{"id":"https://openalex.org/W2071914129","doi":"https://doi.org/10.1523/jneurosci.1683-10.2010","title":"Brain-Derived Neurotrophic Factor Controls Cannabinoid CB1 Receptor Function in the Striatum","display_name":"Brain-Derived Neurotrophic Factor Controls Cannabinoid CB1 Receptor Function in the Striatum","publication_year":2010,"publication_date":"2010-06-16","ids":{"openalex":"https://openalex.org/W2071914129","doi":"https://doi.org/10.1523/jneurosci.1683-10.2010","mag":"2071914129","pmid":"https://pubmed.ncbi.nlm.nih.gov/20554863","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6634565"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.1683-10.2010","doi":"https://doi.org/10.1523/jneurosci.1683-10.2010","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1683-10.2010","pdf_url":"https://www.jneurosci.org/content/jneuro/30/24/8127.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jneurosci.org/content/jneuro/30/24/8127.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"V. De Chiara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V. De Chiara","raw_affiliation_strings":["Clinica Neurologica and Clinica Psichiatrica, Dipartimento di Neuroscienze, Universit\u00e0 Tor Vergata, 00133 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica and Clinica Psichiatrica, Dipartimento di Neuroscienze, Universit\u00e0 Tor Vergata, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050470684","display_name":"Francesco Angelucci","orcid":"https://orcid.org/0000-0002-5956-5925","observed_orcids":["https://orcid.org/0000-0002-5956-5925"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Angelucci","raw_affiliation_strings":["Fondazione Santa Lucia , 00143 Rome , Italy,","Fondazione Santa Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione Santa Lucia , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Fondazione Santa Lucia","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079049956","display_name":"Silvia Rossi","orcid":"https://orcid.org/0000-0003-3257-8248","observed_orcids":["https://orcid.org/0000-0003-3257-8248"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Rossi","raw_affiliation_strings":["Clinica Neurologica and","Fondazione Santa Lucia , 00143 Rome , Italy,","Istituto Neurologico Mediterraneo Neuromed"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica and","institution_ids":[]},{"raw_affiliation_string":"Fondazione Santa Lucia , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Istituto Neurologico Mediterraneo Neuromed","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031150849","display_name":"Alessandra Musella","orcid":"https://orcid.org/0000-0001-7889-9253","observed_orcids":["https://orcid.org/0000-0001-7889-9253"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Musella","raw_affiliation_strings":["Clinica Neurologica and","Fondazione Santa Lucia , 00143 Rome , Italy,","Fondazione Santa Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica and","institution_ids":[]},{"raw_affiliation_string":"Fondazione Santa Lucia , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Fondazione Santa Lucia","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041838697","display_name":"Francesca Cavasinni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Cavasinni","raw_affiliation_strings":["Clinica Neurologica and","Fondazione Santa Lucia , 00143 Rome , Italy,","Fondazione Santa Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica and","institution_ids":[]},{"raw_affiliation_string":"Fondazione Santa Lucia , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Fondazione Santa Lucia","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011103572","display_name":"Cristina Cantarella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Cantarella","raw_affiliation_strings":["Clinica Neurologica and","Fondazione Santa Lucia , 00143 Rome , Italy,","Fondazione Santa Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica and","institution_ids":[]},{"raw_affiliation_string":"Fondazione Santa Lucia , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Fondazione Santa Lucia","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008399113","display_name":"Giorgia Mataluni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Mataluni","raw_affiliation_strings":["Clinica Neurologica and","Fondazione Santa Lucia , 00143 Rome , Italy,","Fondazione Santa Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica and","institution_ids":[]},{"raw_affiliation_string":"Fondazione Santa Lucia , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Fondazione Santa Lucia","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Sacchetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Sacchetti","raw_affiliation_strings":["Clinica Psichiatrica , Dipartimento di Neuroscienze , Universita `Tor Vergata , 00133 Rome , Italy,","University of Rome Tor Vergata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Psichiatrica , Dipartimento di Neuroscienze , Universita `Tor Vergata , 00133 Rome , Italy,","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"University of Rome Tor Vergata","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053360345","display_name":"Francesco Napolitano","orcid":"https://orcid.org/0000-0003-0884-1851","observed_orcids":["https://orcid.org/0000-0003-0884-1851"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Napolitano","raw_affiliation_strings":["Behavioural Neuroscience Laboratory , Centro di Ingegneria Genetica-Biotecnologie Avanzate , 80145 Naples , Italy,","Centro di Ingegneria Genetica -Biotecnologie Avanzate"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioural Neuroscience Laboratory , Centro di Ingegneria Genetica-Biotecnologie Avanzate , 80145 Naples , Italy,","institution_ids":[]},{"raw_affiliation_string":"Centro di Ingegneria Genetica -Biotecnologie Avanzate","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021970002","display_name":"M. Paola Castelli","orcid":"https://orcid.org/0000-0003-3249-4706","observed_orcids":["https://orcid.org/0000-0003-3249-4706"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Castelli","raw_affiliation_strings":["Clinica Neurologica and","Fondazione Santa Lucia , 00143 Rome , Italy,","Fondazione Santa Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica and","institution_ids":[]},{"raw_affiliation_string":"Fondazione Santa Lucia , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Fondazione Santa Lucia","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021425942","display_name":"Carlo Caltagirone","orcid":"https://orcid.org/0000-0002-0189-4515","observed_orcids":["https://orcid.org/0000-0002-0189-4515"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Caltagirone","raw_affiliation_strings":["Clinica Neurologica and","Fondazione Santa Lucia , 00143 Rome , Italy,","Fondazione Santa Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica and","institution_ids":[]},{"raw_affiliation_string":"Fondazione Santa Lucia , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Fondazione Santa Lucia","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021429755","display_name":"Giorgio Bernardi","orcid":"https://orcid.org/0000-0001-8630-6657","observed_orcids":["https://orcid.org/0000-0001-8630-6657","https://orcid.org/0000-0002-2837-2442"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Bernardi","raw_affiliation_strings":["Fondazione Santa Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione Santa Lucia","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084489352","display_name":"Mauro Maccarrone","orcid":"https://orcid.org/0000-0002-3990-2963","observed_orcids":["https://orcid.org/0000-0002-3990-2963"]},"institutions":[{"id":"https://openalex.org/I124326101","display_name":"University of Teramo","ror":"https://ror.org/01yetye73","country_code":"IT","type":"education","lineage":["https://openalex.org/I124326101"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Maccarrone","raw_affiliation_strings":["Dipartimento di Scienze Biomediche , Universita `degli Studi di Teramo , 64100 Teramo , Italy, and","Fondazione Santa Lucia , 00143 Rome , Italy,","Fondazione Santa Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Biomediche , Universita `degli Studi di Teramo , 64100 Teramo , Italy, and","institution_ids":["https://openalex.org/I124326101"]},{"raw_affiliation_string":"Fondazione Santa Lucia , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Fondazione Santa Lucia","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004532849","display_name":"Alessandro Usiello","orcid":"https://orcid.org/0000-0001-9203-853X","observed_orcids":["https://orcid.org/0000-0001-9203-853X"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Usiello","raw_affiliation_strings":["Behavioural Neuroscience Laboratory , Centro di Ingegneria Genetica-Biotecnologie Avanzate , 80145 Naples , Italy,","Dipartimento di Scienze Ambientali , Seconda Universita `di Napoli , 81100 Caserta , Italy","Second Univ. of Naples"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioural Neuroscience Laboratory , Centro di Ingegneria Genetica-Biotecnologie Avanzate , 80145 Naples , Italy,","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Scienze Ambientali , Seconda Universita `di Napoli , 81100 Caserta , Italy","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Second Univ. of Naples","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001899447","display_name":"Diego Centonze","orcid":"https://orcid.org/0000-0002-8390-8545","observed_orcids":["https://orcid.org/0000-0002-8390-8545"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. Centonze","raw_affiliation_strings":["Clinica Neurologica and","Fondazione Santa Lucia , 00143 Rome , Italy,","Fondazione Santa Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica and","institution_ids":[]},{"raw_affiliation_string":"Fondazione Santa Lucia , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Fondazione Santa Lucia","institution_ids":["https://openalex.org/I4210150112"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8133,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.95089609,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"30","issue":"24","first_page":"8127","last_page":"8137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":1.0},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.9300000071525574},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.9380000233650208},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cocaine","display_name":"cocaine","score":0.7120000123977661},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.8479999899864197},{"id":"https://openalex.org/keywords/receptor-sensitization","display_name":"receptor sensitization","score":0.7269999980926514},{"id":"https://openalex.org/keywords/emotional-stress","display_name":"emotional stress","score":0.5149999856948853},{"id":"https://openalex.org/keywords/reward","display_name":"reward","score":0.5339999794960022},{"id":"https://openalex.org/keywords/tyrosine-kinase-signaling","display_name":"tyrosine kinase signaling","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.611958920955658},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.55433189868927},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.5275670289993286},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48118358850479126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4610843062400818},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44253650307655334},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.41949236392974854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40173205733299255},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.37763863801956177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36522161960601807},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.35332685708999634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13473844528198242}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003042","descriptor_name":"Cocaine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006220","descriptor_name":"Haloperidol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018492","descriptor_name":"Dopamine Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018682","descriptor_name":"GABA Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018765","descriptor_name":"Dopamine Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047392","descriptor_name":"beta-Cyclodextrins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053444","descriptor_name":"Inhibitory Postsynaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053444","descriptor_name":"Inhibitory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1523/jneurosci.1683-10.2010","doi":"https://doi.org/10.1523/jneurosci.1683-10.2010","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1683-10.2010","pdf_url":"https://www.jneurosci.org/content/jneuro/30/24/8127.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6634565","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6634565","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:20554863","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20554863","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:art.torvergata.it:2108/9408","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/9408","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unicampania.it:11591/164891","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/164891","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ricerca.univaq.it:11697/155743","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11697/155743","pdf_url":null,"source":{"id":"https://openalex.org/S7407055225","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi dell Aquila","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.1683-10.2010","doi":"https://doi.org/10.1523/jneurosci.1683-10.2010","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1683-10.2010","pdf_url":"https://www.jneurosci.org/content/jneuro/30/24/8127.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071914129.pdf","grobid_xml":"https://content.openalex.org/works/W2071914129.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W66304169","https://openalex.org/W185450831","https://openalex.org/W1513230591","https://openalex.org/W1905669859","https://openalex.org/W1967017538","https://openalex.org/W1967075670","https://openalex.org/W1969060329","https://openalex.org/W1973647403","https://openalex.org/W1974107274","https://openalex.org/W1977988769","https://openalex.org/W1979009659","https://openalex.org/W1979665680","https://openalex.org/W1981274951","https://openalex.org/W1985114553","https://openalex.org/W1986539858","https://openalex.org/W1989780904","https://openalex.org/W1993109240","https://openalex.org/W1993440125","https://openalex.org/W1994304888","https://openalex.org/W1996907251","https://openalex.org/W1998335883","https://openalex.org/W2004273706","https://openalex.org/W2011319923","https://openalex.org/W2013713160","https://openalex.org/W2013819113","https://openalex.org/W2014300083","https://openalex.org/W2015143317","https://openalex.org/W2021320024","https://openalex.org/W2022305864","https://openalex.org/W2025149917","https://openalex.org/W2026114477","https://openalex.org/W2029925283","https://openalex.org/W2030276643","https://openalex.org/W2031111076","https://openalex.org/W2031386216","https://openalex.org/W2033119218","https://openalex.org/W2034746288","https://openalex.org/W2039924325","https://openalex.org/W2042587343","https://openalex.org/W2049804880","https://openalex.org/W2051681662","https://openalex.org/W2053484819","https://openalex.org/W2057719028","https://openalex.org/W2058449221","https://openalex.org/W2059496257","https://openalex.org/W2062367401","https://openalex.org/W2066577103","https://openalex.org/W2070003250","https://openalex.org/W2075201313","https://openalex.org/W2080115646","https://openalex.org/W2080231167","https://openalex.org/W2091146826","https://openalex.org/W2093154691","https://openalex.org/W2094046516","https://openalex.org/W2100344731","https://openalex.org/W2104477830","https://openalex.org/W2104513822","https://openalex.org/W2108286207","https://openalex.org/W2111038577","https://openalex.org/W2114190291","https://openalex.org/W2115444744","https://openalex.org/W2128849538","https://openalex.org/W2133291978","https://openalex.org/W2136532763","https://openalex.org/W2138529679","https://openalex.org/W2139349028","https://openalex.org/W2140178312","https://openalex.org/W2142925967","https://openalex.org/W2150396401","https://openalex.org/W2153198085","https://openalex.org/W2160392194","https://openalex.org/W2165518874","https://openalex.org/W2167088399","https://openalex.org/W2168882723","https://openalex.org/W2169230464","https://openalex.org/W2178107169","https://openalex.org/W2328993203","https://openalex.org/W2332032714","https://openalex.org/W2335656204"],"related_works":["https://openalex.org/W1986626488","https://openalex.org/W2009980006","https://openalex.org/W2038470741","https://openalex.org/W4289342498","https://openalex.org/W2080186237","https://openalex.org/W2122489682","https://openalex.org/W2950817425","https://openalex.org/W2589693579","https://openalex.org/W2902490575","https://openalex.org/W1720473697"],"abstract_inverted_index":{"The":[0,76,99,211],"role":[1,44],"of":[2,49,52,78,101,133,148,183,188,218,235],"brain-derived":[3],"neurotrophic":[4],"factor":[5],"(BDNF)":[6],"in":[7,30,36,45,60,162,170,185],"emotional":[8,47],"processes":[9],"suggests":[10],"an":[11],"interaction":[12],"with":[13,117],"the":[14,20,31,46,61,123,134,146,171,186],"endocannabinoid":[15],"system.":[16,127],"Here,":[17],"we":[18],"addressed":[19],"functional":[21],"interplay":[22],"between":[23],"BDNF":[24,39,55,79,102,135,168,199,223],"and":[25,40,51,71,93,110,142,201,224,227],"cannabinoid":[26,189],"CB(1)":[27],"receptors":[28,95],"(CB(1)Rs)":[29],"striatum,":[32,62,172],"a":[33,43,64,150,180,206,215],"brain":[34],"area":[35],"which":[37],"both":[38,196],"CB(1)s":[41],"play":[42],"consequences":[48],"stress":[50],"rewarding":[53],"experiences.":[54],"potently":[56],"inhibited":[57],"CB(1)R":[58,219,237],"function":[59,105,161],"through":[63,205],"mechanism":[65,207,217],"mediated":[66,221,240],"by":[67,222,241],"altered":[68],"cholesterol":[69,225],"metabolism":[70,226],"membrane":[72],"lipid":[73],"raft":[74],"function.":[75],"effect":[77],"was":[80,106,111],"restricted":[81],"to":[82,157],"CB(1)Rs":[83,89],"controlling":[84],"GABA-mediated":[85],"IPSCs":[86],"(CB(1)R(GABA)),":[87],"whereas":[88],"modulating":[90],"glutamate":[91],"transmission":[92],"GABA(B)":[94],"were":[96,140,143],"not":[97],"affected.":[98],"action":[100,147],"on":[103,209],"CB(1)R(GABA)":[104,138,160,203],"tyrosine":[107],"kinase":[108],"dependent":[109,208],"complete":[112],"even":[113],"after":[114],"receptor":[115,153],"sensitization":[116],"cocaine":[118,194],"or":[119],"environmental":[120],"manipulations":[121],"activating":[122],"dopamine":[124],"(DA)-dependent":[125],"reward":[126],"In":[128],"mice":[129],"lacking":[130],"one":[131],"copy":[132],"gene":[136],"(BDNF(+/-)),":[137],"responses":[139],"potentiated":[141],"preserved":[144],"from":[145],"haloperidol,":[149],"DA":[151,232],"D(2)":[152],"(D(2)R)":[154],"antagonist":[155],"able":[156],"fully":[158],"abolish":[159],"rewarded":[163],"animals.":[164],"Haloperidol":[165],"also":[166],"enhanced":[167],"levels":[169,200],"suggesting":[173],"that":[174,231],"this":[175,242],"neurotrophin":[176],"may":[177],"act":[178],"as":[179],"downstream":[181],"effector":[182],"D(2)Rs":[184],"modulation":[187,234],"signaling.":[190],"Accordingly,":[191],"5":[192],"d":[193],"exposure":[195],"reduced":[197],"striatal":[198,236],"increased":[202],"activity,":[204],"D(2)Rs.":[210],"present":[212],"study":[213],"identifies":[214],"novel":[216],"regulation":[220],"provides":[228],"some":[229],"evidence":[230],"D(2)R-dependent":[233],"activity":[238],"is":[239],"neurotrophin.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}