{"id":"https://openalex.org/W2071411330","doi":"https://doi.org/10.1117/12.2036636","title":"Photoacoustic microscopy with enhanced resolution and imaging depth aided by optical clearing","display_name":"Photoacoustic microscopy with enhanced resolution and imaging depth aided by optical clearing","publication_year":2014,"publication_date":"2014-03-03","ids":{"openalex":"https://openalex.org/W2071411330","doi":"https://doi.org/10.1117/12.2036636","mag":"2071411330"},"language":"en","primary_location":{"id":"doi:10.1117/12.2036636","doi":"https://doi.org/10.1117/12.2036636","is_oa":true,"landing_page_url":"https://doi.org/10.1117/12.2036636","pdf_url":"https://www.spiedigitallibrary.org/conference-proceedings-of-spie/8943/89433A/Photoacoustic-microscopy-with-enhanced-resolution-and-imaging-depth-aided-by/10.1117/12.2036636.pdf","source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.spiedigitallibrary.org/conference-proceedings-of-spie/8943/89433A/Photoacoustic-microscopy-with-enhanced-resolution-and-imaging-depth-aided-by/10.1117/12.2036636.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038012770","display_name":"Yong Zhou","orcid":"https://orcid.org/0000-0002-0455-9763","observed_orcids":["https://orcid.org/0000-0002-0455-9763"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Zhou","raw_affiliation_strings":["Washington Univ. in St. Louis (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington Univ. in St. Louis (United States)","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005956622","display_name":"Junjie Yao","orcid":"https://orcid.org/0000-0002-2381-706X","observed_orcids":["https://orcid.org/0000-0002-2381-706X","https://orcid.org/0000-0002-7278-9325"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junjie Yao","raw_affiliation_strings":["Optical Imaging Laboratory , Department of Biomedical Engineering , Washington University in St. Louis , One Brookings Drive , St. Louis , MO 63130 , USA","Washington Univ. in St.Louis (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Optical Imaging Laboratory , Department of Biomedical Engineering , Washington University in St. Louis , One Brookings Drive , St. Louis , MO 63130 , USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington Univ. in St.Louis (United States)","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008233636","display_name":"Lihong V. Wang","orcid":"https://orcid.org/0000-0001-9783-4383","observed_orcids":["https://orcid.org/0000-0001-9783-4383"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihong V. Wang","raw_affiliation_strings":["Washington Univ. in St. Louis (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington Univ. in St. Louis (United States)","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.160676,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"8943","issue":null,"first_page":"89433A","last_page":"89433A"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optical-resolution-photoacoustic-microscopy","display_name":"optical-resolution photoacoustic microscopy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/optical-tissue-clearing","display_name":"optical tissue clearing","score":0.7710000276565552},{"id":"https://openalex.org/keywords/glycerol","display_name":"glycerol","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tissue-scattering","display_name":"tissue scattering","score":0.8320000171661377},{"id":"https://openalex.org/keywords/imaging-depth","display_name":"imaging depth","score":0.6679999828338623},{"id":"https://openalex.org/keywords/spatial-resolution","display_name":"spatial resolution","score":0.7789999842643738},{"id":"https://openalex.org/keywords/in-vivo-imaging","display_name":"in vivo imaging","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.6850336790084839},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6796402931213379},{"id":"https://openalex.org/C193493375","wikidata":"https://www.wikidata.org/wiki/Q1306232","display_name":"Penetration depth","level":2,"score":0.6349923610687256},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.6150912642478943},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.610234797000885},{"id":"https://openalex.org/C77017923","wikidata":"https://www.wikidata.org/wiki/Q912313","display_name":"Optical microscope","level":3,"score":0.5556488037109375},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.5470671057701111},{"id":"https://openalex.org/C120456961","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Light scattering","level":3,"score":0.5172967910766602},{"id":"https://openalex.org/C191486275","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Scattering","level":2,"score":0.51563560962677},{"id":"https://openalex.org/C54932901","wikidata":"https://www.wikidata.org/wiki/Q7187705","display_name":"Photoacoustic imaging in biomedicine","level":2,"score":0.48893895745277405},{"id":"https://openalex.org/C92630104","wikidata":"https://www.wikidata.org/wiki/Q4115103","display_name":"Optical imaging","level":2,"score":0.4600541293621063},{"id":"https://openalex.org/C132771110","wikidata":"https://www.wikidata.org/wiki/Q506922","display_name":"Adaptive optics","level":2,"score":0.4152362048625946},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.4101613759994507},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.34601303935050964},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.3217533826828003},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.18739929795265198},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.09195488691329956},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0787026584148407},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1117/12.2036636","doi":"https://doi.org/10.1117/12.2036636","is_oa":true,"landing_page_url":"https://doi.org/10.1117/12.2036636","pdf_url":"https://www.spiedigitallibrary.org/conference-proceedings-of-spie/8943/89433A/Photoacoustic-microscopy-with-enhanced-resolution-and-imaging-depth-aided-by/10.1117/12.2036636.pdf","source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmh:oai:authors.library.caltech.edu:89561","doi":null,"is_oa":false,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20180912-093609284","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book Section"}],"best_oa_location":{"id":"doi:10.1117/12.2036636","doi":"https://doi.org/10.1117/12.2036636","is_oa":true,"landing_page_url":"https://doi.org/10.1117/12.2036636","pdf_url":"https://www.spiedigitallibrary.org/conference-proceedings-of-spie/8943/89433A/Photoacoustic-microscopy-with-enhanced-resolution-and-imaging-depth-aided-by/10.1117/12.2036636.pdf","source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1721933186","display_name":"Photon tunneling: Shedding new light on biomedicine","funder_award_id":"DP1EB016986","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G3209647093","display_name":"RECOVERY OF OPTICAL ABSORPTION COEFFICIENT IN QUANTITATIVE PHOTOACOUSTIC IMAGING","funder_award_id":"R01EB008085","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6941673650","display_name":"Photoacoustic / Optical / Ultrasonic Imaging of Sentinel Lymph Nodes and Metastas","funder_award_id":"U54CA136398","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7834233048","display_name":"Monitoring of Breast Neoadjuvant Therapy by Thermo- and Photo- Acoustic Tomograph","funder_award_id":"R01CA134539","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8323953650","display_name":"PHOTOACOUSTIC MICROSCOPY OF NEOVASCULARIZATION IN RENAL CANCER GROWTH AND THERAPY","funder_award_id":"R01CA159959","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071411330.pdf","grobid_xml":"https://content.openalex.org/works/W2071411330.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1985102305","https://openalex.org/W1995131110","https://openalex.org/W1998412854","https://openalex.org/W2007968467","https://openalex.org/W2030964111","https://openalex.org/W2061184858","https://openalex.org/W2066776174","https://openalex.org/W2084017774","https://openalex.org/W2119229455","https://openalex.org/W4236016244"],"related_works":["https://openalex.org/W2007968467","https://openalex.org/W1970958191","https://openalex.org/W2073476526","https://openalex.org/W4200441706","https://openalex.org/W4389664525","https://openalex.org/W3019535483","https://openalex.org/W4408852293","https://openalex.org/W2179111218","https://openalex.org/W2051884756","https://openalex.org/W4410546972"],"abstract_inverted_index":{"Both":[0],"the":[1,44],"spatial":[2],"resolution":[3],"and":[4,59],"maximum":[5],"penetration":[6],"depth":[7,16],"of":[8,47],"optical-resolution":[9],"photoacoustic":[10],"microscopy":[11],"(ORPAM)":[12],"deteriorate":[13],"sharply":[14],"with":[15],"due":[17],"to":[18,30],"strong":[19],"light":[20],"scattering":[21],"in":[22,38,57,60],"tissue.":[23],"To":[24],"reduce":[25],"tissue":[26],"scattering,":[27],"we":[28],"propose":[29],"use":[31],"glycerol":[32],"as":[33],"an":[34],"optical":[35,54],"clearing":[36,55],"agent":[37],"OR-PAM.":[39],"Our":[40],"results":[41],"show":[42],"that":[43],"imaging":[45],"performance":[46],"OR-PAM":[48],"can":[49],"be":[50],"greatly":[51],"enhanced":[52],"by":[53],"both":[56],"vitro":[58],"vivo.":[61]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}