{"id":"https://openalex.org/W2071900272","doi":"https://doi.org/10.1210/jcem-57-6-1305","title":"IMMUNOREACTIVE CORTICOTROPIN-RELEASING FACTOR CONCENTRATIONS IN CEREBROSPINAL FLUID FROM PATIENTS WITH HYPOTHALAMIC-PITUITARY-ADRENAL DISORDERS","display_name":"IMMUNOREACTIVE CORTICOTROPIN-RELEASING FACTOR CONCENTRATIONS IN CEREBROSPINAL FLUID FROM PATIENTS WITH HYPOTHALAMIC-PITUITARY-ADRENAL DISORDERS","publication_year":1983,"publication_date":"1983-12-01","ids":{"openalex":"https://openalex.org/W2071900272","doi":"https://doi.org/10.1210/jcem-57-6-1305","mag":"2071900272","pmid":"https://pubmed.ncbi.nlm.nih.gov/6605358"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-57-6-1305","doi":"https://doi.org/10.1210/jcem-57-6-1305","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-57-6-1305","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034252789","display_name":"Naoki Tomori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NAOKI TOMORI","raw_affiliation_strings":["Department of Medicine, Tokyo Women\u2019s Medical College Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Women\u2019s Medical College Tokyo","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103386515","display_name":"Toshihiro Suda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TOSHIHIRO SUDA","raw_affiliation_strings":["Department of Medicine, Tokyo Women\u2019s Medical College Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Women\u2019s Medical College Tokyo","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108463557","display_name":"FUMIKO TOZAWA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"FUMIKO TOZAWA","raw_affiliation_strings":["Department of Medicine, Tokyo Women\u2019s Medical College Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Women\u2019s Medical College Tokyo","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030293363","display_name":"Hiroshi Demura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROSHI DEMURA","raw_affiliation_strings":["Department of Medicine, Tokyo Women\u2019s Medical College Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Women\u2019s Medical College Tokyo","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033893823","display_name":"KAZUO SHIZUME","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KAZUO SHIZUME","raw_affiliation_strings":["Department of Medicine, Tokyo Women\u2019s Medical College Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Women\u2019s Medical College Tokyo","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109927823","display_name":"Toraichi Mouri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TORAICHI MOURI","raw_affiliation_strings":["Second Department of Medicine, Tohoku University School of Medicine Sendai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Medicine, Tohoku University School of Medicine Sendai","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.2773,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.77385159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"57","issue":"6","first_page":"1305","last_page":"1307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.42239999771118164,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.42239999771118164,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.3264000117778778,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.17919999361038208,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.996999979019165},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cushing-disease","display_name":"Cushing's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nelson-s-syndrome","display_name":"Nelson's syndrome","score":0.9160000085830688},{"id":"https://openalex.org/keywords/sheehan-syndrome","display_name":"Sheehan's syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/addison-s-disease","display_name":"Addison's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pituitary-adenomectomy","display_name":"pituitary adenomectomy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/plasma-corticosteroids","display_name":"plasma corticosteroids","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8447946310043335},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8371918201446533},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.7955257892608643},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6160005331039429},{"id":"https://openalex.org/C2779435821","wikidata":"https://www.wikidata.org/wiki/Q219102","display_name":"Cushing syndrome","level":2,"score":0.6078827381134033},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5633873343467712},{"id":"https://openalex.org/C2776810848","wikidata":"https://www.wikidata.org/wiki/Q1947304","display_name":"Cushing's disease","level":3,"score":0.5098256468772888},{"id":"https://openalex.org/C2777817097","wikidata":"https://www.wikidata.org/wiki/Q8282","display_name":"Addison's disease","level":3,"score":0.5014827251434326},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.35383063554763794},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.15178120136260986}],"mesh":[{"descriptor_ui":"D000224","descriptor_name":"Addison Disease","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000307","descriptor_name":"Adrenal Gland Diseases","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D003480","descriptor_name":"Cushing Syndrome","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D003480","descriptor_name":"Cushing Syndrome","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004700","descriptor_name":"Endocrine System Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007018","descriptor_name":"Hypopituitarism","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009347","descriptor_name":"Nelson Syndrome","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D010900","descriptor_name":"Pituitary Diseases","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-57-6-1305","doi":"https://doi.org/10.1210/jcem-57-6-1305","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-57-6-1305","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:6605358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6605358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1980466482","https://openalex.org/W1994335238","https://openalex.org/W2034584065","https://openalex.org/W2077179723","https://openalex.org/W2087590197","https://openalex.org/W2095036452","https://openalex.org/W2615509544"],"related_works":["https://openalex.org/W2100168361","https://openalex.org/W2084971207","https://openalex.org/W2077325982","https://openalex.org/W2015500498","https://openalex.org/W2024285133","https://openalex.org/W653395922","https://openalex.org/W2005374622","https://openalex.org/W3023014720","https://openalex.org/W2013822441","https://openalex.org/W2069586323"],"abstract_inverted_index":{"The":[0],"concentrations":[1,61,95,118],"of":[2,50],"immunoreactive":[3],"corticotropin-releasing":[4],"factor":[5],"(I-CRF)":[6],"in":[7,19,52,62,96],"human":[8],"cerebrospinal":[9],"fluid":[10],"(CSF)":[11],"were":[12,54,72,89],"measured":[13],"utilizing":[14],"immunoaffinity":[15],"chromatography":[16],"and":[17,35,47,69,86],"RIA":[18],"patients":[20,25,65,82,99],"with":[21,26,57,66,83,100],"no":[22],"endocrine":[23],"disease,":[24,28],"Cushing's":[27,67,101],"Nelson's":[29,84],"syndrome,":[30,32],"Sheehan's":[31,70],"Addison's":[33,87],"disease":[34,68,88,102],"steroid":[36],"treated":[37],"patients.":[38],"On":[39],"high":[40],"performance":[41],"liquid":[42],"chromatography,":[43],"the":[44,91],"elution":[45],"profile":[46],"retention":[48],"time":[49],"I-CRF":[51,60,94,117],"CSF":[53,63,97,116],"not":[55],"identical":[56],"ovine":[58],"CRF.":[59],"from":[64,76,81,98],"syndrome":[71,85],"lower":[73],"than":[74],"those":[75,80],"normal":[77,92,105],"subjects,":[78],"however":[79],"within":[90],"range.":[93],"returned":[103],"to":[104],"levels":[106],"2-9":[107],"months":[108],"after":[109],"pituitary":[110],"adenomectomy.":[111],"These":[112],"results":[113],"suggest":[114],"that":[115],"are":[119],"reduced":[120],"by":[121],"increased":[122],"plasma":[123],"corticosteroid":[124],"levels.":[125]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
