{"id":"https://openalex.org/W2072018719","doi":"https://doi.org/10.1046/j.1365-2249.1996.d01-633.x","title":"Correlation between expression of antibodies to histone H2B and clinical activity in HIV-infected individuals","display_name":"Correlation between expression of antibodies to histone H2B and clinical activity in HIV-infected individuals","publication_year":1996,"publication_date":"1996-04-01","ids":{"openalex":"https://openalex.org/W2072018719","doi":"https://doi.org/10.1046/j.1365-2249.1996.d01-633.x","mag":"2072018719","pmid":"https://pubmed.ncbi.nlm.nih.gov/8603524","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2200381"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2249.1996.d01-633.x","doi":"https://doi.org/10.1046/j.1365-2249.1996.d01-633.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2249.1996.d01-633.x","pdf_url":"https://academic.oup.com/cei/article-pdf/104/1/18/42203683/j.1365-2249.1996.d01-633.x.pdf","source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/cei/article-pdf/104/1/18/42203683/j.1365-2249.1996.d01-633.x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080420577","display_name":"W. Williams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W M Williams","raw_affiliation_strings":["IDEC Pharmaceuticals Corporation, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IDEC Pharmaceuticals Corporation, La Jolla, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031793079","display_name":"Alice Whalley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A S Whalley","raw_affiliation_strings":["IDEC Pharmaceuticals Corporation, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IDEC Pharmaceuticals Corporation, La Jolla, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084456380","display_name":"R Comacchio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R M Comacchio","raw_affiliation_strings":["Department of Immunology, The Medical College of St Bartholomew\u2019s Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Medical College of St Bartholomew\u2019s Hospital, London","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J Rosenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Rosenberg","raw_affiliation_strings":["IDEC Pharmaceuticals Corporation, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IDEC Pharmaceuticals Corporation, La Jolla, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003005694","display_name":"Richard A. Watts","orcid":"https://orcid.org/0000-0002-2846-4769","observed_orcids":["https://orcid.org/0000-0002-2846-4769"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R A Watts","raw_affiliation_strings":["Department of Rheumatology Research, University College and the Middlesex Hospital Medical School, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology Research, University College and the Middlesex Hospital Medical School, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065798696","display_name":"David Alan Isenberg","orcid":"https://orcid.org/0000-0001-9514-2455","observed_orcids":["https://orcid.org/0000-0001-9514-2455"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D A Isenberg","raw_affiliation_strings":["Department of Rheumatology Research, University College and the Middlesex Hospital Medical School, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology Research, University College and the Middlesex Hospital Medical School, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041128223","display_name":"J A Mc Cutchan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Mc Cutchan","raw_affiliation_strings":["Division of Infectious Diseases, University of California School of Medicine, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, University of California School of Medicine, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109844757","display_name":"W J Morrow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"W J W Morrow","raw_affiliation_strings":["IDEC Pharmaceuticals Corporation, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IDEC Pharmaceuticals Corporation, La Jolla, CA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109844757"],"corresponding_institution_ids":[],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":0.3941,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.60653105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"104","issue":"1","first_page":"18","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-h2b","display_name":"histone H2B","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.9480000138282776},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.8560000061988831},{"id":"https://openalex.org/keywords/lymphadenopathy","display_name":"lymphadenopathy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8610000014305115},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6690000295639038},{"id":"https://openalex.org/keywords/immunological-cross-reactivity","display_name":"immunological cross-reactivity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/t-cell-depletion","display_name":"T cell depletion","score":0.5429999828338623},{"id":"https://openalex.org/keywords/clinical-activity","display_name":"clinical activity","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7301648855209351},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7263240218162537},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.691528856754303},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6112550497055054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6097851395606995},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5181766748428345},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48687973618507385},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.45350387692451477},{"id":"https://openalex.org/C2779320353","wikidata":"https://www.wikidata.org/wiki/Q1416887","display_name":"Histone H2B","level":4,"score":0.4347417950630188},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4264858067035675},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23845285177230835},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06688433885574341},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018451","descriptor_name":"Homosexuality, Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1365-2249.1996.d01-633.x","doi":"https://doi.org/10.1046/j.1365-2249.1996.d01-633.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2249.1996.d01-633.x","pdf_url":"https://academic.oup.com/cei/article-pdf/104/1/18/42203683/j.1365-2249.1996.d01-633.x.pdf","source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2200381","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2200381","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:8603524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8603524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1046/j.1365-2249.1996.d01-633.x","doi":"https://doi.org/10.1046/j.1365-2249.1996.d01-633.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2249.1996.d01-633.x","pdf_url":"https://academic.oup.com/cei/article-pdf/104/1/18/42203683/j.1365-2249.1996.d01-633.x.pdf","source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072018719.pdf","grobid_xml":"https://content.openalex.org/works/W2072018719.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W86423223","https://openalex.org/W256324524","https://openalex.org/W1513310349","https://openalex.org/W1526402321","https://openalex.org/W1921925233","https://openalex.org/W1965228684","https://openalex.org/W1969899610","https://openalex.org/W1970567270","https://openalex.org/W1973727813","https://openalex.org/W1996839499","https://openalex.org/W2002581043","https://openalex.org/W2010033210","https://openalex.org/W2010941357","https://openalex.org/W2011571744","https://openalex.org/W2014888345","https://openalex.org/W2017173745","https://openalex.org/W2023517807","https://openalex.org/W2029625233","https://openalex.org/W2035610539","https://openalex.org/W2035733815","https://openalex.org/W2039199257","https://openalex.org/W2049463886","https://openalex.org/W2067244066","https://openalex.org/W2075135942","https://openalex.org/W2085721436","https://openalex.org/W2090995436","https://openalex.org/W2092493820","https://openalex.org/W2094069017","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2109834875","https://openalex.org/W2126350898","https://openalex.org/W2141002693","https://openalex.org/W2400126894","https://openalex.org/W2413408037","https://openalex.org/W2414174843","https://openalex.org/W2416412096","https://openalex.org/W2417549700","https://openalex.org/W2417782082","https://openalex.org/W3028018960"],"related_works":["https://openalex.org/W2045244924","https://openalex.org/W227540472","https://openalex.org/W2303735994","https://openalex.org/W4411029114","https://openalex.org/W3095172170","https://openalex.org/W7096902932","https://openalex.org/W2044300456","https://openalex.org/W2061935372","https://openalex.org/W2031414863","https://openalex.org/W2056824230"],"abstract_inverted_index":{"Levels":[0],"of":[1,32,40,54,65,83,91,106,115,130],"autoantibodies":[2,108],"specific":[3],"for":[4],"the":[5,52,62,66,81,92,104,113,128,131],"histone,":[6],"H2B,":[7],"were":[8,43,109],"measured":[9],"in":[10,45,127],"individuals":[11],"with":[12,17,25,47,51,76,100],"HIV":[13],"infection.":[14],"In":[15,56],"comparison":[16],"normal":[18],"(uninfected)":[19],"controls,":[20],"infected":[21],"patients,":[22],"particularly":[23],"those":[24],"symptomatic":[26],"disease,":[27],"had":[28],"significantly":[29],"elevated":[30],"titres":[31,105],"anti-H2B":[33],"antibodies.":[34],"Longitudinal":[35],"studies":[36],"confirmed":[37],"that":[38,122],"levels":[39],"these":[41,123],"antibodies":[42,124],"highest":[44],"patients":[46],"lymphadenopathy":[48],"and":[49],"declined":[50],"development":[53],"AIDS.":[55],"preliminary":[57],"experiments":[58],"designed":[59],"to":[60,72,111],"determine":[61],"biological":[63],"significance":[64],"anti-histone":[67],"antibodies,":[68],"H2B":[69,107],"was":[70],"shown":[71,97],"be":[73],"immunologically":[74],"cross-reactive":[75],"an":[77],"18-kD":[78,93],"antigen":[79,94],"on":[80],"surface":[82],"HIV-infected":[84],"or":[85],"mitogen-activated":[86],"CD4+":[87],"cells.":[88],"Protein":[89],"sequencing":[90],"has":[95],"since":[96],"complete":[98],"homology":[99],"histone":[101],"H2B.":[102],"Because":[103],"found":[110],"parallel":[112],"numbers":[114],"circulating":[116],"CD4":[117],"cells,":[118],"it":[119],"is":[120],"possible":[121],"are":[125],"involved":[126],"destruction":[129],"helper/inducer":[132],"T":[133],"lymphocyte":[134],"population.":[135]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}