{"id":"https://openalex.org/W2071199891","doi":"https://doi.org/10.1016/j.ymthe.2004.07.014","title":"Impact of E1a Modifications on Tumor-Selective Adenoviral Replication and Toxicity","display_name":"Impact of E1a Modifications on Tumor-Selective Adenoviral Replication and Toxicity","publication_year":2004,"publication_date":"2004-08-25","ids":{"openalex":"https://openalex.org/W2071199891","doi":"https://doi.org/10.1016/j.ymthe.2004.07.014","mag":"2071199891","pmid":"https://pubmed.ncbi.nlm.nih.gov/15451459"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymthe.2004.07.014","doi":"https://doi.org/10.1016/j.ymthe.2004.07.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2004.07.014","pdf_url":"http://www.cell.com/article/S1525001604013437/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S1525001604013437/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019447215","display_name":"Harald Sauthoff","orcid":"https://orcid.org/0000-0001-9258-4135","observed_orcids":["https://orcid.org/0000-0001-9258-4135"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harald Sauthoff","raw_affiliation_strings":["Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA","Department of Medicine, New York University School of Medicine, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016837994","display_name":"Teona Pipiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teona Pipiya","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090170191","display_name":"Sheila Heitner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheila Heitner","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100347304","display_name":"Shu Chen","orcid":"https://orcid.org/0009-0006-2406-0309","observed_orcids":["https://orcid.org/0009-0006-2406-0309","https://orcid.org/0000-0003-4384-0811","https://orcid.org/0009-0006-9009-9973"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu Chen","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056512786","display_name":"Bertram Bleck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bertram Bleck","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087232063","display_name":"Joan Reibman","orcid":"https://orcid.org/0000-0001-7878-1511","observed_orcids":["https://orcid.org/0000-0001-7878-1511"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Reibman","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Chang","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011463944","display_name":"Robert G. Norman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G. Norman","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008330886","display_name":"William N. Rom","orcid":"https://orcid.org/0000-0002-8793-7028","observed_orcids":["https://orcid.org/0000-0002-8793-7028"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William N. Rom","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065874974","display_name":"John G. Hay","orcid":"https://orcid.org/0000-0003-3807-4075","observed_orcids":["https://orcid.org/0000-0003-3807-4075"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John G. Hay","raw_affiliation_strings":["Cancer Institute, New York University School of Medicine, New York, NY 10016, USA","Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","Department of Pathology, New York University School of Medicine, New York, NY 10016, USA","Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Pathology, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Division of Pulmonary & Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065874974"],"corresponding_institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":1.4122,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.80244537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"10","issue":"4","first_page":"749","last_page":"757"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-cytotoxicity","display_name":"viral cytotoxicity","score":0.7820000052452087},{"id":"https://openalex.org/keywords/growth-arrested-cells","display_name":"growth-arrested cells","score":0.7630000114440918},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.842963457107544},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.8297815322875977},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.7359820008277893},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6361111998558044},{"id":"https://openalex.org/C2777283488","wikidata":"https://www.wikidata.org/wiki/Q7095181","display_name":"Oncolytic adenovirus","level":4,"score":0.495309978723526},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4555742144584656},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42594006657600403},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3978004455566406},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37506046891212463},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37162309885025024},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3309685289859772},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1857675313949585},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14175459742546082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1048215925693512},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05372011661529541}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017500","descriptor_name":"Adenovirus E1A Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017500","descriptor_name":"Adenovirus E1A Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ymthe.2004.07.014","doi":"https://doi.org/10.1016/j.ymthe.2004.07.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2004.07.014","pdf_url":"http://www.cell.com/article/S1525001604013437/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"pmid:15451459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15451459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ymthe.2004.07.014","doi":"https://doi.org/10.1016/j.ymthe.2004.07.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2004.07.014","pdf_url":"http://www.cell.com/article/S1525001604013437/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5547855133","display_name":null,"funder_award_id":"R01CA89086","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5871354284","display_name":"General Clinical Research Center","funder_award_id":"M01RR000096","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7878872285","display_name":"Diesel Exhaust Particles and Mucosal Immunity","funder_award_id":"R01ES010187","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8237979311","display_name":"Strategies to Enhance Adenoviral Mediated Tumor Killing","funder_award_id":"5r01ca089086-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8328985725","display_name":"Spread of Replicating Adenovirus in Pancreatic Tumors","funder_award_id":"R01CA102053","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071199891.pdf"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1491631791","https://openalex.org/W1531166036","https://openalex.org/W1542161618","https://openalex.org/W1567384233","https://openalex.org/W1602446144","https://openalex.org/W1781724529","https://openalex.org/W1846023877","https://openalex.org/W1903745386","https://openalex.org/W1911649157","https://openalex.org/W1978870802","https://openalex.org/W2003850700","https://openalex.org/W2015967163","https://openalex.org/W2016080258","https://openalex.org/W2017471019","https://openalex.org/W2021787959","https://openalex.org/W2035309695","https://openalex.org/W2040015936","https://openalex.org/W2046318087","https://openalex.org/W2051033051","https://openalex.org/W2054519549","https://openalex.org/W2069409615","https://openalex.org/W2083009248","https://openalex.org/W2087714421","https://openalex.org/W2094246972","https://openalex.org/W2096005665","https://openalex.org/W2103182211","https://openalex.org/W2106604176","https://openalex.org/W2110592777","https://openalex.org/W2113127264","https://openalex.org/W2117210608","https://openalex.org/W2117928617","https://openalex.org/W2130515002","https://openalex.org/W2131308181","https://openalex.org/W2144706906","https://openalex.org/W2144891310","https://openalex.org/W2148487263","https://openalex.org/W2161541723","https://openalex.org/W2165703532","https://openalex.org/W2172238536","https://openalex.org/W2175108733","https://openalex.org/W2180993978","https://openalex.org/W2317910127","https://openalex.org/W6638305974","https://openalex.org/W6638832143"],"related_works":["https://openalex.org/W4377564840","https://openalex.org/W7074158079","https://openalex.org/W1985327490","https://openalex.org/W2059771582","https://openalex.org/W2049918810","https://openalex.org/W2469032155","https://openalex.org/W2168450687","https://openalex.org/W1993938068","https://openalex.org/W6981300132","https://openalex.org/W2020677057"],"abstract_inverted_index":{"Replicating":[0],"adenoviral":[1],"vectors":[2],"are":[3],"capable":[4],"of":[5,22,48,79,98,138,149,161,247,255,272,286,308],"multiplying":[6],"up":[7],"to":[8,20,34,39,55,123,152,208,249,262],"a":[9,15,240,300,314],"thousandfold":[10],"in":[11,63,67,71,131,156,175,181,198,213,217,227,297],"the":[12,49,80,95,99,114,139,147,150,200,203,250,273,282,295,303,309],"target":[13],"cell,":[14],"property":[16],"that":[17,46,52,244],"might":[18],"prove":[19],"be":[21,86,281],"tremendous":[23],"potential":[24],"for":[25,120],"cancer":[26,35,135,263],"therapy.":[27],"However,":[28,74,292],"restricting":[29],"viral":[30,69,127,165,189,223,288],"replication":[31,70,166,190,224,233,289],"and":[32,117,129,134,167,191,202,225,234,290],"toxicity":[33],"cells":[36,92,264],"is":[37,245],"essential":[38],"optimize":[40],"safety.":[41],"It":[42],"has":[43],"been":[44],"proposed":[45],"modifications":[47,84],"E1a":[50,83,143,243,278],"protein":[51],"impair":[53],"binding":[54,248,311],"Rb":[56],"or":[57,306],"p300":[58],"will":[59],"prevent":[60],"S-phase":[61,125,210],"induction":[62,211],"normal":[64,91,133,176,183,215,228],"cells,":[65],"resulting":[66],"selective":[68],"tumor":[72],"cells.":[73,136,158,229],"it":[75],"remains":[76],"uncertain":[77],"which":[78],"several":[81,107],"possible":[82],"would":[85],"most":[87,283],"effective":[88],"at":[89,110],"protecting":[90],"without":[93],"compromising":[94],"oncolytic":[96],"effect":[97,160],"vector.":[100],"In":[101,269],"this":[102,162,219],"study,":[103],"we":[104],"have":[105],"expressed":[106],"E1a-deletion":[108],"mutants":[109],"high":[111],"levels":[112],"using":[113],"CMV":[115],"promoter":[116],"tested":[118],"them":[119],"their":[121],"ability":[122,148],"facilitate":[124],"induction,":[126],"replication,":[128],"cytotoxicity":[130,168,174,192,226,235,317],"both":[132,199],"Deletion":[137],"Rb-binding":[140,204,274,304],"domain":[141,205],"within":[142,277,294,302],"only":[144],"slightly":[145],"decreased":[146],"virus":[151,220,241],"induce":[153],"S":[154],"phase":[155],"growth-arrested":[157,214],"The":[159],"deletion":[163,271,293,301,307],"on":[164],"was":[169,172,187,237],"variable.":[170],"There":[171],"reduced":[173,222],"bronchial":[177],"epithelial":[178],"cells;":[179,216],"however,":[180],"some":[182],"cell":[184],"types":[185],"there":[186],"equal":[188],"compared":[193,265],"with":[194,266,299],"wild":[195],"type.":[196],"Deletions":[197],"N-terminus":[201,296],"were":[206,259],"required":[207],"block":[209],"effectively":[212],"addition,":[218],"demonstrated":[221],"An":[230],"equally":[231,260],"favorable":[232,316],"profile":[236],"induced":[238],"by":[239],"expressing":[242],"incapable":[246],"transcriptional":[251],"adapter":[252],"motif":[253],"(TRAM)":[254],"p300.":[256],"All":[257],"viruses":[258],"cytotoxic":[261],"wild-type":[267],"virus.":[268],"conclusion,":[270],"site":[275],"alone":[276],"may":[279],"not":[280],"efficacious":[284],"means":[285],"targeting":[287],"toxicity.":[291],"conjunction":[298],"domain,":[305,312],"p300-TRAM":[310],"induces":[313],"more":[315],"profile.":[318]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
