{"id":"https://openalex.org/W2071594958","doi":"https://doi.org/10.1159/000028274","title":"N-Acetylheparin Pretreatment Reduces Infarct Size in the Rabbit","display_name":"N-Acetylheparin Pretreatment Reduces Infarct Size in the Rabbit","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2071594958","doi":"https://doi.org/10.1159/000028274","mag":"2071594958","pmid":"https://pubmed.ncbi.nlm.nih.gov/9925968"},"language":"en","primary_location":{"id":"doi:10.1159/000028274","doi":"https://doi.org/10.1159/000028274","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000028274","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103581193","display_name":"James L. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James L. Park","raw_affiliation_strings":["Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Mich., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Mich., USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111562887","display_name":"Kenneth S. Kilgore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth S. Kilgore","raw_affiliation_strings":["(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042521771","display_name":"Keith B. Naylor","orcid":"https://orcid.org/0000-0001-9871-8317","observed_orcids":["https://orcid.org/0000-0001-9871-8317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith B. Naylor","raw_affiliation_strings":["Institute for Healthcare Policy and Innovation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Healthcare Policy and Innovation","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111875752","display_name":"Erin A. Booth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin A. Booth","raw_affiliation_strings":["(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012360986","display_name":"Kerri Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kerri L. Murphy","raw_affiliation_strings":["(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111482904","display_name":"Benedict Robert Lucchesi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benedict R. Lucchesi","raw_affiliation_strings":["Samuel and Jean Frankel Cardiovascular Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel and Jean Frankel Cardiovascular Center","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0334,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.85564756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"58","issue":"3","first_page":"120","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.8679999709129333},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8930000066757202},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/membrane-attack-complex","display_name":"membrane attack complex","score":0.9610000252723694},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.9869999885559082},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8960000276565552},{"id":"https://openalex.org/keywords/coronary-artery-occlusion","display_name":"coronary artery occlusion","score":0.7279999852180481},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C2779884254","wikidata":"https://www.wikidata.org/wiki/Q492162","display_name":"Rabbit (cipher)","level":2,"score":0.5743353366851807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47106167674064636},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4327915608882904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4108560085296631},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.409902960062027},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3534463047981262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31350743770599365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3073350787162781},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20805948972702026},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.12896767258644104}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015938","descriptor_name":"Complement Membrane Attack Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018375","descriptor_name":"Neutrophil Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000028274","doi":"https://doi.org/10.1159/000028274","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000028274","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},{"id":"pmid:9925968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9925968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320309652","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320332682","display_name":"Medical School, University of Michigan","ror":"https://ror.org/00jmfr291"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W186000098","https://openalex.org/W1510017290","https://openalex.org/W1536005089","https://openalex.org/W1574660002","https://openalex.org/W1582917949","https://openalex.org/W1638095527","https://openalex.org/W1641784081","https://openalex.org/W1673972157","https://openalex.org/W1775749144","https://openalex.org/W1980982223","https://openalex.org/W1993363980","https://openalex.org/W2013911376","https://openalex.org/W2020358486","https://openalex.org/W2026653177","https://openalex.org/W2042096327","https://openalex.org/W2044615120","https://openalex.org/W2045224306","https://openalex.org/W2125461166","https://openalex.org/W2135192106","https://openalex.org/W2148075784","https://openalex.org/W2254604473","https://openalex.org/W2324675759","https://openalex.org/W2460635108","https://openalex.org/W4321746742"],"related_works":["https://openalex.org/W2135192106","https://openalex.org/W2460635108","https://openalex.org/W2362004986","https://openalex.org/W2045224306","https://openalex.org/W1972289553","https://openalex.org/W2024774247","https://openalex.org/W2103461735","https://openalex.org/W2261154282","https://openalex.org/W2127181528","https://openalex.org/W1986962475"],"abstract_inverted_index":{"The":[0],"ability":[1],"of":[2,32,47,55,113,142],"the":[3,10,33,74,116,164],"heparin":[4],"derivative,":[5],"N-acetylheparin":[6],"(NHEP)":[7],"to":[8,44,95,136,155],"protect":[9,163],"heart":[11],"from":[12,73,132,138,147],"regional":[13,48],"ischemia/reperfusion":[14],"injury":[15],"was":[16,26],"examined":[17],"in":[18,70,80,98,130,151],"vivo.":[19],"NHEP":[20,84,161],"(2":[21],"mg/kg":[22],"i.v.)":[23],"or":[24],"vehicle":[25,102],"administered":[27],"2":[28],"h":[29,54],"before":[30],"occlusion":[31],"left":[34],"circumflex":[35],"coronary":[36],"(LCX)":[37],"artery.":[38],"Open-chest,":[39],"anesthetized":[40],"rabbits":[41,81,99],"were":[42,68,149],"subjected":[43],"30":[45],"min":[46],"myocardial":[49],"ischemia":[50],"followed":[51],"by":[52,92,121,125,166],"5":[53],"reperfusion.":[56],"Myocardial":[57],"myeloperoxidase":[58,122],"activity,":[59,123],"membrane":[60],"attack":[61],"complex":[62],"(MAC)":[63],"deposition":[64],"and":[65,144,170],"IL-8":[66,145],"generation":[67],"assessed":[69,120],"supernatant":[71],"samples":[72],"area":[75],"at":[76],"risk.":[77],"Infarct":[78],"size":[79,97],"pretreated":[82],"with":[83],"(32.5":[85],"+/-":[86,104],"3.8%,":[87],"n":[88,106],"=":[89,107,110],"10)":[90],"decreased":[91],"41%":[93],"compared":[94,135,154],"infarct":[96],"that":[100,160],"received":[101],"(55.3":[103],"4.9%,":[105],"10;":[108],"p":[109],"0.002).":[111],"Accumulation":[112],"neutrophils":[114],"within":[115],"ischemic":[117],"region,":[118],"as":[119],"declined":[124],"45%":[126],"(p":[127],"<":[128],"0.05)":[129],"AAR":[131,137,148],"NHEP-treated":[133],"animals":[134,153],"vehicle-treated":[139],"animals.":[140],"Levels":[141],"MAC":[143],"obtained":[146],"less":[150],"NHEP-pretreated":[152],"controls.":[156],"These":[157],"results":[158],"suggest":[159],"may":[162],"myocardium":[165],"inhibiting":[167],"complement":[168],"activation":[169],"subsequent":[171],"neutrophil":[172],"infiltration.":[173]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}