{"id":"https://openalex.org/W2071992906","doi":"https://doi.org/10.1523/jneurosci.1009-09.2009","title":"Otoferlin Is Critical for a Highly Sensitive and Linear Calcium-Dependent Exocytosis at Vestibular Hair Cell Ribbon Synapses","display_name":"Otoferlin Is Critical for a Highly Sensitive and Linear Calcium-Dependent Exocytosis at Vestibular Hair Cell Ribbon Synapses","publication_year":2009,"publication_date":"2009-08-26","ids":{"openalex":"https://openalex.org/W2071992906","doi":"https://doi.org/10.1523/jneurosci.1009-09.2009","mag":"2071992906","pmid":"https://pubmed.ncbi.nlm.nih.gov/19710301","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2966717"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.1009-09.2009","doi":"https://doi.org/10.1523/jneurosci.1009-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1009-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/34/10474.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/29/34/10474.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057129752","display_name":"Didier Dulon","orcid":"https://orcid.org/0000-0003-1541-6861","observed_orcids":["https://orcid.org/0000-0003-1541-6861"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210112727","display_name":"H\u00f4pital Pellegrin","ror":"https://ror.org/02x581406","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210112727"]},{"id":"https://openalex.org/I4405256745","display_name":"Universit\u00e9 Bordeaux Segalen","ror":"https://ror.org/04gbzm373","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530","https://openalex.org/I4405256745"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Didier Dulon","raw_affiliation_strings":["Universit\u00e9 Victor Segalen Bordeaux 2, Institut des Neurosciences de Bordeaux, Equipe Neurophysiologie de la Synapse Auditive, Inserm, Unit\u00e9 Mixte de Recherche en Sant\u00e9 587, Centre Hospitalier Universitaire H\u00f4pital Pellegrin, 33076 Bordeaux, France. didier.dulon@inserm.fr","Universit\u00e9 Victor Segalen Bordeaux 2, Institut des Neurosciences de Bordeaux, Equipe Neurophysiologie de la Synapse Auditive, Inserm, Unit\u00e9 Mixte de Recherche en Sant\u00e9 587, Centre Hospitalier Universitaire H\u00f4pital Pellegrin, 33076 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Victor Segalen Bordeaux 2, Institut des Neurosciences de Bordeaux, Equipe Neurophysiologie de la Synapse Auditive, Inserm, Unit\u00e9 Mixte de Recherche en Sant\u00e9 587, Centre Hospitalier Universitaire H\u00f4pital Pellegrin, 33076 Bordeaux, France. didier.dulon@inserm.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210112727","https://openalex.org/I4405256745"]},{"raw_affiliation_string":"Universit\u00e9 Victor Segalen Bordeaux 2, Institut des Neurosciences de Bordeaux, Equipe Neurophysiologie de la Synapse Auditive, Inserm, Unit\u00e9 Mixte de Recherche en Sant\u00e9 587, Centre Hospitalier Universitaire H\u00f4pital Pellegrin, 33076 Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210112727","https://openalex.org/I4405256745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024266430","display_name":"Saa\u00efd Safieddine","orcid":"https://orcid.org/0000-0002-6159-0572","observed_orcids":["https://orcid.org/0000-0002-6159-0572"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Saaid Safieddine","raw_affiliation_strings":["Institut Pasteur et Universit\u00e9 Pierre et Marie Curie, Unit\u00e9 de G\u00e9n\u00e9tique et Physiologie de l\u2019Audition, INSERM UMRS 587, 75015 Paris, France","\u2002Institut Pasteur, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur et Universit\u00e9 Pierre et Marie Curie, Unit\u00e9 de G\u00e9n\u00e9tique et Physiologie de l\u2019Audition, INSERM UMRS 587, 75015 Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I157536573","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"\u2002Institut Pasteur, Paris","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088524796","display_name":"Sherri M. Jones","orcid":"https://orcid.org/0000-0001-5018-3659","observed_orcids":["https://orcid.org/0000-0001-5018-3659"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]},{"id":"https://openalex.org/I4405256745","display_name":"Universit\u00e9 Bordeaux Segalen","ror":"https://ror.org/04gbzm373","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530","https://openalex.org/I4405256745"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Sherri M. Jones","raw_affiliation_strings":["Department of Communication Sciences and Disorders , East Carolina University , Greenville , North Carolina 27858 , and","Universite \u00b4Victor Segalen Bordeaux","Special Education and Communication Disorders"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Communication Sciences and Disorders , East Carolina University , Greenville , North Carolina 27858 , and","institution_ids":["https://openalex.org/I186335123"]},{"raw_affiliation_string":"Universite \u00b4Victor Segalen Bordeaux","institution_ids":["https://openalex.org/I4405256745"]},{"raw_affiliation_string":"Special Education and Communication Disorders","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072048458","display_name":"Christine Petit","orcid":"https://orcid.org/0000-0002-9069-002X","observed_orcids":["https://orcid.org/0000-0002-9069-002X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Petit","raw_affiliation_strings":["Coll\u00e8ge de France, 11 place Marcelin Berthelot, 75005 Paris, France","Institut Pasteur et Universit\u00e9 Pierre et Marie Curie, Unit\u00e9 de G\u00e9n\u00e9tique et Physiologie de l\u2019Audition, INSERM UMRS 587, 75015 Paris, France","College de France","Institut Pasteur Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coll\u00e8ge de France, 11 place Marcelin Berthelot, 75005 Paris, France","institution_ids":["https://openalex.org/I187986737"]},{"raw_affiliation_string":"Institut Pasteur et Universit\u00e9 Pierre et Marie Curie, Unit\u00e9 de G\u00e9n\u00e9tique et Physiologie de l\u2019Audition, INSERM UMRS 587, 75015 Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I157536573","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"College de France","institution_ids":["https://openalex.org/I187986737"]},{"raw_affiliation_string":"Institut Pasteur Paris","institution_ids":["https://openalex.org/I157536573"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5057129752"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210112727","https://openalex.org/I4405256745"],"apc_list":null,"apc_paid":null,"fwci":5.1828,"has_fulltext":true,"cited_by_count":149,"citation_normalized_percentile":{"value":0.96049443,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"29","issue":"34","first_page":"10474","last_page":"10487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.4595000147819519,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.4595000147819519,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.3086000084877014,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.16419999301433563,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/otoferlin","display_name":"otoferlin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ribbon-synapses","display_name":"ribbon synapses","score":0.6290000081062317},{"id":"https://openalex.org/keywords/vestibular-hair-cells","display_name":"vestibular hair cells","score":0.9300000071525574},{"id":"https://openalex.org/keywords/synaptic-vesicle-exocytosis","display_name":"synaptic vesicle exocytosis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/calcium-sensitivity","display_name":"calcium sensitivity","score":0.5849999785423279},{"id":"https://openalex.org/keywords/c2-domain-proteins","display_name":"C2 domain proteins","score":0.5899999737739563},{"id":"https://openalex.org/keywords/voltage-gated-calcium-channels","display_name":"voltage-gated calcium channels","score":0.8669999837875366},{"id":"https://openalex.org/keywords/utricle","display_name":"utricle","score":0.6539999842643738},{"id":"https://openalex.org/keywords/linear-transfer-function","display_name":"linear transfer function","score":0.6420000195503235},{"id":"https://openalex.org/keywords/hair-cell-synapses","display_name":"hair cell synapses","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C38120836","wikidata":"https://www.wikidata.org/wiki/Q7322268","display_name":"Ribbon synapse","level":5,"score":0.9009788632392883},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.8081498742103577},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.6696275472640991},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.5939720273017883},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5840142369270325},{"id":"https://openalex.org/C190041318","wikidata":"https://www.wikidata.org/wiki/Q596832","display_name":"Vestibular system","level":2,"score":0.5610044002532959},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.4766339063644409},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.46198946237564087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3920704126358032},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3541250228881836},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3465469479560852},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.31921154260635376},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.27944621443748474},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.26001954078674316},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.25495797395706177},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15033811330795288},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1302891969680786},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.09789618849754333},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000054","descriptor_name":"Acceleration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081412","descriptor_name":"Myosin VIIa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014725","descriptor_name":"Vestibular Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018069","descriptor_name":"Hair Cells, Vestibular","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D018069","descriptor_name":"Hair Cells, Vestibular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018069","descriptor_name":"Hair Cells, Vestibular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018069","descriptor_name":"Hair Cells, Vestibular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.1009-09.2009","doi":"https://doi.org/10.1523/jneurosci.1009-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1009-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/34/10474.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:19710301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19710301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2966717","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2966717/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-04159603v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04159603v1/document","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroscience, 2009, 29 (34), pp.10474-10487. &#x27E8;10.1523/JNEUROSCI.1009-09.2009&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.1009-09.2009","doi":"https://doi.org/10.1523/jneurosci.1009-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1009-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/34/10474.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4031671326","display_name":"Genetic basis for gravity receptor dysfunction in mice","funder_award_id":"R01DC006443","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G8704084870","display_name":null,"funder_award_id":"R0I DCOD6443","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320327813","display_name":"Fondation Voir et Entendre","ror":"https://ror.org/01ph0t361"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071992906.pdf","grobid_xml":"https://content.openalex.org/works/W2071992906.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W292677728","https://openalex.org/W1514853979","https://openalex.org/W1544571810","https://openalex.org/W1809106246","https://openalex.org/W1857461960","https://openalex.org/W1884550795","https://openalex.org/W1900274922","https://openalex.org/W1968669554","https://openalex.org/W1977604087","https://openalex.org/W1980682773","https://openalex.org/W1983078818","https://openalex.org/W1986338824","https://openalex.org/W1986501237","https://openalex.org/W1986887647","https://openalex.org/W1992558318","https://openalex.org/W1992961518","https://openalex.org/W1994478913","https://openalex.org/W1995607637","https://openalex.org/W1998473889","https://openalex.org/W2002412931","https://openalex.org/W2002473366","https://openalex.org/W2013906012","https://openalex.org/W2019766891","https://openalex.org/W2028448785","https://openalex.org/W2030538664","https://openalex.org/W2035018673","https://openalex.org/W2037741778","https://openalex.org/W2038283307","https://openalex.org/W2040224852","https://openalex.org/W2050427247","https://openalex.org/W2060988973","https://openalex.org/W2061018405","https://openalex.org/W2067622608","https://openalex.org/W2069665279","https://openalex.org/W2071320656","https://openalex.org/W2074128133","https://openalex.org/W2074378742","https://openalex.org/W2076259791","https://openalex.org/W2078039971","https://openalex.org/W2078577861","https://openalex.org/W2079971040","https://openalex.org/W2084945219","https://openalex.org/W2091448118","https://openalex.org/W2092333102","https://openalex.org/W2095470391","https://openalex.org/W2108065590","https://openalex.org/W2111698011","https://openalex.org/W2112155455","https://openalex.org/W2125659451","https://openalex.org/W2134573308","https://openalex.org/W2138642831","https://openalex.org/W2139939841","https://openalex.org/W2146174593","https://openalex.org/W2154546815","https://openalex.org/W2155756146","https://openalex.org/W2157932735","https://openalex.org/W2161496609","https://openalex.org/W2215581998","https://openalex.org/W2228008925","https://openalex.org/W2403950416","https://openalex.org/W2431648789","https://openalex.org/W4256057870"],"related_works":["https://openalex.org/W2078577861","https://openalex.org/W2767645678","https://openalex.org/W4404114332","https://openalex.org/W2905709173","https://openalex.org/W4408883797","https://openalex.org/W2071320656","https://openalex.org/W7098242796","https://openalex.org/W1965234374","https://openalex.org/W2920484977","https://openalex.org/W2104737125"],"abstract_inverted_index":{"Otoferlin,":[0],"a":[1,83,151],"C2-domain-containing":[2],"Ca(2+)":[3,89,94,100,107,113,130,134,142,153],"binding":[4],"protein,":[5],"is":[6,148],"required":[7],"for":[8,150],"synaptic":[9],"exocytosis":[10,125],"in":[11,30,50,69],"auditory":[12],"hair":[13,80,123,168],"cells.":[14],"However,":[15],"its":[16],"exact":[17],"role":[18],"remains":[19],"essentially":[20],"unknown.":[21],"Intriguingly":[22],"enough,":[23],"no":[24],"balance":[25],"defect":[26],"has":[27],"been":[28],"observed":[29,103],"otoferlin-deficient":[31],"(Otof(-/-))":[32],"mice.":[33,64],"Here,":[34],"we":[35,72],"show":[36,73],"that":[37,74,146,156],"the":[38,106,112,166],"vestibular":[39,167],"nerve":[40],"compound":[41],"action":[42],"potentials":[43],"evoked":[44],"during":[45,117],"transient":[46],"linear":[47,85,99,160],"acceleration":[48],"ramps":[49],"Otof(-/-)":[51,122],"mice":[52],"display":[53,82],"higher":[54],"threshold,":[55],"lower":[56],"amplitude,":[57],"and":[58,77,96,132,140,159],"increased":[59],"latency":[60],"compared":[61],"with":[62],"wild-type":[63],"Using":[65],"patch-clamp":[66],"capacitance":[67],"measurement":[68],"intact":[70],"utricles,":[71],"type":[75,78],"I":[76],"II":[79],"cells":[81],"remarkable":[84],"transfer":[86],"function":[87,155],"between":[88],"entry,":[90],"flowing":[91],"through":[92],"voltage-activated":[93],"channels,":[95],"exocytosis.":[97],"This":[98],"dependence":[101],"was":[102],"when":[104],"changing":[105],"channel":[108,116],"open":[109],"probability":[110],"or":[111],"flux":[114],"per":[115],"various":[118],"test":[119],"potentials.":[120],"In":[121],"cells,":[124],"displays":[126],"slower":[127],"kinetics,":[128],"reduced":[129],"sensitivity,":[131],"nonlinear":[133],"dependence,":[135],"despite":[136],"morphologically":[137],"normal":[138,141],"synapses":[139],"currents.":[143],"We":[144],"conclude":[145],"otoferlin":[147],"essential":[149],"high-affinity":[152],"sensor":[154],"allows":[157],"efficient":[158],"encoding":[161],"of":[162],"low-intensity":[163],"stimuli":[164],"at":[165],"cell":[169],"synapse.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
