{"id":"https://openalex.org/W2072000337","doi":"https://doi.org/10.1242/dev.00400","title":"The role of the zebrafishnodal-related genessquintandcyclopsin patterning of mesendoderm","display_name":"The role of the zebrafishnodal-related genessquintandcyclopsin patterning of mesendoderm","publication_year":2003,"publication_date":"2003-03-18","ids":{"openalex":"https://openalex.org/W2072000337","doi":"https://doi.org/10.1242/dev.00400","mag":"2072000337","pmid":"https://pubmed.ncbi.nlm.nih.gov/12642489"},"language":"en","primary_location":{"id":"doi:10.1242/dev.00400","doi":"https://doi.org/10.1242/dev.00400","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.00400","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075494526","display_name":"Scott T. Dougan","orcid":"https://orcid.org/0000-0003-0214-4772","observed_orcids":["https://orcid.org/0000-0003-0214-4772"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott T. Dougan","raw_affiliation_strings":["Department of Developmental Biology, Stanford University School of Medicine,Stanford, CA 94305, USA","Present address: Department of Cellular Biology, University of Georgia, 724 Biological Sciences Building, Athens, GA 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Stanford University School of Medicine,Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Present address: Department of Cellular Biology, University of Georgia, 724 Biological Sciences Building, Athens, GA 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015651996","display_name":"Rachel M. Warga","orcid":"https://orcid.org/0009-0009-7117-6322","observed_orcids":["https://orcid.org/0009-0009-7117-6322"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel M. Warga","raw_affiliation_strings":["Department of Biology, University of Rochester, Rochester, NY 14627, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rochester, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085611535","display_name":"Donald A. Kane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald A. Kane","raw_affiliation_strings":["Department of Biology, University of Rochester, Rochester, NY 14627, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rochester, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066848145","display_name":"Alexander F. Schier","orcid":"https://orcid.org/0000-0001-7645-5325","observed_orcids":["https://orcid.org/0000-0001-7645-5325","https://orcid.org/0000-0002-5317-494X"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander F. Schier","raw_affiliation_strings":["Developmental Genetics Program, Skirball Institute of Biomolecular Medicine,Department of Cell Biology, New York University School of Medicine, New York,NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Genetics Program, Skirball Institute of Biomolecular Medicine,Department of Cell Biology, New York University School of Medicine, New York,NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018736408","display_name":"William S. Talbot","orcid":"https://orcid.org/0000-0002-2048-7472","observed_orcids":["https://orcid.org/0000-0002-2048-7472"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William S. Talbot","raw_affiliation_strings":["Department of Developmental Biology, Stanford University School of Medicine,Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Stanford University School of Medicine,Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5018736408"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":2.7342,"has_fulltext":false,"cited_by_count":200,"citation_normalized_percentile":{"value":0.9123601,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"130","issue":"9","first_page":"1837","last_page":"1851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nodal-signaling","display_name":"Nodal signaling","score":0.9010000228881836},{"id":"https://openalex.org/keywords/strabismus","display_name":"strabismus","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cyclops","display_name":"Cyclops","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dorsoventral-patterning","display_name":"dorsoventral patterning","score":0.843999981880188},{"id":"https://openalex.org/keywords/animal-vegetal-axis","display_name":"animal-vegetal axis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tgf-beta-superfamily","display_name":"TGF-beta superfamily","score":0.753000020980835},{"id":"https://openalex.org/keywords/endoderm-induction","display_name":"endoderm induction","score":0.7269999980926514},{"id":"https://openalex.org/keywords/mesoderm-induction","display_name":"mesoderm induction","score":0.8309999704360962},{"id":"https://openalex.org/keywords/autoregulation","display_name":"autoregulation","score":0.878000020980835},{"id":"https://openalex.org/keywords/zebrafish-mutants","display_name":"zebrafish mutants","score":0.8119999766349792},{"id":"https://openalex.org/keywords/blastula","display_name":"blastula","score":0.5389999747276306},{"id":"https://openalex.org/keywords/gastrula","display_name":"gastrula","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C83330619","wikidata":"https://www.wikidata.org/wiki/Q21124872","display_name":"NODAL","level":2,"score":0.9332374334335327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8545764088630676},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.7664797306060791},{"id":"https://openalex.org/C2777164004","wikidata":"https://www.wikidata.org/wiki/Q331858","display_name":"Endoderm","level":4,"score":0.6746052503585815},{"id":"https://openalex.org/C205583638","wikidata":"https://www.wikidata.org/wiki/Q7046607","display_name":"Nodal signaling","level":5,"score":0.6496337652206421},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.6290532350540161},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47812166810035706},{"id":"https://openalex.org/C6047887","wikidata":"https://www.wikidata.org/wiki/Q420811","display_name":"Blastula","level":5,"score":0.42216914892196655},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.4182065427303314},{"id":"https://openalex.org/C2776133846","wikidata":"https://www.wikidata.org/wiki/Q243469","display_name":"Notochord","level":4,"score":0.4120437502861023},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3811075687408447},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34707406163215637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.280120313167572},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.27920296788215637},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.19116955995559692},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.1831490397453308},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.13952258229255676}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004707","descriptor_name":"Endoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055456","descriptor_name":"Nodal Signaling Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055457","descriptor_name":"Nodal Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1242/dev.00400","doi":"https://doi.org/10.1242/dev.00400","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.00400","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:12642489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12642489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.unibas.ch:74883","doi":null,"is_oa":false,"landing_page_url":"https://edoc.unibas.ch/74883/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401836","display_name":"edoc (University of Basel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1850255","host_organization_name":"University of Basel","host_organization_lineage":["https://openalex.org/I1850255"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1625856714","display_name":" GASTRULATION IN THE VERTEBRATE EMBRYO","funder_award_id":"R01GM057825","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1772223067","display_name":"GENETICS OF MORPHOGENESIS OF VERTEBRATE GASTRULATION","funder_award_id":"R01GM058513","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5964742504","display_name":null,"funder_award_id":"GM 56211","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W23956445","https://openalex.org/W75491002","https://openalex.org/W1486617321","https://openalex.org/W1489916230","https://openalex.org/W1513929030","https://openalex.org/W1527223408","https://openalex.org/W1533376056","https://openalex.org/W1651423553","https://openalex.org/W1824369405","https://openalex.org/W1838303488","https://openalex.org/W1861727770","https://openalex.org/W1888475523","https://openalex.org/W1890963650","https://openalex.org/W1938764043","https://openalex.org/W1959073095","https://openalex.org/W1970341768","https://openalex.org/W1970452404","https://openalex.org/W1971805461","https://openalex.org/W1978122588","https://openalex.org/W1978541292","https://openalex.org/W1982334530","https://openalex.org/W1996551832","https://openalex.org/W2005494875","https://openalex.org/W2007817359","https://openalex.org/W2010041789","https://openalex.org/W2012493304","https://openalex.org/W2014371162","https://openalex.org/W2015929447","https://openalex.org/W2019598289","https://openalex.org/W2023574734","https://openalex.org/W2025123418","https://openalex.org/W2026112588","https://openalex.org/W2029514251","https://openalex.org/W2031411430","https://openalex.org/W2035246955","https://openalex.org/W2037143749","https://openalex.org/W2055726879","https://openalex.org/W2067256177","https://openalex.org/W2067545062","https://openalex.org/W2068037010","https://openalex.org/W2071475719","https://openalex.org/W2078058386","https://openalex.org/W2078784347","https://openalex.org/W2079406338","https://openalex.org/W2082955515","https://openalex.org/W2086526467","https://openalex.org/W2090509734","https://openalex.org/W2091821419","https://openalex.org/W2092088384","https://openalex.org/W2094808414","https://openalex.org/W2096614956","https://openalex.org/W2098175174","https://openalex.org/W2102144828","https://openalex.org/W2103946015","https://openalex.org/W2105884976","https://openalex.org/W2110442916","https://openalex.org/W2111479560","https://openalex.org/W2115686163","https://openalex.org/W2116428404","https://openalex.org/W2120643964","https://openalex.org/W2125349610","https://openalex.org/W2126042045","https://openalex.org/W2129835280","https://openalex.org/W2131716017","https://openalex.org/W2132845755","https://openalex.org/W2136732727","https://openalex.org/W2138978169","https://openalex.org/W2147350988","https://openalex.org/W2147556163","https://openalex.org/W2152859543","https://openalex.org/W2156212940","https://openalex.org/W2160922979","https://openalex.org/W2165857084","https://openalex.org/W2166658859","https://openalex.org/W2166697185","https://openalex.org/W2181871091","https://openalex.org/W2187773990","https://openalex.org/W2188181349","https://openalex.org/W2188347498","https://openalex.org/W2204701853","https://openalex.org/W4321429191"],"related_works":["https://openalex.org/W2067545062","https://openalex.org/W2022992789","https://openalex.org/W1568774846","https://openalex.org/W1489916230","https://openalex.org/W2047522987","https://openalex.org/W2391635715","https://openalex.org/W2072190909","https://openalex.org/W7097600682","https://openalex.org/W2773878580","https://openalex.org/W4281569172"],"abstract_inverted_index":{"Nodal":[0,31,52,129,181,248],"signals,":[1],"a":[2,126,174],"subclass":[3],"of":[4,8,13,51,93,149,180,186,191,212,231],"the":[5,23,47,62,106,117,133,136,177,187,192,200,228,254,257],"TGFbeta":[6],"superfamily":[7],"secreted":[9],"factors,":[10],"induce":[11,220],"formation":[12],"mesoderm":[14,145],"and":[15,26,42,49,66,69,76,89,110,139,143,151,237],"endoderm":[16,107],"in":[17,36,73,120,131,164,183,195,207,223,235],"vertebrate":[18],"embryos.":[19],"We":[20],"have":[21],"examined":[22],"possible":[24],"dorsoventral":[25,184],"animal-vegetal":[27,137],"patterning":[28,132,185],"roles":[29],"for":[30,128,176,203],"signals":[32,130,182,249],"by":[33],"using":[34],"mutations":[35],"two":[37],"zebrafish":[38],"nodal-related":[39,204],"genes,":[40],"squint":[41,54,150,236],"cyclops,":[43],"to":[44,116,199,247],"manipulate":[45],"genetically":[46],"levels":[48,148],"timing":[50,230],"activity.":[53],"mutants":[55,79,239],"lack":[56],"dorsal":[57,83,94,142,232,242],"mesendodermal":[58,95],"gene":[59,70,194,205],"expression":[60,71,211,222],"at":[61,250],"late":[63],"blastula":[64],"stage,":[65],"fate":[67],"mapping":[68],"studies":[72],"sqt(-/-);":[74,77,166,169],"cyc(+/+)":[75,170],"cyc(+/-)":[78,167],"show":[80],"that":[81,141,241],"some":[82],"marginal":[84,155,243],"cells":[85,156,197,244],"inappropriately":[86],"form":[87],"hindbrain":[88],"spinal":[90],"cord":[91],"instead":[92],"derivatives.":[96],"The":[97],"effects":[98],"on":[99],"ventrolateral":[100,144,224],"mesendoderm":[101,134,233],"are":[102,113],"less":[103],"severe,":[104],"although":[105],"is":[108],"reduced":[109],"muscle":[111],"precursors":[112],"located":[114],"nearer":[115],"margin":[118],"than":[119],"wild":[121],"type.":[122],"Our":[123],"results":[124],"support":[125],"role":[127,175],"along":[135],"axis":[138],"indicate":[140],"require":[146],"different":[147,201],"cyclops":[152,193,213,221,238],"function.":[153],"Dorsal":[154,210],"were":[157],"not":[158],"transformed":[159],"toward":[160],"more":[161],"lateral":[162],"fates":[163],"either":[165],"or":[168],"embryos,":[171],"arguing":[172],"against":[173],"graded":[178],"action":[179],"mesendoderm.":[188],"Differential":[189],"regulation":[190],"these":[196,208],"contributes":[198],"requirements":[202],"function":[206],"cells.":[209,225],"requires":[214],"Nodal-dependent":[215],"autoregulation,":[216],"whereas":[217],"other":[218],"factors":[219],"In":[226],"addition,":[227],"differential":[229],"induction":[234],"suggests":[240],"can":[245],"respond":[246],"stages":[251],"ranging":[252],"from":[253],"mid-blastula":[255],"through":[256],"mid-gastrula.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}