{"id":"https://openalex.org/W2071050165","doi":"https://doi.org/10.1371/journal.ppat.1004030","title":"Microbial Pathogens Trigger Host DNA Double-Strand Breaks Whose Abundance Is Reduced by Plant Defense Responses","display_name":"Microbial Pathogens Trigger Host DNA Double-Strand Breaks Whose Abundance Is Reduced by Plant Defense Responses","publication_year":2014,"publication_date":"2014-04-03","ids":{"openalex":"https://openalex.org/W2071050165","doi":"https://doi.org/10.1371/journal.ppat.1004030","mag":"2071050165","pmid":"https://pubmed.ncbi.nlm.nih.gov/24699527","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3974866"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1004030","doi":"https://doi.org/10.1371/journal.ppat.1004030","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004030","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004030&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004030&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035859391","display_name":"Junqi Song","orcid":"https://orcid.org/0000-0002-2555-3408","observed_orcids":["https://orcid.org/0000-0002-2555-3408","https://orcid.org/0009-0008-8336-7006"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junqi Song","raw_affiliation_strings":["Department of Plant Pathology, University of Wisconsin - Madison, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Pathology, University of Wisconsin - Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020822578","display_name":"Andrew F. Bent","orcid":"https://orcid.org/0000-0001-6610-9525","observed_orcids":["https://orcid.org/0000-0001-6610-9525"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew F. Bent","raw_affiliation_strings":["Department of Plant Pathology, University of Wisconsin - Madison, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Pathology, University of Wisconsin - Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020822578"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":12.8983,"has_fulltext":true,"cited_by_count":113,"citation_normalized_percentile":{"value":0.99039924,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"10","issue":"4","first_page":"e1004030","last_page":"e1004030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11578","display_name":"Plant Pathogenic Bacteria Studies","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-syringae-pv-tomato","display_name":"Pseudomonas syringae pv. tomato","score":0.9240000247955322},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.8610000014305115},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7879999876022339},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.7580000162124634},{"id":"https://openalex.org/keywords/salicylic-acid","display_name":"salicylic acid","score":0.7210000157356262},{"id":"https://openalex.org/keywords/jasmonic-acid","display_name":"jasmonic acid","score":0.890999972820282},{"id":"https://openalex.org/keywords/npr1","display_name":"NPR1","score":0.8090000152587891},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7319999933242798},{"id":"https://openalex.org/keywords/plant-immunity","display_name":"plant immunity","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8396605253219604},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7546560168266296},{"id":"https://openalex.org/C2780381237","wikidata":"https://www.wikidata.org/wiki/Q311202","display_name":"Pseudomonas syringae","level":3,"score":0.662155032157898},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.5821583867073059},{"id":"https://openalex.org/C2779080361","wikidata":"https://www.wikidata.org/wiki/Q415311","display_name":"Jasmonic acid","level":3,"score":0.5440738201141357},{"id":"https://openalex.org/C200148052","wikidata":"https://www.wikidata.org/wiki/Q5958568","display_name":"Hypersensitive response","level":4,"score":0.5131045579910278},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.468569278717041},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.45458707213401794},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.41873428225517273},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3712049722671509},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.366332471370697},{"id":"https://openalex.org/C2778221352","wikidata":"https://www.wikidata.org/wiki/Q193572","display_name":"Salicylic acid","level":2,"score":0.3220394253730774},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.26083308458328247},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25634628534317017},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.22317296266555786},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16354599595069885},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.10288593173027039}],"mesh":[{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010935","descriptor_name":"Plant Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010935","descriptor_name":"Plant Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018744","descriptor_name":"DNA, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018744","descriptor_name":"DNA, Plant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044224","descriptor_name":"Pseudomonas syringae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.ppat.1004030","doi":"https://doi.org/10.1371/journal.ppat.1004030","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004030","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004030&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2960750","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3974866","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24699527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24699527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3974866","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3974866/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.788.6952","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.788.6952","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c3/49/ppat.1004030.PMC3974866.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:855b49fdc0014b259c83f3bc90145882","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/855b49fdc0014b259c83f3bc90145882","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 10, Iss 4, p e1004030 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/986345","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Microbial_Pathogens_Trigger_Host_DNA_Double_Strand_Breaks_Whose_Abundance_Is_Reduced_by_Plant_Defense_Responses_/986345","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1004030","doi":"https://doi.org/10.1371/journal.ppat.1004030","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004030","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004030&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G245096775","display_name":"Poly (ADP-ribosyl)ation in Plant Responses to Pathogens","funder_award_id":"1022397","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071050165.pdf","grobid_xml":"https://content.openalex.org/works/W2071050165.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W63478407","https://openalex.org/W1490085827","https://openalex.org/W1520434148","https://openalex.org/W1542991358","https://openalex.org/W1913575892","https://openalex.org/W1969464492","https://openalex.org/W1970503468","https://openalex.org/W1975359899","https://openalex.org/W1978459114","https://openalex.org/W1980137739","https://openalex.org/W1980815569","https://openalex.org/W1985050464","https://openalex.org/W1985775217","https://openalex.org/W1987527386","https://openalex.org/W1991327249","https://openalex.org/W1991615875","https://openalex.org/W1997857978","https://openalex.org/W1998180584","https://openalex.org/W1998499862","https://openalex.org/W2008185037","https://openalex.org/W2009202775","https://openalex.org/W2010854320","https://openalex.org/W2012759709","https://openalex.org/W2026621373","https://openalex.org/W2030206081","https://openalex.org/W2030593279","https://openalex.org/W2030763718","https://openalex.org/W2034028219","https://openalex.org/W2041211295","https://openalex.org/W2041366235","https://openalex.org/W2041656651","https://openalex.org/W2045188502","https://openalex.org/W2045446234","https://openalex.org/W2050089738","https://openalex.org/W2051193631","https://openalex.org/W2059555945","https://openalex.org/W2059971395","https://openalex.org/W2062084967","https://openalex.org/W2062453241","https://openalex.org/W2065064903","https://openalex.org/W2066422357","https://openalex.org/W2071041070","https://openalex.org/W2073181394","https://openalex.org/W2075479850","https://openalex.org/W2077436902","https://openalex.org/W2081184882","https://openalex.org/W2081760732","https://openalex.org/W2082249342","https://openalex.org/W2089643849","https://openalex.org/W2090374605","https://openalex.org/W2096923819","https://openalex.org/W2097317013","https://openalex.org/W2097656283","https://openalex.org/W2104767298","https://openalex.org/W2106424272","https://openalex.org/W2108650254","https://openalex.org/W2109960177","https://openalex.org/W2112817646","https://openalex.org/W2113117904","https://openalex.org/W2116788801","https://openalex.org/W2117396466","https://openalex.org/W2117779598","https://openalex.org/W2117807796","https://openalex.org/W2118514901","https://openalex.org/W2121501444","https://openalex.org/W2122478791","https://openalex.org/W2125208091","https://openalex.org/W2128252882","https://openalex.org/W2129742189","https://openalex.org/W2132459109","https://openalex.org/W2137390279","https://openalex.org/W2137871007","https://openalex.org/W2138323191","https://openalex.org/W2139742148","https://openalex.org/W2140302681","https://openalex.org/W2143057647","https://openalex.org/W2143382538","https://openalex.org/W2145200068","https://openalex.org/W2148937130","https://openalex.org/W2150328349","https://openalex.org/W2153047151","https://openalex.org/W2153536602","https://openalex.org/W2159827069","https://openalex.org/W2160801475","https://openalex.org/W2161031307","https://openalex.org/W2162059428","https://openalex.org/W2162888767","https://openalex.org/W2164671653","https://openalex.org/W2169439222","https://openalex.org/W2171788269","https://openalex.org/W2172027477","https://openalex.org/W2184448971","https://openalex.org/W2323754190","https://openalex.org/W3160305883"],"related_works":["https://openalex.org/W7095752009","https://openalex.org/W4387073037","https://openalex.org/W2470509468","https://openalex.org/W4390414936","https://openalex.org/W1583647338","https://openalex.org/W2140007159","https://openalex.org/W4403503226","https://openalex.org/W4378783054","https://openalex.org/W2039053553","https://openalex.org/W2984132607"],"abstract_inverted_index":{"Immune":[0],"responses":[1],"and":[2,29,81,108,154,206,209],"DNA":[3,42,50,105,122,194,244],"damage":[4,43,123],"repair":[5],"are":[6,103],"two":[7],"fundamental":[8],"processes":[9],"that":[10,25,130,185],"have":[11],"been":[12,115],"characterized":[13],"extensively,":[14],"but":[15],"the":[16,56,109,144,147,178,227,260],"links":[17],"between":[18],"them":[19],"remain":[20],"largely":[21],"unknown.":[22],"We":[23],"report":[24],"multiple":[26],"bacterial,":[27],"fungal":[28],"oomycete":[30],"plant":[31,40,99,243],"pathogen":[32,186],"species":[33,94],"induce":[34,88,171,242],"double-strand":[35],"breaks":[36],"(DSBs)":[37],"in":[38,124,133,135,143,177,221,265],"host":[39,111,121,189],"DNA.":[41],"detected":[44],"by":[45,60,152,203,210],"histone":[46],"\u03b3-H2AX":[47,218],"abundance":[48,197],"or":[49,160,166],"comet":[51],"assays":[52],"arose":[53],"hours":[54],"before":[55],"disease-associated":[57],"necrosis":[58],"caused":[59],"virulent":[61],"Pseudomonas":[62,82],"syringae":[63,139],"pv.":[64],"tomato.":[65],"Necrosis-inducing":[66],"paraquat":[67],"did":[68,86],"not":[69,87],"cause":[70,119,192],"detectable":[71,173],"DSBs":[72,176,200],"at":[73],"similar":[74],"stages":[75],"after":[76],"application.":[77],"Non-pathogenic":[78],"E.":[79],"coli":[80],"fluorescens":[83],"bacteria":[84],"also":[85],"DSBs.":[89],"Elevation":[90],"of":[91,120,146,162,175,180,198,217,229,233,262],"reactive":[92],"oxygen":[93],"(ROS)":[95],"is":[96],"common":[97],"during":[98],"immune":[100],"responses,":[101],"ROS":[102,112],"known":[104],"damaging":[106],"agents,":[107],"infection-induced":[110,193,199],"burst":[113,150],"has":[114],"implicated":[116],"as":[117],"a":[118,172],"animal":[125],"studies.":[126],"However,":[127],"we":[128],"found":[129],"DSB":[131],"formation":[132,216],"Arabidopsis":[134,222],"response":[136],"to":[137,170,250,259],"P.":[138],"infection":[140],"still":[141,219],"occurs":[142],"absence":[145,179],"infection-associated":[148],"oxidative":[149],"mediated":[151],"AtrbohD":[153],"AtrbohF.":[155],"Plant":[156,246],"MAMP":[157],"receptor":[158],"stimulation":[159],"application":[161],"defense-activating":[163],"salicylic":[164,204],"acid":[165,168,205],"jasmonic":[167],"failed":[169],"level":[174],"introduced":[181],"pathogens,":[182],"further":[183],"suggesting":[184,226],"activities":[187],"beyond":[188],"defense":[190,247],"activation":[191],"damage.":[195,245],"The":[196],"was":[201],"reduced":[202],"NPR1-mediated":[207],"defenses,":[208],"certain":[211],"R":[212],"gene-mediated":[213],"defenses.":[214],"Infection-induced":[215],"occurred":[220],"atr/atm":[223],"double":[224],"mutants,":[225],"presence":[228],"an":[230],"alternative":[231],"mediator":[232],"pathogen-induced":[234],"H2AX":[235],"phosphorylation.":[236],"In":[237],"summary,":[238],"pathogenic":[239],"microorganisms":[240],"can":[241],"mechanisms":[248],"help":[249],"suppress":[251],"rather":[252],"than":[253],"promote":[254],"this":[255],"damage,":[256],"thereby":[257],"contributing":[258],"maintenance":[261],"genome":[263],"integrity":[264],"somatic":[266],"tissues.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
