{"id":"https://openalex.org/W2071917841","doi":"https://doi.org/10.1039/c4fo00565a","title":"Immunoregulatory effects on Caco-2 cells and mice of exopolysaccharides isolated from Lactobacillus acidophilus NCFM","display_name":"Immunoregulatory effects on Caco-2 cells and mice of exopolysaccharides isolated from Lactobacillus acidophilus NCFM","publication_year":2014,"publication_date":"2014-09-30","ids":{"openalex":"https://openalex.org/W2071917841","doi":"https://doi.org/10.1039/c4fo00565a","mag":"2071917841","pmid":"https://pubmed.ncbi.nlm.nih.gov/25340590"},"language":"en","primary_location":{"id":"doi:10.1039/c4fo00565a","doi":"https://doi.org/10.1039/c4fo00565a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c4fo00565a","pdf_url":null,"source":{"id":"https://openalex.org/S2483688756","display_name":"Food & Function","issn_l":"2042-6496","issn":["2042-6496","2042-650X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Funct.","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100360963","display_name":"Li Li","orcid":"https://orcid.org/0000-0001-5187-8890","observed_orcids":["https://orcid.org/0000-0001-5187-8890"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Li","raw_affiliation_strings":["Key Laboratory of Dairy Science, Ministry of Education, College of Food Science and Engineering, Northeast Agricultural University, Harbin 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Dairy Science, Ministry of Education, College of Food Science and Engineering, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023694096","display_name":"Yujun Jiang","orcid":"https://orcid.org/0000-0002-2857-2137","observed_orcids":["https://orcid.org/0000-0002-2857-2137"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Jun Jiang","raw_affiliation_strings":["Key Laboratory of Dairy Science, Ministry of Education, College of Food Science and Engineering, Northeast Agricultural University, Harbin 150030, China","National Research Center of Dairy Engineering and Technology, Northeast Agricultural University, Harbin 150086, China","Synergetic Innovation Center of Food Safety and Nutrition, Northeast Agricultural University, Harbin 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Dairy Science, Ministry of Education, College of Food Science and Engineering, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"National Research Center of Dairy Engineering and Technology, Northeast Agricultural University, Harbin 150086, China","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"Synergetic Innovation Center of Food Safety and Nutrition, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076237587","display_name":"Xiangyi Yang","orcid":"https://orcid.org/0009-0004-9486-9694","observed_orcids":["https://orcid.org/0009-0004-9486-9694"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang-Yi Yang","raw_affiliation_strings":["Key Laboratory of Dairy Science, Ministry of Education, College of Food Science and Engineering, Northeast Agricultural University, Harbin 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Dairy Science, Ministry of Education, College of Food Science and Engineering, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100690096","display_name":"Ying Liu","orcid":"https://orcid.org/0000-0002-7355-3648","observed_orcids":["https://orcid.org/0000-0002-7355-3648"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Liu","raw_affiliation_strings":["Key Laboratory of Dairy Science, Ministry of Education, College of Food Science and Engineering, Northeast Agricultural University, Harbin 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Dairy Science, Ministry of Education, College of Food Science and Engineering, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100614566","display_name":"Jinyu Wang","orcid":"https://orcid.org/0000-0001-5689-6174","observed_orcids":["https://orcid.org/0000-0001-5689-6174"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Yu Wang","raw_affiliation_strings":["Key Laboratory of Dairy Science, Ministry of Education, College of Food Science and Engineering, Northeast Agricultural University, Harbin 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Dairy Science, Ministry of Education, College of Food Science and Engineering, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070959943","display_name":"Chaoxin Man","orcid":"https://orcid.org/0000-0003-2050-4639","observed_orcids":["https://orcid.org/0000-0003-2050-4639"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chao-Xin Man","raw_affiliation_strings":["National Research Center of Dairy Engineering and Technology, Northeast Agricultural University, Harbin 150086, China","Synergetic Innovation Center of Food Safety and Nutrition, Northeast Agricultural University, Harbin 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Center of Dairy Engineering and Technology, Northeast Agricultural University, Harbin 150086, China","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"Synergetic Innovation Center of Food Safety and Nutrition, Northeast Agricultural University, Harbin 150030, China","institution_ids":["https://openalex.org/I169572211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070959943"],"corresponding_institution_ids":["https://openalex.org/I169572211"],"apc_list":null,"apc_paid":null,"fwci":3.641,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.91638595,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"12","first_page":"3261","last_page":"3268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exopolysaccharides","display_name":"exopolysaccharides","score":0.9190000295639038},{"id":"https://openalex.org/keywords/lactobacillus-acidophilus-ncfm","display_name":"Lactobacillus acidophilus NCFM","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.984000027179718},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/interleukin-1-alpha","display_name":"interleukin-1 alpha","score":0.9039999842643738},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pentraxin-3","display_name":"pentraxin 3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9649999737739563},{"id":"https://openalex.org/keywords/p38-mapk-signaling","display_name":"p38 MAPK signaling","score":0.9739999771118164},{"id":"https://openalex.org/keywords/functional-foods","display_name":"functional foods","score":0.5320000052452087},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.5490000247955322},{"id":"https://openalex.org/keywords/intestinal-immune-response","display_name":"intestinal immune response","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C2777221637","wikidata":"https://www.wikidata.org/wiki/Q132644","display_name":"Lactobacillus acidophilus","level":4,"score":0.9186927080154419},{"id":"https://openalex.org/C193176779","wikidata":"https://www.wikidata.org/wiki/Q5016050","display_name":"Caco-2","level":3,"score":0.7478305697441101},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5419512391090393},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.47424760460853577},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.47158730030059814},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3704795837402344},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.34683310985565186},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32488977909088135},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.294630229473114},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27565231919288635},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1898510456085205},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.12939971685409546},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06733328104019165}],"mesh":[{"descriptor_ui":"D000099153","descriptor_name":"Pentraxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000683","descriptor_name":"Serum Amyloid P-Component","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000683","descriptor_name":"Serum Amyloid P-Component","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000683","descriptor_name":"Serum Amyloid P-Component","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000683","descriptor_name":"Serum Amyloid P-Component","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000683","descriptor_name":"Serum Amyloid P-Component","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000683","descriptor_name":"Serum Amyloid P-Component","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007779","descriptor_name":"Lactobacillus acidophilus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007779","descriptor_name":"Lactobacillus acidophilus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007779","descriptor_name":"Lactobacillus acidophilus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053582","descriptor_name":"Interleukin-1alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053582","descriptor_name":"Interleukin-1alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053582","descriptor_name":"Interleukin-1alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053582","descriptor_name":"Interleukin-1alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053582","descriptor_name":"Interleukin-1alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053582","descriptor_name":"Interleukin-1alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/c4fo00565a","doi":"https://doi.org/10.1039/c4fo00565a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c4fo00565a","pdf_url":null,"source":{"id":"https://openalex.org/S2483688756","display_name":"Food & Function","issn_l":"2042-6496","issn":["2042-6496","2042-650X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Funct.","raw_type":"journal-article"},{"id":"pmid:25340590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25340590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food & function","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6100000143051147}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321530","display_name":"Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences","ror":"https://ror.org/011rf9d86"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W318010536","https://openalex.org/W643457710","https://openalex.org/W1508454670","https://openalex.org/W1511939330","https://openalex.org/W1561346346","https://openalex.org/W1968834637","https://openalex.org/W1971368653","https://openalex.org/W1975159841","https://openalex.org/W1975746608","https://openalex.org/W1978307351","https://openalex.org/W1982819010","https://openalex.org/W1988309094","https://openalex.org/W1988464004","https://openalex.org/W1989624993","https://openalex.org/W1995493011","https://openalex.org/W1996717460","https://openalex.org/W2001149205","https://openalex.org/W2004400025","https://openalex.org/W2012012511","https://openalex.org/W2015760801","https://openalex.org/W2016530442","https://openalex.org/W2017963660","https://openalex.org/W2024530909","https://openalex.org/W2029509561","https://openalex.org/W2043126004","https://openalex.org/W2043178026","https://openalex.org/W2046054091","https://openalex.org/W2046553947","https://openalex.org/W2047267137","https://openalex.org/W2052995488","https://openalex.org/W2058568791","https://openalex.org/W2058858720","https://openalex.org/W2059674129","https://openalex.org/W2064806648","https://openalex.org/W2067601334","https://openalex.org/W2073770875","https://openalex.org/W2085979981","https://openalex.org/W2086444687","https://openalex.org/W2088455030","https://openalex.org/W2091923005","https://openalex.org/W2092087950","https://openalex.org/W2094863064","https://openalex.org/W2097747132","https://openalex.org/W2100077532","https://openalex.org/W2104330483","https://openalex.org/W2104572857","https://openalex.org/W2115559525","https://openalex.org/W2116242309","https://openalex.org/W2120320533","https://openalex.org/W2126048922","https://openalex.org/W2126905359","https://openalex.org/W2128902675","https://openalex.org/W2134317940","https://openalex.org/W2149191610","https://openalex.org/W2149636508","https://openalex.org/W2166759276","https://openalex.org/W3145430398","https://openalex.org/W4211094163"],"related_works":["https://openalex.org/W3096403201","https://openalex.org/W3210893488","https://openalex.org/W3185933123","https://openalex.org/W2349850256","https://openalex.org/W2324544850","https://openalex.org/W2273356168","https://openalex.org/W1964389618","https://openalex.org/W2394115999","https://openalex.org/W1993544710","https://openalex.org/W2096453211"],"abstract_inverted_index":{"On":[0],"the":[1,14,33,44,99,103,110,146,150],"basis":[2],"of":[3,10,17,107,127,175],"our":[4],"previous":[5],"results":[6],"on":[7,98],"potential":[8],"immunoregulation":[9,166],"Lactobacillus":[11],"acidophilus":[12,23,157],"NCFM,":[13],"immunoregulatory":[15,176],"effects":[16],"exopolysaccharides":[18],"(EPS)":[19],"isolated":[20],"from":[21,155],"L.":[22,156],"NCFM":[24,158],"and":[25,65,80,105,115,124,133,145,167],"their":[26],"regulating":[27],"mechanisms":[28],"are":[29],"further":[30],"investigated":[31],"in":[32,43,90,102,142,164,178],"current":[34],"research.":[35],"Stimulated":[36],"by":[37],"EPS":[38,128,130,153],"preparations,":[39],"four":[40,92],"immune-related":[41],"genes":[42,93,151],"human":[45],"colorectal":[46],"adenocarcinoma":[47],"cell":[48],"line":[49],"Caco-2":[50,143],"cells,":[51,144],"namely,":[52],"interleukin-1\u03b1":[53],"(IL-1\u03b1),":[54],"chemokine":[55],"C-C":[56],"motif":[57],"2":[58],"(CCL2),":[59],"tumor":[60],"necrosis":[61],"factor":[62],"\u03b1":[63],"(TNF-\u03b1),":[64],"pentraxin":[66],"3":[67],"(PTX3),":[68],"first":[69],"showed":[70,94],"an":[71,161],"increase":[72,126],"at":[73,77,83],"2-4":[74],"h,":[75,79],"peaked":[76],"4":[78],"then":[81],"decreased":[82],"4-12":[84],"h.":[85],"Similar":[86],"trends":[87],"were":[88],"observed":[89],"vivo:":[91],"transient":[95],"expression":[96],"(highest":[97],"4th":[100],"day)":[101],"cecum":[104],"colon":[106],"mice.":[108],"Meanwhile,":[109],"organ":[111],"coefficient,":[112],"clearance":[113],"index":[114,117],"phagocytic":[116],"all":[118],"significantly":[119],"increased":[120],"with":[121],"time":[122],"extension":[123],"dose":[125],"stimulation.":[129],"triggered":[131],"NF-\u03baB":[132],"p38":[134],"mitogen-activated":[135],"protein":[136],"kinase":[137],"(p38":[138],"MAPK)":[139],"signaling":[140],"pathways":[141,148],"activated":[147],"initiated":[149],"expression.":[152],"compounds":[154],"may":[159],"play":[160],"important":[162],"role":[163],"host":[165],"might":[168],"be":[169],"applied":[170],"as":[171],"a":[172],"new":[173],"type":[174],"agent":[177],"functional":[179],"foods.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}