{"id":"https://openalex.org/W2071142855","doi":"https://doi.org/10.1089/ten.tea.2008.0664","title":"Efficient Derivation of Alveolar Type II Cells from Embryonic Stem Cells for In Vivo Application","display_name":"Efficient Derivation of Alveolar Type II Cells from Embryonic Stem Cells for In Vivo Application","publication_year":2009,"publication_date":"2009-04-23","ids":{"openalex":"https://openalex.org/W2071142855","doi":"https://doi.org/10.1089/ten.tea.2008.0664","mag":"2071142855","pmid":"https://pubmed.ncbi.nlm.nih.gov/19388834","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2811058"},"language":"en","primary_location":{"id":"doi:10.1089/ten.tea.2008.0664","doi":"https://doi.org/10.1089/ten.tea.2008.0664","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tea.2008.0664","pdf_url":null,"source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2811058","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025171918","display_name":"Blair R. Roszell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blair Roszell","raw_affiliation_strings":["School of Biomedical Engineering, Sciences, and Health Systems, Drexel University, Philadelphia, Pennsylvania","University of Connecticut Health Center, Farmington, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Sciences, and Health Systems, Drexel University, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"University of Connecticut Health Center, Farmington, Connecticut","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007627568","display_name":"Mark J. Mondrinos","orcid":"https://orcid.org/0000-0002-2704-9440","observed_orcids":["https://orcid.org/0000-0002-2704-9440"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Mondrinos","raw_affiliation_strings":["School of Biomedical Engineering, Sciences, and Health Systems, Drexel University, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Sciences, and Health Systems, Drexel University, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029329935","display_name":"Ariel Seaton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariel Seaton","raw_affiliation_strings":["University of Connecticut Health Center, Farmington, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut Health Center, Farmington, Connecticut","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005643951","display_name":"Donald M. Simons","orcid":"https://orcid.org/0009-0003-0154-0279","observed_orcids":["https://orcid.org/0009-0003-0154-0279"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald M. Simons","raw_affiliation_strings":["School of Biomedical Engineering, Sciences, and Health Systems, Drexel University, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Sciences, and Health Systems, Drexel University, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078933662","display_name":"Sirma H. Koutzaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sirma H. Koutzaki","raw_affiliation_strings":["School of Biomedical Engineering, Sciences, and Health Systems, Drexel University, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Sciences, and Health Systems, Drexel University, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074252067","display_name":"Guo\u2010Hua Fong","orcid":"https://orcid.org/0000-0001-5792-6486","observed_orcids":["https://orcid.org/0000-0001-5792-6486"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guo-Hua Fong","raw_affiliation_strings":["University of Connecticut Health Center, Farmington, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut Health Center, Farmington, Connecticut","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040485847","display_name":"Peter I. Lelkes","orcid":"https://orcid.org/0000-0003-4954-3498","observed_orcids":["https://orcid.org/0000-0003-4954-3498"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter I. Lelkes","raw_affiliation_strings":["School of Biomedical Engineering, Sciences, and Health Systems, Drexel University, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Sciences, and Health Systems, Drexel University, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025618990","display_name":"Christine M Finck","orcid":"https://orcid.org/0000-0003-1771-7844","observed_orcids":["https://orcid.org/0000-0003-1771-7844"]},"institutions":[{"id":"https://openalex.org/I4210101648","display_name":"Connecticut Children's Medical Center","ror":"https://ror.org/01a1jjn24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101648"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christine M. Finck","raw_affiliation_strings":["Connecticut Children's Medical Center, Hartford, Connecticut","University of Connecticut Health Center, Farmington, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connecticut Children's Medical Center, Hartford, Connecticut","institution_ids":["https://openalex.org/I4210101648"]},{"raw_affiliation_string":"University of Connecticut Health Center, Farmington, Connecticut","institution_ids":["https://openalex.org/I75929689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025618990","https://openalex.org/A5040485847"],"corresponding_institution_ids":["https://openalex.org/I4210101648","https://openalex.org/I72816309","https://openalex.org/I75929689"],"apc_list":null,"apc_paid":null,"fwci":2.6645,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.9086352,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"15","issue":"11","first_page":"3351","last_page":"3365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.9100000262260437},{"id":"https://openalex.org/keywords/lung-epithelial-differentiation","display_name":"lung epithelial differentiation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/definitive-endoderm","display_name":"definitive endoderm","score":0.8690000176429749},{"id":"https://openalex.org/keywords/activin","display_name":"activin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/wnt3a","display_name":"Wnt3a","score":0.9940000176429749},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-2","display_name":"fibroblast growth factor 2","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/lung-regeneration","display_name":"lung regeneration","score":0.5059999823570251},{"id":"https://openalex.org/keywords/surfactant-proteins","display_name":"surfactant proteins","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2777164004","wikidata":"https://www.wikidata.org/wiki/Q331858","display_name":"Endoderm","level":4,"score":0.908348798751831},{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.8052340745925903},{"id":"https://openalex.org/C191548132","wikidata":"https://www.wikidata.org/wiki/Q2355306","display_name":"Histogenesis","level":3,"score":0.7517565488815308},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.616559624671936},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5668087601661682},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.46753665804862976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4649580419063568},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.46060827374458313},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.4311921298503876},{"id":"https://openalex.org/C2779854577","wikidata":"https://www.wikidata.org/wiki/Q191341","display_name":"Alveolar cells","level":3,"score":0.43065446615219116},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38530418276786804},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3602074682712555},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32183289527893066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28557097911834717},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27341902256011963},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.21075457334518433},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16830343008041382},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09916374087333679},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0617394745349884},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1089/ten.tea.2008.0664","doi":"https://doi.org/10.1089/ten.tea.2008.0664","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tea.2008.0664","pdf_url":null,"source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2811058","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2811058","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Eng Part A","raw_type":"Text"},{"id":"pmid:19388834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19388834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue engineering. Part A","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2811058","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2811058","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Eng Part A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3169116259","display_name":"Optimal Derivation of Murine Embryonic Distal Airway Stem Cells","funder_award_id":"R01HL104258","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320310017","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1502147118","https://openalex.org/W1503724004","https://openalex.org/W1504736885","https://openalex.org/W1605730424","https://openalex.org/W1958163310","https://openalex.org/W1965419330","https://openalex.org/W1969921713","https://openalex.org/W1973876666","https://openalex.org/W1974447758","https://openalex.org/W1977305659","https://openalex.org/W1982748372","https://openalex.org/W1984512384","https://openalex.org/W1989298450","https://openalex.org/W1992358636","https://openalex.org/W1992581245","https://openalex.org/W1993359142","https://openalex.org/W1993556299","https://openalex.org/W1995640088","https://openalex.org/W2001508112","https://openalex.org/W2003165802","https://openalex.org/W2017241568","https://openalex.org/W2019156031","https://openalex.org/W2033113800","https://openalex.org/W2033791639","https://openalex.org/W2038404321","https://openalex.org/W2054090141","https://openalex.org/W2056983875","https://openalex.org/W2059944938","https://openalex.org/W2076098479","https://openalex.org/W2084276316","https://openalex.org/W2090594538","https://openalex.org/W2097110666","https://openalex.org/W2100715279","https://openalex.org/W2107277218","https://openalex.org/W2108186386","https://openalex.org/W2110806916","https://openalex.org/W2112986981","https://openalex.org/W2114360920","https://openalex.org/W2115142051","https://openalex.org/W2123933100","https://openalex.org/W2127500462","https://openalex.org/W2131045156","https://openalex.org/W2132556256","https://openalex.org/W2139020188","https://openalex.org/W2139373056","https://openalex.org/W2153685871","https://openalex.org/W2157212231","https://openalex.org/W2165871414","https://openalex.org/W2168223713","https://openalex.org/W2168583421","https://openalex.org/W2170494259","https://openalex.org/W2316940904","https://openalex.org/W2396242620","https://openalex.org/W2474870364","https://openalex.org/W4238010870"],"related_works":["https://openalex.org/W2084276316","https://openalex.org/W1265713662","https://openalex.org/W2040111843","https://openalex.org/W85700997","https://openalex.org/W1992358636","https://openalex.org/W2347047854","https://openalex.org/W2474870364","https://openalex.org/W2082363243","https://openalex.org/W2340624796","https://openalex.org/W2094022515"],"abstract_inverted_index":{"In":[0],"the":[1,105,186],"present":[2],"study,":[3],"mouse":[4],"embryonic":[5],"stem":[6],"cells":[7,17,82,111,158,166,173,206],"(ESCs)":[8],"were":[9,174],"differentiated":[10],"into":[11,62,177],"alveolar":[12],"epithelial":[13,27,75],"type":[14],"II":[15],"(AEII)":[16],"for":[18,207],"endotracheal":[19],"injection.":[20],"These":[21],"enriched":[22,202],"lung-like":[23,205],"populations":[24],"expressed":[25],"lung":[26,74,172,187],"markers":[28],"SP-A,":[29],"SP-B,":[30],"SP-C,":[31],"and":[32,112,125,156],"CC10.":[33],"First":[34],"we":[35],"show":[36],"that":[37,92,99,192],"rapid":[38],"differentiation":[39,59],"of":[40,48,60,93,104,121,154,163,182,195,200,204],"ESCs":[41,61],"requires":[42],"a":[43,57,71,151,193],"dissociated":[44,132],"seeding":[45,134],"method":[46],"instead":[47],"an":[49,201],"embryoid":[50],"body":[51],"culture":[52],"method.":[53],"We":[54],"then":[55],"investigated":[56],"two-step":[58],"definitive":[63,114],"endoderm":[64,115,137],"by":[65,109],"activin":[66,94,140],"or":[67],"A549-conditioned":[68],"medium":[69,79],"as":[70],"precursor":[72],"to":[73,85,149],"cells.":[76],"When":[77],"conditioned":[78],"from":[80,167],"A549":[81,110],"was":[83,89,147],"used":[84],"derive":[86],"endoderm,":[87],"yield":[88,138],"increased":[90],"above":[91],"alone.":[95,141],"Further":[96],"studies":[97],"showed":[98],"Wnt3a":[100,126],"may":[101,197],"be":[102],"one":[103],"secreted":[106],"factors":[107],"produced":[108],"promotes":[113],"differentiation,":[116],"in":[117,209],"part,":[118],"through":[119],"suppression":[120],"primitive":[122],"endoderm.":[123,169],"Activin":[124],"together":[127],"at":[128],"appropriate":[129],"doses":[130],"with":[131,180],"cell":[133],"promoted":[135],"greater":[136],"than":[139],"Next,":[142],"fibroblast":[143],"growth":[144],"factor":[145],"2":[146],"shown":[148],"induce":[150],"dose-dependent":[152],"expression":[153],"SPC,":[155],"these":[157],"contained":[159],"lamellar":[160],"bodies":[161],"characteristic":[162],"mature":[164],"AEII":[165,183],"ESC-derived":[168],"Finally,":[170],"ES-derived":[171],"endotracheally":[175],"injected":[176],"preterm":[178],"mice":[179],"evidence":[181],"distribution":[184],"within":[185],"parenchyma.":[188],"This":[189],"study":[190],"concludes":[191],"recapitulation":[194],"development":[196],"enhance":[198],"derivation":[199],"population":[203],"use":[208],"cell-based":[210],"therapy.":[211]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}