{"id":"https://openalex.org/W2071673579","doi":"https://doi.org/10.1074/jbc.272.16.10608","title":"The Ras-related Protein Rheb Is Farnesylated and Antagonizes Ras Signaling and Transformation","display_name":"The Ras-related Protein Rheb Is Farnesylated and Antagonizes Ras Signaling and Transformation","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2071673579","doi":"https://doi.org/10.1074/jbc.272.16.10608","mag":"2071673579","pmid":"https://pubmed.ncbi.nlm.nih.gov/9099708"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.272.16.10608","doi":"https://doi.org/10.1074/jbc.272.16.10608","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.16.10608","pdf_url":"http://www.jbc.org/article/S0021925818407326/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925818407326/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Geoffrey J. Clark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Geoffrey J. Clark","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, USA","Department of Pharmacology University of North Carolina Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology University of North Carolina Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011112601","display_name":"Michael S. Kinch","orcid":"https://orcid.org/0000-0003-3939-3756","observed_orcids":["https://orcid.org/0000-0003-3939-3756"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Kinch","raw_affiliation_strings":["Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907-1246"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907-1246","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042601212","display_name":"Kelley Rogers-Graham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelley Rogers-Graham","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103060677","display_name":"Sa\u0131\u0308d M. Sebti","orcid":"https://orcid.org/0000-0001-5163-1038","observed_orcids":["https://orcid.org/0000-0001-5163-1038"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Said M. Sebti","raw_affiliation_strings":["Moffitt Cancer Research Center, University of South Florida, Tampa, Florida 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Research Center, University of South Florida, Tampa, Florida 33612","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044268981","display_name":"Andrew D. Hamilton","orcid":"https://orcid.org/0000-0002-0538-175X","observed_orcids":["https://orcid.org/0000-0002-0538-175X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Hamilton","raw_affiliation_strings":["Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064063895","display_name":"Channing J. Der","orcid":"https://orcid.org/0000-0002-7751-2747","observed_orcids":["https://orcid.org/0000-0002-7751-2747"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Channing J. Der","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.8445,"has_fulltext":true,"cited_by_count":177,"citation_normalized_percentile":{"value":0.91672982,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"272","issue":"16","first_page":"10608","last_page":"10615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheb","display_name":"Rheb","score":0.9900000095367432},{"id":"https://openalex.org/keywords/protein-farnesyltransferase","display_name":"farnesyltransferase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/protein-farnesylation","display_name":"farnesylation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.7379999756813049},{"id":"https://openalex.org/keywords/farnesyltransferase-inhibitors","display_name":"farnesyltransferase inhibitors","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C2778937405","wikidata":"https://www.wikidata.org/wiki/Q18031127","display_name":"RHEB","level":5,"score":0.9750852584838867},{"id":"https://openalex.org/C2777827897","wikidata":"https://www.wikidata.org/wiki/Q5436005","display_name":"Farnesyltransferase inhibitor","level":5,"score":0.898331344127655},{"id":"https://openalex.org/C2778396349","wikidata":"https://www.wikidata.org/wiki/Q410994","display_name":"Farnesyltransferase","level":4,"score":0.857043981552124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5469967126846313},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4985034465789795},{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.4572664201259613},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.4390909969806671},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.416865736246109},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.40183109045028687},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3558560013771057},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23611611127853394},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.16794395446777344},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10720738768577576},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000076205","descriptor_name":"Ras Homolog Enriched in Brain Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017368","descriptor_name":"Protein Prenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020559","descriptor_name":"Monomeric GTP-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.272.16.10608","doi":"https://doi.org/10.1074/jbc.272.16.10608","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.16.10608","pdf_url":"http://www.jbc.org/article/S0021925818407326/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9099708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9099708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.272.16.10608","doi":"https://doi.org/10.1074/jbc.272.16.10608","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.16.10608","pdf_url":"http://www.jbc.org/article/S0021925818407326/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G189168454","display_name":"FUNCTION OF RAS ONCOGENE PROTEIN RELATED RAB PROTEINS","funder_award_id":"7r01ca055008-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1992624342","display_name":null,"funder_award_id":"CA42978","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2689287157","display_name":"Rho Family Proteins and Malignant Transformation","funder_award_id":"R01CA063071","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2862013380","display_name":null,"funder_award_id":"CA 55008","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2986049845","display_name":"Biological Activity of Ras Oncogenes","funder_award_id":"5r01ca042978-30","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G860286890","display_name":null,"funder_award_id":"CA63071","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000341580","display_name":null,"funder_award_id":"CA42978","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071673579.pdf","grobid_xml":"https://content.openalex.org/works/W2071673579.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W92308392","https://openalex.org/W93564758","https://openalex.org/W164957562","https://openalex.org/W166287817","https://openalex.org/W1515372146","https://openalex.org/W1517546728","https://openalex.org/W1518252063","https://openalex.org/W1542009924","https://openalex.org/W1547066932","https://openalex.org/W1585517331","https://openalex.org/W1836607268","https://openalex.org/W1873642659","https://openalex.org/W1887673489","https://openalex.org/W1946879166","https://openalex.org/W1948317796","https://openalex.org/W1970606222","https://openalex.org/W1971241138","https://openalex.org/W1977598234","https://openalex.org/W1979016878","https://openalex.org/W1979027806","https://openalex.org/W1982297304","https://openalex.org/W1983501834","https://openalex.org/W1984751884","https://openalex.org/W1988156929","https://openalex.org/W1989480480","https://openalex.org/W1989839956","https://openalex.org/W1992405604","https://openalex.org/W1994811935","https://openalex.org/W2005189737","https://openalex.org/W2008256490","https://openalex.org/W2012189464","https://openalex.org/W2012806962","https://openalex.org/W2018724145","https://openalex.org/W2029872541","https://openalex.org/W2043335974","https://openalex.org/W2047743989","https://openalex.org/W2055611855","https://openalex.org/W2057513340","https://openalex.org/W2058795586","https://openalex.org/W2061234826","https://openalex.org/W2064129448","https://openalex.org/W2067900518","https://openalex.org/W2068032848","https://openalex.org/W2074339256","https://openalex.org/W2083260280","https://openalex.org/W2083506343","https://openalex.org/W2091349388","https://openalex.org/W2091757239","https://openalex.org/W2091800872","https://openalex.org/W2093226717","https://openalex.org/W2099478687","https://openalex.org/W2106546975","https://openalex.org/W2115638428","https://openalex.org/W2133283920","https://openalex.org/W2145065899","https://openalex.org/W2146055738","https://openalex.org/W2156398385","https://openalex.org/W2158608327","https://openalex.org/W2160680191","https://openalex.org/W2176636090","https://openalex.org/W2254098459","https://openalex.org/W2333641896","https://openalex.org/W2396380924","https://openalex.org/W2414650200","https://openalex.org/W2416140720","https://openalex.org/W2464202324","https://openalex.org/W2470643593"],"related_works":["https://openalex.org/W2056739666","https://openalex.org/W1848923750","https://openalex.org/W1193444410","https://openalex.org/W2013287800","https://openalex.org/W4313042430","https://openalex.org/W2055429090","https://openalex.org/W2407608806","https://openalex.org/W2131551219","https://openalex.org/W2032206809","https://openalex.org/W1976321476"],"abstract_inverted_index":{"Presently,":[0],"nothing":[1],"is":[2,53,132,179],"known":[3],"about":[4],"the":[5,8,19,65,119,196],"function":[6,77,131,183],"of":[7,23,80,97,110,124,136,149,198],"Ras-related":[9,100],"protein":[10],"Rheb.":[11],"Since":[12],"Rheb":[13,46,76,88,115,130,150,167,182],"shares":[14],"significant":[15],"sequence":[16],"identity":[17],"with":[18,32,48,78],"core":[20],"effector":[21],"domains":[22],"Ras":[24,70,81,98,137,153,203],"and":[25,72,82,99,102,106,138,155,159,171],"KRev-1/Rap1A,":[26],"it":[27,59,178],"may":[28,60,184,193],"share":[29],"functional":[30],"similarities":[31],"these":[33,199],"two":[34],"structurally":[35],"related,":[36],"yet":[37],"functionally":[38],"distinct,":[39],"small":[40],"GTPases.":[41],"Furthermore,":[42],"since":[43],"like":[44,165],"Ras,":[45,166],"terminates":[47],"a":[49,62],"COOH":[50],"terminus":[51],"that":[52,68,89,135,164,181],"likely":[54],"to":[55,140,146,174,195,201],"signal":[56],"for":[57,64],"farnesylation,":[58],"be":[61,185],"target":[63],"farnesyltransferase":[66,175,188],"inhibitors":[67,189,200],"block":[69],"processing":[71],"function.":[73],"To":[74],"compare":[75],"those":[79],"KRev-1,":[83,147],"we":[84],"introduced":[85],"mutations":[86],"into":[87],"generate":[90],"constitutively":[91],"active":[92],"or":[93,113,121],"dominant":[94],"negative":[95],"forms":[96],"proteins":[101,168],"were":[103],"designated":[104],"Rheb(64L)":[105],"Rheb(20N),":[107],"respectively.":[108],"Expression":[109],"wild":[111],"type":[112],"mutant":[114],"did":[116],"not":[117],"alter":[118],"morphology":[120],"growth":[122],"properties":[123],"NIH":[125],"3T3":[126],"cells.":[127],"Thus,":[128,177],"aberrant":[129],"distinct":[133],"from":[134],"fails":[139],"cause":[141],"cellular":[142],"transformation.":[143,204],"Instead,":[144],"similar":[145],"co-expression":[148],"antagonized":[151],"oncogenic":[152],"transformation":[154],"signaling.":[156],"In":[157],"vitro":[158],"in":[160],"vivo":[161],"analyses":[162],"showed":[163],"are":[169,172],"farnesylated":[170],"sensitive":[173],"inhibition.":[176],"possible":[180],"inhibited":[186],"by":[187],"treatment":[190],"and,":[191],"consequently,":[192],"contribute":[194],"ability":[197],"impair":[202]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}