{"id":"https://openalex.org/W2071732862","doi":"https://doi.org/10.1210/en.141.11.4247","title":"Trophinin Expression in the Mouse Uterus Coincides with Implantation and Is Hormonally Regulated But Not Induced by Implanting Blastocysts","display_name":"Trophinin Expression in the Mouse Uterus Coincides with Implantation and Is Hormonally Regulated But Not Induced by Implanting Blastocysts","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W2071732862","doi":"https://doi.org/10.1210/en.141.11.4247","mag":"2071732862","pmid":"https://pubmed.ncbi.nlm.nih.gov/11089559"},"language":"en","primary_location":{"id":"doi:10.1210/en.141.11.4247","doi":"https://doi.org/10.1210/en.141.11.4247","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.141.11.4247","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036460159","display_name":"Nao Suzuki","orcid":"https://orcid.org/0000-0002-7440-8127","observed_orcids":["https://orcid.org/0000-0002-7440-8127"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nao Suzuki","raw_affiliation_strings":["The Burnham Institute (N.S., D.N., S.K., K.S., M.N.F.), La Jolla, California 92037;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Burnham Institute (N.S., D.N., S.K., K.S., M.N.F.), La Jolla, California 92037;","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069280614","display_name":"Daita Nadano","orcid":"https://orcid.org/0000-0003-4473-4236","observed_orcids":["https://orcid.org/0000-0003-4473-4236"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daita Nadano","raw_affiliation_strings":["The Burnham Institute (N.S., D.N., S.K., K.S., M.N.F.), La Jolla, California 92037;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Burnham Institute (N.S., D.N., S.K., K.S., M.N.F.), La Jolla, California 92037;","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071299965","display_name":"Bibhash C. Paria","orcid":"https://orcid.org/0000-0002-1183-8648","observed_orcids":["https://orcid.org/0000-0002-1183-8648"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bibhash C. Paria","raw_affiliation_strings":["Departments of Pediatrics and Molecular and Integrative Physiology (B.C.P.), University of Kansas Medical Center, Kansas City, Kansas 66160"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Molecular and Integrative Physiology (B.C.P.), University of Kansas Medical Center, Kansas City, Kansas 66160","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sergey Kupriyanov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergey Kupriyanov","raw_affiliation_strings":["The Burnham Institute (N.S., D.N., S.K., K.S., M.N.F.), La Jolla, California 92037;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Burnham Institute (N.S., D.N., S.K., K.S., M.N.F.), La Jolla, California 92037;","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100819307","display_name":"Kazuhiro Sugihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuhiro Sugihara","raw_affiliation_strings":["The Burnham Institute (N.S., D.N., S.K., K.S., M.N.F.), La Jolla, California 92037;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Burnham Institute (N.S., D.N., S.K., K.S., M.N.F.), La Jolla, California 92037;","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006762365","display_name":"Michiko N. Fukuda","orcid":"https://orcid.org/0000-0003-4120-0490","observed_orcids":["https://orcid.org/0000-0003-4120-0490"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michiko N. Fukuda","raw_affiliation_strings":["The Burnham Institute (N.S., D.N., S.K., K.S., M.N.F.), La Jolla, California 92037;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Burnham Institute (N.S., D.N., S.K., K.S., M.N.F.), La Jolla, California 92037;","institution_ids":["https://openalex.org/I188891513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006762365"],"corresponding_institution_ids":["https://openalex.org/I188891513"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.3572,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.79551395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"141","issue":"11","first_page":"4247","last_page":"4254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uterine-gene-expression","display_name":"uterine gene expression","score":0.6970000267028809},{"id":"https://openalex.org/keywords/embryo-implantation","display_name":"embryo implantation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/estrogen-regulation","display_name":"estrogen regulation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pseudopregnancy","display_name":"pseudopregnancy","score":0.8069999814033508},{"id":"https://openalex.org/keywords/delayed-implant-placement","display_name":"delayed implantation","score":0.925000011920929},{"id":"https://openalex.org/keywords/endometrial-luminal-epithelium","display_name":"endometrial luminal epithelium","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ovarian-hormones","display_name":"ovarian hormones","score":0.5730000138282776},{"id":"https://openalex.org/keywords/mouse-uterus","display_name":"mouse uterus","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.7500334978103638},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6556887626647949},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6376867294311523},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.46236684918403625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3724033236503601},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3321470618247986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3030441403388977}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010064","descriptor_name":"Embryo Implantation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/en.141.11.4247","doi":"https://doi.org/10.1210/en.141.11.4247","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.141.11.4247","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/endo.141.11.7738","doi":"https://doi.org/10.1210/endo.141.11.7738","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.141.11.7738","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:11089559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11089559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1290887568","display_name":"EXPRESSION AND IN VIVO ROLE OF TROPHININ IN MICE","funder_award_id":"R01HD034108","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2062700741","display_name":"HISTAMINE LIGAND RECEPTOR SIGNALING IN IMPLANTATION","funder_award_id":"R01HD037394","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W2936964","https://openalex.org/W29570827","https://openalex.org/W57892688","https://openalex.org/W106141755","https://openalex.org/W149777472","https://openalex.org/W182589694","https://openalex.org/W1484163259","https://openalex.org/W1573450491","https://openalex.org/W1965181820","https://openalex.org/W1967933840","https://openalex.org/W1975116894","https://openalex.org/W1976079453","https://openalex.org/W1986021241","https://openalex.org/W1991241006","https://openalex.org/W1994238315","https://openalex.org/W1998077865","https://openalex.org/W2007746864","https://openalex.org/W2007813753","https://openalex.org/W2022820785","https://openalex.org/W2023306710","https://openalex.org/W2025258456","https://openalex.org/W2026511788","https://openalex.org/W2046613812","https://openalex.org/W2047672708","https://openalex.org/W2052164094","https://openalex.org/W2060693884","https://openalex.org/W2067514944","https://openalex.org/W2075784188","https://openalex.org/W2080364963","https://openalex.org/W2080391647","https://openalex.org/W2086747507","https://openalex.org/W2100837269","https://openalex.org/W2111642864","https://openalex.org/W2116419603","https://openalex.org/W2127150853","https://openalex.org/W2149539740","https://openalex.org/W2150811210","https://openalex.org/W2162628009","https://openalex.org/W2188130411","https://openalex.org/W2320368148","https://openalex.org/W4241815492","https://openalex.org/W6604724124"],"related_works":["https://openalex.org/W4242115080","https://openalex.org/W2585303568","https://openalex.org/W2362103874","https://openalex.org/W2352503769","https://openalex.org/W1541170357","https://openalex.org/W2105318015","https://openalex.org/W2091665241","https://openalex.org/W2002059029","https://openalex.org/W2007095142","https://openalex.org/W2025258456"],"abstract_inverted_index":{"Trophinin":[0,62,93],"mediates":[1],"apical":[2],"cell":[3,8],"adhesion":[4],"between":[5],"two":[6],"human":[7],"lines,":[9],"trophoblastic":[10],"teratocarcinoma":[11],"and":[12,26,95,118,133,174],"endometrial":[13,188],"adenocarcinoma.":[14],"In":[15,42,122],"humans,":[16],"trophinin":[17,36,47,109,126,168,183],"is":[18,63],"specifically":[19],"expressed":[20,50,65],"in":[21,24,66,99,108,114,130,154,158,185],"cells":[22],"involved":[23],"implantation":[25,124],"early":[27],"placentation.":[28],"The":[29],"present":[30],"study":[31],"was":[32,85],"undertaken":[33],"to":[34],"establish":[35],"expression":[37,84,110,169,184],"by":[38,87,91,111,170],"the":[39,43,52,57,67,100,112,115,155,159,171,186],"mouse":[40,45,69,102,172],"uterus.":[41,103,160],"pregnant":[44],"uterus,":[46,173],"transcripts":[48,94],"are":[49],"during":[51],"time":[53],"which":[54],"coincides":[55],"with":[56,145],"timing":[58],"of":[59],"blastocyst":[60,156,178],"implantation.":[61],"also":[64],"nonpregnant":[68],"uterus":[70],"at":[71],"estrus":[72],"stage.":[73],"Uteri":[74],"from":[75],"ovariectomized":[76],"mice":[77],"did":[78],"not":[79,90],"express":[80],"trophinin,":[81],"whereas":[82,136],"strong":[83],"induced":[86],"estrogen":[88],"but":[89],"progesterone.":[92],"protein":[96],"were":[97,106,128,139,151],"found":[98,129],"pseudopregnant":[101,119],"No":[104],"differences":[105],"detected":[107,152],"uteri":[113],"pregnant,":[116],"pseudopregnant,":[117],"received":[120],"blastocysts.":[121],"delayed":[123],"model,":[125],"proteins":[127],"both":[131],"luminal":[132,189],"glandular":[134],"epithelium,":[135],"dormant":[137],"blastocysts":[138],"negative":[140],"for":[141],"trophinin.":[142],"Upon":[143],"activation":[144],"estrogen,":[146],"however,":[147],"no":[148,180],"significant":[149],"changes":[150],"either":[153],"or":[157],"These":[161],"results":[162],"indicate":[163],"that":[164,175],"ovarian":[165],"hormones":[166],"regulate":[167],"an":[176],"implanting":[177],"has":[179],"effect":[181],"on":[182],"surrounding":[187],"epithelial":[190],"cells.":[191]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}