{"id":"https://openalex.org/W2071068624","doi":"https://doi.org/10.1517/14712598.3.8.1215","title":"Haematopoietic cell transplantation in the treatment of sickle cell disease","display_name":"Haematopoietic cell transplantation in the treatment of sickle cell disease","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2071068624","doi":"https://doi.org/10.1517/14712598.3.8.1215","mag":"2071068624","pmid":"https://pubmed.ncbi.nlm.nih.gov/14640947"},"language":"en","primary_location":{"id":"doi:10.1517/14712598.3.8.1215","doi":"https://doi.org/10.1517/14712598.3.8.1215","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14712598.3.8.1215","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109197019","display_name":"Robert C. Atkins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert C Atkins","raw_affiliation_strings":["Children's Hospital and Research Center at Oakland, Blood and Marrow Transplantation Program, 747 52nd Street, Oakland, CA 94609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital and Research Center at Oakland, Blood and Marrow Transplantation Program, 747 52nd Street, Oakland, CA 94609, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040299600","display_name":"Mark C. Walters","orcid":"https://orcid.org/0000-0002-6515-4559","observed_orcids":["https://orcid.org/0000-0002-6515-4559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark C Walters","raw_affiliation_strings":["Children\u2019s Hospital & Research Center at Oakland, Blood and Marrow Transplantation Program, 747 52nd Street, Oakland, CA 94609, USA. mwalters@mail.cho.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital & Research Center at Oakland, Blood and Marrow Transplantation Program, 747 52nd Street, Oakland, CA 94609, USA. mwalters@mail.cho.org","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1085,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.10465116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"3","issue":"8","first_page":"1215","last_page":"1224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.04619999974966049,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9390000104904175},{"id":"https://openalex.org/keywords/allogeneic-haematopoietic-cell-transplantation","display_name":"allogeneic haematopoietic cell transplantation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hla-matched-sibling-donor","display_name":"matched sibling donor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/transplant-related-morbidity","display_name":"transplant-related morbidity","score":0.6859999895095825},{"id":"https://openalex.org/keywords/acute-chest-syndrome","display_name":"acute chest syndrome","score":0.9079999923706055},{"id":"https://openalex.org/keywords/vaso-occlusive-crisis","display_name":"vaso-occlusive crisis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hemoglobinopathies","display_name":"hemoglobinopathies","score":0.9350000023841858},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.842187762260437},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6674239635467529},{"id":"https://openalex.org/C2780976302","wikidata":"https://www.wikidata.org/wiki/Q4677915","display_name":"Acute chest syndrome","level":4,"score":0.6674002408981323},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6498236656188965},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.567051112651825},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5485565662384033},{"id":"https://openalex.org/C2993713153","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Hematopoietic cell","level":4,"score":0.4919562041759491},{"id":"https://openalex.org/C2779668550","wikidata":"https://www.wikidata.org/wiki/Q1642147","display_name":"Hemoglobinopathy","level":3,"score":0.4150873124599457},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3886513411998749},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38383254408836365},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.29668986797332764},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.29099780321121216},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1488431990146637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.061747968196868896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006453","descriptor_name":"Hemoglobinopathies","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006650","descriptor_name":"Histocompatibility Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014019","descriptor_name":"Tissue Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1517/14712598.3.8.1215","doi":"https://doi.org/10.1517/14712598.3.8.1215","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14712598.3.8.1215","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},{"id":"doi:10.1517/eobt.3.8.1215.21287","doi":"https://doi.org/10.1517/eobt.3.8.1215.21287","is_oa":false,"landing_page_url":"https://doi.org/10.1517/eobt.3.8.1215.21287","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},{"id":"pmid:14640947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14640947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on biological therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2693099098","display_name":null,"funder_award_id":"HL 68091","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6769809523","display_name":null,"funder_award_id":"HL 68177","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8931057634","display_name":"Induction of Stable Chimerism for Sickle Cell Anemia","funder_award_id":"U01HL068091","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W16054780","https://openalex.org/W118418797","https://openalex.org/W145680385","https://openalex.org/W176663286","https://openalex.org/W179330073","https://openalex.org/W196567407","https://openalex.org/W1508585281","https://openalex.org/W1565345042","https://openalex.org/W1597151660","https://openalex.org/W1976293536","https://openalex.org/W1979620570","https://openalex.org/W1982989569","https://openalex.org/W1989516517","https://openalex.org/W1997713243","https://openalex.org/W2014605437","https://openalex.org/W2025561889","https://openalex.org/W2032487385","https://openalex.org/W2042416746","https://openalex.org/W2058670553","https://openalex.org/W2063625476","https://openalex.org/W2066869496","https://openalex.org/W2077174747","https://openalex.org/W2082172298","https://openalex.org/W2083152756","https://openalex.org/W2085598706","https://openalex.org/W2086766106","https://openalex.org/W2095016051","https://openalex.org/W2109135798","https://openalex.org/W2111444354","https://openalex.org/W2127100465","https://openalex.org/W2133971325","https://openalex.org/W2141187979","https://openalex.org/W2147068163","https://openalex.org/W2147182596","https://openalex.org/W2151452421","https://openalex.org/W2153317915","https://openalex.org/W2165945045","https://openalex.org/W2214563359","https://openalex.org/W2313541759","https://openalex.org/W2314213298","https://openalex.org/W2315168906","https://openalex.org/W2317711008","https://openalex.org/W2323303736","https://openalex.org/W2323849691","https://openalex.org/W2324143840","https://openalex.org/W2327912446","https://openalex.org/W2330393631","https://openalex.org/W2330713242","https://openalex.org/W2334263927","https://openalex.org/W2335947470","https://openalex.org/W2336378782","https://openalex.org/W2339482838","https://openalex.org/W2409444339","https://openalex.org/W2412227310","https://openalex.org/W2417514869","https://openalex.org/W4292341608"],"related_works":["https://openalex.org/W2086766106","https://openalex.org/W2414594214","https://openalex.org/W7096632157","https://openalex.org/W1992294822","https://openalex.org/W4200421961","https://openalex.org/W2624685611","https://openalex.org/W2161887063","https://openalex.org/W3120893964","https://openalex.org/W2092625636","https://openalex.org/W2154323693"],"abstract_inverted_index":{"Allogeneic":[0],"haematopoietic":[1],"cell":[2,21],"transplantation":[3],"(HCT)":[4],"is":[5,101],"presently":[6],"the":[7,12,54,94],"only":[8],"treatment":[9],"which":[10],"offers":[11],"possibility":[13],"of":[14,27,56,69,80,96],"a":[15],"cure":[16],"for":[17,45,82,99],"patients":[18,28,46,98],"with":[19],"sickle":[20],"disease":[22],"(SCD).":[23],"While":[24],"approximately":[25],"84%":[26],"survive":[29],"disease-free":[30],"after":[31],"human":[32],"leukocyte":[33],"antigen":[34],"(HLA)-identical":[35],"sibling":[36],"donor":[37],"HCT,":[38],"this":[39],"therapy":[40],"has":[41],"traditionally":[42],"been":[43],"reserved":[44],"who":[47],"have":[48,65],"suffered":[49],"serious":[50],"complications":[51,64,89],"due":[52],"to":[53],"risk":[55],"transplant-related":[57,88],"morbidity":[58],"and":[59,76,92],"mortality.":[60],"Typically,":[61],"these":[62],"sickle-related":[63],"included":[66],"recurrent":[67,73],"episodes":[68,75],"acute":[70],"chest":[71],"syndrome,":[72],"vaso-occlusive":[74],"stroke.":[77],"The":[78],"future":[79],"HCT":[81,100],"haemoglobinopathies":[83],"undoubtedly":[84],"will":[85],"evolve":[86],"as":[87,93],"are":[90],"reduced":[91],"process":[95],"selecting":[97],"refined.":[102]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
