{"id":"https://openalex.org/W2071663692","doi":"https://doi.org/10.1016/s0197-4580(00)83255-8","title":"Role of intracellular cholesterol compartmentation in APP processing and A\u03b2generation","display_name":"Role of intracellular cholesterol compartmentation in APP processing and A\u03b2generation","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2071663692","doi":"https://doi.org/10.1016/s0197-4580(00)83255-8","mag":"2071663692"},"language":"en","primary_location":{"id":"doi:10.1016/s0197-4580(00)83255-8","doi":"https://doi.org/10.1016/s0197-4580(00)83255-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0197-4580(00)83255-8","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078374361","display_name":"Luigi Puglielli","orcid":"https://orcid.org/0000-0003-0259-8424","observed_orcids":["https://orcid.org/0000-0003-0259-8424"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luigi Puglielli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043316539","display_name":"Genevi\u00e8ve Konopka","orcid":"https://orcid.org/0000-0002-3363-7302","observed_orcids":["https://orcid.org/0000-0002-3363-7302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Genevieve Konopka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026555467","display_name":"Laura A. Mackenzie Ingano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura A. Mackenzie Ingano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050004777","display_name":"Rudolph E. Tanzi","orcid":"https://orcid.org/0000-0002-7032-1454","observed_orcids":["https://orcid.org/0000-0002-7032-1454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rudolph E. Tanzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090395755","display_name":"Dora M. Kovacs","orcid":"https://orcid.org/0000-0003-1785-3248","observed_orcids":["https://orcid.org/0000-0003-1785-3248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dora M. Kovacs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18188792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":null,"first_page":"206","last_page":"206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracellular-cholesterol","display_name":"intracellular cholesterol","score":0.8529999852180481},{"id":"https://openalex.org/keywords/app-processing","display_name":"APP processing","score":0.9169999957084656},{"id":"https://openalex.org/keywords/amyloid-beta-production","display_name":"amyloid-beta production","score":0.871999979019165},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7200000286102295},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.620041012763977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35404127836227417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1785685122013092}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0197-4580(00)83255-8","doi":"https://doi.org/10.1016/s0197-4580(00)83255-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0197-4580(00)83255-8","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089563599","https://openalex.org/W2047757447","https://openalex.org/W2024670119","https://openalex.org/W2917923633","https://openalex.org/W2007037233","https://openalex.org/W1974070738","https://openalex.org/W2085380173","https://openalex.org/W4252723855","https://openalex.org/W2057621083","https://openalex.org/W2062600117"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
