kupari":[72,217,290,814,1184,1494],"et":[73,218,291,815,1185,1495],"al.,":[74],"on":[75,312,332,1247,1378,1508,1525],"page":[76],"1790":[77],"For":[78],"more":[79],"than":[80,516,923,1315],"30":[81,559,612,651],"years,":[82],"development":[84,276,585,707,719,1103],"concentric":[86],"left":[87,508],"(LV)":[89],"pressure":[92,313,326,381,505,524,691,700,997,1015,1148],"overload":[93,382,692,701,998],"was":[94,131,280,362,501,540,583,590,605,622,921,1167,1232,1350,1389,1432,1453],"considered":[95,1168],"adaptive":[96,176,229,377,532,570,660,683,710,844,945,973,1144],"because":[97,1373,1384],"parallel":[99],"deposition":[100],"new":[102],"sarcomeres":[103],"corresponding":[106],"LV":[107,113,142,147,162,168,197,211,230,253,263,278,325,378,400,422,450,468,474,484,488,802,836,845,855,864,875,881,902,907,938,946,955,974,980,1033,1045,1106,1135,1164,1202,1206,1218,1230,1235,1242,1248,1258,1265,1271,1281,1295,1311,1319,1326,1333,1337,1343,1369,1374,1379,1385,1401,1414,1418,1424,1429,1451,1462,1484,1526],"wall":[108,115,144,169,402,424,436,476,856,887,1136,1165,1219,1272,1307,1338,1370,1419,1436,1442,1477],"thickening":[109],"succeeded":[110,529],"normalizing":[112],"stress":[116,145,331,403,477,857,1137,1166,1339,1420],"despite":[117,191,206,432],"high":[119],"intracavitary":[120],"pressure.1":[122],"In":[123,235,461,519,714,1006,1150,1426],"stenosis,":[125,246,1160],"validity":[127,772],"paradigm":[130,174,375,1146,1157],"demonstrated":[132,157,1094],"haemodynamic":[134],"studies,":[135,155],"which":[136,156,411,589,753,995,1064,1221,1291],"established":[137,1029],"an":[138,249,441,491,709,906,992,1310,1365,1411],"inverse":[139,167,250,1398],"relationship":[140,251],"between":[141,252,646,1400,1459],"ejection":[148],"fraction":[149],"(EF)":[150],"clinical":[153,173,322,731,968,984,1489,1514],"outcome":[154],"worse":[158],"post-operative":[159,1179],"prognosis":[160],"if":[161],"performance":[163,1349],"fell":[164],"below":[165],"stress\u2013LVEF":[170],"relationship.2,3":[171],"myocardial":[177,315,1066,1510],"developing":[179],"during":[180,380],"progression":[181,747,758,779],"stenosis":[184,733,761,782,800,833,861,891,928,942,951,1039,1530],"clearly":[185,528],"withstood":[186],"test":[188,770],"time":[190],"mounting":[193],"epidemiological":[194],"evidence":[195,311,811,900,936,1507],"being":[199,513,517,1471,1500],"associated":[200,1060],"with":[201,243,367,452,466,490,716,762,835,843,931,944,953,972,978,1051,1061,1098,1263,1364,1466,1538],"excess":[202],"cardiac":[203,408,463,639],"mortality":[204],"ominous":[208],"significance":[209],"congenital":[214],"stenosis.":[216,234,750],"al.4":[219,292,1186,1496],"were":[220,301,418,557,576,642,656,673,893,1016],"first":[222,385,1502],"challenge":[224],"time-honoured":[226],"concept":[227],"a":[236,259,364,384,413,541,625,806,851,989,1003,1048,1085,1139,1341,1422,1467,1474,1487],"carefully":[237],"designed":[238],"prospective":[239,295,959],"study":[240,296,680,960,1182,1210,1359,1492],"patients":[242,266,834,862,892,929,943,952,971,977,1020,1256,1262,1293,1317],"isolated":[244],"they":[247,300,564,1193,1222],"observed":[248,1472],"mass":[254,882,908,1010,1236,1243,1375,1402,1430],"index":[255,883,909,1011,1237,1244,1376,1382,1388,1403,1431],"LVEF":[257,1405,1460,1469],"higher":[260,1018,1468,1475],"prevalence":[261],"suffering":[267],"failure.":[270,678,791,1024,1054],"They":[271],"therefore":[272,1351],"concluded":[273,502],"that":[274,373,503,648,665,682,694,798,1154],"actually":[281,1464],"promoting":[282],"failure":[284,594,722,826,897,933,1161,1395],"instead":[285],"preventing":[287],"it.":[288],"When":[289,555],"started":[293],"their":[294,1209,1346,1522],"5":[297],"years":[298],"ago,":[299],"well":[302,1329],"ahead":[303],"crowd":[306],"appreciating":[308],"emerging":[309],"basic":[310,1506],"overload-induced":[314],"translating":[319],"it":[320,500,1546],"cardiology.5":[323],"During":[324],"overload,":[327,506,525],"raised":[329],"biomechanical":[330],"cardiomyocytes":[334],"stimulates":[335],"various":[336],"signal":[337],"transduction":[338],"pathways":[339],"nucleus6":[342],"induces":[344],"autocrine":[345],"production":[346],"secretion":[348],"angiotensin":[350,765],"II":[351],"endothelin,":[353],"whose":[354],"receptors":[355],"coupled":[357],"Gq":[359,371],"proteins.":[360],"It":[361],"mouse":[365],"model":[366,543,727],"cardiorestricted":[368],"deficiency":[369],"signalling":[372],"received":[383,611,650,667],"serious":[386],"blow.7":[387],"After":[388,426],"1":[389],"week":[390],"constriction,":[393,431],"control":[394,438],"mice":[395,439,465,1097],"showed":[396],"complete":[397],"normalization":[398,434],"contrast":[405],"gene-targeted":[409,464],"mice,":[410],"had":[412,649,666,899],"blunted":[414,467],"hypertrophic":[415],"response":[416],"unable":[419],"reduce":[421],"stress.":[425,1371],"8":[427,480],"weeks":[428],"initial":[433,699],"stress,":[437,1220],"developed":[440,565,1022,1331],"increase":[442,1269],"chamber":[444],"dimensions":[445],"progressive":[447],"deterioration":[448],"function":[451,489,1197],"echocardiographic":[453,492],"fractional":[454,493],"shortening":[455,494],"falling":[456],"from":[457,976,1122,1288],"59":[458],"35%.":[460],"contrast,":[462],"persistent":[471,852,1215],"elevation":[472,853,1216],"showed,":[478],"after":[479,600,630],"weeks,":[481],"only":[482],"limited":[483],"dilatation":[485],"preserved":[487],"52%.":[496],"From":[497],"these":[498,538,717,1041],"experiments,":[499],"ventricle":[509],"is":[510,734,804,877,1084,1138],"better":[511,1195],"off":[512],"\u2018stressed":[514],"out\u2019":[515],"hypertrophied.":[518],"other":[520],"models":[521,539],"experimental":[523],"investigators,":[526],"however,":[527,1213],"creating":[531],"physiological":[534],"hypertrophy.":[535,981,1203],"One":[536],"rat":[542],"right":[545],"(RV)":[547],"caused":[549],"monocrotaline":[551],"(MCT)-induced":[552],"pulmonary":[553,567,587],"hypertension.8":[554],"rats":[556,575,609,647,664],"given":[558,577],"mg/kg":[560,579,615,652,669],"MCT":[562,601,631,654,671],"subcutaneously,":[563],"slow-onset":[566],"hypertension":[568,1027,1057],"RV":[571,593,603,620,661,677],"hypertrophy,":[572,865,947],"but":[573,1118],"when":[574,619,874,1234,1428],"80":[578,614,668],"MCT,":[581],"there":[582],"rapid":[584],"hypertension,":[588],"accompanied":[591,785],"premature":[596],"death.":[597],"Fourteen":[598],"days":[599,629],"injection,":[602,632],"still":[606],"identical":[607],"having":[610,1324],"MCT.":[617],"However,":[618],"myocardium":[621,705],"subjected":[623],"microarray":[626],"analysis":[627],"14":[628],"63":[633],"genes":[634,640],"out":[635],"3010":[638],"screened":[641],"already":[643],"differentially":[644],"going":[657,674],"develop":[659,676],"implies":[681],"does":[685,1211],"precede":[687],"maladaptive":[688,712,954,979,1004,1049,1105,1483,1509],"magnitude":[696],"stimulus":[702],"pre-destines":[703],"phenotype.":[713,1005],"accordance":[715],"results,":[718],"mice-aortic":[725],"constriction":[726],"related,":[735],"respectively,":[736],"tightness":[739],"band":[743],"valvular":[749,760,781,1517],"Clinical":[751],"trials,":[752],"try":[754],"slow":[756],"statins":[763],"converting":[766,793],"enzyme":[767],"inhibitors,":[768],"could":[769,986,1119,1328],"assumption":[775],"demonstrating":[777],"slower":[778],"be":[784,1111,1170,1362,1408],"reduced":[787],"incidence":[788],"Before":[792],"iconoclastic":[796,1523,1540],"view":[797],"maladaptive,":[805],"critical":[807],"appraisal":[808],"provided":[812],"al.":[816],"seems":[817],"justified.":[818],"following":[820],"issues":[821],"concern:":[824],"(i)":[825],"identify":[828],"characterize":[831],"no":[839,848,1325,1352],"failure,":[841],"i.e.":[842],"hypertrophy;":[846],"(ii)":[847],"demonstration":[849],"without":[863],"(iii)":[867],"presence":[868],"discordant":[870],"LVEF\u2013LV":[871],"relationships":[873],"assessed":[878],"either":[879],"relative":[886,1435,1476],"thickness.":[888,1478],"Sixty-three":[889],"free":[894],"defined":[904],">110":[910],"g/m2":[911,916],"women":[913],">134":[915],"men.":[918],"group":[920,925,1279],"larger":[922,1391],"presenting":[930],"similar":[935],"(n=39).":[940],"Aortic":[941],"therefore,":[948],"outnumbered":[949],"population.":[961],"investigators":[963],"failed":[964,1224],"look":[966],"for":[967,1032,1173,1177,1257,1340,1421,1455,1499],"features":[969,985],"discriminating":[970,983],"Such":[982],"have":[987,1298,1330],"identified":[988],"hormonal":[990,1129],"environmental":[993,1131],"background,":[994],"predisposes":[996],"evolve":[1001],"into":[1002],"respect,":[1008],"body":[1009],"arterial":[1013],"blood":[1014],"significantly":[1017,1390],"who":[1021],"Obesity":[1025,1055],"risk":[1030],"factors":[1031],"diastolic":[1034,1052],"dysfunction9":[1035],"as":[1037,1092,1192,1286,1323],"progresses,":[1040],"comorbidities":[1042],"can":[1043,1260,1406],"direct":[1044],"towards":[1047],"phenotype":[1050],"both":[1059,1172],"insulin":[1062],"resistance,":[1063],"lowers":[1065],"nitric":[1067],"oxide":[1068],"(NO)":[1069],"content":[1070,1083],"reducing":[1072],"protein":[1073],"kinase":[1074],"B-mediated":[1075],"endothelial":[1076],"NO":[1077,1082],"synthase":[1078],"(NOS3)":[1079],"phosphorylation.":[1080],"Myocardial":[1081],"potent":[1086],"modulator":[1087],"process":[1091],"recently":[1093],"transgenic":[1096],"cardiomyocyte-restricted":[1099],"NOS3":[1100],"overexpression.10":[1101],"Hence,":[1102],"should":[1108],"ascribed":[1112],"gene":[1116],"programme":[1117],"also":[1120,1245,1407],"result":[1121],"deleterious":[1123],"modification":[1124,1481],"its":[1126,1252],"expression":[1127],"factors.":[1132],"Normalization":[1133],"key":[1140],"feature":[1141],"overload.":[1149],"original":[1152],"studies":[1153],"applied":[1155],"normalize":[1163,1336,1417],"responsible":[1171],"contractile":[1174,1196,1348],"dysfunction2":[1175],"poor":[1178],"outcome.3":[1180],"comes":[1187],"opposite":[1190],"conclusion":[1191],"observe":[1194],"absence":[1200],"Absence":[1204],"not,":[1212],"imply":[1214],"unfortunately":[1223],"measure.":[1226],"As":[1227,1537],"mentioned":[1228],"earlier,":[1229],"diagnosed":[1233],"exceeded":[1238],"pre-set":[1239],"values.":[1240],"Because":[1241],"depends":[1246,1377],"end-diastolic":[1249,1312,1380,1386,1446],"volume":[1250,1381,1387],"index,":[1251],"use":[1253],"categorize":[1255],"cause":[1261],"small":[1264,1342],"volumes":[1266],"moderate":[1268],"thickness":[1273,1308,1437,1443],"end":[1275],"up":[1276],"\u2018without":[1280,1294],"hypertrophy\u2019.":[1282,1320],"indeed":[1284],"happened":[1285],"evident":[1287],"Table":[1289],"3,":[1290],"shows":[1292],"hypertrophy\u2019":[1296],"elevated":[1299],"septal":[1300,1439],"(13\u00b10.3":[1301],"mm)":[1302,1306],"posterior":[1304,1441],"(12\u00b10.4":[1305],"diameter":[1313],"smaller":[1314],"\u2018with":[1318],"Patients":[1321],"labelled":[1322],"sufficient":[1332],"cavity":[1344],"superior":[1347],"surprise.":[1353],"To":[1354],"clarify":[1355],"issue,":[1357],"needs":[1360],"implemented":[1363],"invasive":[1366,1535],"assessment":[1367],"Finally,":[1372],"group,":[1396],"relation":[1399,1458],"explained":[1409],"inadequacy":[1412,1449],"large":[1423],"cavity.":[1425],"fact,":[1427],"replaced":[1433],"(i.e.":[1438],"divided":[1444],"diameter),":[1447],"accounted":[1454],"reversed,":[1465],"now":[1470],"at":[1473],"Avoidance":[1479],"remains":[1486],"major":[1488],"challenge.":[1490],"deserves":[1497],"credit":[1498],"translate":[1504],"recent":[1505],"setting":[1515],"disease.":[1519],"At":[1520],"present,":[1521],"idea":[1524],"awaits":[1531],"further":[1532],"confirmation":[1533],"studies.":[1536],"all":[1539],"acts,":[1541],"history":[1542],"will":[1543],"tell":[1544],"whether":[1545],"cleared":[1547],"perspectives":[1548],"spoiled":[1550],"view.":[1552],"doi:10.1093/eurheartj/ehi290":[1553]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}