{"id":"https://openalex.org/W2071956236","doi":"https://doi.org/10.1177/09680519000060060501","title":"Cellular activating properties and morphology of membrane-bound and purified meningococcal lipopolysaccharide","display_name":"Cellular activating properties and morphology of membrane-bound and purified meningococcal lipopolysaccharide","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W2071956236","doi":"https://doi.org/10.1177/09680519000060060501","mag":"2071956236","pmid":"https://pubmed.ncbi.nlm.nih.gov/11521068"},"language":"en","primary_location":{"id":"doi:10.1177/09680519000060060501","doi":"https://doi.org/10.1177/09680519000060060501","is_oa":false,"landing_page_url":"https://doi.org/10.1177/09680519000060060501","pdf_url":null,"source":{"id":"https://openalex.org/S14555865","display_name":"Journal of Endotoxin Research","issn_l":"0968-0519","issn":["0968-0519","1743-2839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endotoxin Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032945013","display_name":"Anna Kristina Bjerre","orcid":"https://orcid.org/0000-0002-1421-0098","observed_orcids":["https://orcid.org/0000-0002-1421-0098"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Anna Bjerre","raw_affiliation_strings":["Department of Pediatrics, Ullev\u00c5l University Hospital, Oslo, Norway,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Ullev\u00c5l University Hospital, Oslo, Norway,","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019429719","display_name":"Berit Sletbakk Brusletto","orcid":"https://orcid.org/0000-0002-1042-1365","observed_orcids":["https://orcid.org/0000-0002-1042-1365"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Berit Brusletto","raw_affiliation_strings":["Department of Clinical Chemistry, Ullev\u00c5l University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Ullev\u00c5l University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068583234","display_name":"Einar Rosenqvist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1333353642","display_name":"Norwegian Institute of Public Health","ror":"https://ror.org/046nvst19","country_code":"NO","type":"government","lineage":["https://openalex.org/I1333353642","https://openalex.org/I4210149801","https://openalex.org/I4210163359"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Einar Rosenqvist","raw_affiliation_strings":["Department of Vaccinology, National Institute of Public Health, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vaccinology, National Institute of Public Health, Oslo, Norway","institution_ids":["https://openalex.org/I1333353642"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004981977","display_name":"Ellen Namork","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1333353642","display_name":"Norwegian Institute of Public Health","ror":"https://ror.org/046nvst19","country_code":"NO","type":"government","lineage":["https://openalex.org/I1333353642","https://openalex.org/I4210149801","https://openalex.org/I4210163359"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ellen Namork","raw_affiliation_strings":["Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway","institution_ids":["https://openalex.org/I1333353642"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083337086","display_name":"Peter Kierulf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Peter Kierulf","raw_affiliation_strings":["Department of Clinical Chemistry, Ullev\u00c5l University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Ullev\u00c5l University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060028331","display_name":"Reidun \u00d8vsteb\u00f8","orcid":"https://orcid.org/0000-0001-8009-7903","observed_orcids":["https://orcid.org/0000-0001-8009-7903"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Reidun \u00d8vsteb\u00f8","raw_affiliation_strings":["Department of Clinical Chemistry, Ullev\u00c5l University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Ullev\u00c5l University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111604703","display_name":"Gun-Britt Jo\u00f8","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Gun-Britt Jo\u00f8","raw_affiliation_strings":["Department of Clinical Chemistry, Ullev\u00c5l University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Ullev\u00c5l University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042575652","display_name":"Petter Brandtzaeg","orcid":"https://orcid.org/0000-0002-0667-1097","observed_orcids":["https://orcid.org/0000-0002-0667-1097"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Petter Brandtz\u00e6g","raw_affiliation_strings":["Department of Pediatrics, Ullev\u00c5l University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Ullev\u00c5l University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3314,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.79496968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"6","issue":"6","first_page":"437","last_page":"445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neisseria-meningitidis","display_name":"Neisseria meningitidis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/outer-membrane-vesicles","display_name":"outer membrane vesicles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.4860000014305115},{"id":"https://openalex.org/keywords/monocyte-activation","display_name":"monocyte activation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9879999756813049},{"id":"https://openalex.org/keywords/procoagulant-activity","display_name":"procoagulant activity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anti-cd14-antibody","display_name":"anti-CD14 antibody","score":0.8939999938011169},{"id":"https://openalex.org/keywords/limulus-amebocyte-lysate-assay","display_name":"Limulus amebocyte lysate assay","score":0.8349999785423279},{"id":"https://openalex.org/keywords/meningococcal-disease","display_name":"meningococcal disease","score":0.5839999914169312},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.8970861434936523},{"id":"https://openalex.org/C2776487282","wikidata":"https://www.wikidata.org/wiki/Q2104567","display_name":"Limulus","level":2,"score":0.8411505818367004},{"id":"https://openalex.org/C2778458888","wikidata":"https://www.wikidata.org/wiki/Q154625","display_name":"Neisseria meningitidis","level":3,"score":0.7129224538803101},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.6532267332077026},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.6296473741531372},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.6216759085655212},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5714352130889893},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5552164316177368},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5371708273887634},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.46788495779037476},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.42837467789649963},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42776015400886536},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.37122946977615356},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.35002726316452026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3292190134525299},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2795209288597107},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24318614602088928},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.124163419008255},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008033","descriptor_name":"Limulus Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009345","descriptor_name":"Neisseria meningitidis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D009345","descriptor_name":"Neisseria meningitidis","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009345","descriptor_name":"Neisseria meningitidis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/09680519000060060501","doi":"https://doi.org/10.1177/09680519000060060501","is_oa":false,"landing_page_url":"https://doi.org/10.1177/09680519000060060501","pdf_url":null,"source":{"id":"https://openalex.org/S14555865","display_name":"Journal of Endotoxin Research","issn_l":"0968-0519","issn":["0968-0519","1743-2839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endotoxin Research","raw_type":"journal-article"},{"id":"doi:10.1179/096805100101532397","doi":"https://doi.org/10.1179/096805100101532397","is_oa":false,"landing_page_url":"https://doi.org/10.1179/096805100101532397","pdf_url":null,"source":{"id":"https://openalex.org/S14555865","display_name":"Journal of Endotoxin Research","issn_l":"0968-0519","issn":["0968-0519","1743-2839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endotoxin Research","raw_type":"journal-article"},{"id":"pmid:11521068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11521068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of endotoxin research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8600000143051147,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W19323755","https://openalex.org/W1596047355","https://openalex.org/W1693554971","https://openalex.org/W1965028224","https://openalex.org/W1967160966","https://openalex.org/W1974380375","https://openalex.org/W1986876282","https://openalex.org/W2019083734","https://openalex.org/W2026620070","https://openalex.org/W2028446105","https://openalex.org/W2029157767","https://openalex.org/W2032799812","https://openalex.org/W2042302062","https://openalex.org/W2043346193","https://openalex.org/W2044375638","https://openalex.org/W2051596822","https://openalex.org/W2064626913","https://openalex.org/W2065367168","https://openalex.org/W2065679787","https://openalex.org/W2075665371","https://openalex.org/W2081441884","https://openalex.org/W2088292756","https://openalex.org/W2096532993","https://openalex.org/W2110313414","https://openalex.org/W2120556801","https://openalex.org/W2121544368","https://openalex.org/W2129319296","https://openalex.org/W2312210953","https://openalex.org/W2319878230","https://openalex.org/W2406278224","https://openalex.org/W2410359120"],"related_works":["https://openalex.org/W2062834575","https://openalex.org/W1585148001","https://openalex.org/W2484809182","https://openalex.org/W2415003003","https://openalex.org/W2034873347","https://openalex.org/W1994107410","https://openalex.org/W2036493378","https://openalex.org/W7221557804","https://openalex.org/W2087462605","https://openalex.org/W2109328536"],"abstract_inverted_index":{"Neisseria":[0],"meningitidis,":[1],"the":[2,39,81,101,119,145],"cause":[3],"of":[4,42,50,65,80,115,147,152,195],"epidemic":[5],"meningitis":[6],"and":[7,54,73,138,149,190,198],"acute":[8],"lethal":[9],"sepsis,":[10],"synthesizes":[11],"surplus":[12],"lipopolysaccharides":[13],"(LPSs)":[14],"during":[15],"growth,":[16],"which":[17],"are":[18],"released":[19],"as":[20],"outer":[21,44],"membrane":[22,45],"vesicles":[23,46],"(OMV)":[24],"or":[25,136],"\"blebs\".":[26],"Meningococcal":[27],"disease":[28],"severity":[29],"is":[30],"related":[31],"to":[32,48,97,112,170],"plasma":[33,102,111],"LPS":[34,63,99,116],"levels.":[35],"We":[36],"have":[37],"compared":[38],"biological":[40,124],"activities":[41],"native":[43],"(nOMV)":[47],"those":[49],"purified":[51,171,188,196],"Nm-LPS":[52,189,197],"(Nm-LPS)":[53],"LPS-depleted":[55],"OMV":[56],"(dOMV)":[57],"prepared":[58],"from":[59],"N.":[60],"meningitidis.":[61],"The":[62,78,89,104,123,192],"content":[64],"nOMV":[66,161,185,199],"was":[67,83,95,126,181],"determined":[68],"spectrophotometrically":[69],"by":[70,74,85,203],"quantifying":[71],"KDO":[72],"silver-stained":[75],"SDS-PAGE":[76],"gels.":[77],"morphology":[79],"preparations":[82,105],"studied":[84],"transmission":[86],"electron":[87],"microscopy.":[88],"Limulus":[90],"amoebocyte":[91],"lysate":[92],"(LAL)":[93],"assay":[94],"used":[96],"quantify":[98],"in":[100,108,118,155],"solutions.":[103],"were":[106,200],"diluted":[107],"endotoxin-free":[109],"heparin":[110],"equal":[113],"amounts":[114],"(w/w)":[117],"range":[120],"50-5000":[121],"pg/ml.":[122],"reactivity":[125],"tested":[127],"by:":[128],"(i)":[129],"a":[130,140,204],"monocyte":[131],"target-assay":[132],"(monocyte":[133],"purity":[134],">":[135],"=96%);":[137],"(ii)":[139],"whole":[141],"blood":[142],"model,":[143],"measuring":[144],"secretion":[146],"TNF-alpha":[148],"IL-6":[150],"induction":[151],"procoagulant":[153],"activity":[154,180],"monocytes":[156],"(PCA).":[157],"In":[158],"both":[159],"models,":[160],"induced":[162,175],"dose-dependent":[163],"cell":[164],"responses":[165,194],"(TNF-alpha,":[166],"IL-6,":[167],"PCA)":[168],"similar":[169],"Nm-LPS,":[172],"whereas":[173],"dOMV":[174],"minimal":[176],"responses.":[177],"However,":[178],"LAL":[179],"significantly":[182],"higher":[183],"for":[184,187],"than":[186],"dOMV.":[191],"cellular":[193],"reduced":[201],"(>95%)":[202],"specific":[205],"anti-CD14-antibody.":[206]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}