{"id":"https://openalex.org/W2071768705","doi":"https://doi.org/10.1212/wnl.52.6.1230","title":"Estriol ameliorates autoimmune demyelinating disease","display_name":"Estriol ameliorates autoimmune demyelinating disease","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2071768705","doi":"https://doi.org/10.1212/wnl.52.6.1230","mag":"2071768705","pmid":"https://pubmed.ncbi.nlm.nih.gov/10214749"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.52.6.1230","doi":"https://doi.org/10.1212/wnl.52.6.1230","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.52.6.1230","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113204155","display_name":"S. Kim","orcid":"https://orcid.org/0009-0005-3671-3779","observed_orcids":["https://orcid.org/0009-0005-3671-3779"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Kim","raw_affiliation_strings":["From the Departments of Neurology (S. KimS.M. Liva, M.A. Dalal, and Dr. Voskuhl) and Pathology and Laboratory Medicine/Neuropathology (Dr. Verity), University of California Los Angeles School of Medicine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (S. KimS.M. Liva, M.A. Dalal, and Dr. Voskuhl) and Pathology and Laboratory Medicine/Neuropathology (Dr. Verity), University of California Los Angeles School of Medicine, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111836812","display_name":"Stephanie M. Liva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.M. Liva","raw_affiliation_strings":["From the Departments of Neurology (S. KimS.M. Liva, M.A. Dalal, and Dr. Voskuhl) and Pathology and Laboratory Medicine/Neuropathology (Dr. Verity), University of California Los Angeles School of Medicine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (S. KimS.M. Liva, M.A. Dalal, and Dr. Voskuhl) and Pathology and Laboratory Medicine/Neuropathology (Dr. Verity), University of California Los Angeles School of Medicine, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111558826","display_name":"Mira A. Dalal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.A. Dalal","raw_affiliation_strings":["From the Departments of Neurology (S. KimS.M. Liva, M.A. Dalal, and Dr. Voskuhl) and Pathology and Laboratory Medicine/Neuropathology (Dr. Verity), University of California Los Angeles School of Medicine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (S. KimS.M. Liva, M.A. Dalal, and Dr. Voskuhl) and Pathology and Laboratory Medicine/Neuropathology (Dr. Verity), University of California Los Angeles School of Medicine, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112014108","display_name":"M. Anthony Verity","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.A. Verity","raw_affiliation_strings":["From the Departments of Neurology (S. KimS.M. Liva, M.A. Dalal, and Dr. Voskuhl) and Pathology and Laboratory Medicine/Neuropathology (Dr. Verity), University of California Los Angeles School of Medicine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (S. KimS.M. Liva, M.A. Dalal, and Dr. Voskuhl) and Pathology and Laboratory Medicine/Neuropathology (Dr. Verity), University of California Los Angeles School of Medicine, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028071943","display_name":"Rhonda R. Voskuhl","orcid":"https://orcid.org/0000-0003-2620-4346","observed_orcids":["https://orcid.org/0000-0003-2620-4346"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.R. Voskuhl","raw_affiliation_strings":["From the Departments of Neurology (S. KimS.M. Liva, M.A. Dalal, and Dr. Voskuhl) and Pathology and Laboratory Medicine/Neuropathology (Dr. Verity), University of California Los Angeles School of Medicine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (S. KimS.M. Liva, M.A. Dalal, and Dr. Voskuhl) and Pathology and Laboratory Medicine/Neuropathology (Dr. Verity), University of California Los Angeles School of Medicine, CA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":8.3405,"has_fulltext":false,"cited_by_count":268,"citation_normalized_percentile":{"value":0.98196195,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"52","issue":"6","first_page":"1230","last_page":"1230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estriol","display_name":"estriol","score":0.996999979019165},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.968999981880188},{"id":"https://openalex.org/keywords/autoimmune-demyelinating-disease","display_name":"autoimmune demyelinating disease","score":0.925000011920929},{"id":"https://openalex.org/keywords/th1-mediated-autoimmunity","display_name":"Th1-mediated autoimmunity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.7049999833106995},{"id":"https://openalex.org/keywords/myelin-basic-protein","display_name":"myelin basic protein","score":0.8180000185966492},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8730000257492065},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.8090000152587891},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.6919999718666077},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2777335581","wikidata":"https://www.wikidata.org/wiki/Q409721","display_name":"Estriol","level":3,"score":0.776758074760437},{"id":"https://openalex.org/C2778531937","wikidata":"https://www.wikidata.org/wiki/Q1186703","display_name":"Demyelinating disease","level":3,"score":0.7508159875869751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6431093215942383},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.5915610194206238},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4724369943141937},{"id":"https://openalex.org/C2908708501","wikidata":"https://www.wikidata.org/wiki/Q1186703","display_name":"Demyelinating Disorder","level":3,"score":0.4578785300254822},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.36855727434158325},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35289227962493896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24602016806602478},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.06947299838066101}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004964","descriptor_name":"Estriol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004964","descriptor_name":"Estriol","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004964","descriptor_name":"Estriol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.52.6.1230","doi":"https://doi.org/10.1212/wnl.52.6.1230","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.52.6.1230","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:10214749","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10214749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1902828296","display_name":"IMMUNE MECHANISMS UNDERLYING GENDER DIFFERENCES IN EAE","funder_award_id":"R01NS036680","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3158171751","display_name":null,"funder_award_id":"NS36680-01","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332502","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1504285588","https://openalex.org/W1519441922","https://openalex.org/W1527289118","https://openalex.org/W1527404918","https://openalex.org/W1532866158","https://openalex.org/W1544586439","https://openalex.org/W1582870359","https://openalex.org/W1605865008","https://openalex.org/W1897632974","https://openalex.org/W1974821266","https://openalex.org/W1976983817","https://openalex.org/W1981533854","https://openalex.org/W1983895762","https://openalex.org/W1994953189","https://openalex.org/W2007840608","https://openalex.org/W2008269957","https://openalex.org/W2011768190","https://openalex.org/W2017841541","https://openalex.org/W2020725121","https://openalex.org/W2021942428","https://openalex.org/W2033459445","https://openalex.org/W2036072927","https://openalex.org/W2042213948","https://openalex.org/W2048327985","https://openalex.org/W2053516651","https://openalex.org/W2057696929","https://openalex.org/W2062794300","https://openalex.org/W2072325998","https://openalex.org/W2073883348","https://openalex.org/W2074788705","https://openalex.org/W2078399501","https://openalex.org/W2092625116","https://openalex.org/W2105808377","https://openalex.org/W2106274323","https://openalex.org/W2120389604","https://openalex.org/W2136806464","https://openalex.org/W2137758122","https://openalex.org/W2156422253","https://openalex.org/W2161154771","https://openalex.org/W2319459971","https://openalex.org/W2418634795","https://openalex.org/W4212936275","https://openalex.org/W4313343449"],"related_works":["https://openalex.org/W2157275878","https://openalex.org/W2038361314","https://openalex.org/W2106115061","https://openalex.org/W2514167322","https://openalex.org/W2087558651","https://openalex.org/W2062283207","https://openalex.org/W2106519567","https://openalex.org/W2074788705","https://openalex.org/W1984306421","https://openalex.org/W2393514726"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,8,40,72,97,142,149,170,182,207],"use":[4,210],"of":[5,10,42,75,99,128,138,141,169,185,211],"estriol":[6,117,121,212],"in":[7,45,69,197],"treatment":[9,83,95,105,108],"experimental":[11],"autoimmune":[12,19,23,31,219],"encephalomyelitis":[13,24],"(EAE)":[14],"and":[15,50,64,85,88,215],"other":[16,216],"cell":[17],"mediated":[18],"diseases.":[20],"BACKGROUND:":[21],"Experimental":[22],"is":[25,35],"a":[26,36,194,204],"T":[27,176],"helper":[28],"1":[29],"(Th1)-mediated":[30],"demyelinating":[32],"disease":[33],"that":[34,114,119,221],"useful":[37],"model":[38],"for":[39,148,206,213],"study":[41],"immune":[43,198],"responses":[44,90,158],"MS.":[46],"Interestingly,":[47],"both":[48],"EAE":[49,100,132,161],"MS":[51,214],"have":[52],"been":[53],"shown":[54,179],"to":[55,180],"be":[56,181],"ameliorated":[57],"during":[58,71,123,200,223],"late":[59,124,224],"pregnancy.":[60,225],"METHODS:":[61],"Estriol,":[62],"progesterone,":[63],"placebo":[65,104],"pellets":[66],"were":[67,80,91,126,163,178],"implanted":[68],"mice":[70,133,162],"effector":[73],"phase":[74],"adoptive":[76],"EAE.":[77],"Disease":[78],"scores":[79],"compared":[81,102],"between":[82],"groups,":[84],"autoantigen-specific":[86],"humoral":[87],"cellular":[89],"examined.":[92],"RESULTS:":[93],"Estriol":[94,112,192],"reduced":[96],"severity":[98],"significantly":[101,135,166],"with":[103],"whereas":[106],"progesterone":[107],"had":[109,134],"no":[110],"effect.":[111],"doses":[113],"induced":[115],"serum":[116,139],"levels":[118,122,137],"approximated":[120],"pregnancy":[125,201],"capable":[127],"ameliorating":[129],"disease.":[130],"Estriol-treated":[131],"higher":[136],"antibodies":[140],"immunoglobulin":[143],"(Ig)":[144],"G1":[145],"isotype":[146],"specific":[147],"autoantigen":[150],"myelin":[151],"basic":[152],"protein":[153],"(MBP).":[154],"Further,":[155],"MBP-specific":[156],"T-lymphocyte":[157],"from":[159],"estriol-treated":[160],"characterized":[164],"by":[165],"increased":[167],"production":[168],"Th2":[171],"cytokine":[172],"interleukin":[173],"10":[174],"(IL-10).":[175],"lymphocytes":[177],"primary":[183],"source":[184],"IL-10":[186],"within":[187],"antigen-stimulated":[188],"splenocyte":[189],"populations.":[190],"CONCLUSIONS:":[191],"as":[193],"hormone":[195],"involved":[196],"changes":[199],"may":[202],"provide":[203],"basis":[205],"novel":[208],"therapeutic":[209],"putative":[217],"Th1-mediated":[218],"diseases":[220],"improve":[222]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
