{"id":"https://openalex.org/W2071574953","doi":"https://doi.org/10.1038/sj.leu.2404875","title":"Mouse models and the RANKL/OPG axis in myeloma bone disease","display_name":"Mouse models and the RANKL/OPG axis in myeloma bone disease","publication_year":2007,"publication_date":"2007-09-19","ids":{"openalex":"https://openalex.org/W2071574953","doi":"https://doi.org/10.1038/sj.leu.2404875","mag":"2071574953","pmid":"https://pubmed.ncbi.nlm.nih.gov/17878922"},"language":"en","primary_location":{"id":"doi:10.1038/sj.leu.2404875","doi":"https://doi.org/10.1038/sj.leu.2404875","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.leu.2404875","pdf_url":"https://www.nature.com/articles/2404875.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/2404875.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007747233","display_name":"David Dingli","orcid":"https://orcid.org/0000-0001-7477-3004","observed_orcids":["https://orcid.org/0000-0001-7477-3004"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Dingli","raw_affiliation_strings":["Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN, USA","Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051470930","display_name":"Stephen J. Russell","orcid":"https://orcid.org/0009-0007-8925-5163","observed_orcids":["https://orcid.org/0009-0007-8925-5163","https://orcid.org/0000-0002-0799-6432"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S J Russell","raw_affiliation_strings":["Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN, USA","Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"10","first_page":"2090","last_page":"2093"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/myeloma-bone-disease","display_name":"myeloma bone disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/rankl-opg-axis","display_name":"RANKL/OPG axis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bone-destruction","display_name":"bone destruction","score":0.6660000085830688},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7120000123977661},{"id":"https://openalex.org/keywords/orthotopic-model","display_name":"orthotopic model","score":0.734000027179718},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.9210000038146973},{"id":"https://openalex.org/keywords/bone-marrow-stroma","display_name":"bone marrow stroma","score":0.7549999952316284},{"id":"https://openalex.org/keywords/osteolytic-lesions","display_name":"osteolytic lesions","score":0.8050000071525574},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.4000000059604645},{"id":"https://openalex.org/keywords/hypercalcemia","display_name":"hypercalcemia","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.8434522151947021},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6701128482818604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.518743097782135},{"id":"https://openalex.org/C2776169692","wikidata":"https://www.wikidata.org/wiki/Q4941552","display_name":"Bone disease","level":3,"score":0.49869728088378906},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.457839697599411},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.42416226863861084},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41197603940963745},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4107978343963623},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.4104352593421936},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3839160203933716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3605789840221405},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32482242584228516},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.2554027736186981},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08650970458984375},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001847","descriptor_name":"Bone Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053245","descriptor_name":"RANK Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053245","descriptor_name":"RANK Ligand","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.leu.2404875","doi":"https://doi.org/10.1038/sj.leu.2404875","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.leu.2404875","pdf_url":"https://www.nature.com/articles/2404875.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"pmid:17878922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17878922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Comment"}],"best_oa_location":{"id":"doi:10.1038/sj.leu.2404875","doi":"https://doi.org/10.1038/sj.leu.2404875","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.leu.2404875","pdf_url":"https://www.nature.com/articles/2404875.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071574953.pdf","grobid_xml":"https://content.openalex.org/works/W2071574953.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W30364595","https://openalex.org/W51418634","https://openalex.org/W94332232","https://openalex.org/W174335789","https://openalex.org/W196876215","https://openalex.org/W1522278345","https://openalex.org/W1534645474","https://openalex.org/W1839671168","https://openalex.org/W1901720315","https://openalex.org/W1944909911","https://openalex.org/W1970183845","https://openalex.org/W1970407863","https://openalex.org/W1986310612","https://openalex.org/W1995616953","https://openalex.org/W1996805174","https://openalex.org/W1999077925","https://openalex.org/W2004209804","https://openalex.org/W2010707503","https://openalex.org/W2017529916","https://openalex.org/W2026798098","https://openalex.org/W2055123176","https://openalex.org/W2055966182","https://openalex.org/W2058142453","https://openalex.org/W2066000727","https://openalex.org/W2066639236","https://openalex.org/W2074174622","https://openalex.org/W2103101762","https://openalex.org/W2106751714","https://openalex.org/W2135392289","https://openalex.org/W2137050029","https://openalex.org/W2137676632","https://openalex.org/W2140353133","https://openalex.org/W2148489270","https://openalex.org/W2151788901","https://openalex.org/W2168307206","https://openalex.org/W2169802771","https://openalex.org/W2308068770","https://openalex.org/W2323955045","https://openalex.org/W2326577933","https://openalex.org/W2400360654","https://openalex.org/W2412146140"],"related_works":["https://openalex.org/W1996560056","https://openalex.org/W2169802771","https://openalex.org/W2140016154","https://openalex.org/W2408784386","https://openalex.org/W7098127039","https://openalex.org/W1520073092","https://openalex.org/W2061059033","https://openalex.org/W2620554681","https://openalex.org/W2133260436","https://openalex.org/W4239579164"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
