{"id":"https://openalex.org/W2071934663","doi":"https://doi.org/10.1155/2010/479364","title":"Molecular and Therapeutic Potential and Toxicity of Valproic Acid","display_name":"Molecular and Therapeutic Potential and Toxicity of Valproic Acid","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2071934663","doi":"https://doi.org/10.1155/2010/479364","mag":"2071934663","pmid":"https://pubmed.ncbi.nlm.nih.gov/20798865"},"language":"en","primary_location":{"id":"doi:10.1155/2010/479364","doi":"https://doi.org/10.1155/2010/479364","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2010/479364","pdf_url":"https://downloads.hindawi.com/journals/bmri/2010/479364.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedicine and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/bmri/2010/479364.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089870040","display_name":"S\u00e9bastien Chateauvieux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095859","display_name":"H\u00f4pital Kirchberg","ror":"https://ror.org/00t1xpx62","country_code":"LU","type":"healthcare","lineage":["https://openalex.org/I4210095859"]},{"id":"https://openalex.org/I4405269690","display_name":"Fondation Recherche Cancer et Sang","ror":"https://ror.org/04y9qgr69","country_code":"LU","type":"nonprofit","lineage":["https://openalex.org/I4405269690"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Chateauvieux","raw_affiliation_strings":["Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer (LBMCC), \u201cFondation de Recherche Cancer et Sang\u201d, H\u00f4pital Kirchberg, Kirchberg 2540, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer (LBMCC), \u201cFondation de Recherche Cancer et Sang\u201d, H\u00f4pital Kirchberg, Kirchberg 2540, Luxembourg","institution_ids":["https://openalex.org/I4210095859","https://openalex.org/I4405269690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036714305","display_name":"Franck Morceau","orcid":"https://orcid.org/0000-0002-7945-3779","observed_orcids":["https://orcid.org/0000-0002-7945-3779"]},"institutions":[{"id":"https://openalex.org/I4210095859","display_name":"H\u00f4pital Kirchberg","ror":"https://ror.org/00t1xpx62","country_code":"LU","type":"healthcare","lineage":["https://openalex.org/I4210095859"]},{"id":"https://openalex.org/I4405269690","display_name":"Fondation Recherche Cancer et Sang","ror":"https://ror.org/04y9qgr69","country_code":"LU","type":"nonprofit","lineage":["https://openalex.org/I4405269690"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Franck Morceau","raw_affiliation_strings":["Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer (LBMCC), \u201cFondation de Recherche Cancer et Sang\u201d, H\u00f4pital Kirchberg, Kirchberg 2540, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer (LBMCC), \u201cFondation de Recherche Cancer et Sang\u201d, H\u00f4pital Kirchberg, Kirchberg 2540, Luxembourg","institution_ids":["https://openalex.org/I4210095859","https://openalex.org/I4405269690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109328326","display_name":"Mario A. Dicato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095859","display_name":"H\u00f4pital Kirchberg","ror":"https://ror.org/00t1xpx62","country_code":"LU","type":"healthcare","lineage":["https://openalex.org/I4210095859"]},{"id":"https://openalex.org/I4405269690","display_name":"Fondation Recherche Cancer et Sang","ror":"https://ror.org/04y9qgr69","country_code":"LU","type":"nonprofit","lineage":["https://openalex.org/I4405269690"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Mario Dicato","raw_affiliation_strings":["Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer (LBMCC), \u201cFondation de Recherche Cancer et Sang\u201d, H\u00f4pital Kirchberg, Kirchberg 2540, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer (LBMCC), \u201cFondation de Recherche Cancer et Sang\u201d, H\u00f4pital Kirchberg, Kirchberg 2540, Luxembourg","institution_ids":["https://openalex.org/I4210095859","https://openalex.org/I4405269690"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018593253","display_name":"Marc F. Diederich","orcid":"https://orcid.org/0000-0003-0115-4725","observed_orcids":["https://orcid.org/0000-0003-0115-4725"]},"institutions":[{"id":"https://openalex.org/I4210095859","display_name":"H\u00f4pital Kirchberg","ror":"https://ror.org/00t1xpx62","country_code":"LU","type":"healthcare","lineage":["https://openalex.org/I4210095859"]},{"id":"https://openalex.org/I4405269690","display_name":"Fondation Recherche Cancer et Sang","ror":"https://ror.org/04y9qgr69","country_code":"LU","type":"nonprofit","lineage":["https://openalex.org/I4405269690"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Marc Diederich","raw_affiliation_strings":["Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer (LBMCC), \u201cFondation de Recherche Cancer et Sang\u201d, H\u00f4pital Kirchberg, Kirchberg 2540, Luxembourg"],"raw_orcid":"https://orcid.org/0000-0003-0115-4725","affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer (LBMCC), \u201cFondation de Recherche Cancer et Sang\u201d, H\u00f4pital Kirchberg, Kirchberg 2540, Luxembourg","institution_ids":["https://openalex.org/I4210095859","https://openalex.org/I4405269690"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":22.2923,"has_fulltext":true,"cited_by_count":512,"citation_normalized_percentile":{"value":0.9965387,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"2010","issue":null,"first_page":"1","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.5512999892234802,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.5512999892234802,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.40139999985694885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mood-stabilizers","display_name":"mood stabilizers","score":0.9710000157356262},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.949999988079071},{"id":"https://openalex.org/keywords/ion-channel-inhibition","display_name":"ion channel inhibition","score":0.9150000214576721},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6690000295639038},{"id":"https://openalex.org/keywords/epilepsy-treatment","display_name":"epilepsy treatment","score":0.503000020980835},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.4410000145435333},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.9318491220474243},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.6976956129074097},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.6787741780281067},{"id":"https://openalex.org/C2780550438","wikidata":"https://www.wikidata.org/wiki/Q2622367","display_name":"Mood stabilizer","level":4,"score":0.6186762452125549},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5765957236289978},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5411573648452759},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5165578126907349},{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.49505797028541565},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.46216368675231934},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4612743854522705},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.43070006370544434},{"id":"https://openalex.org/C85240754","wikidata":"https://www.wikidata.org/wiki/Q14914420","display_name":"HDAC1","level":5,"score":0.42736801505088806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32102394104003906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29970234632492065},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28373682498931885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25280970335006714},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.13129711151123047},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2010/479364","doi":"https://doi.org/10.1155/2010/479364","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2010/479364","pdf_url":"https://downloads.hindawi.com/journals/bmri/2010/479364.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedicine and Biotechnology","raw_type":"journal-article"},{"id":"pmid:20798865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20798865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedicine & biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2926634","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2926634","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Biomed Biotechnol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:47886d23acd047b685e5e7200dbfb0dc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/47886d23acd047b685e5e7200dbfb0dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biomedicine and Biotechnology, Vol 2010 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2010/479364","doi":"https://doi.org/10.1155/2010/479364","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2010/479364","pdf_url":"https://downloads.hindawi.com/journals/bmri/2010/479364.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedicine and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8299999833106995}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4995248789","display_name":"Natural Products and related Redox Catalysts: Basic Research and Applications in Medicine and Agriculture","funder_award_id":"215009","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320326415","display_name":"Een H\u00e4erz fir kriibskrank Kanner","ror":"https://ror.org/04vn83f14"},{"id":"https://openalex.org/F4320327210","display_name":"Fondation\u00a0Recherche Cancer et Sang","ror":"https://ror.org/04y9qgr69"},{"id":"https://openalex.org/F4320337753","display_name":"Interreg","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071934663.pdf","grobid_xml":"https://content.openalex.org/works/W2071934663.grobid-xml"},"referenced_works_count":152,"referenced_works":["https://openalex.org/W58243263","https://openalex.org/W199768745","https://openalex.org/W1546245460","https://openalex.org/W1605104953","https://openalex.org/W1641419369","https://openalex.org/W1705585006","https://openalex.org/W1808354531","https://openalex.org/W1868426883","https://openalex.org/W1899314386","https://openalex.org/W1936316061","https://openalex.org/W1965716861","https://openalex.org/W1966416069","https://openalex.org/W1966864702","https://openalex.org/W1968317137","https://openalex.org/W1970437622","https://openalex.org/W1970772467","https://openalex.org/W1976844018","https://openalex.org/W1977227142","https://openalex.org/W1977307548","https://openalex.org/W1980182274","https://openalex.org/W1982777272","https://openalex.org/W1982827921","https://openalex.org/W1983406399","https://openalex.org/W1983817059","https://openalex.org/W1983819128","https://openalex.org/W1984025642","https://openalex.org/W1984760496","https://openalex.org/W1987017438","https://openalex.org/W1987687980","https://openalex.org/W1992638161","https://openalex.org/W1993106716","https://openalex.org/W1993760950","https://openalex.org/W1995773014","https://openalex.org/W2000431894","https://openalex.org/W2000630787","https://openalex.org/W2002564108","https://openalex.org/W2004223360","https://openalex.org/W2006677458","https://openalex.org/W2009177754","https://openalex.org/W2010078940","https://openalex.org/W2010437021","https://openalex.org/W2010628201","https://openalex.org/W2011925152","https://openalex.org/W2012670964","https://openalex.org/W2014116775","https://openalex.org/W2015538824","https://openalex.org/W2015886726","https://openalex.org/W2016555829","https://openalex.org/W2024980136","https://openalex.org/W2025375708","https://openalex.org/W2026549010","https://openalex.org/W2026674733","https://openalex.org/W2028494426","https://openalex.org/W2029993808","https://openalex.org/W2030817366","https://openalex.org/W2032346637","https://openalex.org/W2032766514","https://openalex.org/W2034076446","https://openalex.org/W2034717262","https://openalex.org/W2035711389","https://openalex.org/W2037463562","https://openalex.org/W2038179898","https://openalex.org/W2039098916","https://openalex.org/W2043024635","https://openalex.org/W2043467387","https://openalex.org/W2043710418","https://openalex.org/W2044099352","https://openalex.org/W2044389296","https://openalex.org/W2044465556","https://openalex.org/W2044780101","https://openalex.org/W2046195169","https://openalex.org/W2046717651","https://openalex.org/W2050087154","https://openalex.org/W2051358018","https://openalex.org/W2052665087","https://openalex.org/W2053145026","https://openalex.org/W2053631011","https://openalex.org/W2054576779","https://openalex.org/W2055856886","https://openalex.org/W2057743987","https://openalex.org/W2062270769","https://openalex.org/W2063692415","https://openalex.org/W2064310618","https://openalex.org/W2064790466","https://openalex.org/W2065743602","https://openalex.org/W2066238494","https://openalex.org/W2066853749","https://openalex.org/W2070952627","https://openalex.org/W2071888464","https://openalex.org/W2071942614","https://openalex.org/W2072611697","https://openalex.org/W2075075391","https://openalex.org/W2077912953","https://openalex.org/W2078901327","https://openalex.org/W2081167060","https://openalex.org/W2082629538","https://openalex.org/W2083213809","https://openalex.org/W2084417286","https://openalex.org/W2085053844","https://openalex.org/W2090746329","https://openalex.org/W2091090528","https://openalex.org/W2091318514","https://openalex.org/W2092915190","https://openalex.org/W2093688721","https://openalex.org/W2094916309","https://openalex.org/W2094999596","https://openalex.org/W2096324109","https://openalex.org/W2097145992","https://openalex.org/W2099803844","https://openalex.org/W2101415724","https://openalex.org/W2111153939","https://openalex.org/W2112011735","https://openalex.org/W2113012646","https://openalex.org/W2113195478","https://openalex.org/W2114264201","https://openalex.org/W2122315592","https://openalex.org/W2128304537","https://openalex.org/W2131525073","https://openalex.org/W2133475697","https://openalex.org/W2134225758","https://openalex.org/W2135085078","https://openalex.org/W2136103407","https://openalex.org/W2136494061","https://openalex.org/W2139900098","https://openalex.org/W2140103101","https://openalex.org/W2143425153","https://openalex.org/W2148104091","https://openalex.org/W2148147266","https://openalex.org/W2150515158","https://openalex.org/W2154214290","https://openalex.org/W2154256241","https://openalex.org/W2161173479","https://openalex.org/W2166861522","https://openalex.org/W2167746292","https://openalex.org/W2167966778","https://openalex.org/W2168589849","https://openalex.org/W2171048675","https://openalex.org/W2184007568","https://openalex.org/W2184179662","https://openalex.org/W2318410985","https://openalex.org/W2318853133","https://openalex.org/W2335878131","https://openalex.org/W2395636938","https://openalex.org/W2398636557","https://openalex.org/W2402860696","https://openalex.org/W2407617555","https://openalex.org/W2411203184","https://openalex.org/W2411406559","https://openalex.org/W2416015142","https://openalex.org/W2417642704","https://openalex.org/W2992737874","https://openalex.org/W4237847849"],"related_works":["https://openalex.org/W4252635045","https://openalex.org/W2331131861","https://openalex.org/W1580990163","https://openalex.org/W4362414993","https://openalex.org/W2030301626","https://openalex.org/W2101830790","https://openalex.org/W2910460606","https://openalex.org/W2133124834","https://openalex.org/W2098249941","https://openalex.org/W4237142232"],"abstract_inverted_index":{"Valproic":[0],"acid":[1],"(VPA),":[2],"a":[3,16,65],"branched":[4],"short-chain":[5],"fatty":[6],"acid,":[7],"is":[8,64],"widely":[9,66],"used":[10,67],"as":[11,143,145],"an":[12,95,128],"antiepileptic":[13],"drug":[14],"and":[15,32,57,85,136],"mood":[17],"stabilizer.":[18],"Antiepileptic":[19],"properties":[20],"have":[21],"been":[22],"attributed":[23],"to":[24,76,126],"inhibition":[25],"of":[26,33,50,80,98,103,130],"Gamma":[27],"Amino":[28],"Butyrate":[29],"(GABA)":[30],"transaminobutyrate":[31],"ion":[34],"channels.":[35],"VPA":[36,63,104,135],"was":[37],"recently":[38],"classified":[39],"among":[40],"the":[41,48,77,109,131],"Histone":[42],"Deacetylase":[43],"Inhibitors,":[44],"acting":[45],"directly":[46],"at":[47],"level":[49],"gene":[51],"transcription":[52,59],"by":[53],"inhibiting":[54],"histone":[55],"deacetylation":[56],"making":[58],"sites":[60],"more":[61],"accessible.":[62],"drug,":[68],"particularly":[69],"for":[70],"children":[71],"suffering":[72],"from":[73],"epilepsy.":[74],"Due":[75],"increasing":[78,96],"number":[79,97],"clinical":[81],"trials":[82],"involving":[83,134],"VPA,":[84],"interesting":[86],"results":[87],"obtained,":[88],"this":[89],"molecule":[90],"will":[91],"be":[92],"implicated":[93],"in":[94,108,116],"therapies.":[99],"However":[100],"side":[101,138],"effects":[102,139],"are":[105,113],"substantially":[106],"described":[107],"literature":[110],"whereas":[111],"they":[112],"poorly":[114],"discussed":[115],"articles":[117],"focusing":[118],"on":[119],"its":[120,137,146],"therapeutic":[121],"use.":[122],"This":[123],"paper":[124],"aims":[125],"give":[127],"overview":[129],"different":[132],"clinical-trials":[133],"encountered":[140],"during":[141],"treatment":[142],"well":[144],"molecular":[147],"properties.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":42},{"year":2021,"cited_by_count":46},{"year":2020,"cited_by_count":42},{"year":2019,"cited_by_count":35},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":34},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":43},{"year":2013,"cited_by_count":37},{"year":2012,"cited_by_count":28}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}