{"id":"https://openalex.org/W2071990094","doi":"https://doi.org/10.1038/leu.2013.71","title":"Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis","display_name":"Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis","publication_year":2013,"publication_date":"2013-03-05","ids":{"openalex":"https://openalex.org/W2071990094","doi":"https://doi.org/10.1038/leu.2013.71","mag":"2071990094","pmid":"https://pubmed.ncbi.nlm.nih.gov/23459451","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3677140"},"language":"en","primary_location":{"id":"doi:10.1038/leu.2013.71","doi":"https://doi.org/10.1038/leu.2013.71","is_oa":true,"landing_page_url":"https://doi.org/10.1038/leu.2013.71","pdf_url":"https://www.nature.com/articles/leu201371.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/leu201371.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024612499","display_name":"Animesh Dev Pardanani","orcid":"https://orcid.org/0000-0002-9084-4148","observed_orcids":["https://orcid.org/0000-0002-9084-4148"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Pardanani","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070798358","display_name":"Rebecca R. Laborde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R R Laborde","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006929029","display_name":"Terra L. Lasho","orcid":"https://orcid.org/0000-0002-0315-5230","observed_orcids":["https://orcid.org/0000-0002-0315-5230"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T L Lasho","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078452873","display_name":"Christy M. Finke","orcid":"https://orcid.org/0009-0006-2843-9025","observed_orcids":["https://orcid.org/0009-0006-2843-9025"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Finke","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080965667","display_name":"Kebede H. Begna","orcid":"https://orcid.org/0000-0003-2730-8593","observed_orcids":["https://orcid.org/0000-0003-2730-8593"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Begna","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008422091","display_name":"Aref Al\u2010Kali","orcid":"https://orcid.org/0000-0002-0824-3715","observed_orcids":["https://orcid.org/0000-0002-0824-3715"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Al-Kali","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084606047","display_name":"William J. Hogan","orcid":"https://orcid.org/0000-0002-5841-4105","observed_orcids":["https://orcid.org/0000-0002-5841-4105"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W J Hogan","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085360755","display_name":"Mark Robert Litzow","orcid":"https://orcid.org/0000-0002-9816-6302","observed_orcids":["https://orcid.org/0000-0002-9816-6302"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M R Litzow","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085479273","display_name":"Alexey A. Leontovich","orcid":"https://orcid.org/0009-0002-2014-8996","observed_orcids":["https://orcid.org/0009-0002-2014-8996"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Leontovich","raw_affiliation_strings":["Health Sciences Research, Mayo Clinic, Rochester, MN, USA","Health Sciences Research Mayo Clinic Rochester USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Sciences Research, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Health Sciences Research Mayo Clinic Rochester USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020139920","display_name":"Mark Marion Kowalski","orcid":"https://orcid.org/0000-0001-9590-6259","observed_orcids":["https://orcid.org/0000-0001-9590-6259"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kowalski","raw_affiliation_strings":["YM BioSciences Inc., Mississauga, ON, USA","YM BioSciences Inc., Mississauga, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YM BioSciences Inc., Mississauga, ON, USA","institution_ids":[]},{"raw_affiliation_string":"YM BioSciences Inc., Mississauga, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016216479","display_name":"Ayalew Tefferi","orcid":"https://orcid.org/0000-0003-4605-3821","observed_orcids":["https://orcid.org/0000-0003-4605-3821"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A Tefferi","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology, Dept of Medicine, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016216479"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":16.484,"has_fulltext":true,"cited_by_count":234,"citation_normalized_percentile":{"value":0.99636445,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"27","issue":"6","first_page":"1322","last_page":"1327"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jak1-2-inhibitor","display_name":"JAK1/2 inhibitor","score":0.9380000233650208},{"id":"https://openalex.org/keywords/myelofibrosis","display_name":"myelofibrosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.7960000038146973},{"id":"https://openalex.org/keywords/post-polycythemia-vera-myelofibrosis","display_name":"post-polycythemia vera myelofibrosis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/essential-thrombocythemia","display_name":"essential thrombocythemia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.5400000214576721},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/transfusion-independence","display_name":"transfusion independence","score":0.7720000147819519},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.8769999742507935},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/hyperlipasemia","display_name":"hyperlipasemia","score":0.8259999752044678},{"id":"https://openalex.org/keywords/plasma-cytokine-levels","display_name":"plasma cytokines","score":0.6510000228881836},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.8786223530769348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8656899333000183},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6650803089141846},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6280579566955566},{"id":"https://openalex.org/C2777753580","wikidata":"https://www.wikidata.org/wiki/Q1441305","display_name":"Constitutional symptoms","level":3,"score":0.6245685815811157},{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.6078116297721863},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5953454971313477},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5419387221336365},{"id":"https://openalex.org/C2776112149","wikidata":"https://www.wikidata.org/wiki/Q7383611","display_name":"Ruxolitinib","level":4,"score":0.5129732489585876},{"id":"https://openalex.org/C2781057849","wikidata":"https://www.wikidata.org/wiki/Q1368780","display_name":"Essential thrombocythemia","level":3,"score":0.4676624834537506},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.45656758546829224},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4239239990711212},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.3249324858188629},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08357235789299011}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053613","descriptor_name":"Janus Kinase 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D055728","descriptor_name":"Primary Myelofibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/leu.2013.71","doi":"https://doi.org/10.1038/leu.2013.71","is_oa":true,"landing_page_url":"https://doi.org/10.1038/leu.2013.71","pdf_url":"https://www.nature.com/articles/leu201371.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2674640","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3677140","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3677140","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3677140","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Text"},{"id":"pmid:23459451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23459451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/leu.2013.71","doi":"https://doi.org/10.1038/leu.2013.71","is_oa":true,"landing_page_url":"https://doi.org/10.1038/leu.2013.71","pdf_url":"https://www.nature.com/articles/leu201371.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071990094.pdf","grobid_xml":"https://content.openalex.org/works/W2071990094.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1991495650","https://openalex.org/W1995149934","https://openalex.org/W2010293026","https://openalex.org/W2028803880","https://openalex.org/W2029318743","https://openalex.org/W2029466025","https://openalex.org/W2049793290","https://openalex.org/W2049965335","https://openalex.org/W2058251910","https://openalex.org/W2061377922","https://openalex.org/W2105496815","https://openalex.org/W2111141291","https://openalex.org/W2111148790","https://openalex.org/W2115351357","https://openalex.org/W2116043577","https://openalex.org/W2121743767","https://openalex.org/W2123633897","https://openalex.org/W2127559749","https://openalex.org/W2149055075","https://openalex.org/W2159962994"],"related_works":["https://openalex.org/W7099623589","https://openalex.org/W2590801373","https://openalex.org/W2550982834","https://openalex.org/W2543681710","https://openalex.org/W2584614183","https://openalex.org/W2593992051","https://openalex.org/W2012828222","https://openalex.org/W2105496815","https://openalex.org/W1986595955","https://openalex.org/W4293399574"],"abstract_inverted_index":{"JAK-STAT":[0],"is":[1,171],"a":[2,22,28,125,192],"rational":[3],"drug":[4,195],"target":[5],"in":[6,32,116,162,182],"myelofibrosis":[7],"(MF)":[8],"given":[9],"its":[10],"association":[11],"with":[12,34],"JAK2/MPL":[13],"mutations":[14],"and":[15,46,74,78,91,96,106,153,174,179,187],"aberrant":[16],"inflammatory":[17],"cytokine":[18,186],"expression.":[19],"We":[20],"conducted":[21],"Phase":[23],"1/2":[24],"trial":[25],"of":[26,164],"CYT387,":[27],"potent":[29],"JAK1/2":[30],"inhibitor,":[31],"patients":[33,81,111,135,165],"high-":[35],"or":[36,39],"intermediate-risk":[37],"primary":[38],"post-polycythemia":[40],"vera/essential":[41],"thrombocythemia":[42],"MF.":[43],"Pre-planned":[44],"safety":[45],"efficacy":[47],"analysis":[48],"has":[49],"been":[50],"completed":[51],"for":[52],"the":[53,58,62,117],"initial":[54],"60":[55],"patients.":[56,184],"In":[57],"dose-escalation":[59],"phase":[60],"(n=21),":[61],"maximum-tolerated":[63],"dose":[64],"was":[65,160],"300":[66,89],"mg/day":[67,90],"based":[68],"on":[69],"reversible":[70],"grade":[71,168],"3":[72],"headache":[73,154],"asymptomatic":[75],"hyperlipasemia.":[76],"Twenty-one":[77],"18":[79],"additional":[80],"were":[82,104,113],"accrued":[83],"at":[84],"two":[85],"biologically":[86],"effective":[87],"doses,":[88],"150":[92],"mg/day,":[93],"respectively.":[94,108],"Anemia":[95],"spleen":[97,178],"responses,":[98],"per":[99],"International":[100],"Working":[101],"Group":[102],"criteria,":[103],"59%":[105],"48%,":[107],"Among":[109],"33":[110],"who":[112],"red":[114],"cell-transfused":[115],"month":[118],"prior":[119],"to":[120],"study":[121],"entry,":[122],"70%":[123],"achieved":[124],"minimum":[126],"12-week":[127],"period":[128],"without":[129],"transfusions":[130],"(range":[131],"4.7->18.3":[132],"months).":[133],"Most":[134],"experienced":[136],"constitutional":[137],"symptoms":[138],"improvement.":[139],"Grade":[140],"3/4":[141],"adverse":[142],"reactions":[143],"included":[144],"thrombocytopenia":[145],"(32%),":[146],"hyperlipasemia":[147],"(5%),":[148],"elevated":[149],"liver":[150],"transaminases":[151],"(3%)":[152],"(3%).":[155],"New-onset":[156],"treatment-related":[157],"peripheral":[158],"neuropathy":[159],"observed":[161],"22%":[163],"(sensory":[166],"symptoms,":[167],"1).":[169],"CYT387":[170],"well":[172],"tolerated":[173],"produces":[175],"significant":[176],"anemia,":[177],"symptom":[180],"responses":[181],"MF":[183],"Plasma":[185],"gene":[188],"expression":[189],"studies":[190],"suggested":[191],"broad":[193],"anticytokine":[194],"effect.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":41},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":36},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}