{"id":"https://openalex.org/W207179366","doi":null,"title":"Differentiation of human surface upper airway epithelial cells in primary culture on a floating collagen gel.","display_name":"Differentiation of human surface upper airway epithelial cells in primary culture on a floating collagen gel.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W207179366","mag":"207179366","pmid":"https://pubmed.ncbi.nlm.nih.gov/7689028"},"language":"en","primary_location":{"id":"pmid:7689028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7689028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epithelial cell biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043688664","display_name":"Martine Chevillard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Chevillard","raw_affiliation_strings":["INSERM U.314, CHR Maison-Blanche, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U.314, CHR Maison-Blanche, Reims, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074116425","display_name":"Jocelyne Hinnrasky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Hinnrasky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110231328","display_name":"D. Pierrot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Pierrot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111756242","display_name":"J.M. Zahm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Zahm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109528504","display_name":"J.M. Klossek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Klossek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109283634","display_name":"\u00c9dith Puchelle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Puchelle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1409,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.74744629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"1","first_page":"17","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.2883000075817108,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.2883000075817108,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.2793000042438507,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0697999969124794,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/upper-airway-epithelium","display_name":"upper airway epithelium","score":0.8349999785423279},{"id":"https://openalex.org/keywords/epithelial-differentiation","display_name":"epithelial differentiation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.7620000243186951},{"id":"https://openalex.org/keywords/ciliogenesis","display_name":"ciliogenesis","score":0.6330000162124634},{"id":"https://openalex.org/keywords/ciliary-beat-frequency","display_name":"ciliary beat frequency","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mucociliary-function","display_name":"mucociliary function","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mucin-secretion","display_name":"mucin secretion","score":0.765999972820282},{"id":"https://openalex.org/keywords/basal-cells","display_name":"basal cells","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5709969997406006},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5614209771156311},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.5520346164703369},{"id":"https://openalex.org/C195267511","wikidata":"https://www.wikidata.org/wiki/Q5119969","display_name":"Ciliogenesis","level":3,"score":0.5373318195343018},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5081064701080322},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4857071340084076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4465496242046356},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.4258185625076294},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.41046178340911865},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4048750400543213},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3295634388923645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07895612716674805},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07296785712242126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009296","descriptor_name":"Nasal Cavity","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009296","descriptor_name":"Nasal Cavity","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016895","descriptor_name":"Culture Media, Serum-Free","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7689028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7689028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epithelial cell biology","raw_type":"Journal Article"},{"id":"mag:207179366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7689028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2314425663","https://openalex.org/W1981569852","https://openalex.org/W7056559574","https://openalex.org/W2408470715","https://openalex.org/W2009106902","https://openalex.org/W2521133499","https://openalex.org/W7488085","https://openalex.org/W2059234792","https://openalex.org/W7005635496","https://openalex.org/W2079709116"],"abstract_inverted_index":{"The":[0,15,129],"differentiation":[1,76,235],"of":[2,43,53,63,68,77,85,103,109,122,132,162,170,190,221,249],"human":[3,230],"nasal":[4],"surface":[5],"epithelial":[6,45,78,117,177,233],"cells":[7,17,46,57,79,113,118,135,178,192,204,223,251],"in":[8,29,119,198,236],"primary":[9,199],"three-dimensional":[10],"(3D)":[11],"culture":[12],"was":[13,147,224],"studied.":[14],"dissociated":[16],"were":[18,47,205],"seeded":[19],"on":[20,80,153,207],"type":[21],"I":[22],"and":[23,27,36,51,95,114,124,187,218],"IV":[24],"collagen":[25,54,71,87,209,255],"gel":[26,210,256],"grown":[28,206],"a":[30,69,86,104,184,208],"serum-free":[31],"medium":[32],"supplemented":[33],"with":[34,164],"hormones":[35],"growth":[37],"factors.":[38],"During":[39],"the":[40,56,66,75,101,120,133,138,150,168,176,180,203,219,246,250,253],"first":[41],"days":[42,62,197],"culture,":[44,64,237],"infrequently":[48],"differentiated.":[49],"Detachment":[50],"retraction":[52],"by":[55,90,240,245],"generally":[58],"occurred":[59],"after":[60],"8-10":[61],"allowing":[65],"formation":[67,102],"floating":[70,254],"gel.":[72],"This":[73],"induced":[74],"3D":[81,247],"cord-like":[82,181],"structures":[83,182],"consisting":[84,108],"core":[88],"surrounded":[89],"well-differentiated":[91],"cells.":[92,128],"Under":[93],"scanning":[94],"transmission":[96],"electron":[97],"microscopy,":[98],"we":[99],"observed":[100],"pseudostratified":[105],"respiratory-type":[106],"epithelium":[107],"columnar":[110],"mature":[111],"ciliated":[112,134,191],"secretory":[115],"cells,":[116],"process":[121],"ciliogenesis,":[123],"small":[125],"pyramidal":[126],"basal":[127],"videomicroscopic":[130],"analysis":[131],"showed":[136,167],"that":[137,229],"mean":[139],"ciliary":[140],"beating":[141,189],"frequency":[142],"(12.2":[143],"+/-":[144,157],"1":[145],"Hz)":[146],"close":[148],"to":[149,212],"values":[151],"obtained":[152],"polyp":[154],"explants":[155],"(11.7":[156],"0.8":[158],"Hz).":[159],"Immunocytochemical":[160],"localization":[161],"secretion":[163],"mucin-specific":[165],"antibodies":[166],"expression":[169],"mucous":[171],"cell":[172,234],"function.":[173],"In":[174],"addition,":[175],"within":[179],"maintained":[183],"differentiated":[185,222],"morphology":[186],"active":[188],"for":[193],"more":[194,216],"than":[195],"35":[196],"culture.":[200],"Conversely,":[201],"when":[202],"attached":[211],"plastic,":[213],"they":[214],"remained":[215],"flattened":[217],"number":[220],"lower.":[225],"These":[226],"results":[227],"suggest":[228],"upper":[231],"airway":[232],"as":[238],"assessed":[239],"mucociliary":[241],"function,":[242],"is":[243],"enhanced":[244],"organization":[248],"around":[252],"substrate.":[257]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
