{"id":"https://openalex.org/W2071911784","doi":"https://doi.org/10.1074/jbc.m803519200","title":"FTDP-17 Mutations in Tau Alter the Regulation of Microtubule Dynamics","display_name":"FTDP-17 Mutations in Tau Alter the Regulation of Microtubule Dynamics","publication_year":2008,"publication_date":"2008-10-22","ids":{"openalex":"https://openalex.org/W2071911784","doi":"https://doi.org/10.1074/jbc.m803519200","mag":"2071911784","pmid":"https://pubmed.ncbi.nlm.nih.gov/18940799"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m803519200","doi":"https://doi.org/10.1074/jbc.m803519200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m803519200","pdf_url":"http://www.jbc.org/article/S0021925820496498/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820496498/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005724379","display_name":"Adria C. LeBoeuf","orcid":"https://orcid.org/0000-0002-2931-1510","observed_orcids":["https://orcid.org/0000-0002-2931-1510"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adria C. LeBoeuf","raw_affiliation_strings":["Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA","Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, Rockefeller University, New York, New York 1002","Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, California 93106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, Rockefeller University, New York, New York 1002","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]},{"raw_affiliation_string":"Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, California 93106","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013689370","display_name":"Sasha F. Levy","orcid":"https://orcid.org/0000-0002-0923-1636","observed_orcids":["https://orcid.org/0000-0002-0923-1636"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sasha F. Levy","raw_affiliation_strings":["Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York 10003","Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, California 93106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York 10003","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, California 93106","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109607528","display_name":"Michelle A. Gaylord","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Gaylord","raw_affiliation_strings":["Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, California 93106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, California 93106","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103014125","display_name":"Arnab Bhattacharya","orcid":"https://orcid.org/0000-0001-7331-0788","observed_orcids":["https://orcid.org/0000-0001-7331-0788"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I94234084","display_name":"Indian Institute of Technology Kanpur","ror":"https://ror.org/05pjsgx75","country_code":"IN","type":"education","lineage":["https://openalex.org/I94234084"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Arnab Bhattacharya","raw_affiliation_strings":["Department of Computer Science and Engineering, Indian Institute of Technology, 208016 Kanpur, India","Department of Computer Science, University of California, Santa Barbara, California 93106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Indian Institute of Technology, 208016 Kanpur, India","institution_ids":["https://openalex.org/I94234084"]},{"raw_affiliation_string":"Department of Computer Science, University of California, Santa Barbara, California 93106","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036639779","display_name":"Ambuj K. Singh","orcid":"https://orcid.org/0000-0002-1997-7140","observed_orcids":["https://orcid.org/0000-0002-1997-7140"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ambuj K. Singh","raw_affiliation_strings":["Department of Computer Science, University of California, Santa Barbara, California 93106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California, Santa Barbara, California 93106","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103013124","display_name":"Mary Ann Jordan","orcid":"https://orcid.org/0000-0002-7037-7829","observed_orcids":["https://orcid.org/0000-0002-7037-7829"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Ann Jordan","raw_affiliation_strings":["Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, California 93106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, California 93106","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109074162","display_name":"Leslie Wilson","orcid":"https://orcid.org/0000-0003-1403-0799","observed_orcids":["https://orcid.org/0000-0003-1403-0799"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie Wilson","raw_affiliation_strings":["Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, California 93106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, California 93106","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039595355","display_name":"Stuart C. Feinstein","orcid":"https://orcid.org/0000-0002-1662-6759","observed_orcids":["https://orcid.org/0000-0002-1662-6759"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stuart C. Feinstein","raw_affiliation_strings":["Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, California 93106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, California 93106","institution_ids":["https://openalex.org/I154570441"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5039595355"],"corresponding_institution_ids":["https://openalex.org/I154570441"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.0078,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.85475655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"283","issue":"52","first_page":"36406","last_page":"36415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.7459999918937683},{"id":"https://openalex.org/keywords/ftdp-17","display_name":"FTDP-17","score":0.9110000133514404},{"id":"https://openalex.org/keywords/microtubule-dynamics","display_name":"microtubule dynamics","score":0.8690000176429749},{"id":"https://openalex.org/keywords/microtubule-dynamic-instability","display_name":"microtubule dynamic instability","score":0.8119999766349792},{"id":"https://openalex.org/keywords/tau-mutations","display_name":"tau mutations","score":0.6610000133514404},{"id":"https://openalex.org/keywords/microtubule-binding","display_name":"microtubule binding","score":0.7799999713897705},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.8659999966621399},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.7354714870452881},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.6037312746047974},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3974769711494446},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35688191652297974},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3407062292098999},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.24275535345077515},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m803519200","doi":"https://doi.org/10.1074/jbc.m803519200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m803519200","pdf_url":"http://www.jbc.org/article/S0021925820496498/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:18940799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18940799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2606000","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2606000","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m803519200","doi":"https://doi.org/10.1074/jbc.m803519200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m803519200","pdf_url":"http://www.jbc.org/article/S0021925820496498/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6899999976158142}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1547296715","display_name":null,"funder_award_id":"NS-35010","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1924282673","display_name":null,"funder_award_id":"NS 13560","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2437833076","display_name":null,"funder_award_id":"ITR-0331697","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3042470309","display_name":"Information Technology Research (ITR):  Next-Generation Bio-Molecular Imaging and Information Discovery","funder_award_id":"0331697","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3839501248","display_name":null,"funder_award_id":"CA-57291","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4083626969","display_name":"Structure and Function of Tau Protein","funder_award_id":"5r01ns035010-14","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4085019234","display_name":"Mechanisms of Action of Anti-Mitotic Drugs","funder_award_id":"R01CA057291","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4983054899","display_name":"Mechanism and Control of Brain Microtubule Dynamics","funder_award_id":"5r01ns013560-32","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000216907","display_name":null,"funder_award_id":"NS\u201035010","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320320712","display_name":"Indian Institute of Technology Kanpur","ror":"https://ror.org/05pjsgx75"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071911784.pdf","grobid_xml":"https://content.openalex.org/works/W2071911784.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W150987474","https://openalex.org/W570519621","https://openalex.org/W1509571186","https://openalex.org/W1511517753","https://openalex.org/W1560764577","https://openalex.org/W1600934558","https://openalex.org/W1965709917","https://openalex.org/W1970576728","https://openalex.org/W1971579914","https://openalex.org/W1971775491","https://openalex.org/W1972355725","https://openalex.org/W1974322112","https://openalex.org/W1974760231","https://openalex.org/W1976628554","https://openalex.org/W1984770038","https://openalex.org/W1984939118","https://openalex.org/W1988829843","https://openalex.org/W1988884999","https://openalex.org/W1994030229","https://openalex.org/W1994336523","https://openalex.org/W1994790971","https://openalex.org/W1997634729","https://openalex.org/W1999486169","https://openalex.org/W2000303735","https://openalex.org/W2001752726","https://openalex.org/W2002347888","https://openalex.org/W2008675281","https://openalex.org/W2012405577","https://openalex.org/W2012666269","https://openalex.org/W2013013393","https://openalex.org/W2015005644","https://openalex.org/W2032576201","https://openalex.org/W2038120434","https://openalex.org/W2038396295","https://openalex.org/W2039069312","https://openalex.org/W2046092556","https://openalex.org/W2046624741","https://openalex.org/W2053652338","https://openalex.org/W2054933404","https://openalex.org/W2075042517","https://openalex.org/W2075530100","https://openalex.org/W2075791440","https://openalex.org/W2079082863","https://openalex.org/W2079655651","https://openalex.org/W2081451333","https://openalex.org/W2089571690","https://openalex.org/W2095577036","https://openalex.org/W2102701929","https://openalex.org/W2103913931","https://openalex.org/W2117526022","https://openalex.org/W2123513862","https://openalex.org/W2127229268","https://openalex.org/W2131954429","https://openalex.org/W2135309154","https://openalex.org/W2140631432","https://openalex.org/W2142286619","https://openalex.org/W2159377066","https://openalex.org/W2159643400","https://openalex.org/W2159994020","https://openalex.org/W2162643935","https://openalex.org/W2165300068","https://openalex.org/W2165988981","https://openalex.org/W2182661714","https://openalex.org/W2418501929","https://openalex.org/W4230565756"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"Mutations":[0],"affecting":[1],"either":[2,110],"the":[3,8,19,29,36,56,65,71,111,154,161,165,172,181,184,217],"structure":[4],"or":[5,106,113],"regulation":[6],"of":[7,33,67,75,116,134,143,150,168],"microtubule-associated":[9],"protein":[10],"Tau":[11,34,59,68,117,135,194,203,241],"cause":[12],"neuronal":[13,228],"cell":[14,48,229],"death":[15,230],"and":[16,50,93,146,153,231,239],"dementia.":[17],"However,":[18],"molecular":[20],"mechanisms":[21],"mediating":[22],"these":[23],"deleterious":[24],"effects":[25],"remain":[26],"unclear.":[27],"Among":[28],"most":[30],"characterized":[31],"activities":[32,148],"is":[35],"ability":[37,66,122],"to":[38,43,69,83,109,123,178],"regulate":[39,70,124],"microtubule":[40,80,86,89,125,144,169,223],"dynamics,":[41,170],"known":[42],"be":[44],"essential":[45],"for":[46,226,237],"proper":[47],"function":[49],"viability.":[51],"Here":[52],"we":[53,96],"have":[54],"tested":[55,100],"hypothesis":[57],"that":[58,98],"mutations":[60],"causing":[61],"neurodegeneration":[62],"also":[63,198],"alter":[64],"dynamic":[72],"instability":[73],"behaviors":[74],"microtubules.":[76],"Using":[77],"in":[78],"vitro":[79],"dynamics":[81],"assays":[82],"assess":[84],"average":[85],"growth":[87,90],"rates,":[88],"rate":[91],"distributions,":[92],"catastrophe":[94],"frequencies,":[95],"found":[97],"all":[99],"mutants":[101],"possessing":[102],"amino":[103],"acid":[104],"substitutions":[105],"deletions":[107],"mapping":[108],"repeat":[112],"interrepeat":[114,155,162,182],"regions":[115],"do":[118],"indeed":[119],"compromise":[120],"its":[121],"dynamics.":[126],"Further":[127],"mutational":[128],"analyses":[129],"suggest":[130],"a":[131,222,233],"novel":[132,234],"mechanism":[133,225],"regulatory":[136,147,213],"action":[137],"based":[138],"on":[139,183,192,201],"an":[140],"\"alternative":[141],"core\"":[142],"binding":[145],"composed":[149],"two":[151],"repeats":[152,174],"between":[156],"them.":[157],"In":[158],"this":[159],"model,":[160],"serves":[163],"as":[164,176],"primary":[166],"regulator":[167],"whereas":[171],"flanking":[173],"serve":[175],"tethers":[177],"properly":[179],"position":[180],"microtubule.":[185],"Importantly,":[186],"since":[187],"there":[188,196],"are":[189,197,219],"multiple":[190,199],"interrepeats":[191],"each":[193,202,205],"molecule,":[195,204],"cores":[200],"with":[206,221],"distinct":[207],"mechanistic":[208,235],"capabilities,":[209],"thereby":[210],"providing":[211],"significant":[212],"potential.":[214],"Taken":[215],"together,":[216],"data":[218],"consistent":[220],"misregulation":[224],"Tau-mediated":[227],"provide":[232],"model":[236],"normal":[238],"pathological":[240],"action.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-18T09:31:52.927876","created_date":"2016-06-24T00:00:00"}
