{"id":"https://openalex.org/W2071749331","doi":"https://doi.org/10.1016/s0165-2427(00)00213-0","title":"Detection of cytokines in bovine colostrum","display_name":"Detection of cytokines in bovine colostrum","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W2071749331","doi":"https://doi.org/10.1016/s0165-2427(00)00213-0","mag":"2071749331","pmid":"https://pubmed.ncbi.nlm.nih.gov/11044552"},"language":"en","primary_location":{"id":"doi:10.1016/s0165-2427(00)00213-0","doi":"https://doi.org/10.1016/s0165-2427(00)00213-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-2427(00)00213-0","pdf_url":null,"source":{"id":"https://openalex.org/S194416120","display_name":"Veterinary Immunology and Immunopathology","issn_l":"0165-2427","issn":["0165-2427","1873-2534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Immunology and Immunopathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107391658","display_name":"Katsuro Hagiwara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79669737","display_name":"Rakuno Gakuen University","ror":"https://ror.org/014rqt829","country_code":"JP","type":"education","lineage":["https://openalex.org/I79669737"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Katsuro Hagiwara","raw_affiliation_strings":["Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan. k-hagi@rakuno.ac.jp","Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan. k-hagi@rakuno.ac.jp","institution_ids":["https://openalex.org/I79669737"]},{"raw_affiliation_string":"Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan","institution_ids":["https://openalex.org/I79669737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113910486","display_name":"Satoshi Kataoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79669737","display_name":"Rakuno Gakuen University","ror":"https://ror.org/014rqt829","country_code":"JP","type":"education","lineage":["https://openalex.org/I79669737"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Kataoka","raw_affiliation_strings":["Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan","institution_ids":["https://openalex.org/I79669737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049203265","display_name":"Hitoki Yamanaka","orcid":"https://orcid.org/0000-0002-3134-3036","observed_orcids":["https://orcid.org/0000-0002-3134-3036"]},"institutions":[{"id":"https://openalex.org/I79669737","display_name":"Rakuno Gakuen University","ror":"https://ror.org/014rqt829","country_code":"JP","type":"education","lineage":["https://openalex.org/I79669737"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoki Yamanaka","raw_affiliation_strings":["Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan","institution_ids":["https://openalex.org/I79669737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081156080","display_name":"Rikio KIRISAWA","orcid":"https://orcid.org/0000-0002-6360-9169","observed_orcids":["https://orcid.org/0000-0002-6360-9169"]},"institutions":[{"id":"https://openalex.org/I79669737","display_name":"Rakuno Gakuen University","ror":"https://ror.org/014rqt829","country_code":"JP","type":"education","lineage":["https://openalex.org/I79669737"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rikio Kirisawa","raw_affiliation_strings":["Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan","institution_ids":["https://openalex.org/I79669737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073928383","display_name":"Hiroshi Iwai","orcid":"https://orcid.org/0000-0003-2646-8173","observed_orcids":["https://orcid.org/0000-0003-2646-8173"]},"institutions":[{"id":"https://openalex.org/I79669737","display_name":"Rakuno Gakuen University","ror":"https://ror.org/014rqt829","country_code":"JP","type":"education","lineage":["https://openalex.org/I79669737"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Iwai","raw_affiliation_strings":["Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan","institution_ids":["https://openalex.org/I79669737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5107391658"],"corresponding_institution_ids":["https://openalex.org/I79669737"],"apc_list":{"value":3250,"currency":"USD","value_usd":3250},"apc_paid":null,"fwci":11.9797,"has_fulltext":false,"cited_by_count":186,"citation_normalized_percentile":{"value":0.98681099,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"76","issue":"3-4","first_page":"183","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13540","display_name":"Animal Diversity and Health Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-colostrum","display_name":"bovine colostrum","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9890000224113464},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/neonatal-immunity","display_name":"neonatal immunity","score":0.968999981880188},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7070000171661377},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8560000061988831},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9850000143051147},{"id":"https://openalex.org/keywords/whey","display_name":"whey","score":0.703000009059906},{"id":"https://openalex.org/keywords/stage-of-lactation","display_name":"lactation stage","score":0.75},{"id":"https://openalex.org/keywords/mammary-gland","display_name":"mammary gland","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cytokine-mrna-expression","display_name":"cytokine mRNA expression","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C2779073587","wikidata":"https://www.wikidata.org/wiki/Q192746","display_name":"Colostrum","level":3,"score":0.9830664396286011},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.7326764464378357},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6582654118537903},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6456601023674011},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.616899311542511},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.5103978514671326},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5066064596176147},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.47018563747406006},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4368413984775543},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40930771827697754},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35998132824897766},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.27206799387931824},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.18437036871910095},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0983228087425232},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003126","descriptor_name":"Colostrum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003126","descriptor_name":"Colostrum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004587","descriptor_name":"Electrophoresis, Agar Gel","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0165-2427(00)00213-0","doi":"https://doi.org/10.1016/s0165-2427(00)00213-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-2427(00)00213-0","pdf_url":null,"source":{"id":"https://openalex.org/S194416120","display_name":"Veterinary Immunology and Immunopathology","issn_l":"0165-2427","issn":["0165-2427","1873-2534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Immunology and Immunopathology","raw_type":"journal-article"},{"id":"pmid:11044552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11044552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary immunology and immunopathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.4359000027179718}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323505","display_name":"Universidad de La Frontera","ror":"https://ror.org/04v0snf24"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W20187760","https://openalex.org/W116386214","https://openalex.org/W176653346","https://openalex.org/W195705858","https://openalex.org/W1515994079","https://openalex.org/W1942668068","https://openalex.org/W1964904914","https://openalex.org/W1966789703","https://openalex.org/W1978206130","https://openalex.org/W1985811262","https://openalex.org/W1987974017","https://openalex.org/W1989658278","https://openalex.org/W2024493483","https://openalex.org/W2027337852","https://openalex.org/W2034080425","https://openalex.org/W2037896833","https://openalex.org/W2051404714","https://openalex.org/W2054050862","https://openalex.org/W2057942926","https://openalex.org/W2058631376","https://openalex.org/W2071336984","https://openalex.org/W2077666059","https://openalex.org/W2093135340","https://openalex.org/W2094125542","https://openalex.org/W2104417744","https://openalex.org/W2206659032","https://openalex.org/W2314807329","https://openalex.org/W2409021378","https://openalex.org/W2521109995","https://openalex.org/W4285719527","https://openalex.org/W6604718755","https://openalex.org/W6607218889","https://openalex.org/W6726795175"],"related_works":["https://openalex.org/W2137535997","https://openalex.org/W2021466153","https://openalex.org/W2376515156","https://openalex.org/W2063470546","https://openalex.org/W2034413752","https://openalex.org/W7120344669","https://openalex.org/W2065621676","https://openalex.org/W89741150","https://openalex.org/W2057969641","https://openalex.org/W1974355354"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
