{"id":"https://openalex.org/W2071927618","doi":"https://doi.org/10.1371/journal.pone.0068391","title":"Tagging of Genomic STAT3 and STAT1 with Fluorescent Proteins and Insertion of a Luciferase Reporter in the Cyclin D1 Gene Provides a Modified A549 Cell Line to Screen for Selective STAT3 Inhibitors","display_name":"Tagging of Genomic STAT3 and STAT1 with Fluorescent Proteins and Insertion of a Luciferase Reporter in the Cyclin D1 Gene Provides a Modified A549 Cell Line to Screen for Selective STAT3 Inhibitors","publication_year":2013,"publication_date":"2013-07-09","ids":{"openalex":"https://openalex.org/W2071927618","doi":"https://doi.org/10.1371/journal.pone.0068391","mag":"2071927618","pmid":"https://pubmed.ncbi.nlm.nih.gov/23950841","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732202"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0068391","doi":"https://doi.org/10.1371/journal.pone.0068391","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0068391","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0068391&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0068391&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Andrey Samsonov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155949","display_name":"Sigma-Aldrich (United States)","ror":"https://ror.org/02manjm47","country_code":"US","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4210111614","https://openalex.org/I4387155949"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrey Samsonov","raw_affiliation_strings":["Cell-Based Assays/Reporter Cell Lines, Sigma-Aldrich, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell-Based Assays/Reporter Cell Lines, Sigma-Aldrich, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I4387155949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026298971","display_name":"Nathan Zenser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155949","display_name":"Sigma-Aldrich (United States)","ror":"https://ror.org/02manjm47","country_code":"US","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4210111614","https://openalex.org/I4387155949"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Zenser","raw_affiliation_strings":["Cell-Based Assays/Reporter Cell Lines, Sigma-Aldrich, St. Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell-Based Assays/Reporter Cell Lines, Sigma-Aldrich, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I4387155949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403393","display_name":"Fan Zhang","orcid":"https://orcid.org/0000-0001-6798-2422","observed_orcids":["https://orcid.org/0000-0001-6798-2422"]},"institutions":[{"id":"https://openalex.org/I4387155949","display_name":"Sigma-Aldrich (United States)","ror":"https://ror.org/02manjm47","country_code":"US","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4210111614","https://openalex.org/I4387155949"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Zhang","raw_affiliation_strings":["Cell-Based Assays/Reporter Cell Lines, Sigma-Aldrich, St. Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell-Based Assays/Reporter Cell Lines, Sigma-Aldrich, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I4387155949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100659999","display_name":"Hongyi Zhang","orcid":"https://orcid.org/0000-0003-3408-2959","observed_orcids":["https://orcid.org/0000-0003-3408-2959"]},"institutions":[{"id":"https://openalex.org/I4387155949","display_name":"Sigma-Aldrich (United States)","ror":"https://ror.org/02manjm47","country_code":"US","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4210111614","https://openalex.org/I4387155949"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongyi Zhang","raw_affiliation_strings":["Cell-Based Assays/Reporter Cell Lines, Sigma-Aldrich, St. Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell-Based Assays/Reporter Cell Lines, Sigma-Aldrich, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I4387155949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013201639","display_name":"John R. Fetter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155949","display_name":"Sigma-Aldrich (United States)","ror":"https://ror.org/02manjm47","country_code":"US","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4210111614","https://openalex.org/I4387155949"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Fetter","raw_affiliation_strings":["Cell-Based Assays/Reporter Cell Lines, Sigma-Aldrich, St. Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell-Based Assays/Reporter Cell Lines, Sigma-Aldrich, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I4387155949"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009120439","display_name":"Dmitry Malkov","orcid":"https://orcid.org/0000-0001-5504-6987","observed_orcids":["https://orcid.org/0000-0001-5504-6987"]},"institutions":[{"id":"https://openalex.org/I4387155949","display_name":"Sigma-Aldrich (United States)","ror":"https://ror.org/02manjm47","country_code":"US","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4210111614","https://openalex.org/I4387155949"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dmitry Malkov","raw_affiliation_strings":["Cell-Based Assays/Reporter Cell Lines, Sigma-Aldrich, St. Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell-Based Assays/Reporter Cell Lines, Sigma-Aldrich, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I4387155949"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009120439"],"corresponding_institution_ids":["https://openalex.org/I4387155949"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.6757,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.90147147,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"7","first_page":"e68391","last_page":"e68391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":1.0},{"id":"https://openalex.org/keywords/stat3-inhibitor","display_name":"STAT3 inhibitor","score":0.8489999771118164},{"id":"https://openalex.org/keywords/fluorescent-protein-labeling","display_name":"fluorescent protein tagging","score":0.7609999775886536},{"id":"https://openalex.org/keywords/zinc-finger-nucleases","display_name":"zinc finger nucleases","score":0.8399999737739563},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.8840000033378601},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/luciferase-reporter","display_name":"luciferase reporter","score":0.9829999804496765},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.746999979019165},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.6669999957084656},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7900000214576721},{"id":"https://openalex.org/keywords/high-content-screening","display_name":"high-content screening","score":0.8140000104904175},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.5690000057220459},{"id":"https://openalex.org/keywords/chimeric-fusion-protein","display_name":"chimeric fusion protein","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.6398687958717346},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5854589939117432},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5410638451576233},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.47686704993247986},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.4556148946285248},{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.4478052854537964},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.43375542759895325},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.42728865146636963},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41026103496551514},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31854188442230225},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.30645066499710083},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.30622851848602295},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2482626736164093},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.19131571054458618},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.18880200386047363},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18164509534835815},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10845962166786194},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000097573","descriptor_name":"Red Fluorescent Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0068391","doi":"https://doi.org/10.1371/journal.pone.0068391","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0068391","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0068391&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2735213","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732202","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3732202","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732202","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23950841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23950841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e9e45ae816534c99a92803e81deea84d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e9e45ae816534c99a92803e81deea84d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 7, p e68391 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/742218","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Tagging_of_Genomic_STAT3_and_STAT1_with_Fluorescent_Proteins_and_Insertion_of_a_Luciferase_Reporter_in_the_Cyclin_D1_Gene_Provides_a_Modified_A549_Cell_Line_to_Screen_for_Selective_STAT3_Inhibitors_/742218","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0068391","doi":"https://doi.org/10.1371/journal.pone.0068391","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0068391","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0068391&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7200000286102295}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071927618.pdf","grobid_xml":"https://content.openalex.org/works/W2071927618.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W35995934","https://openalex.org/W106928741","https://openalex.org/W137477965","https://openalex.org/W1527291357","https://openalex.org/W1970916644","https://openalex.org/W1978564046","https://openalex.org/W1980529461","https://openalex.org/W1980817114","https://openalex.org/W1991013609","https://openalex.org/W2000707284","https://openalex.org/W2007264976","https://openalex.org/W2007840001","https://openalex.org/W2010169031","https://openalex.org/W2017768095","https://openalex.org/W2021164055","https://openalex.org/W2029638319","https://openalex.org/W2030870798","https://openalex.org/W2035401705","https://openalex.org/W2044227662","https://openalex.org/W2053055233","https://openalex.org/W2055125531","https://openalex.org/W2059660229","https://openalex.org/W2069531817","https://openalex.org/W2071411482","https://openalex.org/W2074356752","https://openalex.org/W2074702359","https://openalex.org/W2079295092","https://openalex.org/W2083275885","https://openalex.org/W2102153675","https://openalex.org/W2104940497","https://openalex.org/W2115427861","https://openalex.org/W2116033689","https://openalex.org/W2116565356","https://openalex.org/W2117525838","https://openalex.org/W2117862793","https://openalex.org/W2128094872","https://openalex.org/W2129532336","https://openalex.org/W2135962129","https://openalex.org/W2151047671","https://openalex.org/W2162983277","https://openalex.org/W2169106672","https://openalex.org/W2171903133","https://openalex.org/W2187852838","https://openalex.org/W2341161896","https://openalex.org/W2587870279"],"related_works":["https://openalex.org/W2067808775","https://openalex.org/W4313359659","https://openalex.org/W2078021701","https://openalex.org/W1990287990","https://openalex.org/W2029778736","https://openalex.org/W2117525838","https://openalex.org/W2101061199","https://openalex.org/W602973491","https://openalex.org/W2887654174","https://openalex.org/W2230354098"],"abstract_inverted_index":{"Signal":[0],"transducer":[1],"and":[2,21,32,52,61,94,111,192,196,243,254,260],"activator":[3],"of":[4,90,98,108,128,134,146,173,231,238,263,281],"transcription":[5],"3":[6],"(STAT3)":[7],"is":[8,13,276],"an":[9],"oncogenic":[10],"protein":[11,57],"that":[12,77,143,272],"constitutively":[14],"activated":[15,80],"in":[16,36,74,105,160,171,215,225,267],"numerous":[17],"cancer":[18,46,294],"cell":[19,161,218,228,244,249],"lines":[20],"human":[22],"cancers.":[23],"Another":[24],"STAT":[25],"family":[26],"member,":[27],"STAT1,":[28],"possesses":[29],"cancer-inhibitory":[30],"properties":[31],"can":[33],"promote":[34],"apoptosis":[35],"tumor":[37],"cells":[38,76,123,135,269],"upon":[39],"activation.":[40],"To":[41,168],"better":[42],"characterize":[43],"these":[44],"important":[45],"related":[47],"genes,":[48],"we":[49,177],"tagged":[50],"STAT3":[51,92,110,140,151,233,265],"STAT1":[53,100,112,274],"loci":[54],"with":[55,118,136],"fluorescent":[56,109],"(FP)":[58],"sequences":[59],"(RFP":[60],"GFP":[62],"respectively)":[63],"by":[64,201],"targeted":[65],"integration":[66,103],"via":[67],"zinc":[68],"finger":[69],"nuclease":[70],"(ZFN)--mediated":[71],"homologous":[72],"recombination":[73],"A549":[75],"express":[78],"aberrantly":[79],"STAT3.":[81],"We":[82],"inserted":[83],"the":[84,88,91,96,99,122,188,194,216,273],"FP":[85],"transgenes":[86],"at":[87,95],"N-terminus":[89],"locus":[93],"C-terminus":[97],"locus.":[101],"The":[102,210,247],"resulted":[104],"endogenous":[106,174,283],"expression":[107,172],"chimeric":[113],"fusion":[114],"proteins.":[115],"When":[116],"stimulated":[117],"IL-6":[119],"or":[120,130],"IFN-\u03b3,":[121],"showed":[124,142],"robust":[125],"nuclear":[126],"translocation":[127,145],"RFP-STAT3":[129],"STAT1-GFP,":[131],"respectively.":[132],"Pre-incubation":[133],"a":[137,183,202,207,226,232,252],"known":[138],"specific":[139],"inhibitor":[141,234],"IFN-\u03b3-induced":[144],"STAT1-GFP":[147],"was":[148,213],"not":[149,277],"impaired.":[150],"activates":[152],"multiple":[153],"downstream":[154],"targets":[155],"such":[156],"as":[157],"genes":[158],"involved":[159],"cycle":[162],"progression":[163],"-":[164],"e.g.":[165],"cyclin":[166,175,189,197,239],"D1.":[167],"detect":[169],"changes":[170],"D1,":[176],"used":[178],"ZFN":[179,287],"technology":[180,288],"to":[181,205,220,236,292],"insert":[182],"secreted":[184],"luciferase":[185,195,211],"reporter":[186],"behind":[187],"D1":[190,198,240],"promoter":[191,241],"separated":[193],"coding":[199],"regions":[200],"2A":[203],"sequence":[204],"induce":[206],"translational":[208],"skip.":[209],"insertion":[212],"made":[214],"RFP-STAT3/STAT1-GFP":[217],"line":[219,250],"have":[221],"all":[222],"three":[223],"reporters":[224],"single":[227],"line.":[229],"Addition":[230],"led":[235],"suppression":[237],"activity":[242],"growth":[245],"arrest.":[246],"triple-modified":[248],"provides":[251],"simple":[253],"convenient":[255],"method":[256],"for":[257],"high-content":[258],"screening":[259],"pre-clinical":[261],"testing":[262],"potential":[264],"inhibitors":[266],"live":[268],"while":[270],"ensuring":[271],"pathway":[275],"affected.":[278],"This":[279],"approach":[280],"reporting":[282],"gene":[284],"activities":[285],"using":[286],"could":[289],"be":[290],"applied":[291],"other":[293],"targets.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
