{"id":"https://openalex.org/W2071919400","doi":"https://doi.org/10.1021/ja404004v","title":"A Ratiometric Two-Photon Fluorescent Probe Reveals Reduction in Mitochondrial H 2 S Production in Parkinson\u2019s Disease Gene Knockout Astrocytes","display_name":"A Ratiometric Two-Photon Fluorescent Probe Reveals Reduction in Mitochondrial H 2 S Production in Parkinson\u2019s Disease Gene Knockout Astrocytes","publication_year":2013,"publication_date":"2013-06-07","ids":{"openalex":"https://openalex.org/W2071919400","doi":"https://doi.org/10.1021/ja404004v","mag":"2071919400","pmid":"https://pubmed.ncbi.nlm.nih.gov/23745510"},"language":"en","primary_location":{"id":"doi:10.1021/ja404004v","doi":"https://doi.org/10.1021/ja404004v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja404004v","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113639729","display_name":"Sung Keun Bae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Keun Bae","raw_affiliation_strings":["Division of Energy Systems research, Ajou University, Suwon 443?749, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Energy Systems research, Ajou University, Suwon 443?749, Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041724950","display_name":"Cheol Ho Heo","orcid":"https://orcid.org/0000-0002-3786-9696","observed_orcids":["https://orcid.org/0000-0002-3786-9696"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Cheol Ho Heo","raw_affiliation_strings":["Division of Energy Systems research, Ajou University, Suwon 443?749, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Energy Systems research, Ajou University, Suwon 443?749, Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005350687","display_name":"Dong\u2010Joo Choi","orcid":"https://orcid.org/0000-0003-3222-7130","observed_orcids":["https://orcid.org/0000-0003-3222-7130"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong Joo Choi","raw_affiliation_strings":["Department of Pharmacology/Neuroscience\rGraduate Program, Ajou University School of Medicine, Suwon 443-721,\rKorea","Department of Pharmacology/Neuroscience#R#Graduate Program, Ajou University School of Medicine, Suwon 443-721,#R#Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology/Neuroscience\rGraduate Program, Ajou University School of Medicine, Suwon 443-721,\rKorea","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"Department of Pharmacology/Neuroscience#R#Graduate Program, Ajou University School of Medicine, Suwon 443-721,#R#Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Debabrata Sen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Debabrata Sen","raw_affiliation_strings":["Division of Energy Systems research, Ajou University, Suwon 443?749, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Energy Systems research, Ajou University, Suwon 443?749, Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040492220","display_name":"Eun-hye Joe","orcid":"https://orcid.org/0000-0002-5710-4156","observed_orcids":["https://orcid.org/0000-0002-5710-4156"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Eun-Hye Joe","raw_affiliation_strings":["Department of Pharmacology/Neuroscience\rGraduate Program, Ajou University School of Medicine, Suwon 443-721,\rKorea","Department of Pharmacology/Neuroscience#R#Graduate Program, Ajou University School of Medicine, Suwon 443-721,#R#Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology/Neuroscience\rGraduate Program, Ajou University School of Medicine, Suwon 443-721,\rKorea","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"Department of Pharmacology/Neuroscience#R#Graduate Program, Ajou University School of Medicine, Suwon 443-721,#R#Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057432547","display_name":"Bong Rae Cho","orcid":"https://orcid.org/0000-0001-8560-5399","observed_orcids":["https://orcid.org/0000-0001-8560-5399"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Bong Rae Cho","raw_affiliation_strings":["Department of Chemistry,\rKorea\rUniversity, Seoul 136-701, Korea","Department of Chemistry,#R#Korea#R#University, Seoul 136-701, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry,\rKorea\rUniversity, Seoul 136-701, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Department of Chemistry,#R#Korea#R#University, Seoul 136-701, Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085197346","display_name":"Hwan Myung Kim","orcid":"https://orcid.org/0000-0002-4112-9009","observed_orcids":["https://orcid.org/0000-0002-4112-9009"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hwan Myung Kim","raw_affiliation_strings":["Division of Energy Systems research, Ajou University, Suwon 443?749, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Energy Systems research, Ajou University, Suwon 443?749, Korea","institution_ids":["https://openalex.org/I57664883"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040492220","https://openalex.org/A5057432547","https://openalex.org/A5085197346"],"corresponding_institution_ids":["https://openalex.org/I197347611","https://openalex.org/I57664883"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":26.9473,"has_fulltext":false,"cited_by_count":411,"citation_normalized_percentile":{"value":0.99874608,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"135","issue":"26","first_page":"9915","last_page":"9923"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-sulfide","display_name":"hydrogen sulfide","score":0.9819999933242798},{"id":"https://openalex.org/keywords/ratiometric-fluorescent-probe","display_name":"ratiometric fluorescent probe","score":0.8090000152587891},{"id":"https://openalex.org/keywords/two-photon-imaging","display_name":"two-photon imaging","score":0.722000002861023},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cystathionine-beta-synthase","display_name":"cystathionine beta-synthase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dj-1","display_name":"DJ-1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6460000276565552},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.546999990940094},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6340000033378601},{"id":"https://openalex.org/keywords/brain-slices","display_name":"brain slices","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8172370195388794},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.6446145176887512},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6345680952072144},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5865064263343811},{"id":"https://openalex.org/C16525657","wikidata":"https://www.wikidata.org/wiki/Q5201183","display_name":"Cystathionine beta synthase","level":4,"score":0.5683104991912842},{"id":"https://openalex.org/C47785574","wikidata":"https://www.wikidata.org/wiki/Q373859","display_name":"Two-photon excitation microscopy","level":3,"score":0.5516272783279419},{"id":"https://openalex.org/C2780564542","wikidata":"https://www.wikidata.org/wiki/Q170591","display_name":"Hydrogen sulfide","level":3,"score":0.5431302189826965},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.47679662704467773},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4511305093765259},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.44061994552612305},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40136972069740295},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3586638569831848},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32597342133522034},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.30337637662887573},{"id":"https://openalex.org/C518881349","wikidata":"https://www.wikidata.org/wiki/Q682","display_name":"Sulfur","level":2,"score":0.26113492250442505},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.10632357001304626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10478392243385315},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000071617","descriptor_name":"Protein Deglycase DJ-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006862","descriptor_name":"Hydrogen Sulfide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D006862","descriptor_name":"Hydrogen Sulfide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006862","descriptor_name":"Hydrogen Sulfide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/ja404004v","doi":"https://doi.org/10.1021/ja404004v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja404004v","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:23745510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23745510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:repository.ajou.ac.kr:201003/9875","doi":null,"is_oa":false,"landing_page_url":"http://repository.ajou.ac.kr/handle/201003/9875","pdf_url":null,"source":{"id":"https://openalex.org/S4306401331","display_name":"AJOU Open Repository (Ajou University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57664883","host_organization_name":"Ajou University","host_organization_lineage":["https://openalex.org/I57664883"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1592009867","https://openalex.org/W1964527234","https://openalex.org/W1964603841","https://openalex.org/W1969629330","https://openalex.org/W1976306764","https://openalex.org/W1976642472","https://openalex.org/W1979840983","https://openalex.org/W1987530130","https://openalex.org/W1989548393","https://openalex.org/W1990847293","https://openalex.org/W1991344098","https://openalex.org/W2001860274","https://openalex.org/W2002360764","https://openalex.org/W2005980540","https://openalex.org/W2010704492","https://openalex.org/W2013052548","https://openalex.org/W2017487964","https://openalex.org/W2025281064","https://openalex.org/W2030044320","https://openalex.org/W2033920804","https://openalex.org/W2039761924","https://openalex.org/W2043100807","https://openalex.org/W2045070686","https://openalex.org/W2045910150","https://openalex.org/W2050044028","https://openalex.org/W2055707104","https://openalex.org/W2057225928","https://openalex.org/W2063207603","https://openalex.org/W2066338296","https://openalex.org/W2077608361","https://openalex.org/W2078249788","https://openalex.org/W2079054696","https://openalex.org/W2080740820","https://openalex.org/W2081447694","https://openalex.org/W2094123053","https://openalex.org/W2108036428","https://openalex.org/W2117497185","https://openalex.org/W2122438668","https://openalex.org/W2131988270","https://openalex.org/W2135793165","https://openalex.org/W2141610173","https://openalex.org/W2147607085","https://openalex.org/W2154414424","https://openalex.org/W2162668590","https://openalex.org/W2164552868","https://openalex.org/W2164663685","https://openalex.org/W2167460696","https://openalex.org/W2312956300","https://openalex.org/W2316448356","https://openalex.org/W2326387614","https://openalex.org/W2328781931","https://openalex.org/W2331722871","https://openalex.org/W2333590887"],"related_works":["https://openalex.org/W2904918921","https://openalex.org/W4383371886","https://openalex.org/W3040840607","https://openalex.org/W7155359294","https://openalex.org/W2616895924","https://openalex.org/W2741031203","https://openalex.org/W1976306764","https://openalex.org/W2396792039","https://openalex.org/W7212194073","https://openalex.org/W3037146333"],"abstract_inverted_index":{"Hydrogen":[0],"sulfide":[1],"(H2S)":[2],"is":[3,108],"a":[4,20,58,109,133,182,186],"multifunctional":[5],"signaling":[6],"molecule":[7],"that":[8,25,106,125,162,176],"exerts":[9],"neuroprotective":[10],"effects":[11],"in":[12,41,61,68,103,141,148,166],"oxidative":[13],"stress.":[14],"In":[15,129],"this":[16],"article,":[17],"we":[18],"report":[19],"mitochondria-localized":[21],"two-photon":[22,49],"probe,":[23],"SHS-M2,":[24],"can":[26],"be":[27,179],"excited":[28],"by":[29],"750":[30],"nm":[31],"femtosecond":[32],"pulses":[33],"and":[34,44,57,76,88,115,151,175],"employed":[35],"for":[36],"ratiometric":[37,113],"detection":[38],"of":[39,95,118,173,188],"H2S":[40,96,127,139,164],"live":[42],"astrocytes":[43,104,150,167],"living":[45],"brain":[46,152],"slices":[47],"using":[48],"microscopy":[50],"(TPM).":[51],"SHS-M2":[52,102,177],"shows":[53],"bright":[54],"two-photon-excited":[55],"fluorescence":[56],"marked":[59],"change":[60],"emission":[62],"color":[63],"from":[64,79],"blue":[65],"to":[66,70,170,184],"yellow":[67],"response":[69],"H2S,":[71],"low":[72],"cytotoxicity,":[73],"easy":[74],"loading,":[75],"minimum":[77],"interference":[78],"other":[80],"biologically":[81],"relevant":[82],"species":[83],"including":[84,191],"reactive":[85],"sulfur,":[86],"oxygen,":[87],"nitrogen":[89],"species,":[90],"thereby":[91],"allowing":[92],"quantitative":[93],"analysis":[94,114],"levels.":[97],"Molecular":[98],"TPM":[99],"imaging":[100],"with":[101,143],"revealed":[105],"there":[107],"correlation":[110],"between":[111],"the":[112,122,171],"expression":[116,156],"levels":[117,165],"cystathionine":[119],"\u03b2-synthase":[120],"(CBS),":[121],"major":[123],"enzyme":[124],"catalyzes":[126],"production.":[128],"studies":[130],"involving":[131],"DJ-1,":[132],"Parkinson's":[134],"disease":[135],"(PD)":[136],"gene,":[137],"attenuated":[138],"production":[140],"comparison":[142],"wild-type":[144],"controls":[145],"was":[146,157],"observed":[147],"DJ-1-knockout":[149],"slices,":[153],"where":[154],"CBS":[155],"decreased.":[158],"These":[159],"findings":[160],"demonstrate":[161],"reduced":[163],"may":[168,178],"contribute":[169],"development":[172],"PD":[174],"useful":[180],"as":[181],"marker":[183],"detect":[185],"risk":[187],"neurodegenerative":[189],"diseases,":[190],"PD.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":32},{"year":2017,"cited_by_count":45},{"year":2016,"cited_by_count":54},{"year":2015,"cited_by_count":58},{"year":2014,"cited_by_count":52},{"year":2013,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}