{"id":"https://openalex.org/W2072019643","doi":"https://doi.org/10.1097/ccm.0b013e3181743d77","title":"Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury*","display_name":"Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury*","publication_year":2008,"publication_date":"2008-05-29","ids":{"openalex":"https://openalex.org/W2072019643","doi":"https://doi.org/10.1097/ccm.0b013e3181743d77","mag":"2072019643","pmid":"https://pubmed.ncbi.nlm.nih.gov/18496376"},"language":"en","primary_location":{"id":"doi:10.1097/ccm.0b013e3181743d77","doi":"https://doi.org/10.1097/ccm.0b013e3181743d77","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ccm.0b013e3181743d77","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2072019643"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046264726","display_name":"Guy Rosenthal","orcid":"https://orcid.org/0000-0003-4331-6542","observed_orcids":["https://orcid.org/0000-0003-4331-6542"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guy Rosenthal","raw_affiliation_strings":["Department of Neurosurgery, University of California, San Francisco, USA","Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of California, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Francisco","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010173440","display_name":"J. Claude Hemphill","orcid":"https://orcid.org/0000-0003-4019-7525","observed_orcids":["https://orcid.org/0000-0003-4019-7525"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Claude Hemphill","raw_affiliation_strings":["From the Departments of Neurosurgery (GR, CM, DM, GTM) and Neurology (JCH) and the Program in Bioinformatics (MS), University of California, San Francisco","and Department of Neurological Survey (WO), University of Pittsburgh, Pittsburgh, PA","Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurosurgery (GR, CM, DM, GTM) and Neurology (JCH) and the Program in Bioinformatics (MS), University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"and Department of Neurological Survey (WO), University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Francisco","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065855561","display_name":"Marco D. Sorani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marco Sorani","raw_affiliation_strings":["From the Departments of Neurosurgery (GR, CM, DM, GTM) and Neurology (JCH) and the Program in Bioinformatics (MS), University of California, San Francisco","and Department of Neurological Survey (WO), University of Pittsburgh, Pittsburgh, PA","Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurosurgery (GR, CM, DM, GTM) and Neurology (JCH) and the Program in Bioinformatics (MS), University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"and Department of Neurological Survey (WO), University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Francisco","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103744954","display_name":"Christine Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Martin","raw_affiliation_strings":["From the Departments of Neurosurgery (GR, CM, DM, GTM) and Neurology (JCH) and the Program in Bioinformatics (MS), University of California, San Francisco","and Department of Neurological Survey (WO), University of Pittsburgh, Pittsburgh, PA","Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurosurgery (GR, CM, DM, GTM) and Neurology (JCH) and the Program in Bioinformatics (MS), University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"and Department of Neurological Survey (WO), University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Francisco","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041719015","display_name":"Diane J. Morabito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Morabito","raw_affiliation_strings":["From the Departments of Neurosurgery (GR, CM, DM, GTM) and Neurology (JCH) and the Program in Bioinformatics (MS), University of California, San Francisco","and Department of Neurological Survey (WO), University of Pittsburgh, Pittsburgh, PA","Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurosurgery (GR, CM, DM, GTM) and Neurology (JCH) and the Program in Bioinformatics (MS), University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"and Department of Neurological Survey (WO), University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Francisco","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009859989","display_name":"Walter D. Obrist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter D. Obrist","raw_affiliation_strings":["From the Departments of Neurosurgery (GR, CM, DM, GTM) and Neurology (JCH) and the Program in Bioinformatics (MS), University of California, San Francisco","and Department of Neurological Survey (WO), University of Pittsburgh, Pittsburgh, PA","Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurosurgery (GR, CM, DM, GTM) and Neurology (JCH) and the Program in Bioinformatics (MS), University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"and Department of Neurological Survey (WO), University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Francisco","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109130229","display_name":"Geoffrey T. Manley","orcid":"https://orcid.org/0000-0002-0926-3128","observed_orcids":["https://orcid.org/0000-0002-0926-3128"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey T. Manley","raw_affiliation_strings":["From the Departments of Neurosurgery (GR, CM, DM, GTM) and Neurology (JCH) and the Program in Bioinformatics (MS), University of California, San Francisco","and Department of Neurological Survey (WO), University of Pittsburgh, Pittsburgh, PA","Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurosurgery (GR, CM, DM, GTM) and Neurology (JCH) and the Program in Bioinformatics (MS), University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"and Department of Neurological Survey (WO), University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Francisco","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.7992,"has_fulltext":false,"cited_by_count":284,"citation_normalized_percentile":{"value":0.99204894,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"36","issue":"6","first_page":"1917","last_page":"1924"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-tissue-oxygen-tension","display_name":"brain tissue oxygen tension","score":0.9769999980926514},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cerebral-oxygen-delivery","display_name":"cerebral oxygen delivery","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cerebral-metabolic-rate-for-oxygen","display_name":"cerebral oxygen consumption","score":0.8730000257492065},{"id":"https://openalex.org/keywords/regional-cerebral-blood-flow","display_name":"regional cerebral blood flow","score":0.8109999895095825},{"id":"https://openalex.org/keywords/autoregulation","display_name":"autoregulation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cerebral-vasoreactivity","display_name":"cerebral vasoreactivity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/neuromonitoring","display_name":"neuromonitoring","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7502915859222412},{"id":"https://openalex.org/C2993207723","wikidata":"https://www.wikidata.org/wiki/Q4927803","display_name":"Oxygen tension","level":3,"score":0.6967975497245789},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.6488354206085205},{"id":"https://openalex.org/C84359808","wikidata":"https://www.wikidata.org/wiki/Q13365173","display_name":"Cerebral autoregulation","level":4,"score":0.6159312725067139},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5873175263404846},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.5002830028533936},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.4958983361721039},{"id":"https://openalex.org/C2780954326","wikidata":"https://www.wikidata.org/wiki/Q1416096","display_name":"Intracranial pressure","level":2,"score":0.4502529203891754},{"id":"https://openalex.org/C2993864201","wikidata":"https://www.wikidata.org/wiki/Q7873","display_name":"Oxygen transport","level":3,"score":0.4493834376335144},{"id":"https://openalex.org/C119671327","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral circulation","level":2,"score":0.433192640542984},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3293986916542053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3005877733230591},{"id":"https://openalex.org/C111774379","wikidata":"https://www.wikidata.org/wiki/Q1364253","display_name":"Autoregulation","level":3,"score":0.18361890316009521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0922313928604126},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007427","descriptor_name":"Intracranial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010102","descriptor_name":"Oxygen Inhalation Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014193","descriptor_name":"Trauma Centers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015600","descriptor_name":"Glasgow Coma Scale","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/ccm.0b013e3181743d77","doi":"https://doi.org/10.1097/ccm.0b013e3181743d77","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ccm.0b013e3181743d77","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:18496376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18496376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Journal Article"},{"id":"pmid:19318818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19318818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G279855812","display_name":"PREDOCTORAL FELLOWSHIPS FOR STUDENTS WITH DISABILITIES","funder_award_id":"F31NS049691","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3230940654","display_name":null,"funder_award_id":"NS049691","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3382711824","display_name":"Secondary Brain Injury in Intracerebral Hemorrhage","funder_award_id":"K23NS041240","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4562216945","display_name":"Role of Aquaporin-4 Water Channels in Cerebral Edema","funder_award_id":"R01NS050173","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W10007415","https://openalex.org/W414710620","https://openalex.org/W1449393265","https://openalex.org/W1901898169","https://openalex.org/W1912611033","https://openalex.org/W1952336491","https://openalex.org/W1971144058","https://openalex.org/W1987825285","https://openalex.org/W1996443483","https://openalex.org/W1996760171","https://openalex.org/W2000167387","https://openalex.org/W2007420574","https://openalex.org/W2030706848","https://openalex.org/W2051610938","https://openalex.org/W2053620856","https://openalex.org/W2059058279","https://openalex.org/W2097552051","https://openalex.org/W2099727288","https://openalex.org/W2104288604","https://openalex.org/W2105333849","https://openalex.org/W2111156333","https://openalex.org/W2115968594","https://openalex.org/W2117047003","https://openalex.org/W2122901111","https://openalex.org/W2128712943","https://openalex.org/W2139725823","https://openalex.org/W2150833402","https://openalex.org/W2157757992","https://openalex.org/W2167374285","https://openalex.org/W2170128907","https://openalex.org/W2242726375","https://openalex.org/W2260880361","https://openalex.org/W2282247802"],"related_works":["https://openalex.org/W2071520366","https://openalex.org/W4386325937","https://openalex.org/W2155580597","https://openalex.org/W2470228050","https://openalex.org/W2052198847","https://openalex.org/W4296822966","https://openalex.org/W2088926929","https://openalex.org/W2038116453"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Despite":[1],"the":[2,11,119,193,203,230,238,243,263,270],"growing":[3],"clinical":[4,271],"use":[5],"of":[6,14,32,151,177,187,205,225,235,240,251,262,266,273],"brain":[7,16,24,219,274],"tissue":[8,17,83,220,275],"oxygen":[9,18,47,52,74,84,154,160,164,168,178,189,210,221,228,253,257,276],"monitoring,":[10],"specific":[12],"determinants":[13],"low":[15],"tension":[19,161,211,222],"(P(bt)O2)":[20],"following":[21],"severe":[22],"traumatic":[23],"injury":[25],"(TBI)":[26],"remain":[27],"poorly":[28],"defined.":[29],"The":[30],"objective":[31],"this":[33],"study":[34],"was":[35,111,127,198],"to":[36,45,79,81,93,100],"evaluate":[37],"whether":[38],"P(bt)O2":[39,110,201,236,267],"more":[40],"closely":[41],"reflects":[42,50],"variables":[43,186],"related":[44],"cerebral":[46,51,102,123,174,188,208,244,256,264],"diffusion":[48,133,224],"or":[49,255],"delivery":[53,190,254],"and":[54,96,172,191,202,207,223,242],"metabolism.":[55,258],"DESIGN:":[56],"Prospective":[57],"observational":[58],"study.":[59],"SETTING:":[60],"Level":[61],"I":[62],"trauma":[63],"center.":[64],"PATIENTS:":[65],"Fourteen":[66],"TBI":[67],"patients":[68,279],"with":[69,114,129,280],"advanced":[70],"neuromonitoring":[71],"underwent":[72],"an":[73],"challenge":[75,87,98],"(increase":[76,88],"in":[77,89,118,278],"FiO2":[78],"1.0)":[80],"assess":[82,94,101],"reactivity,":[85],"pressure":[86],"mean":[90],"arterial":[91,153],"pressure)":[92],"autoregulation,":[95],"CO2":[97],"(hyperventilation)":[99],"vasoreactivity.":[103],"INTERVENTIONS:":[104],"None.":[105],"MEASUREMENTS":[106],"AND":[107],"MAIN":[108],"RESULTS:":[109],"measured":[112,128],"directly":[113],"a":[115,130,142,215,248],"parenchymal":[116,131],"probe":[117],"least-injured":[120],"hemisphere.":[121],"Local":[122],"blood":[124,137],"flow":[125],"(CBF)":[126],"thermal":[132],"probe.":[134],"Cerebral":[135],"venous":[136,145,159,163],"gases":[138],"were":[139],"drawn":[140],"from":[141],"jugular":[143,157],"bulb":[144,158],"catheter.":[146],"We":[147],"performed":[148],"119":[149],"measurements":[150],"PaO2,":[152],"content":[155,165,169],"(CaO2),":[156],"(PVO2),":[162],"(CVO2),":[166],"arteriovenous":[167,209],"difference":[170,212],"(AVDO2),":[171],"local":[173],"metabolic":[175],"rate":[176],"(locCMRO2).":[179],"In":[180],"multivariable":[181],"analysis":[182],"adjusting":[183],"for":[184],"various":[185],"metabolism,":[192],"only":[194],"statistically":[195],"significant":[196],"relationship":[197],"that":[199],"between":[200,218],"product":[204,239],"CBF":[206,241],"(AVTO2),":[213],"suggesting":[214],"strong":[216],"association":[217],"dissolved":[226],"plasma":[227],"across":[229],"blood-brain":[231],"barrier.":[232],"CONCLUSIONS:":[233],"Measurements":[234],"represent":[237],"AVTO2":[245],"rather":[246],"than":[247],"direct":[249],"measurement":[250],"total":[252],"This":[259],"improved":[260],"understanding":[261],"physiology":[265],"should":[268],"enhance":[269],"utility":[272],"monitoring":[277],"TBI.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}