{"id":"https://openalex.org/W2071546597","doi":"https://doi.org/10.1021/bi971044w","title":"Purification, Characterization, and Synthesis of Three Novel Toxins from the Chinese ScorpionButhus martensi, Which Act on K+Channels","display_name":"Purification, Characterization, and Synthesis of Three Novel Toxins from the Chinese ScorpionButhus martensi, Which Act on K+Channels","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W2071546597","doi":"https://doi.org/10.1021/bi971044w","mag":"2071546597","pmid":"https://pubmed.ncbi.nlm.nih.gov/9354615"},"language":"en","primary_location":{"id":"doi:10.1021/bi971044w","doi":"https://doi.org/10.1021/bi971044w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi971044w","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084564120","display_name":"R\u00e9gine Lebrun","orcid":"https://orcid.org/0000-0002-1491-9013","observed_orcids":["https://orcid.org/0000-0002-1491-9013"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R\u00e9gine Romi-Lebrun","raw_affiliation_strings":["Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038325662","display_name":"Bruno Lebrun","orcid":"https://orcid.org/0000-0003-4403-7342","observed_orcids":["https://orcid.org/0000-0003-4403-7342"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Lebrun","raw_affiliation_strings":["Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110174994","display_name":"Marie\u2010France Martin\u2010Eauclaire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-France Martin-Eauclaire","raw_affiliation_strings":["Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074616307","display_name":"Masaji Ishiguro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Masaji Ishiguro","raw_affiliation_strings":["Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109167388","display_name":"Pierre Escoubas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Escoubas","raw_affiliation_strings":["Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103934613","display_name":"Fang  qi Wu","orcid":"https://orcid.org/0000-0003-2917-8315","observed_orcids":["https://orcid.org/0000-0003-2917-8315","https://orcid.org/0000-0002-6627-3437"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fang Qi Wu","raw_affiliation_strings":["Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068396524","display_name":"Miki Hisada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Miki Hisada","raw_affiliation_strings":["Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071615457","display_name":"Olaf Pongs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olaf Pongs","raw_affiliation_strings":["Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060140050","display_name":"Terumi Nakajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Terumi Nakajima","raw_affiliation_strings":["Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618, Japan, Centre National de la Recherche Scientifique, UMR 6560, Laboratoire de Biochimie, Facult\u00e9 de M\u00e9decine Nord, 13916 Marseille Cedex 20, France, Sichuan Province Institute for Antibiotics, Sanbanqiao 9, Chengdu, China, and Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1294671590"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":12.7521,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.99471143,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"36","issue":"44","first_page":"13473","last_page":"13482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.21699999272823334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scorpion-toxins","display_name":"scorpion toxins","score":0.8679999709129333},{"id":"https://openalex.org/keywords/potassium-channel-blockers","display_name":"potassium channel blockers","score":0.722000002861023},{"id":"https://openalex.org/keywords/kaliotoxin","display_name":"kaliotoxin","score":0.7739999890327454},{"id":"https://openalex.org/keywords/charybdotoxin","display_name":"charybdotoxin","score":0.9110000133514404},{"id":"https://openalex.org/keywords/kv1-3","display_name":"Kv1.3 potassium channel","score":0.8029999732971191},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.8140000104904175},{"id":"https://openalex.org/keywords/calcium-activated-potassium-channels","display_name":"calcium-activated potassium channels","score":0.8100000023841858},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7139999866485596},{"id":"https://openalex.org/keywords/fmoc-solid-phase-peptide-synthesis","display_name":"Fmoc solid-phase peptide synthesis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/toxin-purification","display_name":"toxin purification","score":0.5849999785423279},{"id":"https://openalex.org/keywords/toxin-structure-function","display_name":"toxin structure-function","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C2780419564","wikidata":"https://www.wikidata.org/wiki/Q5087002","display_name":"Charybdotoxin","level":3,"score":0.9459606409072876},{"id":"https://openalex.org/C2910159647","wikidata":"https://www.wikidata.org/wiki/Q19125","display_name":"Scorpion Venoms","level":4,"score":0.8171212673187256},{"id":"https://openalex.org/C2777884321","wikidata":"https://www.wikidata.org/wiki/Q19125","display_name":"Scorpion","level":3,"score":0.7190850973129272},{"id":"https://openalex.org/C2776676993","wikidata":"https://www.wikidata.org/wiki/Q7435406","display_name":"Scorpion toxin","level":4,"score":0.6814212799072266},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.5228127241134644},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47006019949913025},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.4637176990509033},{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.4522188901901245},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4123741686344147},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37301114201545715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35560333728790283},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34420275688171387},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.27686387300491333},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.22300225496292114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21041834354400635},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012508","descriptor_name":"Sarcolemma","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012604","descriptor_name":"Scorpion Venoms","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D012604","descriptor_name":"Scorpion Venoms","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D012604","descriptor_name":"Scorpion Venoms","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018999","descriptor_name":"Charybdotoxin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi971044w","doi":"https://doi.org/10.1021/bi971044w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi971044w","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:9354615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9354615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W573167180","https://openalex.org/W1512465642","https://openalex.org/W1545263835","https://openalex.org/W1555733423","https://openalex.org/W1558096813","https://openalex.org/W1571383380","https://openalex.org/W1579386572","https://openalex.org/W1830737945","https://openalex.org/W1969239953","https://openalex.org/W1985528176","https://openalex.org/W1998469634","https://openalex.org/W2020933618","https://openalex.org/W2032899658","https://openalex.org/W2070015190","https://openalex.org/W2087020604","https://openalex.org/W2106852901","https://openalex.org/W2280944446","https://openalex.org/W2300917456"],"related_works":["https://openalex.org/W7125590600","https://openalex.org/W2083306315","https://openalex.org/W1966883800","https://openalex.org/W1985528176","https://openalex.org/W2437491978","https://openalex.org/W2106043907","https://openalex.org/W2032118370","https://openalex.org/W2120864554","https://openalex.org/W2042766378","https://openalex.org/W2024905449"],"abstract_inverted_index":{"Three":[0],"novel":[1],"toxins":[2,72,119,213],"belonging":[3],"to":[4,12,28,86,121,134,141,150,175,182,206,217],"the":[5,15,18,55,61,74,81,126,152,183,207,223],"scorpion":[6,20,210],"K+":[7,128,155,186,211,227],"channel-inhibitor":[8],"family":[9,225],"were":[10,132,172],"purified":[11],"homogeneity":[13],"from":[14,158],"venom":[16],"of":[17,46,54,73,113,125,146,166,195,226],"Chinese":[19],"Buthus":[21],"martensi.":[22],"They":[23],"have":[24],"been":[25],"identified":[26],"according":[27],"their":[29,35],"molecular":[30],"mass":[31],"(3800-4300":[32],"Da)":[33],"and":[34,39,66,92,149,170,214],"neurotoxicity":[36],"in":[37,101,110,162],"mice":[38,111],"characterized":[40],"as":[41,130],"37-amino":[42],"acid":[43],"peptides.":[44],"One":[45],"them":[47],"shows":[48],"81-87%":[49],"sequence":[50],"identity":[51,70],"with":[52,71,136,177],"members":[53],"kaliotoxin":[56],"group":[57],"(named":[58],"BmKTX),":[59],"whereas":[60],"other":[62,208],"two,":[63],"named":[64],"BmTX1":[65,91,169],"BmTX2,":[67,93],"show":[68,87,201],"65-70%":[69],"charybdotoxin":[75],"group.":[76],"Their":[77],"chemical":[78],"synthesis":[79],"by":[80],"Fmoc":[82],"methodology":[83],"allowed":[84],"us":[85],"that":[88,104],"BmKTX,":[89],"unlike":[90],"possesses":[94],"an":[95],"amidated":[96],"C-terminal":[97],"extremity.":[98],"Toxicity":[99],"assays":[100],"vivo":[102],"established":[103],"they":[105,131],"are":[106],"lethal":[107],"neurotoxic":[108],"agents":[109],"(LD50s":[112],"40-95":[114],"ng":[115],"per":[116],"mouse).":[117],"Those":[118],"proved":[120],"be":[122,218],"potent":[123],"inhibitors":[124],"voltage-gated":[127,154],"channels,":[129],"able":[133],"compete":[135,176],"[125I]kaliotoxin":[137],"for":[138,179,221],"its":[139,180],"binding":[140,181],"rat":[142,159],"brain":[143],"synaptosomes":[144],"(IC50s":[145,165,194],"0.05-1":[147],"nM)":[148],"block":[151],"cloned":[153],"channel":[156,212],"Kv1.3":[157],"brain,":[160],"expressed":[161],"Xenopus":[163],"oocytes":[164],"0.6-1.6":[167],"nM).":[168,197],"BmTX2":[171],"also":[173],"shown":[174],"[125I]charybdotoxin":[178],"high-conductance":[184],"Ca2+-activated":[185],"channels":[187],"present":[188],"on":[189],"bovine":[190],"aorta":[191],"sarcolemmal":[192],"membranes":[193],"0.3-0.6":[196],"These":[198],"new":[199],"sequences":[200],"multipoint":[202],"mutations":[203],"when":[204],"compared":[205],"related":[209],"should":[215],"prove":[216],"useful":[219],"probes":[220],"studying":[222],"diverse":[224],"channels.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
