{"id":"https://openalex.org/W2071476777","doi":"https://doi.org/10.1016/s0960-894x(98)00612-x","title":"Selective chemical modifications of polymyxin B","display_name":"Selective chemical modifications of polymyxin B","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W2071476777","doi":"https://doi.org/10.1016/s0960-894x(98)00612-x","mag":"2071476777","pmid":"https://pubmed.ncbi.nlm.nih.gov/9873740"},"language":"en","primary_location":{"id":"doi:10.1016/s0960-894x(98)00612-x","doi":"https://doi.org/10.1016/s0960-894x(98)00612-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(98)00612-x","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013367977","display_name":"Jay Weinstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jay Weinstein","raw_affiliation_strings":["Schering-Plough Research Institute, Department of Chemistry, Kenilworth, New Jersey 07033-0539, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering-Plough Research Institute, Department of Chemistry, Kenilworth, New Jersey 07033-0539, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035439359","display_name":"Adriano Afonso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriano Afonso","raw_affiliation_strings":["Schering-Plough Research Institute, Department of Chemistry, 2015 Galloping Hill Road, Kenilworth New Jersey 07033-0539, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering-Plough Research Institute, Department of Chemistry, 2015 Galloping Hill Road, Kenilworth New Jersey 07033-0539, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061613255","display_name":"E. L. Moss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugene Moss","raw_affiliation_strings":["Schering-Plough Research Institute, Department of Chemistry, 2015 Galloping Hill Road, Kenilworth New Jersey 07033-0539, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering-Plough Research Institute, Department of Chemistry, 2015 Galloping Hill Road, Kenilworth New Jersey 07033-0539, U.S.A","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023507590","display_name":"George H. Miller","orcid":"https://orcid.org/0000-0003-3161-4200","observed_orcids":["https://orcid.org/0000-0003-3161-4200"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George H. Miller","raw_affiliation_strings":["Schering-Plough Research Institute, Department of Chemistry, 2015 Galloping Hill Road, Kenilworth New Jersey 07033-0539, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering-Plough Research Institute, Department of Chemistry, 2015 Galloping Hill Road, Kenilworth New Jersey 07033-0539, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.3071,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.55691283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"23","first_page":"3391","last_page":"3396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.4918999969959259,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.4918999969959259,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.20340000092983246,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.10360000282526016,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymyxin-b","display_name":"polymyxin B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/di-tert-butyl-dicarbonate","display_name":"di-tert-butyl dicarbonate","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ion-exchange-resins","display_name":"ion exchange resins","score":0.7390000224113464},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.800000011920929},{"id":"https://openalex.org/keywords/peptide-antibiotics","display_name":"peptide antibiotics","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9639979004859924},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.8086013197898865},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.6517614722251892},{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.601850688457489},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5378097891807556},{"id":"https://openalex.org/C184133267","wikidata":"https://www.wikidata.org/wiki/Q5090480","display_name":"Chemical modification","level":2,"score":0.514144241809845},{"id":"https://openalex.org/C2777873363","wikidata":"https://www.wikidata.org/wiki/Q13533436","display_name":"Tetra","level":2,"score":0.48132097721099854},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.477205365896225},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.47448208928108215},{"id":"https://openalex.org/C2780026444","wikidata":"https://www.wikidata.org/wiki/Q1088175","display_name":"Polymyxin B","level":3,"score":0.4644601047039032},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.4598783552646637},{"id":"https://openalex.org/C117760992","wikidata":"https://www.wikidata.org/wiki/Q389137","display_name":"Ion exchange","level":3,"score":0.44236406683921814},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3771817088127136},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.2460860013961792},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.22232329845428467},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.18656033277511597},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13471007347106934},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12331920862197876}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011112","descriptor_name":"Polymyxin B","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0960-894x(98)00612-x","doi":"https://doi.org/10.1016/s0960-894x(98)00612-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(98)00612-x","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:9873740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9873740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1516665537","https://openalex.org/W2031936921","https://openalex.org/W2079479033","https://openalex.org/W2114733690","https://openalex.org/W2175068438"],"related_works":["https://openalex.org/W2079479033","https://openalex.org/W1979593019","https://openalex.org/W2317804241","https://openalex.org/W2398931530","https://openalex.org/W2068817526","https://openalex.org/W2024220820","https://openalex.org/W2025280647","https://openalex.org/W2026683295","https://openalex.org/W2079185801","https://openalex.org/W2047856519"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}