{"id":"https://openalex.org/W2071985117","doi":"https://doi.org/10.1371/journal.pone.0021164","title":"PEDF Regulates Vascular Permeability by a \u03b3-Secretase-Mediated Pathway","display_name":"PEDF Regulates Vascular Permeability by a \u03b3-Secretase-Mediated Pathway","publication_year":2011,"publication_date":"2011-06-17","ids":{"openalex":"https://openalex.org/W2071985117","doi":"https://doi.org/10.1371/journal.pone.0021164","mag":"2071985117","pmid":"https://pubmed.ncbi.nlm.nih.gov/21695048","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117873"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0021164","doi":"https://doi.org/10.1371/journal.pone.0021164","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0021164","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021164&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021164&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101894119","display_name":"Jun Cai","orcid":"https://orcid.org/0009-0008-6734-7494","observed_orcids":["https://orcid.org/0009-0008-6734-7494"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Cai","raw_affiliation_strings":["Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023929740","display_name":"Lin Wu","orcid":"https://orcid.org/0000-0001-9642-223X","observed_orcids":["https://orcid.org/0000-0001-9642-223X"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Wu","raw_affiliation_strings":["Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103737538","display_name":"Xiaoping Qi","orcid":"https://orcid.org/0009-0009-6768-405X","observed_orcids":["https://orcid.org/0009-0009-6768-405X"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoping Qi","raw_affiliation_strings":["Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045419036","display_name":"Sergio Li Calzi","orcid":"https://orcid.org/0000-0001-8963-1519","observed_orcids":["https://orcid.org/0000-0001-8963-1519"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergio Li Calzi","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111552124","display_name":"Sergio Caballero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergio Caballero","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104073420","display_name":"Lynn C. Shaw","orcid":"https://orcid.org/0000-0001-7317-3891","observed_orcids":["https://orcid.org/0000-0001-7317-3891"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn Shaw","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100821096","display_name":"Qing Ruan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Ruan","raw_affiliation_strings":["Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083537513","display_name":"Maria B. Grant","orcid":"https://orcid.org/0000-0002-6470-0255","observed_orcids":["https://orcid.org/0000-0002-6470-0255","https://orcid.org/0000-0002-3602-8844","https://orcid.org/0000-0001-8571-4827"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria B. Grant","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059483104","display_name":"Michael E. Boulton","orcid":"https://orcid.org/0000-0002-0796-1766","observed_orcids":["https://orcid.org/0000-0002-0796-1766"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael E. Boulton","raw_affiliation_strings":["Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5059483104"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.4133,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.94102851,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"6","first_page":"e21164","last_page":"e21164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.7461000084877014,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.7461000084877014,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.12399999797344208,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.1103999987244606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pigment-epithelium-derived-factor","display_name":"pigment epithelium-derived factor","score":0.9539999961853027},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.8799999952316284},{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.8040000200271606},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ve-cadherin","display_name":"VE-cadherin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/claudin-5","display_name":"claudin-5","score":0.996999979019165},{"id":"https://openalex.org/keywords/vegf-receptors","display_name":"VEGF receptors","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/retinal-microvasculature","display_name":"retinal microvasculature","score":0.7229999899864197},{"id":"https://openalex.org/keywords/gamma-secretase-inhibitors","display_name":"gamma-secretase inhibitors","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C52237779","wikidata":"https://www.wikidata.org/wiki/Q18030441","display_name":"PEDF","level":3,"score":0.9476146697998047},{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.6714282631874084},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.6705524325370789},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5853752493858337},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5716636180877686},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.5068691372871399},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.46879515051841736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46692463755607605},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3975464105606079},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35699662566185},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33935070037841797},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31122034788131714},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.24640139937400818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20501860976219177},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.167801171541214},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.09547948837280273},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099152","descriptor_name":"Cadherin 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099174","descriptor_name":"Pigment Epithelium-Derived Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015843","descriptor_name":"Serpins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022005","descriptor_name":"Adherens Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022005","descriptor_name":"Adherens Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0021164","doi":"https://doi.org/10.1371/journal.pone.0021164","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0021164","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021164&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3117873","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117873","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21695048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21695048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b3fe65c16e70408786c394dfa3ceba4e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b3fe65c16e70408786c394dfa3ceba4e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 6, p e21164 (2011)","raw_type":"article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:86998","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/86998/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0021164","doi":"https://doi.org/10.1371/journal.pone.0021164","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0021164","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021164&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5899999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G162802300","display_name":"Vision Research Core","funder_award_id":"P30EY021721","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G2242226579","display_name":null,"funder_award_id":"EY007739","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G458251768","display_name":null,"funder_award_id":"EY-012601","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6022411169","display_name":"Bone Marrow Neuropathy Drives Diabetic Retinopathy","funder_award_id":"R01EY007739","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6436118973","display_name":null,"funder_award_id":"EY-018358","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6597156364","display_name":"Non-canonical VEGF receptor signaling regulates retinal neovascularization","funder_award_id":"R01EY018358","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8732045754","display_name":"NO Dysregulation of the Peripheral Clock in Diabetic Complications","funder_award_id":"R01DK090730","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000176320","display_name":null,"funder_award_id":"EY007739","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000914414","display_name":"Hematopoietic cell mobilization from distinct bone marrow compartments following retinal injury","funder_award_id":"R01EY012601","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071985117.pdf","grobid_xml":"https://content.openalex.org/works/W2071985117.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W29173195","https://openalex.org/W1557788262","https://openalex.org/W1571229160","https://openalex.org/W1903720360","https://openalex.org/W1969448383","https://openalex.org/W1975216289","https://openalex.org/W1977103711","https://openalex.org/W1980092395","https://openalex.org/W1980741996","https://openalex.org/W1982265214","https://openalex.org/W1987294326","https://openalex.org/W1988143227","https://openalex.org/W1988652526","https://openalex.org/W1990644905","https://openalex.org/W1994507795","https://openalex.org/W2008213605","https://openalex.org/W2010045296","https://openalex.org/W2011046688","https://openalex.org/W2013156722","https://openalex.org/W2014437230","https://openalex.org/W2020421781","https://openalex.org/W2022745705","https://openalex.org/W2023065935","https://openalex.org/W2027092108","https://openalex.org/W2033790206","https://openalex.org/W2036022419","https://openalex.org/W2040593473","https://openalex.org/W2043812608","https://openalex.org/W2045390750","https://openalex.org/W2056019080","https://openalex.org/W2057941174","https://openalex.org/W2062643676","https://openalex.org/W2063139027","https://openalex.org/W2066406116","https://openalex.org/W2066912532","https://openalex.org/W2070675602","https://openalex.org/W2080713593","https://openalex.org/W2086256951","https://openalex.org/W2090033168","https://openalex.org/W2091534585","https://openalex.org/W2092745734","https://openalex.org/W2105857956","https://openalex.org/W2111014976","https://openalex.org/W2112215733","https://openalex.org/W2112310766","https://openalex.org/W2114112168","https://openalex.org/W2115060813","https://openalex.org/W2118249577","https://openalex.org/W2118644684","https://openalex.org/W2118741073","https://openalex.org/W2121052112","https://openalex.org/W2122595579","https://openalex.org/W2122982268","https://openalex.org/W2123230988","https://openalex.org/W2129738185","https://openalex.org/W2130639482","https://openalex.org/W2136973716","https://openalex.org/W2137589461","https://openalex.org/W2138447190","https://openalex.org/W2139001910","https://openalex.org/W2140362791","https://openalex.org/W2142377643","https://openalex.org/W2146895939","https://openalex.org/W2154219696","https://openalex.org/W2165344522","https://openalex.org/W2333240020"],"related_works":["https://openalex.org/W7097058462","https://openalex.org/W2066912532","https://openalex.org/W1182220642","https://openalex.org/W2112310766","https://openalex.org/W2333240020","https://openalex.org/W2111014976","https://openalex.org/W948493969","https://openalex.org/W2115060813","https://openalex.org/W2023065935","https://openalex.org/W2056714433"],"abstract_inverted_index":{"Increased":[0],"vascular":[1,9,27,249,271,297],"permeability":[2,47,61,72,272],"is":[3,23,50,197],"an":[4],"inciting":[5],"event":[6],"in":[7,64,76,88,97,103,183,190,192,245],"many":[8],"complications":[10],"including":[11],"diabetic":[12],"retinopathy.":[13],"We":[14],"have":[15],"previously":[16],"reported":[17],"that":[18],"pigment":[19],"epithelium-derived":[20],"factor":[21,30],"(PEDF)":[22],"able":[24],"to":[25,54,73,242],"inhibit":[26],"endothelial":[28,186],"growth":[29],"(VEGF)-induced":[31],"angiogenesis":[32],"through":[33],"a":[34,109,258,274,288],"novel":[35,275],"\u03b3-secretase-dependent":[36],"pathway.":[37],"In":[38,164,266],"this":[39],"study,":[40],"we":[41],"asked":[42],"whether":[43],"inhibition":[44,178],"of":[45,81,93,108,169,179,207,218,228,236,248,261,283],"VEGF-induced":[46,180,270],"by":[48,66,78,158,199,203],"PEDF":[49,96,177,201,268,284],"also":[51,175],"\u03b3-secretase-mediated":[52],"and":[53,70,75,95,124,126,138,144,153,160,189,209,212,224,233,279],"dissect":[55],"the":[56,86,89,104,118,127,145,167,193,216,225,229,246],"potential":[57],"mechanisms":[58],"involved.":[59],"Vascular":[60],"was":[62,133,174,257],"assessed":[63],"vitro":[65],"measuring":[67],"transendothelial":[68],"resistance":[69],"paracellular":[71],"dextran":[74],"vivo":[77,191],"following":[79],"leakage":[80],"intravenous":[82],"FITC-labelled":[83],"albumin":[84],"into":[85],"retina":[87],"presence":[90,105],"or":[91,106,294],"absence":[92,107],"VEGF":[94,150,219],"varying":[98],"combinations.":[99],"Experiments":[100],"were":[101,156],"undertaken":[102,134],"\u03b3-secretase":[110,154,237,276],"inhibitor.":[111],"To":[112],"assess":[113],"junctional":[114,172],"integrity":[115,173],"immunohistochemistry":[116],"for":[117,292],"adherens":[119],"junction":[120,129],"(AJ)":[121],"proteins,":[122,149,231],"VE-cadherin":[123,232],"\u03b2-catenin,":[125],"tight":[128],"(TJ)":[130],"protein,":[131],"claudin-5":[132],"using":[135],"cultured":[136,184],"cells":[137],"flat":[139],"mount":[140],"retinas.":[141],"Protein":[142],"expression":[143,255],"association":[146,217],"between":[147],"AJ":[148,208,222,230,239,264],"receptors":[151,220],"(VEGFRs)":[152],"constituents":[155],"determined":[157],"immunoprecipitation":[159],"Western":[161],"Blot":[162],"analysis.":[163],"selected":[165],"experiments":[166],"effect":[168],"hypoxia":[170,252],"on":[171],"assessed.":[176],"permeability,":[181],"both":[182,215],"microvascular":[185],"cell":[187],"monolayers":[188],"mouse":[194],"retinal":[195],"vasculature,":[196],"mediated":[198],"\u03b3-secretase.":[200],"acted":[202],"a)":[204],"preventing":[205,293],"dissociation":[206,260],"TJ":[210],"proteins":[211,223,240],"b)":[213],"regulating":[214],"with":[221,238],"subsequent":[226],"phosphorylation":[227],"\u03b2-catenin.":[234],"Association":[235],"appears":[241],"be":[243],"critical":[244],"regulation":[247],"permeability.":[250,298],"Although":[251],"increased":[253,296],"VEGFR":[254,262],"there":[256],"significant":[259],"from":[263],"proteins.":[265],"conclusion,":[267],"regulates":[269],"via":[273],"dependent":[277],"pathway":[278],"targeting":[280],"downstream":[281],"effectors":[282],"action":[285],"may":[286],"represent":[287],"promising":[289],"therapeutic":[290],"strategy":[291],"ameliorating":[295]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
