{"id":"https://openalex.org/W2071948601","doi":"https://doi.org/10.1158/0008-5472.can-08-3863","title":"Prognostic Significance of Growth Kinetics in Newly Diagnosed Glioblastomas Revealed by Combining Serial Imaging with a Novel Biomathematical Model","display_name":"Prognostic Significance of Growth Kinetics in Newly Diagnosed Glioblastomas Revealed by Combining Serial Imaging with a Novel Biomathematical Model","publication_year":2009,"publication_date":"2009-11-24","ids":{"openalex":"https://openalex.org/W2071948601","doi":"https://doi.org/10.1158/0008-5472.can-08-3863","mag":"2071948601","pmid":"https://pubmed.ncbi.nlm.nih.gov/19934335"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-08-3863","doi":"https://doi.org/10.1158/0008-5472.can-08-3863","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-3863","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/69/23/9133/2618689/9133.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/69/23/9133/2618689/9133.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047588468","display_name":"Christina Hao Wang","orcid":"https://orcid.org/0000-0001-6734-1051","observed_orcids":["https://orcid.org/0000-0001-6734-1051"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Christina H. Wang","raw_affiliation_strings":["Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","Department of Neurology, University of California, Los Angeles, California","Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I201448701","https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110888833","display_name":"Jason K. Rockhill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Jason K. Rockhill","raw_affiliation_strings":["Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","Department of Neurology, University of California, Los Angeles, California","Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I201448701","https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014909652","display_name":"Maciej M. Mruga\u0142a","orcid":"https://orcid.org/0000-0002-4027-7173","observed_orcids":["https://orcid.org/0000-0002-4027-7173"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Maciej Mrugala","raw_affiliation_strings":["Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","Department of Neurology, University of California, Los Angeles, California","Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I201448701","https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067915745","display_name":"Danielle L. Peacock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Danielle L. Peacock","raw_affiliation_strings":["Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","Department of Neurology, University of California, Los Angeles, California","Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I201448701","https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046758575","display_name":"Albert Lai","orcid":"https://orcid.org/0000-0002-7265-2986","observed_orcids":["https://orcid.org/0000-0002-7265-2986"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Albert Lai","raw_affiliation_strings":["Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","Department of Neurology, University of California, Los Angeles, California","Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I201448701","https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021397553","display_name":"Katy Jusenius","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Katy Jusenius","raw_affiliation_strings":["Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","Department of Neurology, University of California, Los Angeles, California","Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I201448701","https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004889443","display_name":"Joanna Marguerite Wardlaw","orcid":"https://orcid.org/0000-0002-9812-6642","observed_orcids":["https://orcid.org/0000-0002-9812-6642"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Joanna M. Wardlaw","raw_affiliation_strings":["Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","Department of Neurology, University of California, Los Angeles, California","Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I201448701","https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063511816","display_name":"Timothy Francis Cloughesy","orcid":"https://orcid.org/0000-0002-8656-7483","observed_orcids":["https://orcid.org/0000-0002-8656-7483"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Timothy Cloughesy","raw_affiliation_strings":["Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","Department of Neurology, University of California, Los Angeles, California","Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I201448701","https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112106733","display_name":"Alexander M. Spence","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Alexander M. Spence","raw_affiliation_strings":["Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","Department of Neurology, University of California, Los Angeles, California","Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I201448701","https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026346370","display_name":"Russell C. Rockne","orcid":"https://orcid.org/0000-0002-1557-159X","observed_orcids":["https://orcid.org/0000-0002-1557-159X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Russ Rockne","raw_affiliation_strings":["Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","Department of Neurology, University of California, Los Angeles, California","Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I201448701","https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050269879","display_name":"Ellsworth C. Alvord","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Ellsworth C. Alvord","raw_affiliation_strings":["Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","Department of Neurology, University of California, Los Angeles, California","Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I201448701","https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014011778","display_name":"Kristin R. Swanson","orcid":"https://orcid.org/0000-0002-2464-6119","observed_orcids":["https://orcid.org/0000-0002-2464-6119"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Kristin R. Swanson","raw_affiliation_strings":["Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","Department of Neurology, University of California, Los Angeles, California","Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Pathology, 2Radiation Oncology, and 3Neurology, University of Washington, Seattle, Washington; 4Department of Neurology, University of California, Los Angeles, California; and 5Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I201448701","https://openalex.org/I2800150677","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Pathology, Radiation Oncology, and Neurology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5014011778"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I201448701","https://openalex.org/I2800150677","https://openalex.org/I98677209"],"apc_list":null,"apc_paid":null,"fwci":4.4838,"has_fulltext":true,"cited_by_count":231,"citation_normalized_percentile":{"value":0.94659418,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"69","issue":"23","first_page":"9133","last_page":"9140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.33469998836517334,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-growth-kinetics","display_name":"tumor growth kinetics","score":0.984000027179718},{"id":"https://openalex.org/keywords/tumor-proliferation-rate","display_name":"tumor proliferation rate","score":0.6710000038146973},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7260000109672546},{"id":"https://openalex.org/keywords/biomathematical-model","display_name":"biomathematical model","score":0.781000018119812},{"id":"https://openalex.org/keywords/serial-mri","display_name":"serial MRI","score":0.75},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.5249999761581421},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.7680000066757202},{"id":"https://openalex.org/keywords/pre-treatment-imaging","display_name":"pre-treatment imaging","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.8095179796218872},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.6979192495346069},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6155824661254883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5981292724609375},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4659356474876404},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4446234107017517},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.4298486113548279},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4198282063007355},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.384198933839798},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34319964051246643},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2513347864151001},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2075120508670807},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.19967731833457947},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1158/0008-5472.can-08-3863","doi":"https://doi.org/10.1158/0008-5472.can-08-3863","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-3863","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/69/23/9133/2618689/9133.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:19934335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19934335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/192f432d-cb99-4ac2-b815-179bb8e3aeb0","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/192f432d-cb99-4ac2-b815-179bb8e3aeb0","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wang, C H, Rockhill, J K, Mrugala, M, Peacock, D L, Lai, A, Jusenius, K, Wardlaw, J M, Cloughesy, T, Spence, A M, Rockne, R, Alvord, E C & Swanson, K R 2009, 'Prognostic Significance of Growth Kinetics in Newly Diagnosed Glioblastomas Revealed by Combining Serial Imaging with a Novel Biomathematical Model', Cancer Research, vol. 69, no. 23, pp. 9133-9140. https://doi.org/10.1158/0008-5472.CAN-08-3863","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:2464874","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3467150","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3467150","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3467150","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-08-3863","doi":"https://doi.org/10.1158/0008-5472.can-08-3863","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-3863","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/69/23/9133/2618689/9133.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6200000047683716}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G302453807","display_name":null,"funder_award_id":"R01 NS 060752","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306183","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071948601.pdf","grobid_xml":"https://content.openalex.org/works/W2071948601.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W106327360","https://openalex.org/W183416112","https://openalex.org/W196969224","https://openalex.org/W592776629","https://openalex.org/W1520456554","https://openalex.org/W1560814177","https://openalex.org/W1567125309","https://openalex.org/W1606565203","https://openalex.org/W1899213880","https://openalex.org/W1975680998","https://openalex.org/W1975817152","https://openalex.org/W1981472502","https://openalex.org/W1988109237","https://openalex.org/W1990245134","https://openalex.org/W1995539768","https://openalex.org/W1997542574","https://openalex.org/W2006322120","https://openalex.org/W2019438752","https://openalex.org/W2022101728","https://openalex.org/W2025104440","https://openalex.org/W2031628894","https://openalex.org/W2036652458","https://openalex.org/W2038926357","https://openalex.org/W2039335948","https://openalex.org/W2040444076","https://openalex.org/W2055272161","https://openalex.org/W2064214863","https://openalex.org/W2064480398","https://openalex.org/W2067280712","https://openalex.org/W2070718963","https://openalex.org/W2088292624","https://openalex.org/W2092375071","https://openalex.org/W2096287682","https://openalex.org/W2099801199","https://openalex.org/W2105054044","https://openalex.org/W2112130807","https://openalex.org/W2119693288","https://openalex.org/W2121749405","https://openalex.org/W2130257210","https://openalex.org/W2136883754","https://openalex.org/W2137794469","https://openalex.org/W2147725230","https://openalex.org/W2157358125","https://openalex.org/W2171150197","https://openalex.org/W2624094894","https://openalex.org/W2797482815","https://openalex.org/W4242568052","https://openalex.org/W4285719527","https://openalex.org/W6639850997"],"related_works":["https://openalex.org/W2234322404","https://openalex.org/W3208778134","https://openalex.org/W3005931108","https://openalex.org/W4386951147","https://openalex.org/W4223451915","https://openalex.org/W2887359201","https://openalex.org/W4308767530","https://openalex.org/W4220833452","https://openalex.org/W2362999506","https://openalex.org/W4205170363"],"abstract_inverted_index":{"Glioblastomas":[0],"are":[1],"the":[2,17,160,163,173,179,192,196,208,211,221,239],"most":[3],"aggressive":[4],"primary":[5],"brain":[6,18],"tumors,":[7],"characterized":[8],"by":[9],"their":[10,266],"rapid":[11],"proliferation":[12,65,146],"and":[13,37,66,102,135,147,253],"diffuse":[14],"infiltration":[15],"of":[16,32,50,87,105,109,115,162,175,191,195,210,241],"tissue.":[19],"Survival":[20,122],"patterns":[21],"in":[22,46,69,213,237],"patients":[23,71,112,243,260],"with":[24,29,153,244],"glioblastoma":[25,111],"have":[26],"been":[27],"associated":[28,152],"a":[30,41,57,186,247],"number":[31],"clinicopathologic":[33],"factors":[34],"including":[35],"age":[36,134],"neurologic":[38],"status,":[39],"yet":[40],"significant":[42],"quantitative":[43],"link":[44,82],"to":[45,81,90,172,265],"vivo":[47],"growth":[48,101],"kinetics":[49],"each":[51,119],"glioma":[52,63,100],"has":[53],"remained":[54],"elusive.":[55],"Exploiting":[56],"recently":[58],"developed":[59],"tool":[60,249],"for":[61,99,118,129,258,261],"quantifying":[62,142],"net":[64],"invasion":[67,148],"rates":[68,86,117],"individual":[70,214,242],"using":[72],"routinely":[73,229],"available":[74],"magnetic":[75],"resonance":[76],"images":[77],"(MRI),":[78],"we":[79],"propose":[80],"these":[83,116,139],"patient-specific":[84],"kinetic":[85],"biological":[88,143,268],"aggressiveness":[89,144],"prognostic":[91],"significance.":[92],"Using":[93],"our":[94,217],"biologically":[95],"based":[96],"mathematical":[97,251],"model":[98],"invasion,":[103],"examination":[104],"serial":[106],"pretreatment":[107,231,267],"MRIs":[108],"32":[110],"allowed":[113],"quantification":[114],"patient's":[120],"tumor.":[121],"analyses":[123],"revealed":[124],"that":[125,159,225],"even":[126],"when":[127],"controlling":[128],"standard":[130],"clinical":[131,254,262],"parameters":[132,141],"(e.g.,":[133],"Karnofsky":[136],"performance":[137],"status),":[138],"model-defined":[140],"(net":[145],"rates)":[149],"were":[150,170],"significantly":[151],"prognosis.":[154],"One":[155],"hypothesis":[156],"generated":[157],"was":[158],"ratio":[161],"actual":[164],"survival":[165,176,240],"time":[166],"after":[167],"whatever":[168],"therapies":[169],"used":[171],"duration":[174],"predicted":[177],"(by":[178],"model)":[180],"without":[181],"any":[182],"therapy":[183],"would":[184],"provide":[185,201],"therapeutic":[187],"response":[188],"index":[189],"(TRI)":[190],"overall":[193],"effectiveness":[194,209],"therapies.":[197],"The":[198],"TRI":[199],"may":[200,233,256],"important":[202],"information,":[203],"not":[204],"otherwise":[205],"available,":[206],"about":[207],"treatments":[212],"patients.":[215],"To":[216],"knowledge,":[218],"this":[219],"is":[220],"first":[222],"report":[223],"indicating":[224],"dynamic":[226],"insight":[227],"from":[228],"obtained":[230],"imaging":[232,255],"be":[234],"quantitatively":[235],"useful":[236],"characterizing":[238],"glioblastoma.":[245],"Such":[246],"hybrid":[248],"bridging":[250],"modeling":[252],"allow":[257],"stratifying":[259],"studies":[263],"relative":[264],"aggressiveness.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":15}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
