{"id":"https://openalex.org/W2071244442","doi":"https://doi.org/10.1021/bi034672o","title":"Flexible Metal Binding of the Metallo-\u03b2-lactamase Domain: Glyoxalase II Incorporates Iron, Manganese, and Zinc in Vivo","display_name":"Flexible Metal Binding of the Metallo-\u03b2-lactamase Domain: Glyoxalase II Incorporates Iron, Manganese, and Zinc in Vivo","publication_year":2003,"publication_date":"2003-09-20","ids":{"openalex":"https://openalex.org/W2071244442","doi":"https://doi.org/10.1021/bi034672o","mag":"2071244442","pmid":"https://pubmed.ncbi.nlm.nih.gov/14529289"},"language":"en","primary_location":{"id":"doi:10.1021/bi034672o","doi":"https://doi.org/10.1021/bi034672o","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi034672o","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050843400","display_name":"Oliver Schilling","orcid":"https://orcid.org/0000-0001-7678-7653","observed_orcids":["https://orcid.org/0000-0001-7678-7653"]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]},{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Oliver Schilling","raw_affiliation_strings":["EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056","institution_ids":["https://openalex.org/I4210153543","https://openalex.org/I83328450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049183931","display_name":"Nathan Wenzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]},{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Nathan Wenzel","raw_affiliation_strings":["EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056","institution_ids":["https://openalex.org/I4210153543","https://openalex.org/I83328450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043796482","display_name":"Melissa Naylor","orcid":"https://orcid.org/0009-0006-7038-8276","observed_orcids":["https://orcid.org/0009-0006-7038-8276"]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]},{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Melissa Naylor","raw_affiliation_strings":["EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056","institution_ids":["https://openalex.org/I4210153543","https://openalex.org/I83328450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105470867","display_name":"Andreas Vogel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]},{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Andreas Vogel","raw_affiliation_strings":["EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056","institution_ids":["https://openalex.org/I4210153543","https://openalex.org/I83328450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007268290","display_name":"Michael W. Crowder","orcid":"https://orcid.org/0000-0002-3138-0283","observed_orcids":["https://orcid.org/0000-0002-3138-0283"]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]},{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Michael Crowder","raw_affiliation_strings":["EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056","institution_ids":["https://openalex.org/I4210153543","https://openalex.org/I83328450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013459145","display_name":"Christopher A. Makaroff","orcid":"https://orcid.org/0000-0001-6237-1868","observed_orcids":["https://orcid.org/0000-0001-6237-1868"]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]},{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Christopher Makaroff","raw_affiliation_strings":["EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056","institution_ids":["https://openalex.org/I4210153543","https://openalex.org/I83328450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030745631","display_name":"Wolfram Meyer\u2010Klaucke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]},{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Wolfram Meyer-Klaucke","raw_affiliation_strings":["EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation Hamburg, Notkestrasse 85, 22603 Hamburg, Germany, and Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056","institution_ids":["https://openalex.org/I4210153543","https://openalex.org/I83328450"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.2337,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.94761867,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"42","issue":"40","first_page":"11777","last_page":"11786"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.12099999934434891,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glyoxalase-ii","display_name":"glyoxalase II","score":0.9959999918937683},{"id":"https://openalex.org/keywords/iron","display_name":"iron","score":0.6449999809265137},{"id":"https://openalex.org/keywords/manganese","display_name":"manganese","score":0.9990000128746033},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":1.0},{"id":"https://openalex.org/keywords/metal-ion-binding","display_name":"metal ion binding","score":0.5320000052452087},{"id":"https://openalex.org/keywords/histidine-ligands","display_name":"histidine ligands","score":0.6790000200271606},{"id":"https://openalex.org/keywords/metal-metal-distance","display_name":"metal-metal distance","score":0.7289999723434448},{"id":"https://openalex.org/keywords/spin-spin-coupling","display_name":"spin-spin coupling","score":0.5799999833106995},{"id":"https://openalex.org/keywords/metal-ion-selectivity","display_name":"metal ion selectivity","score":0.8510000109672546},{"id":"https://openalex.org/keywords/s-d-lactoylglutathione","display_name":"S-D-lactoylglutathione","score":0.8799999952316284},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.8840000033378601},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.5149999856948853},{"id":"https://openalex.org/keywords/structural-flexibility","display_name":"structural flexibility","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7508609294891357},{"id":"https://openalex.org/C528890316","wikidata":"https://www.wikidata.org/wiki/Q731","display_name":"Manganese","level":2,"score":0.7297099828720093},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.72702956199646},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.6101175546646118},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.576045036315918},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5511866211891174},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.544461727142334},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.4950107932090759},{"id":"https://openalex.org/C187961010","wikidata":"https://www.wikidata.org/wiki/Q260463","display_name":"Electron paramagnetic resonance","level":2,"score":0.49072492122650146},{"id":"https://openalex.org/C17165728","wikidata":"https://www.wikidata.org/wiki/Q423350","display_name":"Metalloprotein","level":3,"score":0.4520620107650757},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4484196603298187},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.44096243381500244},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.321871817111969},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.28559139370918274},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15138384699821472},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.0967455506324768},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099301","descriptor_name":"Hydroxyacylglutathione Hydrolase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004578","descriptor_name":"Electron Spin Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013869","descriptor_name":"Thiolester Hydrolases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013869","descriptor_name":"Thiolester Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019216","descriptor_name":"Metals, Heavy","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi034672o","doi":"https://doi.org/10.1021/bi034672o","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi034672o","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:14529289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14529289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1490792400","https://openalex.org/W1807920597","https://openalex.org/W1971429162","https://openalex.org/W1983108555","https://openalex.org/W1983789194","https://openalex.org/W1986894327","https://openalex.org/W1987875806","https://openalex.org/W2005935589","https://openalex.org/W2013910882","https://openalex.org/W2020329820","https://openalex.org/W2032334111","https://openalex.org/W2037076337","https://openalex.org/W2046855998","https://openalex.org/W2052317605","https://openalex.org/W2067373519","https://openalex.org/W2069986170","https://openalex.org/W2070766403","https://openalex.org/W2070828098","https://openalex.org/W2073607657","https://openalex.org/W2078171437","https://openalex.org/W2083863218","https://openalex.org/W2088439603","https://openalex.org/W2103378158","https://openalex.org/W2343847164","https://openalex.org/W2397884896","https://openalex.org/W2401061572","https://openalex.org/W2937718728","https://openalex.org/W2943739603","https://openalex.org/W3192366276","https://openalex.org/W4211062846"],"related_works":["https://openalex.org/W2034819233","https://openalex.org/W2028100835","https://openalex.org/W1972261407","https://openalex.org/W2597879927","https://openalex.org/W1983108555","https://openalex.org/W2154600206","https://openalex.org/W1966265281","https://openalex.org/W2116372927","https://openalex.org/W2164645645","https://openalex.org/W2007809750"],"abstract_inverted_index":{"Glyoxalase":[0],"II":[1,20,171],"belongs":[2],"to":[3,28,79,113],"the":[4,10,25,60,67,80,150,169,179],"metallo-beta-lactamase":[5],"superfamily":[6],"of":[7,34,51,62,75,88,129,165],"proteins,":[8],"possessing":[9],"characteristic":[11,158],"dinuclear":[12,81,172],"active":[13,82,173],"site.":[14],"Within":[15],"this":[16],"protein":[17],"family,":[18],"glyoxalase":[19,170],"from":[21],"Arabidopsis":[22],"thaliana":[23],"is":[24,111,176],"first":[26],"member":[27],"be":[29,114],"isolated":[30],"with":[31,48,66,84,155],"significant":[32],"amounts":[33],"iron,":[35],"manganese,":[36],"and":[37,93,136,153],"zinc":[38],"when":[39],"being":[40],"recombinantly":[41],"produced":[42],"in":[43,59],"Escherichia":[44],"coli.":[45],"Enzyme":[46],"preparations":[47],"different":[49,127],"ratios":[50],"these":[52],"three":[53,77],"metals":[54,78],"all":[55,76],"yield":[56],"k(cat)/K(M)":[57],"values":[58],"range":[61],"1.5-1.9":[63],"s(-1)":[64],"microM(-1)":[65],"substrate":[68],"S-d-lactoylglutathione.":[69],"X-ray":[70,144],"absorption":[71,145],"spectroscopy":[72,122,146],"reveals":[73],"binding":[74],"site":[83],"5-6-fold":[85],"coordination":[86],"consisting":[87],"2.5":[89,94],"+/-":[90,95,116],"0.5":[91,96],"histidine":[92],"oxygen":[97],"ligands.":[98],"This":[99,160],"model":[100],"does":[101],"not":[102],"distinguish":[103],"site-specific":[104],"or":[105],"distributed":[106],"binding.":[107],"The":[108,139],"metal-metal":[109],"distance":[110],"determined":[112],"3.18":[115],"0.06":[117],"A.":[118],"Electron":[119],"paramagnetic":[120],"resonance":[121],"gives":[123],"evidence":[124],"for":[125,182],"several":[126],"types":[128],"dimetal":[130],"sites,":[131],"including":[132],"spin-coupled":[133],"Fe(III)Fe(II),":[134],"Fe(III)Zn(II),":[135],"Mn(II)Mn(II)":[137],"centers.":[138],"metal-ligand":[140],"distances":[141],"measured":[142],"by":[143],"vary":[147],"depending":[148],"on":[149],"metal":[151,185],"type":[152],"comply":[154],"their":[156],"element-specific,":[157],"values.":[159],"reflects":[161],"a":[162],"high":[163],"degree":[164],"structural":[166,180],"flexibility":[167],"within":[168],"site,":[174],"which":[175],"considered":[177],"as":[178],"basis":[181],"its":[183],"broad":[184],"selectivity.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}