{"id":"https://openalex.org/W2071851324","doi":"https://doi.org/10.1097/mpa.0b013e3181ec124e","title":"The Pathologic Classification of Neuroendocrine Tumors","display_name":"The Pathologic Classification of Neuroendocrine Tumors","publication_year":2010,"publication_date":"2010-07-21","ids":{"openalex":"https://openalex.org/W2071851324","doi":"https://doi.org/10.1097/mpa.0b013e3181ec124e","mag":"2071851324","pmid":"https://pubmed.ncbi.nlm.nih.gov/20664470"},"language":"en","primary_location":{"id":"doi:10.1097/mpa.0b013e3181ec124e","doi":"https://doi.org/10.1097/mpa.0b013e3181ec124e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mpa.0b013e3181ec124e","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016615488","display_name":"David S. Klimstra","orcid":"https://orcid.org/0000-0001-8814-1702","observed_orcids":["https://orcid.org/0000-0001-8814-1702"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David S. Klimstra","raw_affiliation_strings":["Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. klimstrd@mskcc.org","Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. klimstrd@mskcc.org","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030580928","display_name":"Irvin Mark Modlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irvin R. Modlin","raw_affiliation_strings":["Department of Surgery, Yale University School of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Yale University School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076324164","display_name":"Domenico Coppola","orcid":"https://orcid.org/0000-0001-9090-1205","observed_orcids":["https://orcid.org/0000-0001-9090-1205","https://orcid.org/0009-0008-3540-2014"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Domenico Coppola","raw_affiliation_strings":["Anatomic Pathology Department, Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomic Pathology Department, Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110331817","display_name":"Ricardo V. Lloyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo V. Lloyd","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032579505","display_name":"Saul M. Suster","orcid":"https://orcid.org/0000-0001-5483-3508","observed_orcids":["https://orcid.org/0000-0001-5483-3508"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saul Suster","raw_affiliation_strings":["Department of Pathology, Medical College of Wisconsin, Milwaukee, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5016615488"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":8.2999,"has_fulltext":false,"cited_by_count":1067,"citation_normalized_percentile":{"value":0.99151824,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"39","issue":"6","first_page":"707","last_page":"712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13383","display_name":"Tumors and Oncological Cases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroendocrine-tumors","display_name":"neuroendocrine tumors","score":1.0},{"id":"https://openalex.org/keywords/pathological-classification","display_name":"pathological classification","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tumor-nomenclature","display_name":"tumor nomenclature","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tumor-grading","display_name":"tumor grading","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tumor-staging","display_name":"tumor staging","score":0.9290000200271606},{"id":"https://openalex.org/keywords/well-differentiated-neuroendocrine-tumors","display_name":"well-differentiated neuroendocrine tumors","score":0.8140000104904175},{"id":"https://openalex.org/keywords/poorly-differentiated-neuroendocrine-tumors","display_name":"poorly differentiated neuroendocrine tumors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/prognostic-assessment","display_name":"prognostic assessment","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.8328912854194641},{"id":"https://openalex.org/C2781140086","wikidata":"https://www.wikidata.org/wiki/Q557945","display_name":"Confusion","level":2,"score":0.8069368600845337},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.732070803642273},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5107896327972412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48286178708076477},{"id":"https://openalex.org/C514705636","wikidata":"https://www.wikidata.org/wiki/Q863247","display_name":"Nomenclature","level":3,"score":0.46755802631378174},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4208706021308899},{"id":"https://openalex.org/C58642233","wikidata":"https://www.wikidata.org/wiki/Q8269924","display_name":"Taxonomy (biology)","level":2,"score":0.19246360659599304},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.168338805437088},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14075452089309692},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009626","descriptor_name":"Terminology as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018358","descriptor_name":"Neuroendocrine Tumors","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D018358","descriptor_name":"Neuroendocrine Tumors","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/mpa.0b013e3181ec124e","doi":"https://doi.org/10.1097/mpa.0b013e3181ec124e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mpa.0b013e3181ec124e","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},{"id":"pmid:20664470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20664470","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W165108672","https://openalex.org/W206142700","https://openalex.org/W259875475","https://openalex.org/W1578083272","https://openalex.org/W1983339183","https://openalex.org/W1993145619","https://openalex.org/W1994235502","https://openalex.org/W2000987172","https://openalex.org/W2009362475","https://openalex.org/W2010084014","https://openalex.org/W2013750312","https://openalex.org/W2014264072","https://openalex.org/W2021029245","https://openalex.org/W2025095579","https://openalex.org/W2036850360","https://openalex.org/W2036958273","https://openalex.org/W2063178653","https://openalex.org/W2066768964","https://openalex.org/W2071690041","https://openalex.org/W2074731710","https://openalex.org/W2087259349","https://openalex.org/W2098468148","https://openalex.org/W2103931078","https://openalex.org/W2110922803","https://openalex.org/W2139407392","https://openalex.org/W2142267327","https://openalex.org/W2143508466","https://openalex.org/W2145443928","https://openalex.org/W2147094583","https://openalex.org/W2149214723","https://openalex.org/W2260616479","https://openalex.org/W2502134830","https://openalex.org/W4233710688","https://openalex.org/W4247299654","https://openalex.org/W4249518047","https://openalex.org/W4255527167"],"related_works":["https://openalex.org/W2070625017","https://openalex.org/W2508514023","https://openalex.org/W2298024338","https://openalex.org/W2328812748","https://openalex.org/W1972413461","https://openalex.org/W2990744559","https://openalex.org/W2888018398","https://openalex.org/W2588295537","https://openalex.org/W2763813381","https://openalex.org/W2774049761"],"abstract_inverted_index":{"Neuroendocrine":[0],"tumors":[1],"(NETs)":[2],"arise":[3],"in":[4,40,98,115],"most":[5],"organs":[6],"of":[7,19,31,44,51,57,82,95,122,127,131,138,151],"the":[8,41,80,93,113,124,139,143],"body":[9],"and":[10,29,67,85,92,156],"share":[11],"many":[12,75],"common":[13,48,76,140],"pathologic":[14,42,125],"features.":[15],"However,":[16],"a":[17],"variety":[18],"different":[20,52,144],"organ-specific":[21],"systems":[22,56,146],"have":[23],"been":[24],"developed":[25],"for":[26,65],"nomenclature,":[27],"grading,":[28],"staging":[30,68],"NETs,":[32,129],"causing":[33],"much":[34],"confusion.":[35],"This":[36],"review":[37],"examines":[38],"issues":[39],"assessment":[43],"NETs":[45,91],"that":[46],"are":[47,59,74],"among":[49,142],"primaries":[50],"sites.":[53],"The":[54],"various":[55],"nomenclature":[58],"compared":[60],"along":[61],"with":[62],"new":[63],"proposal":[64],"grading":[66],"NETs.":[69],"Although":[70,118],"differences":[71],"persist,":[72],"there":[73],"themes,":[77],"such":[78],"as":[79],"distinction":[81],"well-differentiated":[83],"(low":[84],"intermediate-grade)":[86],"from":[87],"poorly":[88],"differentiated":[89],"(high-grade)":[90],"significance":[94],"proliferative":[96],"rate":[97],"prognostic":[99],"assessment.":[100],"A":[101],"recently":[102],"published":[103],"minimum":[104],"pathology":[105,116],"data":[106],"set":[107],"is":[108],"presented":[109],"to":[110,154],"help":[111],"standardize":[112],"information":[114,152],"reports.":[117],"an":[119,136],"ultimate":[120],"goal":[121],"standardizing":[123],"classification":[126],"all":[128],"irrespective":[130],"primary":[132],"site,":[133],"remains":[134],"elusive,":[135],"understanding":[137],"themes":[141],"current":[145],"will":[147],"permit":[148],"easier":[149],"translation":[150],"relevant":[153],"prognosis":[155],"treatment.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":48},{"year":2022,"cited_by_count":50},{"year":2021,"cited_by_count":54},{"year":2020,"cited_by_count":48},{"year":2019,"cited_by_count":66},{"year":2018,"cited_by_count":76},{"year":2017,"cited_by_count":110},{"year":2016,"cited_by_count":103},{"year":2015,"cited_by_count":121},{"year":2014,"cited_by_count":111},{"year":2013,"cited_by_count":103},{"year":2012,"cited_by_count":77}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}