{"id":"https://openalex.org/W2071923404","doi":"https://doi.org/10.1523/jneurosci.0415-09.2009","title":"Disruption of Cdk5-Associated Phosphorylation of Residue Threonine-161 of the \u03b4-Opioid Receptor: Impaired Receptor Function and Attenuated Morphine Antinociceptive Tolerance","display_name":"Disruption of Cdk5-Associated Phosphorylation of Residue Threonine-161 of the \u03b4-Opioid Receptor: Impaired Receptor Function and Attenuated Morphine Antinociceptive Tolerance","publication_year":2009,"publication_date":"2009-03-18","ids":{"openalex":"https://openalex.org/W2071923404","doi":"https://doi.org/10.1523/jneurosci.0415-09.2009","mag":"2071923404","pmid":"https://pubmed.ncbi.nlm.nih.gov/19295160","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6665260"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.0415-09.2009","doi":"https://doi.org/10.1523/jneurosci.0415-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0415-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/11/3551.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/29/11/3551.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054160369","display_name":"Weiyan Xie","orcid":"https://orcid.org/0000-0001-6029-8521","observed_orcids":["https://orcid.org/0000-0001-6029-8521"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-Yan Xie","raw_affiliation_strings":["Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China. wangy66@bjmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China. wangy66@bjmu.edu.cn","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071186087","display_name":"Yi He","orcid":"https://orcid.org/0000-0002-9503-0565","observed_orcids":["https://orcid.org/0000-0002-9503-0565"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi He","raw_affiliation_strings":["Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China","(Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai, China","Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"(Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076219857","display_name":"Yanrui Yang","orcid":"https://orcid.org/0000-0001-5194-1239","observed_orcids":["https://orcid.org/0000-0001-5194-1239"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Rui Yang","raw_affiliation_strings":["(Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai, China","Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China","Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ya-Fang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya-Fang Li","raw_affiliation_strings":["Neuroscience Research Institute and","Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China","(Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai, China","Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Institute and","institution_ids":[]},{"raw_affiliation_string":"Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"(Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kai Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Kang","raw_affiliation_strings":["Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China","(Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai, China","Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"(Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113634412","display_name":"Bao-Ming Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bao-Ming Xing","raw_affiliation_strings":["Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China","(Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai, China","Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"(Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Wang","raw_affiliation_strings":["Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China","(Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai, China","Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100083, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"(Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5472,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.89542158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"29","issue":"11","first_page":"3551","last_page":"3564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.4661000072956085,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.4661000072956085,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.25369998812675476,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.23720000684261322,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/delta-opioid-receptor","display_name":"delta opioid receptor","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cdk5","display_name":"cyclin-dependent kinase 5","score":0.9110000133514404},{"id":"https://openalex.org/keywords/morphine-tolerance","display_name":"morphine tolerance","score":0.8489999771118164},{"id":"https://openalex.org/keywords/antinociceptive-tolerance","display_name":"antinociceptive tolerance","score":0.9559999704360962},{"id":"https://openalex.org/keywords/receptor-heterodimerization","display_name":"receptor heterodimerization","score":0.6909999847412109},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cell-surface-expression","display_name":"cell surface expression","score":0.9279999732971191},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.7013759613037109},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.660649299621582},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.6210425496101379},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5440220236778259},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5309459567070007},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5181259512901306},{"id":"https://openalex.org/C121738310","wikidata":"https://www.wikidata.org/wiki/Q18248262","display_name":"Cyclin-dependent kinase 5","level":5,"score":0.4701293408870697},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4296427369117737},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.24263161420822144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19873696565628052},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17436620593070984},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051360","descriptor_name":"Cyclin-Dependent Kinase 5","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051360","descriptor_name":"Cyclin-Dependent Kinase 5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051360","descriptor_name":"Cyclin-Dependent Kinase 5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.0415-09.2009","doi":"https://doi.org/10.1523/jneurosci.0415-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0415-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/11/3551.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5639539","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6665260","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6665260","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6665260","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:19295160","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19295160","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.0415-09.2009","doi":"https://doi.org/10.1523/jneurosci.0415-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0415-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/11/3551.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6163195294","display_name":"\u6162\u6027\u75db\u5206\u5b50\u673a\u5236\u63a2\u8ba8\uff0d\u5916\u5468\u4f24\u5bb3\u6027\u4fe1\u606f\u6574\u5408\u5668TRPV1\u8f6c\u5f55\u540e\u8c03\u63a7\u7684\u591a\u5c42\u6b21\u7814\u7a76","funder_award_id":"30830044","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6919812961","display_name":"Cdk5\u5728\u75db\u89c9\u654f\u5316\u4e2d\u7684\u4fe1\u53f7\u901a\u8def\u7814\u7a76","funder_award_id":"30770703","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6954705589","display_name":"CDK5\u5728\u963f\u7247\u8010\u53d7\u53ca\u6210\u763e\u4e2d\u7684\u4f5c\u7528\u53ca\u5176\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def\u7684\u7814\u7a76","funder_award_id":"30371635","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071923404.pdf","grobid_xml":"https://content.openalex.org/works/W2071923404.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1573791744","https://openalex.org/W1637051517","https://openalex.org/W1643951457","https://openalex.org/W1656098835","https://openalex.org/W1929667086","https://openalex.org/W1946022517","https://openalex.org/W1958337791","https://openalex.org/W1966464596","https://openalex.org/W1968901954","https://openalex.org/W1969892646","https://openalex.org/W1972559926","https://openalex.org/W1976637929","https://openalex.org/W1982324570","https://openalex.org/W1985335624","https://openalex.org/W1988306761","https://openalex.org/W1992886240","https://openalex.org/W1998091457","https://openalex.org/W2009204794","https://openalex.org/W2012233280","https://openalex.org/W2021908531","https://openalex.org/W2022806544","https://openalex.org/W2027591014","https://openalex.org/W2028560730","https://openalex.org/W2029463832","https://openalex.org/W2031884917","https://openalex.org/W2033168276","https://openalex.org/W2042562615","https://openalex.org/W2045120136","https://openalex.org/W2051746492","https://openalex.org/W2054978326","https://openalex.org/W2055224707","https://openalex.org/W2063083641","https://openalex.org/W2072159288","https://openalex.org/W2073771628","https://openalex.org/W2088096859","https://openalex.org/W2089746884","https://openalex.org/W2090845744","https://openalex.org/W2094109627","https://openalex.org/W2096562774","https://openalex.org/W2096686163","https://openalex.org/W2114179993","https://openalex.org/W2124430334","https://openalex.org/W2129849162","https://openalex.org/W2131931634","https://openalex.org/W2132503351","https://openalex.org/W2138158469","https://openalex.org/W2143379226","https://openalex.org/W2144022756","https://openalex.org/W2144395492","https://openalex.org/W2147122764","https://openalex.org/W2148875048","https://openalex.org/W2149782003","https://openalex.org/W2168259122","https://openalex.org/W4297627434","https://openalex.org/W4312861583","https://openalex.org/W4406065686"],"related_works":["https://openalex.org/W7099042441","https://openalex.org/W1994752334","https://openalex.org/W7209893230","https://openalex.org/W2585783017","https://openalex.org/W2901151613","https://openalex.org/W3172636842","https://openalex.org/W3146636191","https://openalex.org/W2141543252","https://openalex.org/W1981602327","https://openalex.org/W2113480891"],"abstract_inverted_index":{"Morphine":[0],"is":[1,16,28,87],"the":[2,11,19,24,69,76,80,97,117,144,175,183,190,198,223,230],"most":[3,7],"commonly":[4],"used":[5],"and":[6,96,127,136,195,228],"effective":[8],"analgesic":[9],"in":[10,50,59,68,79,153,222],"clinic.":[12],"However,":[13],"its":[14],"use":[15],"limited":[17],"by":[18],"tolerance.":[20,166],"Evidence":[21],"indicates":[22,210],"that":[23,44,105,156,211],"delta-opioid":[25],"receptor":[26,82],"(DOR)":[27],"essential":[29],"for":[30,89],"morphine":[31,51,150,164,201,226,240],"antinociceptive":[32,52,151,165,202,241],"tolerance;":[33],"however,":[34],"their":[35],"underlying":[36],"mechanisms":[37],"are":[38],"poorly":[39],"understood.":[40],"Here,":[41],"we":[42],"show":[43],"cyclin-dependent":[45],"kinase":[46],"5":[47],"(Cdk5),":[48],"activated":[49],"tolerance,":[53],"directly":[54],"phosphorylates":[55],"DOR":[56,114,135,148,160,180,215,234],"at":[57,85,216,236],"Thr-161":[58,67,86,157,217,237],"DRG":[60],"neurons.":[61],"Cdk5":[62,108,118],"was":[63],"found":[64],"to":[65,131,162,174,238],"phosphorylate":[66],"second":[70,176],"loop":[71,178],"of":[72,94,99,107,112,134,140,147,159,179,187,192,200,214,225,232],"DOR,":[73,95,188],"but":[74],"not":[75],"corresponding":[77,173],"residue":[78],"mu-opioid":[81],"(MOR).":[83],"Phosphorylation":[84],"required":[88],"normal":[90],"cell":[91,124,184],"surface":[92,125,185],"expression":[93,126,186],"formation":[98,191],"DOR-MOR":[100,193],"heterodimers.":[101],"Our":[102],"studies":[103],"indicated":[104],"inhibition":[106],"activity":[109],"or":[110],"overexpression":[111],"a":[113,141,219],"mutant":[115,146],"lacking":[116],"phosphorylation":[119,158,213,235],"site":[120],"displayed":[121],"relatively":[122,128],"low":[123,129],"abilities":[130],"form":[132],"heterodimers":[133],"MOR;":[137],"intrathecal":[138,205],"delivery":[139],"construct":[142],"expressing":[143],"T161A":[145],"attenuated":[149,197],"tolerance":[152,203,227,242],"rats,":[154],"suggesting":[155],"contributed":[161],"Cdk5-mediated":[163,212],"Furthermore,":[167],"an":[168],"engineered":[169],"Tat":[170],"fusion-interfering":[171],"peptide":[172],"intracellular":[177],"(Tat-DOR-2L),":[181],"reduced":[182],"disrupted":[189],"heterodimers,":[194],"significantly":[196],"development":[199,224],"after":[204],"injection.":[206],"The":[207],"present":[208],"study":[209],"plays":[218],"crucial":[220],"role":[221],"suggests":[229],"possibility":[231],"targeting":[233],"attenuate":[239],"during":[243],"pain":[244],"management.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
