{"id":"https://openalex.org/W2071928889","doi":"https://doi.org/10.4161/15548627.2014.984281","title":"How the Atg1 complex assembles to initiate autophagy","display_name":"How the Atg1 complex assembles to initiate autophagy","publication_year":2015,"publication_date":"2015-01-02","ids":{"openalex":"https://openalex.org/W2071928889","doi":"https://doi.org/10.4161/15548627.2014.984281","mag":"2071928889","pmid":"https://pubmed.ncbi.nlm.nih.gov/25700739"},"language":"en","primary_location":{"id":"doi:10.4161/15548627.2014.984281","doi":"https://doi.org/10.4161/15548627.2014.984281","is_oa":true,"landing_page_url":"https://doi.org/10.4161/15548627.2014.984281","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/15548627.2014.984281?needAccess=true&role=button","source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/15548627.2014.984281?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055725138","display_name":"C. Davies","orcid":"https://orcid.org/0000-0001-9559-438X","observed_orcids":["https://orcid.org/0000-0001-9559-438X"]},"institutions":[{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher W Davies","raw_affiliation_strings":["a Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences , University of California, Berkeley ; Berkeley , CA USA","Berkeley, CA USA","Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences , University of California, Berkeley ; Berkeley , CA USA","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I95457486"]},{"raw_affiliation_string":"Berkeley, CA USA","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021521514","display_name":"Goran Stjepanovi\u0107","orcid":"https://orcid.org/0000-0002-4841-9949","observed_orcids":["https://orcid.org/0000-0002-4841-9949"]},"institutions":[{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Goran Stjepanovic","raw_affiliation_strings":["Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley; Berkeley, CA USA","Berkeley, CA USA","Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley; Berkeley, CA USA","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I95457486"]},{"raw_affiliation_string":"Berkeley, CA USA","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061450716","display_name":"James H. Hurley","orcid":"https://orcid.org/0000-0001-5054-5445","observed_orcids":["https://orcid.org/0000-0001-5054-5445"]},"institutions":[{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James H Hurley","raw_affiliation_strings":["Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley; Berkeley, CA USA; Life Sciences Division, Lawrence Berkeley National Lab; Berkeley, CA USA","Berkeley, CA USA","Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley","Life Sciences Division, Lawrence Berkeley National Lab"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley; Berkeley, CA USA; Life Sciences Division, Lawrence Berkeley National Lab; Berkeley, CA USA","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I148283060","https://openalex.org/I95457486"]},{"raw_affiliation_string":"Berkeley, CA USA","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I95457486"]},{"raw_affiliation_string":"Life Sciences Division, Lawrence Berkeley National Lab","institution_ids":["https://openalex.org/I148283060"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061450716"],"corresponding_institution_ids":["https://openalex.org/I103922791","https://openalex.org/I148283060","https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":0.9172,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.7644598,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"1","first_page":"185","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy-initiation","display_name":"autophagy initiation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/atg13","display_name":"ATG13","score":0.8119999766349792},{"id":"https://openalex.org/keywords/protein-complex-assembly","display_name":"protein complex formation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/phagophore-assembly-site","display_name":"phagophore assembly site","score":0.9409999847412109},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.6159999966621399},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C171896709","wikidata":"https://www.wikidata.org/wiki/Q18034663","display_name":"Autophagy-related protein 13","level":5,"score":0.7910853624343872},{"id":"https://openalex.org/C156911925","wikidata":"https://www.wikidata.org/wiki/Q643384","display_name":"Isothermal titration calorimetry","level":2,"score":0.7408543825149536},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7218887805938721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6729822158813477},{"id":"https://openalex.org/C71680706","wikidata":"https://www.wikidata.org/wiki/Q18032908","display_name":"ULK1","level":5,"score":0.49105024337768555},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4403155446052551},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37600424885749817},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30193907022476196},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.08270063996315002},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.08217409253120422},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.0},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.4161/15548627.2014.984281","doi":"https://doi.org/10.4161/15548627.2014.984281","is_oa":true,"landing_page_url":"https://doi.org/10.4161/15548627.2014.984281","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/15548627.2014.984281?needAccess=true&role=button","source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},{"id":"pmid:25700739","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25700739","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3695210","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4502730","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4502730","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4502730","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Autophagy","raw_type":"Text"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt76p8z0jg","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/76p8z0jg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Autophagy, vol 11, iss 1","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt76p8z0jg","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/76p8z0jg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Autophagy, vol 11, iss 1","raw_type":"article"},{"id":"pmh:qt76p8z0jg","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/76p8z0jg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Davies, CW; Stjepanovic, G; & Hurley, JH. (2015). How the Atg1 complex assembles to initiate autophagy. Autophagy, 11(1), 185 - 186. doi: 10.4161/15548627.2014.984281. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/76p8z0jg","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4161/15548627.2014.984281","doi":"https://doi.org/10.4161/15548627.2014.984281","is_oa":true,"landing_page_url":"https://doi.org/10.4161/15548627.2014.984281","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/15548627.2014.984281?needAccess=true&role=button","source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2219769941","display_name":null,"funder_award_id":"F32 GM112301","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G302170711","display_name":null,"funder_award_id":"GM111730","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5109181598","display_name":"The Autophagy Initiation Complexes","funder_award_id":"R01GM111730","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5144155196","display_name":null,"funder_award_id":"GM112301","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071928889.pdf","grobid_xml":"https://content.openalex.org/works/W2071928889.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3030000616","https://openalex.org/W1999558691","https://openalex.org/W2156144699","https://openalex.org/W4307919969","https://openalex.org/W2768302637","https://openalex.org/W1918384196","https://openalex.org/W4389507055","https://openalex.org/W2147305920","https://openalex.org/W1968432606","https://openalex.org/W4220798289"],"abstract_inverted_index":{"The":[0,16,130],"Atg1":[1,29,128],"complex,":[2],"comprising":[3],"Atg1,":[4,76],"Atg13,":[5],"Atg17,":[6],"Atg29,":[7],"and":[8,30,50,63,72,95,102,145],"Atg31,":[9],"is":[10,19,37,78,84],"a":[11,98,148],"key":[12],"initiator":[13],"of":[14,52,75,126],"autophagy.":[15],"Atg17-Atg31-Atg29":[17,113],"subcomplex":[18],"constitutively":[20],"present":[21],"at":[22],"the":[23,33,48,70,111,123,127,133,138,142],"phagophore":[24],"assembly":[25,53,101,124,143],"site":[26],"(PAS),":[27],"while":[28],"Atg13":[31,96],"join":[32],"complex":[34,91],"when":[35],"autophagy":[36],"triggered":[38],"by":[39],"starvation":[40],"or":[41],"other":[42],"signals.":[43],"We":[44,67],"sought":[45],"to":[46,118],"understand":[47],"energetics":[49],"dynamics":[51],"using":[54],"isothermal":[55],"titration":[56],"calorimetry":[57],"(ITC),":[58],"sedimentation":[59],"velocity":[60],"analytical":[61],"ultracentrifugation,":[62],"hydrogen-deuterium":[64],"exchange":[65],"(HDX).":[66],"showed":[68],"that":[69],"membrane":[71],"Atg13-binding":[73],"domain":[74],"Atg1EAT,":[77],"dynamic":[79],"on":[80],"its":[81,87],"own,":[82],"but":[83],"rigidified":[85],"in":[86,141],"high-affinity":[88],"(\u223c100":[89],"nM)":[90],"with":[92,105,110],"Atg13.":[93],"Atg1EAT":[94],"form":[97],"2:2":[99],"dimeric":[100],"together":[103],"associate":[104],"lower":[106],"affinity":[107],"(\u223c10":[108],"\u03bcM)":[109],"2:2:2":[112],"complex.":[114,129],"These":[115],"results":[116],"lead":[117],"an":[119],"overall":[120],"model":[121,131],"for":[122],"pathway":[125],"highlights":[132],"Atg13-Atg17":[134],"binding":[135],"event":[136],"as":[137,147],"weakest":[139],"link":[140],"process":[144],"thus":[146],"natural":[149],"regulatory":[150],"checkpoint.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}