{"id":"https://openalex.org/W2072038245","doi":"https://doi.org/10.3892/ijmm.17.3.503","title":"Repeated intravenous injection of recombinant human hepatocyte growth factor ameliorates liver cirrhosis but causes albuminuria in rats","display_name":"Repeated intravenous injection of recombinant human hepatocyte growth factor ameliorates liver cirrhosis but causes albuminuria in rats","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W2072038245","doi":"https://doi.org/10.3892/ijmm.17.3.503","mag":"2072038245","pmid":"https://pubmed.ncbi.nlm.nih.gov/16465399"},"language":"en","primary_location":{"id":"doi:10.3892/ijmm.17.3.503","doi":"https://doi.org/10.3892/ijmm.17.3.503","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.17.3.503","pdf_url":"https://www.spandidos-publications.com/10.3892/ijmm.17.3.503/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.spandidos-publications.com/10.3892/ijmm.17.3.503/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035237924","display_name":"Kazunori Kusumoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Kusumoto","raw_affiliation_strings":["Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112426083","display_name":"Akio Ido","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Akio Ido","raw_affiliation_strings":["Department of Experimental Therapeutics, Translational Research Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, Translational Research Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074394178","display_name":"Akihiro Moriuchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akihiro Moriuchi","raw_affiliation_strings":["Department of Experimental Therapeutics, Translational Research Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, Translational Research Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008302696","display_name":"Toshiya Katsura","orcid":"https://orcid.org/0000-0002-7789-8803","observed_orcids":["https://orcid.org/0000-0002-7789-8803"]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiya Katsura","raw_affiliation_strings":["Department of Pharmacy, Kyoto University Hospital, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kyoto University Hospital, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091716034","display_name":"Ildeok Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ildeok Kim","raw_affiliation_strings":["Department of Experimental Therapeutics, Translational Research Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, Translational Research Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013632423","display_name":"Yuka Takahama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Takahama","raw_affiliation_strings":["Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001758754","display_name":"Masatsugu Numata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatsugu Numata","raw_affiliation_strings":["Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108410169","display_name":"Mayumi Kodama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayumi Kodama","raw_affiliation_strings":["Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024916484","display_name":"Satoru Hasuike","orcid":"https://orcid.org/0000-0002-5312-5152","observed_orcids":["https://orcid.org/0000-0002-5312-5152"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Hasuike","raw_affiliation_strings":["Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046779019","display_name":"Kenji Nagata","orcid":"https://orcid.org/0000-0002-9955-9431","observed_orcids":["https://orcid.org/0000-0002-9955-9431","https://orcid.org/0000-0001-7861-6372","https://orcid.org/0000-0001-9894-4461"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Nagata","raw_affiliation_strings":["Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081773996","display_name":"Hirofumi Uto","orcid":"https://orcid.org/0000-0002-6976-7483","observed_orcids":["https://orcid.org/0000-0002-6976-7483"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Uto","raw_affiliation_strings":["Department of Experimental Therapeutics , Translational Research Center , Kyoto University Hospital , 54 Shogoin-Kawahara-cho , Sakyo-ku , Kyoto 606-8507 , Japan","Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics , Translational Research Center , Kyoto University Hospital , 54 Shogoin-Kawahara-cho , Sakyo-ku , Kyoto 606-8507 , Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060910700","display_name":"Ken\u2010ichi Inui","orcid":"https://orcid.org/0000-0003-1224-7310","observed_orcids":["https://orcid.org/0000-0003-1224-7310"]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-Ichi Inui","raw_affiliation_strings":["Department of Pharmacy, Kyoto University Hospital, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kyoto University Hospital, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023396801","display_name":"Hirohito Tsubouchi","orcid":"https://orcid.org/0000-0002-3585-6787","observed_orcids":["https://orcid.org/0000-0002-3585-6787"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirohito Tsubouchi","raw_affiliation_strings":["Department of Experimental Therapeutics, Translational Research Center,","Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, Translational Research Center,","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692;","institution_ids":["https://openalex.org/I118574687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112426083"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5361,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.82259508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"3","first_page":"503","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9079999923706055},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/n-nitrosodimethylamine","display_name":"N-nitrosodimethylamine","score":0.906000018119812},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.7839999794960022},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.996999979019165},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9729999899864197},{"id":"https://openalex.org/keywords/recombinant-protein-therapy","display_name":"recombinant protein therapy","score":0.7099999785423279},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.8515971302986145},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.8345423340797424},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6958380341529846},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6224436163902283},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6024606823921204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5618973970413208},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5197769999504089},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4263859689235687},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10172104835510254}],"mesh":[{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004128","descriptor_name":"Dimethylnitrosamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008106","descriptor_name":"Liver Cirrhosis, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijmm.17.3.503","doi":"https://doi.org/10.3892/ijmm.17.3.503","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.17.3.503","pdf_url":"https://www.spandidos-publications.com/10.3892/ijmm.17.3.503/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:16465399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16465399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ijmm.17.3.503","doi":"https://doi.org/10.3892/ijmm.17.3.503","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.17.3.503","pdf_url":"https://www.spandidos-publications.com/10.3892/ijmm.17.3.503/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072038245.pdf","grobid_xml":"https://content.openalex.org/works/W2072038245.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1486074435","https://openalex.org/W1627231359","https://openalex.org/W1907608182","https://openalex.org/W1959063438","https://openalex.org/W1971990317","https://openalex.org/W1978745104","https://openalex.org/W1984254868","https://openalex.org/W1989297142","https://openalex.org/W1992006494","https://openalex.org/W1993246285","https://openalex.org/W2011058457","https://openalex.org/W2013277358","https://openalex.org/W2015599978","https://openalex.org/W2022308645","https://openalex.org/W2025517694","https://openalex.org/W2034747552","https://openalex.org/W2035174231","https://openalex.org/W2037269059","https://openalex.org/W2038221758","https://openalex.org/W2041269746","https://openalex.org/W2051924092","https://openalex.org/W2052520181","https://openalex.org/W2052977290","https://openalex.org/W2058459130","https://openalex.org/W2064385829","https://openalex.org/W2084909984","https://openalex.org/W2096154341","https://openalex.org/W2096230949","https://openalex.org/W2110009365","https://openalex.org/W2121294788","https://openalex.org/W2140911983","https://openalex.org/W2147786790","https://openalex.org/W2183854290","https://openalex.org/W2297531655","https://openalex.org/W2506344357","https://openalex.org/W3185671723","https://openalex.org/W4251934312","https://openalex.org/W4253001397"],"related_works":["https://openalex.org/W2008399598","https://openalex.org/W2143766403","https://openalex.org/W3099317789","https://openalex.org/W2351037285","https://openalex.org/W2084909984","https://openalex.org/W2355768399","https://openalex.org/W2356396164","https://openalex.org/W2978551641","https://openalex.org/W2383404758","https://openalex.org/W2393643865"],"abstract_inverted_index":{"Hepatocyte":[0],"growth":[1],"factor":[2],"(HGF)":[3],"is":[4,181],"a":[5,58,70,135],"promising":[6],"agent":[7],"for":[8,60,72,183],"the":[9,23,73,85,127,130,138,169,184,205,211],"treatment":[10,45,67,107,178,212],"of":[11,15,25,77,82,97,115,141,145,171,186,191,208,213],"liver":[12,40,86,214],"cirrhosis":[13,31,41],"because":[14],"its":[16,33],"mitogenic":[17],"and":[18,35,88,91,118,134,188],"anti-fibrotic":[19],"effects.":[20],"We":[21],"investigated":[22],"effect":[24],"recombinant":[26],"human":[27],"HGF":[28],"(rh-HGF)":[29],"on":[30],"development;":[32],"pharmacokinetics":[34],"nephrotoxicity":[36],"in":[37,63,126,137,196,210],"rats":[38,56],"with":[39,46,65,108,179],"induced":[42],"by":[43,104],"4-week":[44],"dimethylnitrosamine":[47],"(DMN).":[48],"rh-HGF":[49,83,116,146,180,192,209],"(0.3":[50],"mg/kg)":[51],"was":[52,100,120],"intravenously":[53],"administered":[54],"to":[55,123,148,166],"once":[57],"day":[59,71],"4":[61],"weeks":[62,76],"parallel":[64],"DMN":[66,78],"or":[68],"twice":[69],"last":[74],"2":[75],"treatment.":[79],"Repeated":[80,143],"doses":[81,144,190],"increased":[84,117,149,158],"weight":[87],"serum":[89,93,113,159],"albumin,":[90],"reduced":[92],"ALT.":[94],"The":[95],"development":[96],"hepatic":[98],"fibrosis":[99],"inhibited":[101],"more":[102],"efficiently":[103],"extended":[105,177],"low-dose":[106],"rh-HGF.":[109,172],"In":[110],"cirrhotic":[111],"rats,":[112],"levels":[114],"clearance":[119],"decreased,":[121],"leading":[122],"an":[124],"increase":[125],"area":[128],"under":[129],"plasma-concentration":[131],"time":[132],"curve":[133],"decrease":[136],"steady-state":[139],"volume":[140],"distribution.":[142],"led":[147],"urinary":[150],"albumin":[151,163],"excretion,":[152],"but":[153],"no":[154],"rh-HGF-treated":[155],"animals":[156],"developed":[157],"creatinine":[160],"levels.":[161],"Urinary":[162],"excretion":[164],"returned":[165],"baseline":[167],"after":[168],"cessation":[170],"These":[173,199],"results":[174],"suggest":[175],"that":[176],"required":[182],"attenuation":[185],"cirrhosis,":[187],"repeated":[189],"cause":[193],"adverse":[194],"effects":[195],"extra-hepatic":[197],"organs.":[198],"issues":[200],"must":[201],"be":[202],"resolved":[203],"before":[204],"widespread":[206],"application":[207],"cirrhosis.":[215]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
