{"id":"https://openalex.org/W2071067115","doi":"https://doi.org/10.1111/j.1750-3639.2008.00233.x","title":"PI3K Signaling in Glioma\u2014Animal Models and Therapeutic Challenges","display_name":"PI3K Signaling in Glioma\u2014Animal Models and Therapeutic Challenges","publication_year":2008,"publication_date":"2008-12-03","ids":{"openalex":"https://openalex.org/W2071067115","doi":"https://doi.org/10.1111/j.1750-3639.2008.00233.x","mag":"2071067115","pmid":"https://pubmed.ncbi.nlm.nih.gov/19076776","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2614703"},"language":"en","primary_location":{"id":"doi:10.1111/j.1750-3639.2008.00233.x","doi":"https://doi.org/10.1111/j.1750-3639.2008.00233.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1750-3639.2008.00233.x","pdf_url":null,"source":{"id":"https://openalex.org/S9094144","display_name":"Brain Pathology","issn_l":"1015-6305","issn":["1015-6305","1750-3639"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2614703","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Christine K. Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christine K. Cheng","raw_affiliation_strings":["Department of Neurology, University of California, San Francisco, CA 94143, USA. ccheng@ucsf.edu","Departments of Neurology, Pediatrics, Neurological Surgery, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, Ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of California, San Francisco, CA 94143, USA. ccheng@ucsf.edu","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Departments of Neurology, Pediatrics, Neurological Surgery, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, Ca","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111811714","display_name":"Qiwen Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi\u2010Wen Fan","raw_affiliation_strings":["Departments of Neurology, Pediatrics, Neurological Surgery, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, Ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology, Pediatrics, Neurological Surgery, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, Ca","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073603294","display_name":"William A. Weiss","orcid":"https://orcid.org/0000-0003-2230-9132","observed_orcids":["https://orcid.org/0000-0003-2230-9132"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Weiss","raw_affiliation_strings":["Departments of Neurology, Pediatrics, Neurological Surgery, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, Ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology, Pediatrics, Neurological Surgery, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, Ca","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"],"apc_list":{"value":4080,"currency":"USD","value_usd":4080},"apc_paid":null,"fwci":0.864,"has_fulltext":false,"cited_by_count":123,"citation_normalized_percentile":{"value":0.63230922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"19","issue":"1","first_page":"112","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.04580000042915344,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/pten-loss","display_name":"PTEN loss","score":0.996999979019165},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.8799999952316284},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pi3k-regulatory-subunit","display_name":"PI3K regulatory subunit","score":0.7160000205039978},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.7160000205039978},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6050000190734863},{"id":"https://openalex.org/keywords/survival-pathways","display_name":"survival pathways","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8686714172363281},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.8481442332267761},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6376924514770508},{"id":"https://openalex.org/C2781465904","wikidata":"https://www.wikidata.org/wiki/Q14887700","display_name":"P110\u03b1","level":4,"score":0.6087728142738342},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5886217355728149},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5880078077316284},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5845431089401245},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5267464518547058},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5113982558250427},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46015504002571106},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.4536724090576172},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4250243604183197},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37298348546028137},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16505751013755798}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1750-3639.2008.00233.x","doi":"https://doi.org/10.1111/j.1750-3639.2008.00233.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1750-3639.2008.00233.x","pdf_url":null,"source":{"id":"https://openalex.org/S9094144","display_name":"Brain Pathology","issn_l":"1015-6305","issn":["1015-6305","1750-3639"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2614703","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2614703","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathol","raw_type":"Text"},{"id":"pmid:19076776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19076776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain pathology (Zurich, Switzerland)","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2614703","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2614703","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2338490138","display_name":"Medulloblastoma and Metastases","funder_award_id":"R01CA148699","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2841975085","display_name":"Biology and Therapy of High Risk Neuroblastoma","funder_award_id":"P01CA081403","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G287607767","display_name":"Murine Neuroblastoma Models for Preclinical Therapeutics","funder_award_id":"R01CA102321","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4009198825","display_name":"Modifiers of Tumor Susceptibility in Murine Neuroblastoma","funder_award_id":"R01NS055750","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G722582395","display_name":"Mycn and Medulloblastoma","funder_award_id":"R01CA133091","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1523062737","https://openalex.org/W1545503281","https://openalex.org/W1567219202","https://openalex.org/W1908619062","https://openalex.org/W1964353872","https://openalex.org/W1970101770","https://openalex.org/W1971333358","https://openalex.org/W1974128502","https://openalex.org/W1975381965","https://openalex.org/W1977443562","https://openalex.org/W1978981032","https://openalex.org/W1980792888","https://openalex.org/W1984621921","https://openalex.org/W1988242880","https://openalex.org/W1991761103","https://openalex.org/W2009886463","https://openalex.org/W2017499074","https://openalex.org/W2017635846","https://openalex.org/W2025183726","https://openalex.org/W2030645014","https://openalex.org/W2030899725","https://openalex.org/W2033999408","https://openalex.org/W2034691869","https://openalex.org/W2039179232","https://openalex.org/W2040827479","https://openalex.org/W2042142977","https://openalex.org/W2043696829","https://openalex.org/W2046571983","https://openalex.org/W2049786372","https://openalex.org/W2051994565","https://openalex.org/W2064720809","https://openalex.org/W2065447875","https://openalex.org/W2070841378","https://openalex.org/W2074571771","https://openalex.org/W2077582389","https://openalex.org/W2078102222","https://openalex.org/W2079517811","https://openalex.org/W2082209726","https://openalex.org/W2086329101","https://openalex.org/W2087693130","https://openalex.org/W2090748725","https://openalex.org/W2090940799","https://openalex.org/W2100385704","https://openalex.org/W2103894337","https://openalex.org/W2104743043","https://openalex.org/W2109467838","https://openalex.org/W2118029488","https://openalex.org/W2118469376","https://openalex.org/W2119683782","https://openalex.org/W2119785019","https://openalex.org/W2121727754","https://openalex.org/W2124593509","https://openalex.org/W2124937542","https://openalex.org/W2125096000","https://openalex.org/W2125915186","https://openalex.org/W2129012919","https://openalex.org/W2129172946","https://openalex.org/W2134818675","https://openalex.org/W2137124072","https://openalex.org/W2137618229","https://openalex.org/W2139270233","https://openalex.org/W2144323242","https://openalex.org/W2145497092","https://openalex.org/W2156216950","https://openalex.org/W2158305336","https://openalex.org/W2159566901","https://openalex.org/W2159717790","https://openalex.org/W2161810908","https://openalex.org/W2164139183","https://openalex.org/W2167656141","https://openalex.org/W2260076009","https://openalex.org/W2318605753","https://openalex.org/W4243898144"],"related_works":["https://openalex.org/W7098143149","https://openalex.org/W2017786941","https://openalex.org/W12210807","https://openalex.org/W2102509984","https://openalex.org/W6887890368","https://openalex.org/W1976203358","https://openalex.org/W7100324548","https://openalex.org/W2030645014","https://openalex.org/W4250570596","https://openalex.org/W2772818192"],"abstract_inverted_index":{"The":[0,77,109],"PI3":[1],"kinase":[2],"(PI3K)":[3],"family":[4],"plays":[5],"a":[6,69],"complex":[7],"role":[8],"in":[9,21,31,60,115,130],"cell":[10],"biology":[11],"and":[12,42,55,62,75],"metabolism.":[13],"Signaling":[14],"through":[15],"the":[16,50,53,107,121],"PI3Ks":[17],"is":[18,67],"frequently":[19],"activated":[20],"many":[22],"human":[23],"cancers,":[24],"including":[25],"glioblastoma,":[26],"because":[27],"of":[28,35,52,58,65,72,80,95,111],"gain-of-function":[29],"mutations":[30],"PIK3CA":[32],"or":[33],"loss":[34],"PTEN.":[36],"Experiments":[37],"involving":[38],"genetic":[39],"mouse":[40],"models":[41],"small":[43],"molecule":[44],"inhibitors":[45,89],"have":[46],"helped":[47],"to":[48,92,105,117,123],"elucidate":[49],"roles":[51],"regulatory":[54],"catalytic":[56],"subunits":[57],"PI3K":[59,66,84,88,118],"metabolism":[61],"cancer.":[63],"Downstream":[64],"Akt,":[68],"critical":[70],"effector":[71],"growth,":[73],"proliferation":[74],"survival.":[76],"suggested":[78],"dependence":[79],"glioblastoma":[81],"tumors":[82],"on":[83],"signaling":[85],"implies":[86],"that":[87,100,127],"should":[90],"lead":[91],"effective":[93],"killing":[94],"these":[96],"cancer":[97,131],"cells,":[98],"but":[99],"has":[101],"been":[102],"shown":[103],"not":[104],"be":[106],"case.":[108],"engagement":[110],"other":[112],"survival":[113],"pathways":[114],"response":[116],"inhibition":[119],"prompts":[120],"need":[122],"develop":[124],"combination":[125],"therapies":[126],"promote":[128],"cytotoxicity":[129],"cells.":[132]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}