{"id":"https://openalex.org/W2071130833","doi":"https://doi.org/10.1016/s0959-437x(98)80116-0","title":"BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation","display_name":"BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation","publication_year":1998,"publication_date":"1998-08-01","ids":{"openalex":"https://openalex.org/W2071130833","doi":"https://doi.org/10.1016/s0959-437x(98)80116-0","mag":"2071130833","pmid":"https://pubmed.ncbi.nlm.nih.gov/9729721"},"language":"en","primary_location":{"id":"doi:10.1016/s0959-437x(98)80116-0","doi":"https://doi.org/10.1016/s0959-437x(98)80116-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0959-437x(98)80116-0","pdf_url":null,"source":{"id":"https://openalex.org/S116174365","display_name":"Current Opinion in Genetics & Development","issn_l":"0959-437X","issn":["0959-437X","1879-0380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Genetics & Development","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074829260","display_name":"Ken W.Y. Cho","orcid":"https://orcid.org/0000-0001-7282-1770","observed_orcids":["https://orcid.org/0000-0001-7282-1770","https://orcid.org/0000-0003-4816-6985"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ken WY Cho","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California, Irvine 92697, USA. kwcho@uci.edu","Department of Developmental and Cell Biology, University of California, Irvine, 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine 92697, USA. kwcho@uci.edu","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033831242","display_name":"Ira L. Blitz","orcid":"https://orcid.org/0000-0002-0173-3287","observed_orcids":["https://orcid.org/0000-0002-0173-3287"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ira L Blitz","raw_affiliation_strings":["Department of Developmental and Cell Biology, and the Developmental Biology Center, University of California, Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, and the Developmental Biology Center, University of California, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033831242","https://openalex.org/A5074829260"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.8522,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.6996788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"4","first_page":"443","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-morphogenetic-proteins","display_name":"bone morphogenetic proteins","score":0.9919999837875366},{"id":"https://openalex.org/keywords/smad-proteins","display_name":"Smad proteins","score":0.6769999861717224},{"id":"https://openalex.org/keywords/metalloproteinases","display_name":"metalloproteinases","score":0.8360000252723694},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tgf-beta-superfamily","display_name":"TGF-beta superfamily","score":0.9070000052452087},{"id":"https://openalex.org/keywords/bmp-inhibitors","display_name":"BMP inhibitors","score":0.8650000095367432},{"id":"https://openalex.org/keywords/negative-regulation-of-signaling","display_name":"negative regulation of signaling","score":0.8130000233650208},{"id":"https://openalex.org/keywords/intracellular-regulation","display_name":"intracellular regulation","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8612616658210754},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.7807739973068237},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.723861813545227},{"id":"https://openalex.org/C73834784","wikidata":"https://www.wikidata.org/wiki/Q17849752","display_name":"BMPR2","level":4,"score":0.7215343713760376},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6954330205917358},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6177119612693787},{"id":"https://openalex.org/C92028520","wikidata":"https://www.wikidata.org/wiki/Q7395025","display_name":"SUPERFAMILY","level":3,"score":0.570505678653717},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4565325677394867},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43784299492836},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.4135874807834625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26383697986602783},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2608904242515564},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1659526228904724},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0959-437x(98)80116-0","doi":"https://doi.org/10.1016/s0959-437x(98)80116-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0959-437x(98)80116-0","pdf_url":null,"source":{"id":"https://openalex.org/S116174365","display_name":"Current Opinion in Genetics & Development","issn_l":"0959-437X","issn":["0959-437X","1879-0380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Genetics & Development","raw_type":"journal-article"},{"id":"pmid:9729721","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9729721","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in genetics & development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1515719112","https://openalex.org/W1529816420","https://openalex.org/W1553444759","https://openalex.org/W1554593075","https://openalex.org/W1589859980","https://openalex.org/W1607031549","https://openalex.org/W1609684706","https://openalex.org/W1672956489","https://openalex.org/W1816605246","https://openalex.org/W1858153082","https://openalex.org/W1879493681","https://openalex.org/W1968263279","https://openalex.org/W1983653653","https://openalex.org/W1984288177","https://openalex.org/W1988942273","https://openalex.org/W1989722096","https://openalex.org/W1990938412","https://openalex.org/W1992468405","https://openalex.org/W2011175428","https://openalex.org/W2015087426","https://openalex.org/W2024716141","https://openalex.org/W2025019677","https://openalex.org/W2033418096","https://openalex.org/W2036734848","https://openalex.org/W2044384686","https://openalex.org/W2044615295","https://openalex.org/W2048535898","https://openalex.org/W2055110202","https://openalex.org/W2057161685","https://openalex.org/W2059469320","https://openalex.org/W2063341347","https://openalex.org/W2065976288","https://openalex.org/W2070539534","https://openalex.org/W2080546144","https://openalex.org/W2082466352","https://openalex.org/W2093150604","https://openalex.org/W2093417867","https://openalex.org/W2094579915","https://openalex.org/W2099437303","https://openalex.org/W2099681945","https://openalex.org/W2107141327","https://openalex.org/W2117006120","https://openalex.org/W2125068279","https://openalex.org/W2127588196","https://openalex.org/W2130662470","https://openalex.org/W2132008353","https://openalex.org/W2145248956","https://openalex.org/W2145589640","https://openalex.org/W2150073419","https://openalex.org/W2156086003","https://openalex.org/W2165695219","https://openalex.org/W2185475290","https://openalex.org/W2189003807","https://openalex.org/W2294929520","https://openalex.org/W2296436253"],"related_works":["https://openalex.org/W2015272152","https://openalex.org/W2153336711","https://openalex.org/W2217868403","https://openalex.org/W2016465321","https://openalex.org/W2050727462","https://openalex.org/W3157149197","https://openalex.org/W152915302","https://openalex.org/W2079268771","https://openalex.org/W2025573933","https://openalex.org/W2333537887"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}