{"id":"https://openalex.org/W2071271237","doi":"https://doi.org/10.1016/s0006-8993(02)04271-3","title":"Molecular cloning and functional characterization of the OCTN2 transporter at the RBE4 cells, an in vitro model of the blood\u2013brain barrier","display_name":"Molecular cloning and functional characterization of the OCTN2 transporter at the RBE4 cells, an in vitro model of the blood\u2013brain barrier","publication_year":2003,"publication_date":"2003-03-25","ids":{"openalex":"https://openalex.org/W2071271237","doi":"https://doi.org/10.1016/s0006-8993(02)04271-3","mag":"2071271237","pmid":"https://pubmed.ncbi.nlm.nih.gov/12644265"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-8993(02)04271-3","doi":"https://doi.org/10.1016/s0006-8993(02)04271-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-8993(02)04271-3","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Anne Friedrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801798921","display_name":"Helmholtz-Zentrum Dresden-Rossendorf","ror":"https://ror.org/01zy2cs03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801798921"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Anne Friedrich","raw_affiliation_strings":["Forschungszentrum Rossendorf, Dresden, Germany. friedric@mpi-cbg.de","Forschungszentrum Rossendorf, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Forschungszentrum Rossendorf, Dresden, Germany. friedric@mpi-cbg.de","institution_ids":["https://openalex.org/I2801798921"]},{"raw_affiliation_string":"Forschungszentrum Rossendorf, Dresden, Germany","institution_ids":["https://openalex.org/I2801798921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088440923","display_name":"Puttur Devi Prasad","orcid":"https://orcid.org/0000-0002-8455-0186","observed_orcids":["https://orcid.org/0000-0002-8455-0186"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Puttur D. Prasad","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051729685","display_name":"Dorette Freyer","orcid":"https://orcid.org/0000-0003-0082-044X","observed_orcids":["https://orcid.org/0000-0003-0082-044X"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dorette Freyer","raw_affiliation_strings":["Department of Neurology, Universitaetsklinikum Charit\u00e9, Humboldt University, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Universitaetsklinikum Charit\u00e9, Humboldt University, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091451352","display_name":"Vadivel Ganapathy","orcid":"https://orcid.org/0000-0003-0799-6018","observed_orcids":["https://orcid.org/0000-0003-0799-6018"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vadivel Ganapathy","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073720321","display_name":"Peter Brust","orcid":"https://orcid.org/0000-0001-5555-7058","observed_orcids":["https://orcid.org/0000-0001-5555-7058","https://orcid.org/0000-0002-0071-5562"]},"institutions":[{"id":"https://openalex.org/I2801798921","display_name":"Helmholtz-Zentrum Dresden-Rossendorf","ror":"https://ror.org/01zy2cs03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801798921"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Brust","raw_affiliation_strings":["Forschungszentrum Rossendorf, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Forschungszentrum Rossendorf, Dresden, Germany","institution_ids":["https://openalex.org/I2801798921"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801798921"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":2.3942,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.8823763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"968","issue":"1","first_page":"69","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/octn2","display_name":"OCTN2","score":0.996999979019165},{"id":"https://openalex.org/keywords/carnitine-transporter","display_name":"carnitine transporter","score":0.9229999780654907},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7910000085830688},{"id":"https://openalex.org/keywords/rbe4-cells","display_name":"RBE4 cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/brain-endothelial-cells","display_name":"brain endothelial cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/organic-cation-transporters","display_name":"organic cation transporters","score":0.8109999895095825},{"id":"https://openalex.org/keywords/sodium-dependent-transport","display_name":"sodium-dependent transport","score":0.7480000257492065},{"id":"https://openalex.org/keywords/acetyl-l-carnitine","display_name":"acetyl-L-carnitine","score":0.8980000019073486},{"id":"https://openalex.org/keywords/propionylcarnitine","display_name":"propionylcarnitine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tetraethylammonium","display_name":"tetraethylammonium","score":0.9020000100135803},{"id":"https://openalex.org/keywords/transporter-inhibition","display_name":"transporter inhibition","score":0.41600000858306885},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.5770000219345093},{"id":"https://openalex.org/keywords/transporter-expression","display_name":"transporter expression","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C2778435403","wikidata":"https://www.wikidata.org/wiki/Q243309","display_name":"Carnitine","level":2,"score":0.8513444662094116},{"id":"https://openalex.org/C189613389","wikidata":"https://www.wikidata.org/wiki/Q70479817","display_name":"Organic cation transport proteins","level":4,"score":0.7111073732376099},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.6908418536186218},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.644149899482727},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6228160262107849},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5936293005943298},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.49342218041419983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48928162455558777},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.4744114577770233},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45483797788619995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4363628625869751},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34394145011901855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17530810832977295},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074058","descriptor_name":"Solute Carrier Family 22 Member 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002331","descriptor_name":"Carnitine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002331","descriptor_name":"Carnitine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D015655","descriptor_name":"1-Methyl-4-phenylpyridinium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019789","descriptor_name":"Tetraethylammonium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027701","descriptor_name":"Organic Cation Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0006-8993(02)04271-3","doi":"https://doi.org/10.1016/s0006-8993(02)04271-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-8993(02)04271-3","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:12644265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12644265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6000000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W168318287","https://openalex.org/W609865038","https://openalex.org/W1483354304","https://openalex.org/W1528647023","https://openalex.org/W1576523040","https://openalex.org/W1583078219","https://openalex.org/W1606934029","https://openalex.org/W1775749144","https://openalex.org/W1859440284","https://openalex.org/W1965489088","https://openalex.org/W1974763192","https://openalex.org/W1981202063","https://openalex.org/W1984448914","https://openalex.org/W1985631441","https://openalex.org/W1993669883","https://openalex.org/W1996792749","https://openalex.org/W2004063112","https://openalex.org/W2004196371","https://openalex.org/W2005250105","https://openalex.org/W2005343470","https://openalex.org/W2005683036","https://openalex.org/W2008202332","https://openalex.org/W2008215698","https://openalex.org/W2017606692","https://openalex.org/W2022863564","https://openalex.org/W2033674260","https://openalex.org/W2034334213","https://openalex.org/W2040869151","https://openalex.org/W2061078764","https://openalex.org/W2070126342","https://openalex.org/W2072938074","https://openalex.org/W2073650307","https://openalex.org/W2074813983","https://openalex.org/W2080298909","https://openalex.org/W2084917824","https://openalex.org/W2091761748","https://openalex.org/W2092764529","https://openalex.org/W2100713850","https://openalex.org/W2102083512","https://openalex.org/W2104587909","https://openalex.org/W2106454660","https://openalex.org/W2124107218","https://openalex.org/W2138338868","https://openalex.org/W2143808974","https://openalex.org/W2161063911","https://openalex.org/W2161310946","https://openalex.org/W2221978298","https://openalex.org/W2324999561","https://openalex.org/W2340271094","https://openalex.org/W2400663094","https://openalex.org/W2414027522","https://openalex.org/W2522999834","https://openalex.org/W2530665903","https://openalex.org/W4300660235","https://openalex.org/W4313335109","https://openalex.org/W6680510821"],"related_works":["https://openalex.org/W2007178177","https://openalex.org/W1528647023","https://openalex.org/W2166459278","https://openalex.org/W2530665903","https://openalex.org/W1993669883","https://openalex.org/W4297832393","https://openalex.org/W2158793749","https://openalex.org/W1981202063","https://openalex.org/W2034171227","https://openalex.org/W2187145161"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
