{"id":"https://openalex.org/W2071064342","doi":"https://doi.org/10.1159/000123900","title":"The Role of Thyroid Hormone Deiodination in the Regulation of Hypothalamo-Pituitary Function","display_name":"The Role of Thyroid Hormone Deiodination in the Regulation of Hypothalamo-Pituitary Function","publication_year":2008,"publication_date":"2008-03-28","ids":{"openalex":"https://openalex.org/W2071064342","doi":"https://doi.org/10.1159/000123900","mag":"2071064342","pmid":"https://pubmed.ncbi.nlm.nih.gov/6371572"},"language":"en","primary_location":{"id":"doi:10.1159/000123900","doi":"https://doi.org/10.1159/000123900","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000123900","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109048556","display_name":"Michael M. Kaplan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael M. Kaplan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109048556"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9771,"has_fulltext":false,"cited_by_count":127,"citation_normalized_percentile":{"value":0.78406829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"38","issue":"3","first_page":"254","last_page":"260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-hormone-deiodination","display_name":"thyroid hormone deiodination","score":0.9810000061988831},{"id":"https://openalex.org/keywords/type-2-deiodinase","display_name":"type 2 deiodinase","score":0.843999981880188},{"id":"https://openalex.org/keywords/thyroxine-to-triiodothyronine-conversion","display_name":"thyroxine to triiodothyronine conversion","score":0.890999972820282},{"id":"https://openalex.org/keywords/reverse-t3","display_name":"reverse T3","score":0.7990000247955322},{"id":"https://openalex.org/keywords/diiodothyronine","display_name":"diiodothyronine","score":0.8479999899864197},{"id":"https://openalex.org/keywords/anterior-pituitary","display_name":"anterior pituitary","score":0.8190000057220459},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9829999804496765},{"id":"https://openalex.org/keywords/thyrotropin-release","display_name":"thyrotropin release","score":0.7770000100135803},{"id":"https://openalex.org/keywords/growth-hormone-synthesis","display_name":"growth hormone synthesis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/iopanoic-acid","display_name":"iopanoic acid","score":0.9430000185966492},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.9940000176429749},{"id":"https://openalex.org/keywords/thyroid-hormone-deficiency","display_name":"thyroid hormone deficiency","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9019248485565186},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8843733072280884},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.711331844329834},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6934171915054321},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.6819400787353516},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.6786972284317017},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.6486767530441284},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.5661963224411011},{"id":"https://openalex.org/C2776216936","wikidata":"https://www.wikidata.org/wiki/Q24726011","display_name":"Thyrotropin-releasing hormone","level":3,"score":0.5619140267372131},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.5609425902366638},{"id":"https://openalex.org/C182203180","wikidata":"https://www.wikidata.org/wiki/Q324663","display_name":"Endocrine gland","level":3,"score":0.4291008710861206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4137660562992096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40990620851516724},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20440438389778137}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007453","descriptor_name":"Iodide Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008473","descriptor_name":"Median Eminence","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014285","descriptor_name":"Triiodothyronine, Reverse","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000123900","doi":"https://doi.org/10.1159/000123900","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000123900","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},{"id":"pmid:6371572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6371572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2417175990","https://openalex.org/W7095601913","https://openalex.org/W1999347033","https://openalex.org/W2185913682","https://openalex.org/W2120821732","https://openalex.org/W2462074385","https://openalex.org/W2080471601","https://openalex.org/W2138160942","https://openalex.org/W1989906163","https://openalex.org/W7096710070"],"abstract_inverted_index":{"There":[0],"is":[1,31,42,122,175,301],"extensive":[2],"deiodinative":[3],"metabolism":[4],"of":[5,24,39,47,75,111,147,160,186,214,221,223,245,307,309,315,317],"thyroxine":[6],"(T4)":[7],"in":[8,28,129,134,164,168,177,184,189,204,212,226,230,233,248,281,298],"thyroid":[9,35,48,200,224,259,318],"hormone":[10,49,156,225,260,311],"target":[11],"organs,":[12],"including":[13,202],"the":[14,25,29,34,43,53,93,103,107,117,125,130,135,138,145,165,173,178,227,231,249,282,285],"pituitary":[15,105,250,310],"and":[16,21,69,71,79,96,106,153,181,206,210,216,229,251,276,313],"brain.":[17],"In":[18,52],"both":[19,305],"rat":[20],"man,":[22],"most":[23,110],"3,3\u2019,5-triiodothyronine":[26],"(T3)":[27],"body":[30],"produced":[32],"outside":[33],"gland":[36],"by":[37,67,116,284],"deiodination":[38,139,247,264,270],"T4.":[40],"T3":[41,97,114,163,274],"principal":[44],"active":[45],"form":[46],"within":[50],"cells.":[51],"rat,":[54,136],"there":[55],"are":[56,235,241],"at":[57],"least":[58],"three":[59],"enzymatic":[60],"iodothyronine-deiodinating":[61],"pathways":[62],"which":[63],"can":[64,81],"be":[65],"distinguished":[66],"kinetics":[68],"substrate":[70],"inhibitor":[72,140],"specificities.":[73],"Two":[74],"these":[76],"(types":[77],"I":[78],"II)":[80],"convert":[82],"T4":[83,91,148,161],"to":[84,92,98,149,162,199,271,303],"T3.The":[85],"third":[86],"pathway":[87,287],"(type":[88],"III)":[89],"converts":[90],"inactive":[94,100],"reverse-T3":[95,279],"an":[99],"diiodothyronine.":[101],"Both":[102],"anterior":[104,131],"brain":[108,232,273,283],"produce":[109],"their":[112],"intracellular":[113],"locally,":[115],"type-II":[118,215,246,269],"pathway.":[119],"Type-Ill":[120],"activity":[121],"present":[123],"throughout":[124],"brain,":[126],"but":[127],"not":[128,236],"pituitary.":[132,166],"Studies":[133,167],"using":[137],"iopanoic":[141],"acid,":[142],"show":[143],"that":[144,172,243,262,277],"capacities":[146],"inhibit":[150],"thyrotropin":[151],"release":[152],"stimulate":[154],"growth":[155],"synthesis":[157],"require":[158],"conversion":[159],"man":[169,185],"strongly":[170],"suggest":[171],"same":[174],"true":[176],"human":[179],"adenohypophysis,":[180],"a":[182,187,256],"syndrome":[183],"deficiency":[188],"this":[190,299],"process":[191],"possibly":[192],"exists.":[193],"The":[194,219],"hypothalamus":[195,252],"exhibits":[196],"some":[197],"responses":[198],"hormone,":[201],"changes":[203,211],"somatostatin":[205],"substance":[207],"P":[208],"content":[209],"activities":[213],"III":[217],"deiodination.":[218],"mechanism(s)":[220],"action":[222,316],"hypothalamus,":[228],"general,":[234],"yet":[237,292],"well":[238],"understood.":[239],"Speculations":[240],"advanced":[242],"modulation":[244],"could":[253,265],"serve":[254],"as":[255,291],"defense":[257],"against":[258],"deficiency,":[261],"type-Ill":[263],"act":[266],"together":[267],"with":[268],"control":[272,308],"content,":[275],"local":[278],"production":[280],"type-III":[286],"might":[288],"have":[289],"some,":[290],"unidentified,":[293],"physiological":[294],"significance.":[295],"Further":[296],"work":[297],"field":[300],"likely":[302],"elucidate":[304],"mechanisms":[306,314],"secretion":[312],"hormone.":[319]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}