{"id":"https://openalex.org/W2071536655","doi":"https://doi.org/10.4236/oji.2011.13008","title":"Modulation of human B lymphocyte differentiation by therapeutic immunoglobulins: from protein to mRNA levels","display_name":"Modulation of human B lymphocyte differentiation by therapeutic immunoglobulins: from protein to mRNA levels","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2071536655","doi":"https://doi.org/10.4236/oji.2011.13008","mag":"2071536655"},"language":"en","primary_location":{"id":"doi:10.4236/oji.2011.13008","doi":"https://doi.org/10.4236/oji.2011.13008","is_oa":true,"landing_page_url":"https://doi.org/10.4236/oji.2011.13008","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=16650","source":{"id":"https://openalex.org/S2764392898","display_name":"Open Journal of Immunology","issn_l":"2162-450X","issn":["2162-450X","2162-4526"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=16650","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044175155","display_name":"Nathalie Dussault","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1328242539","display_name":"H\u00e9ma-Qu\u00e9bec","ror":"https://ror.org/008jvv944","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I1328242539","https://openalex.org/I2801902503","https://openalex.org/I4210139015"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nathalie Dussault","raw_affiliation_strings":["Recherche et D\u00e9veloppement, H\u00e9ma-Qu\u00e9bec, Qu\u00e9bec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Recherche et D\u00e9veloppement, H\u00e9ma-Qu\u00e9bec, Qu\u00e9bec, Canada;","institution_ids":["https://openalex.org/I1328242539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071002023","display_name":"Nellie Dumont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1328242539","display_name":"H\u00e9ma-Qu\u00e9bec","ror":"https://ror.org/008jvv944","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I1328242539","https://openalex.org/I2801902503","https://openalex.org/I4210139015"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nellie Dumont","raw_affiliation_strings":["Recherche et D\u00e9veloppement, H\u00e9ma-Qu\u00e9bec, Qu\u00e9bec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Recherche et D\u00e9veloppement, H\u00e9ma-Qu\u00e9bec, Qu\u00e9bec, Canada;","institution_ids":["https://openalex.org/I1328242539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070882307","display_name":"Sonia N\u00e9ron","orcid":"https://orcid.org/0000-0002-1755-8866","observed_orcids":["https://orcid.org/0000-0002-1755-8866"]},"institutions":[{"id":"https://openalex.org/I1328242539","display_name":"H\u00e9ma-Qu\u00e9bec","ror":"https://ror.org/008jvv944","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I1328242539","https://openalex.org/I2801902503","https://openalex.org/I4210139015"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Sonia N\u00e9ron","raw_affiliation_strings":["D\u00e9partement de Biochimie et de Microbiologie, Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada","Recherche et D\u00e9veloppement, H\u00e9ma-Qu\u00e9bec, Qu\u00e9bec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Biochimie et de Microbiologie, Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada","institution_ids":["https://openalex.org/I43406934"]},{"raw_affiliation_string":"Recherche et D\u00e9veloppement, H\u00e9ma-Qu\u00e9bec, Qu\u00e9bec, Canada;","institution_ids":["https://openalex.org/I1328242539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070882307"],"corresponding_institution_ids":["https://openalex.org/I1328242539","https://openalex.org/I43406934"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14412527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"01","issue":"03","first_page":"65","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6172000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6172000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.34689998626708984,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/b-cell-differentiation","display_name":"B cell differentiation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/antibody-secretion","display_name":"immunoglobulin secretion","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cd40-cd154-interaction","display_name":"CD40-CD154 interaction","score":0.8799999952316284},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/elisa","display_name":"ELISA","score":0.578000009059906},{"id":"https://openalex.org/keywords/elispot","display_name":"ELISPOT","score":0.9940000176429749},{"id":"https://openalex.org/keywords/real-time-pcr","display_name":"real-time PCR","score":0.824999988079071},{"id":"https://openalex.org/keywords/immunoglobulin-gene-expression","display_name":"immunoglobulin gene expression","score":0.8880000114440918},{"id":"https://openalex.org/keywords/assay-comparison","display_name":"assay comparison","score":0.5440000295639038},{"id":"https://openalex.org/keywords/b-cell-proliferation","display_name":"B cell proliferation","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2779234475","wikidata":"https://www.wikidata.org/wiki/Q14897851","display_name":"CD154","level":5,"score":0.6821233034133911},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.664025604724884},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5175413489341736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4865207076072693},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4639688730239868},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4609419107437134},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.44923171401023865},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4184337258338928},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4153156280517578},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39683353900909424},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3518972396850586},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.33858269453048706},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22071212530136108},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1534895896911621},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1275656521320343},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.10814833641052246}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4236/oji.2011.13008","doi":"https://doi.org/10.4236/oji.2011.13008","is_oa":true,"landing_page_url":"https://doi.org/10.4236/oji.2011.13008","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=16650","source":{"id":"https://openalex.org/S2764392898","display_name":"Open Journal of Immunology","issn_l":"2162-450X","issn":["2162-450X","2162-4526"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4236/oji.2011.13008","doi":"https://doi.org/10.4236/oji.2011.13008","is_oa":true,"landing_page_url":"https://doi.org/10.4236/oji.2011.13008","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=16650","source":{"id":"https://openalex.org/S2764392898","display_name":"Open Journal of Immunology","issn_l":"2162-450X","issn":["2162-450X","2162-4526"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071536655.pdf","grobid_xml":"https://content.openalex.org/works/W2071536655.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1489975317","https://openalex.org/W1517594500","https://openalex.org/W1549201848","https://openalex.org/W1842612335","https://openalex.org/W1899711695","https://openalex.org/W1963773279","https://openalex.org/W1977672571","https://openalex.org/W1985404795","https://openalex.org/W1988727503","https://openalex.org/W1992857382","https://openalex.org/W2010987904","https://openalex.org/W2038751035","https://openalex.org/W2039772940","https://openalex.org/W2054260242","https://openalex.org/W2073878469","https://openalex.org/W2082680993","https://openalex.org/W2083940127","https://openalex.org/W2084574799","https://openalex.org/W2087580612","https://openalex.org/W2089477728","https://openalex.org/W2093852980","https://openalex.org/W2107277218","https://openalex.org/W2118731706","https://openalex.org/W2119788241","https://openalex.org/W2143609794","https://openalex.org/W2147858277","https://openalex.org/W2151324717","https://openalex.org/W2151861759","https://openalex.org/W2163074585","https://openalex.org/W2168353850","https://openalex.org/W2945792041"],"related_works":["https://openalex.org/W2147858277","https://openalex.org/W2039772940","https://openalex.org/W2587976980","https://openalex.org/W1985404795","https://openalex.org/W2042812930","https://openalex.org/W628827282","https://openalex.org/W194043089","https://openalex.org/W1987086910","https://openalex.org/W2036934456","https://openalex.org/W7055938798"],"abstract_inverted_index":{"Several":[0],"groups":[1],"are":[2,25],"investigating":[3],"the":[4,29,67,98,167,177,183],"mechanisms":[5],"of":[6,8,32,50,69,86,105,116,133,169,171,185],"action":[7],"therapeutic":[9],"immunoglobulins":[10,106],"(IVIg)":[11],"in":[12,60],"order":[13],"to":[14,27,36,136,162],"improve":[15],"their":[16,147],"use.":[17,148],"In":[18],"vitro":[19],"models":[20],"such":[21],"as":[22,180,182],"CD40-CD154":[23],"interaction":[24],"necessary":[26],"study":[28],"physiological":[30],"response":[31],"human":[33,70,87],"B":[34,39,88],"lymphocytes":[35,40,89],"IVIg.":[37],"Human":[38],"treated":[41],"with":[42],"IVIg":[43,74,142],"triggers":[44],"a":[45,76,131],"rapid":[46],"phospho-rylation":[47],"(<1":[48],"h)":[49],"extracellular-regulated":[51],"kinases":[52],"1":[53],"and":[54,63,78,81,100,154],"2":[55],"(ERK1/2),":[56],"which":[57],"subsequently":[58],"results":[59,150],"increased":[61],"differentiation":[62],"decreased":[64],"pro-liferation.":[65],"However,":[66],"modulation":[68],"lymphocyte":[71],"physiology":[72],"by":[73,160],"is":[75],"gradual":[77],"cumulative":[79],"process":[80],"requires":[82],"long-term":[83],"experimentation.":[84],"Differentiation":[85],"into":[90],"Ig-secreting":[91],"cells":[92],"can":[93,107,119],"be":[94,108,120],"evaluated":[95],"both":[96],"at":[97],"transcription":[99],"translation":[101],"levels.":[102],"The":[103],"secretion":[104],"assessed":[109],"using":[110,122],"ELISA":[111,153],"or":[112,124,188],"ELISPOTS":[113,155],"whereas":[114],"expression":[115],"immunoglobulin":[117],"genes":[118],"measured":[121],"semi-quantitative":[123],"quantitative":[125],"PCR":[126,164],"methods.":[127],"We":[128],"hereby":[129],"report":[130],"comparison":[132],"these":[134,172],"methods":[135],"explain":[137],"how":[138],"contradictory":[139],"observations":[140,159],"towards":[141],"effects":[143],"could":[144],"result":[145],"from":[146],"Our":[149],"indicate":[151],"that":[152],"will":[156],"provide":[157],"consistent":[158],"opposition":[161],"real-time":[163],"quantification.":[165],"Besides,":[166],"reliability":[168],"each":[170],"me-thods":[173],"remained":[174],"dependent":[175],"on":[176],"stimulation":[178],"period":[179],"well":[181],"preparation":[184],"cellular":[186],"extracts":[187],"cell":[189],"samples":[190],"following":[191],"IVIg-treatment.":[192]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
