{"id":"https://openalex.org/W2071959764","doi":"https://doi.org/10.3928/01477447-20120822-29","title":"Sustained Delivery of BMP-2 and Platelet-rich Plasma-released Growth Factors Contributes to Osteogenesis of Human Adipose-derived Stem Cells","display_name":"Sustained Delivery of BMP-2 and Platelet-rich Plasma-released Growth Factors Contributes to Osteogenesis of Human Adipose-derived Stem Cells","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W2071959764","doi":"https://doi.org/10.3928/01477447-20120822-29","mag":"2071959764","pmid":"https://pubmed.ncbi.nlm.nih.gov/22955409"},"language":"en","primary_location":{"id":"doi:10.3928/01477447-20120822-29","doi":"https://doi.org/10.3928/01477447-20120822-29","is_oa":false,"landing_page_url":"https://doi.org/10.3928/01477447-20120822-29","pdf_url":null,"source":{"id":"https://openalex.org/S157799717","display_name":"Orthopedics","issn_l":"0147-7447","issn":["0147-7447","1938-2367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4320800624","host_organization_name":"Slack Incorporated (United States)","host_organization_lineage":["https://openalex.org/P4320800624"],"host_organization_lineage_names":["Slack Incorporated (United States)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopedics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106632236","display_name":"Linwei Chen","orcid":"https://orcid.org/0000-0003-3851-590X","observed_orcids":["https://orcid.org/0000-0003-3851-590X"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linwei Chen","raw_affiliation_strings":["Department of Orthopaedics, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102360211","display_name":"Xiaolang Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaolang Lu","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430768","display_name":"Li Shi","orcid":"https://orcid.org/0000-0002-4162-7876","observed_orcids":["https://orcid.org/0000-0002-4162-7876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shi Li","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035523998","display_name":"Qizhi Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qizhi Sun","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100729532","display_name":"Wanli Li","orcid":"https://orcid.org/0000-0002-7070-2783","observed_orcids":["https://orcid.org/0000-0002-7070-2783"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wanli Li","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046879304","display_name":"Dianwen Song","orcid":"https://orcid.org/0000-0001-6161-2260","observed_orcids":["https://orcid.org/0000-0001-6161-2260"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dianwen Song","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1029,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.85306969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"35","issue":"9","first_page":"e1402","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.07010000199079514,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.8669999837875366},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.8450000286102295},{"id":"https://openalex.org/keywords/human-adipose-derived-stem-cells","display_name":"human adipose-derived stem cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7900000214576721},{"id":"https://openalex.org/keywords/tissue-engineered-bone","display_name":"tissue-engineered bone","score":0.9240000247955322},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8579999804496765},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.8140000104904175},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.8199999928474426},{"id":"https://openalex.org/keywords/stem-cell-proliferation","display_name":"stem cell proliferation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2780076745","wikidata":"https://www.wikidata.org/wiki/Q613879","display_name":"Platelet-rich plasma","level":3,"score":0.7806827425956726},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.7717167139053345},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.7160412073135376},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.7086986899375916},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.6217042207717896},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5141449570655823},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5041970014572144},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4439897835254669},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.42270639538764954},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.359408974647522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2903204560279846},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.2830579876899719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27493274211883545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22847676277160645},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18732759356498718},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11744403839111328},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06482189893722534},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D053657","descriptor_name":"Platelet-Rich Plasma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3928/01477447-20120822-29","doi":"https://doi.org/10.3928/01477447-20120822-29","is_oa":false,"landing_page_url":"https://doi.org/10.3928/01477447-20120822-29","pdf_url":null,"source":{"id":"https://openalex.org/S157799717","display_name":"Orthopedics","issn_l":"0147-7447","issn":["0147-7447","1938-2367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4320800624","host_organization_name":"Slack Incorporated (United States)","host_organization_lineage":["https://openalex.org/P4320800624"],"host_organization_lineage_names":["Slack Incorporated (United States)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopedics","raw_type":"journal-article"},{"id":"pmid:22955409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22955409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopedics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1747945214","https://openalex.org/W1968416191","https://openalex.org/W1982643221","https://openalex.org/W1982863580","https://openalex.org/W2013443778","https://openalex.org/W2026533633","https://openalex.org/W2064413596","https://openalex.org/W2065415874","https://openalex.org/W2065786046","https://openalex.org/W2081692840","https://openalex.org/W2083744994","https://openalex.org/W2089537633","https://openalex.org/W2093003043","https://openalex.org/W2113398281","https://openalex.org/W2118654275","https://openalex.org/W2128537174","https://openalex.org/W2131978756","https://openalex.org/W2136648378","https://openalex.org/W2149996379","https://openalex.org/W2152536711","https://openalex.org/W2172069215","https://openalex.org/W2318707107","https://openalex.org/W2402072815"],"related_works":["https://openalex.org/W2371698224","https://openalex.org/W3205679907","https://openalex.org/W2351312672","https://openalex.org/W6958614197","https://openalex.org/W2190430248","https://openalex.org/W968066748","https://openalex.org/W2158877983","https://openalex.org/W1529986564","https://openalex.org/W1996998985","https://openalex.org/W2093003043"],"abstract_inverted_index":{"Platelet-rich":[0],"plasma":[1,85],"(PRP)":[2],"has":[3],"a":[4,29,66,152,184,218],"pool":[5],"of":[6,18,36,40,48,61,103,110,133,161,187,192,209,221,229],"multiple":[7],"growth":[8,50,129],"factors":[9,51,130],"efficient":[10],"at":[11,194],"inducing":[12],"the":[13,33,46,56,144,158,175,195,199,226],"proliferation":[14,57,132],"and":[15,52,58,63,73,90,108,140,165,198],"osteogenic":[16,34,227],"differentiation":[17,35,60,160,191,228],"human":[19],"adipose-derived":[20],"stem":[21],"cells":[22],"(hADSCs).":[23],"Bone":[24],"morphogenetic":[25],"protein":[26],"(BMP)-2":[27],"is":[28,215],"strong":[30],"stimulator":[31],"for":[32],"hADSCs.":[37,134,162,230],"The":[38,70,95,117],"purpose":[39],"this":[41],"study":[42],"was":[43,120],"to":[44,64,179],"verify":[45],"effect":[47,154],"PRP-released":[49,128],"microsphere-encapsulated":[53],"BMP-2":[54,150,188,210,224],"on":[55],"osteoblastic":[59,190],"hADSCs":[62,74,111,193],"construct":[65],"novel":[67],"tissue-engineered":[68],"bone.":[69],"BMP-2-loaded":[71],"microspheres":[72],"were":[75,92,115,168],"embedded":[76],"in":[77,112,122,138,143,157,170,174,211,225],"activated":[78],"PRP":[79,156,214,222],"gel.":[80],"Another":[81],"5":[82],"composites":[83,142],"(hADSCs/platelet-poor":[84],"[PPP];":[86],"hADSCs/PRP;":[87],"hADSCs/BMP-2/PPP;":[88],"hADSCs/BMP-2/PRP;":[89],"hADSCs/BMP-2+microspheres/PPP)":[91],"also":[93],"constructed.":[94],"DNA":[96,118],"content,":[97],"alkaline":[98,104],"phosphatase":[99,136],"activity,":[100],"mRNA":[101],"expression":[102],"phosphatase,":[105],"osteopontin,":[106],"osteocalcin,":[107,164],"mineralization":[109,166],"each":[113],"composite":[114,172,177],"compared.":[116],"content":[119],"higher":[121,169],"all":[123],"PRP-containing":[124],"composites,":[125],"meaning":[126,148,182],"that":[127,149,183,206],"stimulated":[131],"Alkaline":[135],"increased":[137],"BMP-2/PRP":[139,176],"BMP-2+microspheres/PRP":[141,171],"first":[145],"7":[146],"days,":[147,181],"had":[151],"synergistic":[153],"with":[155,213],"early":[159,196],"Osteopontin,":[163],"assays":[167],"than":[173,217],"up":[178],"21":[180],"continuous":[185],"delivery":[186,208],"stimulates":[189],"stage":[197],"final":[200],"maturation":[201],"stage.":[202],"These":[203],"results":[204],"suggest":[205],"sustained":[207],"combination":[212],"better":[216],"single":[219],"administration":[220],"or":[223]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
