{"id":"https://openalex.org/W2071080249","doi":"https://doi.org/10.1016/j.sleep.2015.04.001","title":"Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial","display_name":"Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial","publication_year":2015,"publication_date":"2015-04-17","ids":{"openalex":"https://openalex.org/W2071080249","doi":"https://doi.org/10.1016/j.sleep.2015.04.001","mag":"2071080249","pmid":"https://pubmed.ncbi.nlm.nih.gov/26047892"},"language":"en","primary_location":{"id":"doi:10.1016/j.sleep.2015.04.001","doi":"https://doi.org/10.1016/j.sleep.2015.04.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.sleep.2015.04.001","pdf_url":null,"source":{"id":"https://openalex.org/S183718435","display_name":"Sleep Medicine","issn_l":"1389-9457","issn":["1389-9457","1878-5506"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055098749","display_name":"Neely Ivgy-May","orcid":"https://orcid.org/0000-0001-5155-4343","observed_orcids":["https://orcid.org/0000-0001-5155-4343"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Neely Ivgy-May","raw_affiliation_strings":["Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address: mayneely@gmail.com","Merck and Co Inc  Kenilworth NJ USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address: mayneely@gmail.com","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck and Co Inc  Kenilworth NJ USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035075101","display_name":"Frank Ruwe","orcid":"https://orcid.org/0009-0004-2831-2038","observed_orcids":["https://orcid.org/0009-0004-2831-2038"]},"institutions":[{"id":"https://openalex.org/I4210162999","display_name":"MSD (Netherlands)","ror":"https://ror.org/05y28vr04","country_code":"NL","type":"company","lineage":["https://openalex.org/I1285764155","https://openalex.org/I4210162999"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frank Ruwe","raw_affiliation_strings":["MSD, Oss, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MSD, Oss, The Netherlands","institution_ids":["https://openalex.org/I4210162999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042168269","display_name":"Andrew D. Krystal","orcid":"https://orcid.org/0000-0002-6702-781X","observed_orcids":["https://orcid.org/0000-0002-6702-781X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Krystal","raw_affiliation_strings":["Duke University, School of Medicine, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University, School of Medicine, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011832419","display_name":"Thomas G. Roth","orcid":"https://orcid.org/0000-0001-8309-4134","observed_orcids":["https://orcid.org/0000-0001-8309-4134"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Roth","raw_affiliation_strings":["Henry Ford Hospital, Detroit, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hospital, Detroit, MI, USA","institution_ids":["https://openalex.org/I2803043754"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5055098749"],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":{"value":4350,"currency":"USD","value_usd":4350},"apc_paid":null,"fwci":3.646,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.91895536,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"7","first_page":"838","last_page":"844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-insomnia","display_name":"primary insomnia","score":0.8270000219345093},{"id":"https://openalex.org/keywords/insomnia-treatment","display_name":"insomnia treatment","score":0.5740000009536743},{"id":"https://openalex.org/keywords/wake-after-sleep-onset","display_name":"wake after sleep onset","score":0.925000011920929},{"id":"https://openalex.org/keywords/sleep-onset-latency","display_name":"sleep latency","score":0.7369999885559082},{"id":"https://openalex.org/keywords/total-sleep-time","display_name":"total sleep time","score":0.8349999785423279},{"id":"https://openalex.org/keywords/5-ht2a-receptor-antagonist","display_name":"5-HT2A receptor antagonist","score":0.7440000176429749},{"id":"https://openalex.org/keywords/histamine-h1-receptor-antagonists","display_name":"histamine H1 receptor antagonists","score":0.9240000247955322},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6890000104904175},{"id":"https://openalex.org/keywords/rebound-insomnia","display_name":"rebound insomnia","score":0.7149999737739563},{"id":"https://openalex.org/keywords/sleep-quality","display_name":"sleep quality","score":0.6690000295639038},{"id":"https://openalex.org/keywords/nonelderly-adults","display_name":"non-elderly adults","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2910380747","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Primary Insomnia","level":4,"score":0.7888607978820801},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7809017896652222},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7370295524597168},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7366369366645813},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.6944077014923096},{"id":"https://openalex.org/C63759246","wikidata":"https://www.wikidata.org/wiki/Q7539762","display_name":"Sleep onset","level":3,"score":0.6839756965637207},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.6724320650100708},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5345361232757568},{"id":"https://openalex.org/C2781053850","wikidata":"https://www.wikidata.org/wiki/Q7539763","display_name":"Sleep onset latency","level":4,"score":0.5221255421638489},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4812454879283905},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.46612170338630676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42200514674186707},{"id":"https://openalex.org/C2778996325","wikidata":"https://www.wikidata.org/wiki/Q422201","display_name":"Actigraphy","level":3,"score":0.4217430055141449},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.29384559392929077},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08624020218849182},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000078785","descriptor_name":"Mirtazapine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007319","descriptor_name":"Sleep Initiation and Maintenance Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007319","descriptor_name":"Sleep Initiation and Maintenance Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008803","descriptor_name":"Mianserin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008803","descriptor_name":"Mianserin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008803","descriptor_name":"Mianserin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017060","descriptor_name":"Patient Satisfaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.sleep.2015.04.001","doi":"https://doi.org/10.1016/j.sleep.2015.04.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.sleep.2015.04.001","pdf_url":null,"source":{"id":"https://openalex.org/S183718435","display_name":"Sleep Medicine","issn_l":"1389-9457","issn":["1389-9457","1878-5506"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep Medicine","raw_type":"journal-article"},{"id":"pmid:26047892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26047892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307776","display_name":"Merck","ror":"https://ror.org/02891sr49"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W27463876","https://openalex.org/W88627979","https://openalex.org/W1970247745","https://openalex.org/W1973469708","https://openalex.org/W1977894152","https://openalex.org/W1985475522","https://openalex.org/W1985688315","https://openalex.org/W2011808456","https://openalex.org/W2025250287","https://openalex.org/W2029606206","https://openalex.org/W2067855826","https://openalex.org/W2071587244","https://openalex.org/W2072379598","https://openalex.org/W2081272758","https://openalex.org/W2086748723","https://openalex.org/W2091302209","https://openalex.org/W2095314797","https://openalex.org/W2100600420","https://openalex.org/W2104176708","https://openalex.org/W2119644947","https://openalex.org/W2141539363","https://openalex.org/W2162054698","https://openalex.org/W2162158634","https://openalex.org/W3127611755","https://openalex.org/W4231896431","https://openalex.org/W6656742480","https://openalex.org/W6671099320"],"related_works":["https://openalex.org/W2025250287","https://openalex.org/W2481418614","https://openalex.org/W3023070620","https://openalex.org/W3017220265","https://openalex.org/W3093496647","https://openalex.org/W1977894152","https://openalex.org/W2372851835","https://openalex.org/W2066580767","https://openalex.org/W2143433380","https://openalex.org/W4406424096"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}